 Fatty Acids
"Fatty Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
| Descriptor ID |
D005227
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| MeSH Number(s) |
D10.251
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fatty Acids".
Below are MeSH descriptors whose meaning is more specific than "Fatty Acids".
This graph shows the total number of publications written about "Fatty Acids" by people in UAMS Profiles by year, and whether "Fatty Acids" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 2 | 0 | 2 | | 2023 | 0 | 2 | 2 | | 2022 | 0 | 4 | 4 | | 2021 | 1 | 2 | 3 | | 2020 | 0 | 1 | 1 | | 2019 | 2 | 1 | 3 | | 2018 | 0 | 4 | 4 | | 2017 | 1 | 2 | 3 | | 2016 | 4 | 3 | 7 | | 2015 | 2 | 1 | 3 | | 2014 | 0 | 2 | 2 | | 2013 | 1 | 5 | 6 | | 2012 | 2 | 1 | 3 | | 2011 | 0 | 3 | 3 | | 2010 | 3 | 2 | 5 | | 2009 | 2 | 1 | 3 | | 2008 | 3 | 3 | 6 | | 2007 | 2 | 4 | 6 | | 2006 | 4 | 0 | 4 | | 2005 | 0 | 1 | 1 | | 2004 | 4 | 4 | 8 | | 2003 | 3 | 2 | 5 | | 2002 | 1 | 2 | 3 | | 2000 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 1998 | 2 | 0 | 2 | | 1996 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1992 | 1 | 0 | 1 | | 1991 | 0 | 1 | 1 | | 1989 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fatty Acids" by people in Profiles over the past ten years.
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Sobhi HF, Mercer KE, Lan RS, Yeruva L, Ten Have GAM, Deutz NEP, Piccolo BD, Deb?dat J, Pack LM, Adams SH. Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues. J Lipid Res. 2024 Oct; 65(10):100632.
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Wright T, Turnis ME, Grace CR, Li X, Brakefield LA, Wang YD, Xu H, Kaminska E, Climer LK, Mukiza TO, Chang CL, Moldoveanu T, Opferman JT. Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1. Mol Cell. 2024 Apr 04; 84(7):1338-1353.e8.
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Song Q, Wang J, Griffiths A, Lee SM, Iyamu ID, Huang R, Cordoba-Chacon J, Song Z. Nicotinamide N-methyltransferase upregulation contributes to palmitate-elicited peroxisome proliferator-activated receptor transactivation in hepatocytes. Am J Physiol Cell Physiol. 2023 07 01; 325(1):C29-C41.
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Imig JD. Bioactive lipids in hypertension. Adv Pharmacol. 2023; 97:1-35.
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Borges MC, Haycock P, Zheng J, Hemani G, Howe LJ, Schmidt AF, Staley JR, Lumbers RT, Henry A, Lemaitre RN, Gaunt TR, Holmes MV, Davey Smith G, Hingorani AD, Lawlor DA. The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study. Hum Mol Genet. 2022 11 28; 31(23):4034-4054.
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Zhou J, Pang J, Tripathi M, Ho JP, Widjaja AA, Shekeran SG, Cook SA, Suzuki A, Diehl AM, Petretto E, Singh BK, Yen PM. Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression. Nat Commun. 2022 09 03; 13(1):5202.
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Manjar?n R, Dillard K, Coffin M, Hernandez GV, Smith VA, Noland-Lidell T, Gehani TR, Smart HJ, Wheeler K, Sprayberry KA, Edwards MS, Fanter RK, Glanz H, Immoos C, Santiago-Rodriguez TM, Blank JM, Burrin DG, Piccolo BD, Abo-Ismail M, La Frano MR, Maj M. Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD. Am J Physiol Endocrinol Metab. 2022 09 01; 323(3):E187-E206.
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Nagumalli SK, Willett RA, de Conti A, Tryndyak VP, Avigan MI, da Costa GG, Beland FA, Rusyn I, Pogribny IP. Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice. J Nutr Biochem. 2022 11; 109:109108.
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Tripathi M, Singh BK, Zhou J, Tikno K, Widjaja A, Sandireddy R, Arul K, Abdul Ghani SAB, Bee GGB, Wong KA, Pei HJ, Shekeran SG, Sinha RA, Singh MK, Cook SA, Suzuki A, Lim TR, Cheah CC, Wang J, Xiao RP, Zhang X, Chow PKH, Yen PM. Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation. J Hepatol. 2022 11; 77(5):1246-1255.
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Huang D, Chowdhury S, Wang H, Savage SR, Ivey RG, Kennedy JJ, Whiteaker JR, Lin C, Hou X, Oberg AL, Larson MC, Eskandari N, Delisi DA, Gentile S, Huntoon CJ, Voytovich UJ, Shire ZJ, Yu Q, Gygi SP, Hoofnagle AN, Herbert ZT, Lorentzen TD, Calinawan A, Karnitz LM, Weroha SJ, Kaufmann SH, Zhang B, Wang P, Birrer MJ, Paulovich AG. Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer. Cell Rep Med. 2021 12 21; 2(12):100471.
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Imig JD, Cervenka L, Neckar J. Epoxylipids and soluble epoxide hydrolase in heart diseases. Biochem Pharmacol. 2022 01; 195:114866.
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Ruiz de Azua MJ, Cruz-Carri?n ?, Muguerza B, Arola-Arnal A, Suarez M. Seasonal Consumption of Cherries from Different Origins Affects Metabolic Markers and Gene Expression of Lipogenic Enzymes in Rat Liver: A Preliminary Study. Nutrients. 2021 Oct 18; 13(10).
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Ono-Moore KD, Olfert IM, Rutkowsky JM, Chintapalli SV, Willis BJ, Blackburn ML, Williams DK, O'Reilly J, Tolentino T, Lloyd KCK, Adams SH. Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E63-E79.
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Tsai CY, Rosa F, Bionaz M, Rezamand P. Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis. J Dairy Res. 2020 Nov; 87(4):416-423.
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de Conti A, Tryndyak V, Willett RA, Borowa-Mazgaj B, Watson A, Patton R, Khare S, Muskhelishvili L, Olson GR, Avigan MI, Cerniglia CE, Ross SA, Sanyal AJ, Beland FA, Rusyn I, Pogribny IP. Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model. FASEB J. 2020 06; 34(6):7773-7785.
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Grapov D, Fiehn O, Campbell C, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Hoppel CL, Harper ME, Adams SH. Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention. Am J Physiol Endocrinol Metab. 2019 12 01; 317(6):E999-E1014.
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Pedersen KB, Pulliam CF, Patel A, Del Piero F, Watanabe TTN, Wankhade UD, Shankar K, Hicks C, Ronis MJ. Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus. Carcinogenesis. 2019 04 29; 40(2):349-359.
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Barone R, Rizzo R, Tabb? G, Malaguarnera M, Frye RE, Bastin J. Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 16; 20(8).
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McCoin CS, Gillingham MB, Knotts TA, Vockley J, Ono-Moore KD, Blackburn ML, Norman JE, Adams SH. Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid oxidation disorders. Physiol Rep. 2019 03; 7(6):e14037.
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Nazarova EV, Montague CR, Huang L, La T, Russell D, VanderVen BC. The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages. Elife. 2019 02 08; 8.
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Zhang J, Bhattacharyya S, Hickner RC, Light AR, Lambert CJ, Gale BK, Fiehn O, Adams SH. Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: application in rats and humans. Am J Physiol Endocrinol Metab. 2019 01 01; 316(1):E43-E53.
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Rose S, Niyazov DM, Rossignol DA, Goldenthal M, Kahler SG, Frye RE. Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder. Mol Diagn Ther. 2018 10; 22(5):571-593.
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Du X, Liu S, Sun J, Zhang G, Jia Y, Pan Z, Xiang H, He S, Xia Q, Xiao S, Shi W, Quan Z, Liu J, Ma J, Pang B, Wang L, Sun G, Gong W, Jenkins JN, Lou X, Zhu J, Xu H. Dissection of complicate genetic architecture and breeding perspective of cottonseed traits by genome-wide association study. BMC Genomics. 2018 Jun 13; 19(1):451.
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Schafer C, Young ZT, Makarewich CA, Elnwasany A, Kinter C, Kinter M, Szweda LI. Coenzyme A-mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice. J Biol Chem. 2018 05 04; 293(18):6915-6924.
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Huang L, Nazarova EV, Tan S, Liu Y, Russell DG. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J Exp Med. 2018 04 02; 215(4):1135-1152.
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M?ller SM, Ebert F, Bornhorst J, Galla HJ, Francesconi KA, Schwerdtle T. Arsenic-containing hydrocarbons disrupt a model in vitro blood-cerebrospinal fluid barrier. J Trace Elem Med Biol. 2018 Sep; 49:171-177.
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Hardin JS, Gauldin DW, Soliman MK, Chu CJ, Yang YC, Sallam AB. Cataract Surgery Outcomes in Eyes With Primary Epiretinal Membrane. JAMA Ophthalmol. 2018 02 01; 136(2):148-154.
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Fan YY, Fuentes NR, Hou TY, Barhoumi R, Li XC, Deutz NEP, Engelen MPKJ, McMurray DN, Chapkin RS. Remodelling of primary human CD4+ T cell plasma membrane order by n-3 PUFA. Br J Nutr. 2018 01; 119(2):163-175.
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Ibitokou SA, Dillon BE, Sinha M, Szczesny B, Delgadillo A, Reda Abdelrahman D, Szabo C, Abu-Elheiga L, Porter C, Tuvdendorj D, Stephens R. Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection. J Immunol. 2018 01 15; 200(2):643-656.
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Bhattacharyya S, Ali M, Smith WH, Minkler PE, Stoll MS, Hoppel CL, Adams SH. Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation. Am J Physiol Endocrinol Metab. 2017 12 01; 313(6):E690-E698.
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Panasevich MR, Schuster CM, Phillips KE, Meers GM, Chintapalli SV, Wankhade UD, Shankar K, Butteiger DN, Krul ES, Thyfault JP, Rector RS. Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. J Nutr Biochem. 2017 08; 46:125-136.
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Zhang J, Light AR, Hoppel CL, Campbell C, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Hughen RW, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Harper ME, Fiehn O, Adams SH. Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Exp Physiol. 2017 01 01; 102(1):48-69.
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Aguer C, Piccolo BD, Fiehn O, Adams SH, Harper ME. A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3. FASEB J. 2017 02; 31(2):814-827.
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Chintapalli SV, Jayanthi S, Mallipeddi PL, Gundampati R, Suresh Kumar TK, van Rossum DB, Anishkin A, Adams SH. Novel Molecular Interactions of Acylcarnitines and Fatty Acids with Myoglobin. J Biol Chem. 2016 Nov 25; 291(48):25133-25143.
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Allott EH, Arab L, Su LJ, Farnan L, Fontham ET, Mohler JL, Bensen JT, Steck SE. Saturated fat intake and prostate cancer aggressiveness: results from the population-based North Carolina-Louisiana Prostate Cancer Project. Prostate Cancer Prostatic Dis. 2017 03; 20(1):48-54.
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Morris EM, Meers GM, Koch LG, Britton SL, Fletcher JA, Fu X, Shankar K, Burgess SC, Ibdah JA, Rector RS, Thyfault JP. Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis. Am J Physiol Endocrinol Metab. 2016 10 01; 311(4):E749-E760.
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Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem. 2016 Oct 14; 291(42):22207-22217.
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Panasevich MR, Morris EM, Chintapalli SV, Wankhade UD, Shankar K, Britton SL, Koch LG, Thyfault JP, Rector RS. Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G166-79.
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McCoin CS, Piccolo BD, Knotts TA, Matern D, Vockley J, Gillingham MB, Adams SH. Unique plasma metabolomic signatures of individuals with inherited disorders of long-chain fatty acid oxidation. J Inherit Metab Dis. 2016 05; 39(3):399-408.
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Burgeiro A, Fuhrmann A, Cherian S, Espinoza D, Jarak I, Carvalho RA, Loureiro M, Patr?cio M, Antunes M, Carvalho E. Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes. Am J Physiol Endocrinol Metab. 2016 Apr 01; 310(7):E550-64.
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Michaut A, Le Guillou D, Moreau C, Bucher S, McGill MR, Martinais S, Gicquel T, Morel I, Robin MA, Jaeschke H, Fromenty B. A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. Toxicol Appl Pharmacol. 2016 Feb 01; 292:40-55.
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Chintapalli SV, Bhardwaj G, Patel R, Shah N, Patterson RL, van Rossum DB, Anishkin A, Adams SH. Molecular dynamic simulations reveal the structural determinants of Fatty Acid binding to oxy-myoglobin. PLoS One. 2015; 10(6):e0128496.
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Imig JD. Epoxyeicosatrienoic acids, hypertension, and kidney injury. Hypertension. 2015 Mar; 65(3):476-82.
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