 Multidrug Resistance-Associated Proteins
"Multidrug Resistance-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
| Descriptor ID |
D027425
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| MeSH Number(s) |
D12.776.157.530.100.304 D12.776.157.530.450.074.500.500.500 D12.776.543.585.100.304 D12.776.543.585.450.074.500.500.500
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| Concept/Terms |
Multidrug Resistance-Associated Proteins- Multidrug Resistance-Associated Proteins
- Multidrug Resistance Associated Proteins
- Multispecific Organic Anion Transporter
- Multidrug Resistance-Associated Protein
- Multidrug Resistance Associated Protein
- Resistance-Associated Protein, Multidrug
- Multispecific Organic Anion Transport Proteins
- ATP-Binding Cassette, Sub-Family C Proteins
- ATP Binding Cassette, Sub Family C Proteins
- MOAT Protein
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Below are MeSH descriptors whose meaning is more general than "Multidrug Resistance-Associated Proteins".
Below are MeSH descriptors whose meaning is more specific than "Multidrug Resistance-Associated Proteins".
This graph shows the total number of publications written about "Multidrug Resistance-Associated Proteins" by people in UAMS Profiles by year, and whether "Multidrug Resistance-Associated Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2017 | 1 | 0 | 1 | | 2015 | 2 | 1 | 3 | | 2013 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 |
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Below are the most recent publications written about "Multidrug Resistance-Associated Proteins" by people in Profiles over the past ten years.
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Ideozu JE, Zhang X, Pan A, Ashrafi Z, Woods KJ, Hessner MJ, Simpson P, Levy H. Increased Expression of Plasma-Induced ABCC1 mRNA in Cystic Fibrosis. Int J Mol Sci. 2017 Aug 11; 18(8).
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Redan BW, Chegeni M, Ferruzzi MG. Differentiated Caco-2 cell monolayers exhibit adaptation in the transport and metabolism of flavan-3-ols with chronic exposure to both isolated flavan-3-ols and enriched extracts. Food Funct. 2017 Jan 25; 8(1):111-121.
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Zhang W, Deng J, Sunkara M, Morris AJ, Wang C, St Clair D, Vore M. Loss of multidrug resistance-associated protein 1 potentiates chronic doxorubicin-induced cardiac dysfunction in mice. J Pharmacol Exp Ther. 2015 Nov; 355(2):280-7.
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Deng J, Coy D, Zhang W, Sunkara M, Morris AJ, Wang C, Chaiswing L, St Clair D, Vore M, Jungsuwadee P. Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice. J Pharmacol Exp Ther. 2015 Nov; 355(2):272-9.
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Mathias TJ, Natarajan K, Shukla S, Doshi KA, Singh ZN, Ambudkar SV, Baer MR. The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations. Invest New Drugs. 2015 Apr; 33(2):300-9.
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