 Host-Pathogen Interactions
"Host-Pathogen Interactions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The interactions between a host and a pathogen, usually resulting in disease.
| Descriptor ID |
D054884
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| MeSH Number(s) |
G06.590.470 G16.100.380
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| Concept/Terms |
Host-Pathogen Interactions- Host-Pathogen Interactions
- Host Pathogen Interactions
- Host-Pathogen Interaction
- Interaction, Host-Pathogen
- Interactions, Host-Pathogen
- Pathogen-Host Interactions
- Interaction, Pathogen-Host
- Interactions, Pathogen-Host
- Pathogen Host Interactions
- Pathogen-Host Interaction
- Host-Pathogen Relations
- Host Pathogen Relations
- Host-Pathogen Relation
- Relation, Host-Pathogen
- Relations, Host-Pathogen
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Below are MeSH descriptors whose meaning is more general than "Host-Pathogen Interactions".
Below are MeSH descriptors whose meaning is more specific than "Host-Pathogen Interactions".
This graph shows the total number of publications written about "Host-Pathogen Interactions" by people in UAMS Profiles by year, and whether "Host-Pathogen Interactions" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 1 | 2 | | 2022 | 1 | 1 | 2 | | 2021 | 4 | 7 | 11 | | 2020 | 3 | 8 | 11 | | 2019 | 5 | 7 | 12 | | 2018 | 3 | 2 | 5 | | 2017 | 0 | 4 | 4 | | 2016 | 6 | 2 | 8 | | 2015 | 3 | 4 | 7 | | 2014 | 4 | 4 | 8 | | 2013 | 5 | 1 | 6 | | 2012 | 3 | 1 | 4 | | 2011 | 3 | 2 | 5 | | 2010 | 1 | 4 | 5 | | 2009 | 2 | 3 | 5 |
To return to the timeline, click here.
Below are the most recent publications written about "Host-Pathogen Interactions" by people in Profiles over the past ten years.
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Venugopal G, Pechous RD. Yersinia pestis and pneumonic plague: Insight into how a lethal pathogen interfaces with innate immune populations in the lung to cause severe disease. Cell Immunol. 2024 Sep-Oct; 403-404:104856.
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Andrews JT, Zhang Z, Prasad GVRK, Huey F, Nazarova EV, Wang J, Ranaraja A, Weinkopff T, Li LX, Mu S, Birrer MJ, Huang SC, Zhang N, Arg?ello RJ, Philips JA, Mattila JT, Huang L. Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis. Mucosal Immunol. 2024 Oct; 17(5):825-842.
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Sachan M, Brann KR, Fullerton MS, Voth DE, Raghavan R. MicroRNAs Contribute to Host Response to Coxiella burnetii. Infect Immun. 2023 01 24; 91(1):e0019922.
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Sim?es I, Voth DE, Mota LJ. Editorial: Obligate intracellular bacteria: Evasion and adaptative tactics shaping the host-pathogen interface. Front Cell Infect Microbiol. 2022; 12:965554.
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Gobeil SM, Bobay BG, Juvvadi PR, Cole DC, Heitman J, Steinbach WJ, Venters RA, Spicer LD. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. mBio. 2021 12 21; 12(6):e0300021.
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Krystel-Whittemore M, Chan MP, Shalin SC, Sauder KJ, Hudson A, Foreman RK, Hoang MP, Brennick JB, Yan S, Nazarian RM. Deep Herpes. Am J Surg Pathol. 2021 10 01; 45(10):1357-1363.
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Shibata T, Shah S, Evans T, Coleman H, Lieblong BJ, Spencer HJ, Quick CM, Sasagawa T, Stephens OW, Peterson E, Johann D, Lu YC, Nakagawa M. Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed. Front Immunol. 2021; 12:645299.
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Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ. Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies. Cell Stress Chaperones. 2021 09; 26(5):859-868.
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Muecksch F, Weisblum Y, Barnes CO, Schmidt F, Schaefer-Babajew D, Wang Z, C Lorenzi JC, Flyak AI, DeLaitsch AT, Huey-Tubman KE, Hou S, Schiffer CA, Gaebler C, Da Silva J, Poston D, Finkin S, Cho A, Cipolla M, Oliveira TY, Millard KG, Ramos V, Gazumyan A, Rutkowska M, Caskey M, Nussenzweig MC, Bjorkman PJ, Hatziioannou T, Bieniasz PD. Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations. Immunity. 2021 08 10; 54(8):1853-1868.e7.
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Pisu D, Huang L, Narang V, Theriault M, L?-Bury G, Lee B, Lakudzala AE, Mzinza DT, Mhango DV, Mitini-Nkhoma SC, Jambo KC, Singhal A, Mwandumba HC, Russell DG. Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung. J Exp Med. 2021 09 06; 218(9).
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Bowlin A, Roys H, Wanjala H, Bettadapura M, Venugopal G, Surma J, Simon MC, Weinkopff T. Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection. Infect Immun. 2021 07 15; 89(8):e0012421.
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Fullerton MS, Colonne PM, Dragan AL, Brann KR, Kurten RC, Voth DE. Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells. mSphere. 2021 08 25; 6(4):e0044221.
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Dragan AL, Voth DE. Take my breath away: studying pathogen invasion of the human lung using primary tissue models. Pathog Dis. 2021 03 31; 79(4).
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Self WH, Stewart TG, Wheeler AP, El Atrouni W, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, O'Neal HR, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW. Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults. Trials. 2021 Mar 20; 22(1):221.
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Mercado MAB, Du W, Malaviarachchi PA, Gann JI, Li LX. Innate IFN-? Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-? Production Is Highly Redundant in the Female Reproductive Tract. Infect Immun. 2021 02 16; 89(3).
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Carr LE, Virmani MD, Rosa F, Munblit D, Matazel KS, Elolimy AA, Yeruva L. Role of Human Milk Bioactives on Infants' Gut and Immune Health. Front Immunol. 2021; 12:604080.
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Giacalone D, Huang L, Tan S. Exploiting Fluorescent Proteins to Understand Mycobacterium tuberculosis Biology. Methods Mol Biol. 2021; 2314:365-383.
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Morrison SG, Giebel AM, Toh E, Banerjee A, Nelson DE, Morrison RP. A Genital Infection-Attenuated Chlamydia muridarum Mutant Infects the Gastrointestinal Tract and Protects against Genital Tract Challenge. mBio. 2020 11 03; 11(6).
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Salah HM, Mehta JL. Hypothesis: Sex-Related Differences in ACE2 Activity May Contribute to Higher Mortality in Men Versus Women With COVID-19. J Cardiovasc Pharmacol Ther. 2021 03; 26(2):114-118.
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Liang Z, Qin Z, Riker AI, Xi Y. CRISPR/Cas9 ablating viral microRNA promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus. Biochem Biophys Res Commun. 2020 12 17; 533(4):1400-1405.
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Pisu D, Huang L, Rin Lee BN, Grenier JK, Russell DG. Dual RNA-Sequencing of Mycobacterium tuberculosis-Infected Cells from a Murine Infection Model. STAR Protoc. 2020 12 18; 1(3):100123.
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Oh C, Verma A, Aachoui Y. Caspase-11 Non-canonical Inflammasomes in the Lung. Front Immunol. 2020; 11:1895.
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Kamdar HA, Senay B, Mainali S, Lee V, Gulati DK, Greene-Chandos D, Hinduja A, Strohm T. Clinician's Perception of Practice Changes for Stroke During the COVID-19 Pandemic. J Stroke Cerebrovasc Dis. 2020 Oct; 29(10):105179.
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Banerjee SK, Crane SD, Pechous RD. A Dual Role for the Plasminogen Activator Protease During the Preinflammatory Phase of Primary Pneumonic Plague. J Infect Dis. 2020 07 06; 222(3):407-416.
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Realegeno S, Priyamvada L, Kumar A, Blackburn JB, Hartloge C, Puschnik AS, Sambhara S, Olson VA, Carette JE, Lupashin V, Satheshkumar PS. Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread. Viruses. 2020 06 30; 12(7).
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Brann KR, Fullerton MS, Voth DE. Coxiella burnetii Requires Host Eukaryotic Initiation Factor 2a Activity for Efficient Intracellular Replication. Infect Immun. 2020 06 22; 88(7).
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Khalaf OH, Chaki SP, Garcia-Gonzalez DG, Suva LJ, Gaddy D, Arenas-Gamboa AM. Interaction of Brucella abortus with Osteoclasts: a Step toward Understanding Osteoarticular Brucellosis and Vaccine Safety. Infect Immun. 2020 03 23; 88(4).
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Pisu D, Huang L, Grenier JK, Russell DG. Dual RNA-Seq of Mtb-Infected Macrophages In?Vivo Reveals Ontologically Distinct Host-Pathogen Interactions. Cell Rep. 2020 01 14; 30(2):335-350.e4.
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Coleman CM. Determining How Coronaviruses Overcome the Interferon and Innate Immune Response. Methods Mol Biol. 2020; 2203:223-229.
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Morrison K, Manzano M, Chung K, Schipma MJ, Bartom ET, Gottwein E. The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. Cell Rep. 2019 12 03; 29(10):2961-2969.e6.
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Chen J, Del Valle L, Lin HY, Plaisance-Bonstaff K, Forrest JC, Post SR, Qin Z. Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation. Virology. 2019 10; 536:16-19.
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Banerjee SK, Huckuntod SD, Mills SD, Kurten RC, Pechous RD. Modeling Pneumonic Plague in Human Precision-Cut Lung Slices Highlights a Role for the Plasminogen Activator Protease in Facilitating Type 3 Secretion. Infect Immun. 2019 08; 87(8).
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Schwimmer JB, Johnson JS, Angeles JE, Behling C, Belt PH, Borecki I, Bross C, Durelle J, Goyal NP, Hamilton G, Holtz ML, Lavine JE, Mitreva M, Newton KP, Pan A, Simpson PM, Sirlin CB, Sodergren E, Tyagi R, Yates KP, Weinstock GM, Salzman NH. Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2019 10; 157(4):1109-1122.
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Kennedy JL, Pham S, Borish L. Rhinovirus and Asthma Exacerbations. Immunol Allergy Clin North Am. 2019 08; 39(3):335-344.
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Russell DG, Huang L, VanderVen BC. Immunometabolism at the interface between macrophages and pathogens. Nat Rev Immunol. 2019 05; 19(5):291-304.
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Dragan AL, Kurten RC, Voth DE. Characterization of Early Stages of Human Alveolar Infection by the Q Fever Agent Coxiella burnetii. Infect Immun. 2019 03; 87(5).
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Giebel AM, Hu S, Rajaram K, Finethy R, Toh E, Brothwell JA, Morrison SG, Suchland RJ, Stein BD, Coers J, Morrison RP, Nelson DE. Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture. mBio. 2019 04 09; 10(2).
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Kovatcheva-Datchary P, Shoaie S, Lee S, Wahlstr?m A, Nookaew I, Hallen A, Perkins R, Nielsen J, B?ckhed F. Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model. Cell Rep. 2019 03 26; 26(13):3772-3783.e6.
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Cockburn CL, Green RS, Damle SR, Martin RK, Ghahrai NN, Colonne PM, Fullerton MS, Conrad DH, Chalfant CE, Voth DE, Rucks EA, Gilk SD, Carlyon JA. Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens. Life Sci Alliance. 2019 04; 2(2).
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Hobby GP, Karaduta O, Dusio GF, Singh M, Zybailov BL, Arthur JM. Chronic kidney disease and the gut microbiome. Am J Physiol Renal Physiol. 2019 06 01; 316(6):F1211-F1217.
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Huang L, Nazarova EV, Russell DG. Mycobacterium tuberculosis: Bacterial Fitness within the Host Macrophage. Microbiol Spectr. 2019 03; 7(2).
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Nazarova EV, Montague CR, Huang L, La T, Russell D, VanderVen BC. The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages. Elife. 2019 02 08; 8.
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Manzano M, Patil A, Waldrop A, Dave SS, Behdad A, Gottwein E. Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. Nat Commun. 2018 08 15; 9(1):3263.
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Claushuis TAM, de Stoppelaar SF, de Vos AF, Grootemaat AE, van der Wel NN, Roelofs JJTH, Ware J, Van't Veer C, van der Poll T. Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1772-1784.
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Winchell CG, Dragan AL, Brann KR, Onyilagha FI, Kurten RC, Voth DE. Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages. Infect Immun. 2018 05; 86(5).
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Bhattarai D, Worku T, Dad R, Rehman ZU, Gong X, Zhang S. Mechanism of pattern recognition receptors (PRRs) and host pathogen interplay in bovine mastitis. Microb Pathog. 2018 Jul; 120:64-70.
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Huang L, Nazarova EV, Tan S, Liu Y, Russell DG. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J Exp Med. 2018 04 02; 215(4):1135-1152.
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Becker RC, Sexton T, Smyth SS. Translational Implications of Platelets as Vascular First Responders. Circ Res. 2018 02 02; 122(3):506-522.
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Jun SR, Wassenaar TM, Wanchai V, Patumcharoenpol P, Nookaew I, Ussery DW. Suggested mechanisms for Zika virus causing microcephaly: what do the genomes tell us? BMC Bioinformatics. 2017 12 28; 18(Suppl 14):471.
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Spurgeon ME, den Boon JA, Horswill M, Barthakur S, Forouzan O, Rader JS, Beebe DJ, Roopra A, Ahlquist P, Lambert PF. Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E9076-E9085.
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Miller CN, Smith EP, Cundiff JA, Knodler LA, Bailey Blackburn J, Lupashin V, Celli J. A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication. Cell Host Microbe. 2017 Sep 13; 22(3):317-329.e7.
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Huang L, Russell DG. Protective immunity against tuberculosis: what does it look like and how do we find it? Curr Opin Immunol. 2017 Oct; 48:44-50.
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Rowe RK, Pyle DM, Tomlinson AR, Lv T, Hu Z, Gill MA. IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven TH1 differentiation. J Allergy Clin Immunol. 2017 07; 140(1):294-298.e8.
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Coleman CM, Sisk JM, Halasz G, Zhong J, Beck SE, Matthews KL, Venkataraman T, Rajagopalan S, Kyratsous CA, Frieman MB. CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome. J Virol. 2017 Jan 01; 91(1).
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VanderVen BC, Huang L, Rohde KH, Russell DG. The Minimal Unit of Infection: Mycobacterium tuberculosis in the Macrophage. Microbiol Spectr. 2016 12; 4(6).
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Hong M, Schwerk J, Lim C, Kell A, Jarret A, Pangallo J, Loo YM, Liu S, Hagedorn CH, Gale M, Savan R. Interferon lambda 4 expression is suppressed by the host during viral infection. J Exp Med. 2016 11 14; 213(12):2539-2552.
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Colonne PM, Winchell CG, Graham JG, Onyilagha FI, MacDonald LJ, Doeppler HR, Storz P, Kurten RC, Beare PA, Heinzen RA, Voth DE. Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages. PLoS Pathog. 2016 Oct; 12(10):e1005915.
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Colonne PM, Winchell CG, Voth DE. Hijacking Host Cell Highways: Manipulation of the Host Actin Cytoskeleton by Obligate Intracellular Bacterial Pathogens. Front Cell Infect Microbiol. 2016; 6:107.
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Smeltzer MS. Staphylococcus aureus Pathogenesis: The Importance of Reduced Cytotoxicity. Trends Microbiol. 2016 09; 24(9):681-682.
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Liem J, Liu J. Stress Beyond Translation: Poxviruses and More. Viruses. 2016 06 14; 8(6).
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Gokulan K, Khare S, Williams K, Foley SL. Transmissible Plasmid Containing Salmonella enterica Heidelberg Isolates Modulate Cytokine Production During Early Stage of Interaction with Intestinal Epithelial Cells. DNA Cell Biol. 2016 Aug; 35(8):443-53.
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Coleman HN, Greenfield WW, Stratton SL, Vaughn R, Kieber A, Moerman-Herzog AM, Spencer HJ, Hitt WC, Quick CM, Hutchins LF, Mackintosh SG, Edmondson RD, Erickson SW, Nakagawa M. Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination. Cancer Immunol Immunother. 2016 May; 65(5):563-73.
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Sifford JM, Stahl JA, Salinas E, Forrest JC. Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication. J Virol. 2015 Dec 16; 90(5):2571-85.
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Salinas E, Byrum SD, Moreland LE, Mackintosh SG, Tackett AJ, Forrest JC. Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016 02 01; 90(3):1397-413.
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Winchell CG, Steele S, Kawula T, Voth DE. Dining in: intracellular bacterial pathogen interplay with autophagy. Curr Opin Microbiol. 2016 Feb; 29:9-14.
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Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J. Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. Infect Immun. 2015 Dec; 83(12):4740-9.
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Li LX, McSorley SJ. A re-evaluation of the role of B cells in protective immunity to Chlamydia infection. Immunol Lett. 2015 Apr; 164(2):88-93.
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Pechous RD, Broberg CA, Stasulli NM, Miller VL, Goldman WE. In vivo transcriptional profiling of Yersinia pestis reveals a novel bacterial mediator of pulmonary inflammation. mBio. 2015 Feb 17; 6(1):e02302-14.
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Craig AP, Rank RG, Bowlin AK, Wand H, Wilson DP. Target cell limitation constrains chlamydial load in persistent infections: results from mathematical modelling applied to mouse genital tract infection data. Pathog Dis. 2015 Feb; 73(1):1-8.
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Deretic V, Kimura T, Timmins G, Moseley P, Chauhan S, Mandell M. Immunologic manifestations of autophagy. J Clin Invest. 2015 Jan; 125(1):75-84.
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Larson CL, Beare PA, Voth DE, Howe D, Cockrell DC, Bastidas RJ, Valdivia RH, Heinzen RA. Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication. Infect Immun. 2015 Feb; 83(2):661-70.
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