 Giant Cells
"Giant Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
| Descriptor ID |
D015726
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| MeSH Number(s) |
A11.500
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| Concept/Terms |
Giant Cells- Giant Cells
- Cell, Giant
- Cells, Giant
- Giant Cell
- Syncytium
- Polykaryocytes
- Polykaryocyte
- Syncytia
- Giant Cells, Multinucleated
- Cell, Multinucleated Giant
- Cells, Multinucleated Giant
- Giant Cell, Multinucleated
- Multinucleated Giant Cell
- Multinucleated Giant Cells
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Below are MeSH descriptors whose meaning is more general than "Giant Cells".
Below are MeSH descriptors whose meaning is more specific than "Giant Cells".
This graph shows the total number of publications written about "Giant Cells" by people in UAMS Profiles by year, and whether "Giant Cells" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 |
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Below are the most recent publications written about "Giant Cells" by people in Profiles over the past ten years.
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Aykutlu U, Aydin O, Gundogdu B. The pursuit of understanding multinucleated giant cells in indeterminate and malignant thyroid cytology samples. Diagn Cytopathol. 2020 Dec; 48(12):1211-1216.
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Elgawidi A, Mohsin MI, Ali F, Watts A, Monk PN, Thomas MS, Partridge LJ. A role for tetraspanin proteins in regulating fusion induced by Burkholderia thailandensis. Med Microbiol Immunol. 2020 Aug; 209(4):473-487.
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Sachak T, Frankel WL, Arnold CA, Chen W. Multinucleated stromal giant cells in the gastroesophageal junctional and gastric mucosa: a retrospective study. Diagn Pathol. 2019 Jul 27; 14(1):83.
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Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. Activation of dimeric glucocorticoid receptors in osteoclast progenitors potentiates RANKL induced mature osteoclast bone resorbing activity. Bone. 2016 12; 93:43-54.
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