Zalcitabine
"Zalcitabine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
| Descriptor ID |
D016047
|
| MeSH Number(s) |
D03.383.742.680.245.500.950 D13.570.230.329.950 D13.570.230.500.925 D13.570.685.245.500.950
|
| Concept/Terms |
Zalcitabine- Zalcitabine
- Dideoxycytidine
- 2',3'-Dideoxycytidine
- 2',3' Dideoxycytidine
- ddC (Antiviral)
Hivid- Hivid
- Roche Brand of Zalcitabine
- Hoffman-La Roche Brand of Zalcitabine
- HIVID Roche
|
Below are MeSH descriptors whose meaning is more general than "Zalcitabine".
Below are MeSH descriptors whose meaning is more specific than "Zalcitabine".
This graph shows the total number of publications written about "Zalcitabine" by people in UAMS Profiles by year, and whether "Zalcitabine" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zalcitabine" by people in Profiles over the past ten years.
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Yu D, Green B, Marrone A, Guo Y, Kadlubar S, Lin D, Fuscoe J, Pogribny I, Ning B. Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma. Sci Rep. 2015 Feb 23; 5:8534.