 Inhibitor of Apoptosis Proteins
"Inhibitor of Apoptosis Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.
| Descriptor ID |
D051034
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| MeSH Number(s) |
D12.644.360.075.437 D12.776.476.075.437
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| Concept/Terms |
Inhibitor of Apoptosis Proteins- Inhibitor of Apoptosis Proteins
- Apoptosis Proteins Inhibitor
- Inhibitor-Of-Apoptosis Protein
- Inhibitor Of Apoptosis Protein
- Baculoviral Inhibitor Of Apoptosis Repeat Proteins
- IAP Protein (Apoptosis)
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Below are MeSH descriptors whose meaning is more general than "Inhibitor of Apoptosis Proteins".
Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Apoptosis Proteins".
This graph shows the total number of publications written about "Inhibitor of Apoptosis Proteins" by people in UAMS Profiles by year, and whether "Inhibitor of Apoptosis Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2020 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2013 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2007 | 0 | 3 | 3 | | 2006 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inhibitor of Apoptosis Proteins" by people in Profiles over the past ten years.
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Zhang X, He Y, Zhang P, Budamagunta V, Lv D, Thummuri D, Yang Y, Pei J, Yuan Y, Zhou D, Zheng G. Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines. Eur J Med Chem. 2020 Aug 01; 199:112397.
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Gurram B, Hammelev E, Syverson G, Haribhai D, Yan K, Simpson P, Salzman N, Verbsky JW. Intact Regulatory T-Cell Function but Defective Generation of IL-17A-Producing CD4+ T Cells in XIAP Deficiency. J Pediatr Gastroenterol Nutr. 2016 08; 63(2):218-25.
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Trotter TN, Li M, Pan Q, Peker D, Rowan PD, Li J, Zhan F, Suva LJ, Javed A, Yang Y. Myeloma cell-derived Runx2 promotes myeloma progression in bone. Blood. 2015 Jun 04; 125(23):3598-608.
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