Dideoxyadenosine
"Dideoxyadenosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
| Descriptor ID |
D016048
|
| MeSH Number(s) |
D03.438.759.590.138.325.105 D13.570.230.229.105 D13.570.230.500.105 D13.570.583.138.325.105
|
| Concept/Terms |
Dideoxyadenosine- Dideoxyadenosine
- 2',3'-Dideoxyadenosine
- 2',3' Dideoxyadenosine
- ddA (Antiviral)
|
Below are MeSH descriptors whose meaning is more general than "Dideoxyadenosine".
Below are MeSH descriptors whose meaning is more specific than "Dideoxyadenosine".
This graph shows the total number of publications written about "Dideoxyadenosine" by people in UAMS Profiles by year, and whether "Dideoxyadenosine" was a major or minor topic of these publications.
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Below are the most recent publications written about "Dideoxyadenosine" by people in Profiles over the past ten years.