 Germinal Center
"Germinal Center" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.
| Descriptor ID |
D018858
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| MeSH Number(s) |
A10.549.250 A10.549.400.500 A15.382.520.604.250 A15.382.520.604.412.500
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| Concept/Terms |
Germinal Center- Germinal Center
- Center, Germinal
- Centers, Germinal
- Germinal Centers
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Below are MeSH descriptors whose meaning is more general than "Germinal Center".
Below are MeSH descriptors whose meaning is more specific than "Germinal Center".
This graph shows the total number of publications written about "Germinal Center" by people in UAMS Profiles by year, and whether "Germinal Center" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 | | 2020 | 1 | 2 | 3 | | 2018 | 2 | 0 | 2 | | 2017 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2002 | 1 | 0 | 1 |
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Below are the most recent publications written about "Germinal Center" by people in Profiles over the past ten years.
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Maclachlan KH, Bagratuni T, Kastritis E, Ziccheddu B, Lu S, Yellapantula V, Famulare C, Argyropoulos K, Derkach A, Papaemmanuil E, Dogan A, Lesokhin A, Usmani SZ, Landgren CO, Palomba LM, Maura F, Dimopoulos MA. Waldenstr?m macroglobulinemia whole genome reveals prolonged germinal center activity and late copy number aberrations. Blood Adv. 2023 03 28; 7(6):971-981.
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Brown SL, Bauer JJ, Lee J, Ntirandekura E, Stumhofer JS. IgM+ and IgM- memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon rechallenge with P. yoelii. J Leukoc Biol. 2022 11; 112(5):1115-1135.
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O'Neal KA, Latham LE, Ntirandekura E, Foscue CL, Stumhofer JS. ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection. Infect Immun. 2022 03 17; 90(3):e0046821.
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Owens SM, Oldenburg DG, White DW, Forrest JC. Deletion of Murine Gammaherpesvirus Gene M2 in Activation-Induced Cytidine Deaminase-Expressing B Cells Impairs Host Colonization and Viral Reactivation. J Virol. 2020 12 09; 95(1).
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Salama A, Marcellino BK, Saad AG, Teruya-Feldstein J, Firpo-Betancourt A, Abulsayen HA, Grada Z, Hassan M, El Jamal SM. Correlation Analysis Between the Expression of MEF2B, and Germinal Center and Nongerminal Center Markers in Diffuse Large B-Cell Lymphoma. Appl Immunohistochem Mol Morphol. 2020 08; 28(7):e63-e64.
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Latham LE, Wikenheiser DJ, Stumhofer JS. ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium?chabaudi chabaudi AS. PLoS Pathog. 2020 04; 16(4):e1008527.
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Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. Science. 2019 02 08; 363(6427):649-654.
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El Jamal SM, Grada Z, El Dinali MH, Zhou H, Hassan SY, Saad AG, Gibson B, Zhou X, Abulsayen HA, Khadra HS, Friedman J, Shalaby H, Kadi A, Megahed M, Emberesh M, Teruya-Feldstein J, Firpo-Betancourt A, Haikel Y, Fraig M, Hassan M. MEF2B is a member of the BCL6 gene transcriptional complex and induces its expression in diffuse large B-cell lymphoma of the germinal center B-cell-like type. Lab Invest. 2019 04; 99(4):539-550.
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Pina-Oviedo S, Miranda RN, Lin P, Manning JT, Medeiros LJ. Follicular lymphoma with hyaline-vascular Castleman-like features: analysis of 6 cases and review of the literature. Hum Pathol. 2017 10; 68:136-146.
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Pina-Oviedo S, Wang W, Vicknair E, Manning JT, Medeiros LJ. Follicular lymphoma with hyaline-vascular Castleman disease-like follicles and CD20 positive follicular dendritic cells. Pathology. 2017 Aug; 49(5):544-547.
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Olafsdottir TA, Lindqvist M, Nookaew I, Andersen P, Maertzdorf J, Persson J, Christensen D, Zhang Y, Anderson J, Khoomrung S, Sen P, Agger EM, Coler R, Carter D, Meinke A, Rappuoli R, Kaufmann SH, Reed SG, Harandi AM. Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants. Sci Rep. 2016 12 13; 6:39097.
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Wikenheiser DJ, Ghosh D, Kennedy B, Stumhofer JS. The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection. J Immunol. 2016 Jan 15; 196(2):778-91.
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