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William Steinbach

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionInfectious Diseases
AddressS4428A-1 ACH STUR
1 Children’s Way
Little Rock AR 72202
Phone501-364-5262
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    Collapse Research 
    Collapse research activities and funding
    R01AI159684     (STEINBACH, WILLIAM J)Sep 17, 2021 - Aug 31, 2026
    NIH
    Multi-center evaluation of the threat of established and emerging respiratory viral infections in pediatric transplant recipients
    Role: Principal Investigator

    R21AI163301     (STEINBACH, WILLIAM J)Jun 1, 2021 - May 31, 2023
    NIH
    Calcineurin regulatory network control of Aspergillus fumigatus hyphal septation
    Role: Principal Investigator

    R01AI135812     (BURKE, MARTIN D)Jun 8, 2018 - May 31, 2023
    NIH
    Development of non-toxic amphotericin B derivatives targeting invasive fungal infections
    Role: Co-Principal Investigator

    R01AI139032     (STEINBACH, WILLIAM J)Jun 5, 2018 - May 31, 2023
    NIH
    Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
    Role: Principal Investigator

    R21AI132911     (STEINBACH, WILLIAM J)Jan 1, 2018 - Dec 31, 2020
    NIH
    Phosphoproteomic identification of Aspergillus fumigatus virulence-associated protein kinase A downstream effectors
    Role: Principal Investigator

    R44AI131864     (SHAW, KAREN JOY)Aug 18, 2017 - Jul 31, 2019
    NIH
    Developing a novel antifungal targeting Gwt1 for the treatment of invasive aspergillosis and rare mold infections
    Role: Co-Principal Investigator

    R21AI127551     (STEINBACH, WILLIAM J)Dec 15, 2016 - Nov 30, 2019
    NIH
    Defining the Aspergillus fumigatus Calcineurin-Dependent Regulatory Network through Whole Phosphoproteome Analysis
    Role: Principal Investigator

    R43AI110099     (SLUDER, ANN E)Dec 1, 2014 - May 31, 2015
    NIH
    Non-Immunosuppressive Cyclosporine Analogs for Novel Antifungal Therapies
    Role: Co-Principal Investigator

    R01HD081044     (STEINBACH, WILLIAM J)Aug 7, 2014 - May 31, 2020
    NIH
    Fungal biomarkers for diagnosis and response to therapy for pediatric candidemia
    Role: Principal Investigator

    R56AI112595     (HEITMAN, JOSEPH)Aug 4, 2014 - Aug 31, 2021
    NIH
    Structural Biological Development of Fungal-Specific Calcineurin Inhibitors
    Role: Co-Principal Investigator

    R01AI112595     (HEITMAN, JOSEPH)Aug 4, 2014 - Jul 31, 2019
    NIH
    Structural Biological Development of Fungal-Specific Calcineurin Inhibitors
    Role: Co-Principal Investigator

    R01AI103315     (ZAOUTIS, THEOKLIS)Jun 1, 2013 - Nov 30, 2019
    NIH
    Multi-center studies to improve diagnosis and treatment of pediatric candidiasis
    Role: Co-Principal Investigator

    R21AI097541     (STEINBACH, WILLIAM J)Jul 1, 2012 - Jun 30, 2014
    NIH
    Identification of calcineurin-binding proteins in A. fumigatus septum formation
    Role: Principal Investigator

    R56AI077648     (STEINBACH, WILLIAM J)Sep 30, 2010 - Aug 31, 2012
    NIH
    Calcineurin Inhibition to Halt Aspergillus fumigatus Hyphae and Virulence
    Role: Principal Investigator

    K08AI061149     (STEINBACH, WILLIAM J)Aug 1, 2004 - Apr 30, 2010
    NIH
    Calcineurin and Aspergillus fumigatus Pathogenesis
    Role: Principal Investigator

    T32AI052080     (HEITMAN, JOSEPH)Jul 1, 2002 - Jul 31, 2024
    NIH
    Molecular Mycology and Pathogenesis Training Program
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ. Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents. Clin Infect Dis. 2022 Aug 25; 75(2):248-259. PMID: 35134165.
      View in: PubMed
    2. Hoy MJ, Park E, Lee H, Lim WY, Cole DC, DeBouver ND, Bobay BG, Pierce PG, Fox D, Ciofani M, Juvvadi PR, Steinbach W, Hong J, Heitman J. Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. mBio. 2022 06 28; 13(3):e0104922. PMID: 35604094.
      View in: PubMed
    3. Shwab EK, Juvvadi PR, Shaheen SK, Allen J, Waitt G, Soderblom EJ, Asfaw YG, Moseley MA, Steinbach WJ. Protein Kinase A Regulates Autophagy-Associated Proteins Impacting Growth and Virulence of Aspergillus fumigatus. J Fungi (Basel). 2022 Mar 30; 8(4). PMID: 35448585.
      View in: PubMed
    4. Gobeil SM, Bobay BG, Juvvadi PR, Cole DC, Heitman J, Steinbach WJ, Venters RA, Spicer LD. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. mBio. 2021 12 21; 12(6):e0300021. PMID: 34809463.
      View in: PubMed
    5. Hurst JH, Heston SM, Chambers HN, Cunningham HM, Price MJ, Suarez L, Crew CG, Bose S, Aquino JN, Carr ST, Griffin SM, Smith SH, Jenkins K, Pfeiffer TS, Rodriguez J, DeMarco CT, De Naeyer NA, Gurley TC, Louzao R, Zhao C, Cunningham CK, Steinbach WJ, Denny TN, Lugo DJ, Moody MA, Permar SR, Rotta AT, Turner NA, Walter EB, Woods CW, Kelly MS. Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study. Clin Infect Dis. 2021 11 02; 73(9):e2875-e2882. PMID: 33141180.
      View in: PubMed
    6. Fisher BT, Zaoutis TE, Xiao R, Wattier RL, Castagnola E, Pana ZD, Fullenkamp A, Boge CLK, Ross RK, Yildirim I, Palazzi DL, Danziger-Isakov L, Vora SB, Arrieta A, Yin DE, Avilés-Robles M, Sharma T, Tribble AC, Maron G, Berman D, Green M, Sung L, Romero J, Hauger SB, Roilides E, Belani K, Nolt D, Soler-Palacin P, López-Medina E, Muller WJ, Halasa N, Dulek D, Hussain IZB, Pong A, Hoffman J, Rajan S, Gonzalez BE, Hanisch B, Aftandilian C, Carlesse F, Abzug MJ, Huppler AR, Salvatore CM, Ardura MI, Chakrabarti A, Santolaya ME, Localio AR, Steinbach WJ. Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents. J Pediatric Infect Dis Soc. 2021 Aug 10. PMID: 34374424.
      View in: PubMed
    7. Shaheen SK, Juvvadi PR, Allen J, Shwab EK, Cole DC, Asfaw YG, Kapoor M, Shaw KJ, Steinbach WJ. In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0068221. PMID: 34310205.
      View in: PubMed
    8. Arrieta AC, Neely M, Day JC, Rheingold SR, Sue PK, Muller WJ, Danziger-Isakov LA, Chu J, Yildirim I, McComsey GA, Frangoul HA, Chen TK, Statler VA, Steinbach WJ, Yin DE, Hamed K, Jones ME, Lademacher C, Desai A, Micklus K, Phillips DL, Kovanda LL, Walsh TJ. Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients. Antimicrob Agents Chemother. 2021 07 16; 65(8):e0029021. PMID: 34031051.
      View in: PubMed
    9. Dvorak CC, Fisher BT, Esbenshade AJ, Nieder ML, Alexander S, Steinbach WJ, Dang H, Villaluna D, Chen L, Skeens M, Zaoutis TE, Sung L. A Randomized Trial of Caspofungin vs Triazoles Prophylaxis for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplant. J Pediatric Infect Dis Soc. 2021 Apr 30; 10(4):417-425. PMID: 33136159.
      View in: PubMed
    10. Shwab EK, Juvvadi PR, Waitt G, Shaheen S, Allen J, Soderblom EJ, Bobay BG, Asfaw YG, Moseley MA, Steinbach WJ. The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets. mBio. 2020 12 15; 11(6). PMID: 33323509.
      View in: PubMed
    11. Thomas SJ, Young RT, Steinbach WJ, Lugo DJ. Risks and outcomes of adenovirus disease in pediatric hematopoietic stem cell transplant recipients-Comparison of current antiviral treatment options. Transpl Infect Dis. 2021 Apr; 23(2):e13505. PMID: 33174293.
      View in: PubMed
    12. Steinbach WJ. Latest Thoughts on Treating Pediatric Mucormycosis. J Pediatric Infect Dis Soc. 2020 Nov 10; 9(5):640-644. PMID: 33043976.
      View in: PubMed
    13. Roundtree MT, Juvvadi PR, Shwab EK, Cole DC, Steinbach WJ. Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors. Antimicrob Agents Chemother. 2020 09 21; 64(10). PMID: 32660997.
      View in: PubMed
    14. Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, Clancy CJ, Wingard JR, Lockhart SR, Groll AH, Sorrell TC, Bassetti M, Akan H, Alexander BD, Andes D, Azoulay E, Bialek R, Bradsher RW, Bretagne S, Calandra T, Caliendo AM, Castagnola E, Cruciani M, Cuenca-Estrella M, Decker CF, Desai SR, Fisher B, Harrison T, Heussel CP, Jensen HE, Kibbler CC, Kontoyiannis DP, Kullberg BJ, Lagrou K, Lamoth F, Lehrnbecher T, Loeffler J, Lortholary O, Maertens J, Marchetti O, Marr KA, Masur H, Meis JF, Morrisey CO, Nucci M, Ostrosky-Zeichner L, Pagano L, Patterson TF, Perfect JR, Racil Z, Roilides E, Ruhnke M, Prokop CS, Shoham S, Slavin MA, Stevens DA, Thompson GR, Vazquez JA, Viscoli C, Walsh TJ, Warris A, Wheat LJ, White PL, Zaoutis TE, Pappas PG. Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2020 09 12; 71(6):1367-1376. PMID: 31802125.
      View in: PubMed
    15. Hurst JH, Heston SM, Chambers HN, Cunningham HM, Price MJ, Suarez L, Crew CG, Bose S, Aquino JN, Carr ST, Griffin SM, Smith SH, Jenkins K, Pfeiffer TS, Rodriguez J, DeMarco CT, De Naeyer NA, Gurley TC, Louzao R, Cunningham CK, Steinbach WJ, Denny TN, Lugo DJ, Moody MA, Permar SR, Rotta AT, Turner NA, Walter EB, Woods CW, Kelly MS. SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study. medRxiv. 2020 Sep 01. PMID: 32908992.
      View in: PubMed
    16. Groll AH, Abdel-Azim H, Lehrnbecher T, Steinbach WJ, Paschke A, Mangin E, Winchell GA, Waskin H, Bruno CJ. Pharmacokinetics and safety of posaconazole intravenous solution and powder for oral suspension in children with neutropenia: an open-label, sequential dose-escalation trial. Int J Antimicrob Agents. 2020 Sep; 56(3):106084. PMID: 32682946.
      View in: PubMed
    17. Lehrnbecher T, Fisher BT, Phillips B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Castagnola E, Davis BL, Dupuis LL, Egan G, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, van de Wetering M, Wolf J, Cabral S, Robinson PD, Sung L. Guideline for Antibacterial Prophylaxis Administration in Pediatric Cancer and Hematopoietic Stem Cell Transplantation. Clin Infect Dis. 2020 06 24; 71(1):226-236. PMID: 31676904.
      View in: PubMed
    18. Lehrnbecher T, Fisher BT, Phillips B, Beauchemin M, Carlesse F, Castagnola E, Duong N, Dupuis LL, Fioravantti V, Groll AH, Haeusler GM, Roilides E, Science M, Steinbach WJ, Tissing W, Warris A, Patel P, Robinson PD, Sung L. Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients. J Clin Oncol. 2020 09 20; 38(27):3205-3216. PMID: 32459599.
      View in: PubMed
    19. Renshaw H, Juvvadi PR, Cole DC, Steinbach WJ. The class V myosin interactome of the human pathogen Aspergillus fumigatus reveals novel interactions with COPII vesicle transport proteins. Biochem Biophys Res Commun. 2020 06 18; 527(1):232-237. PMID: 32446373.
      View in: PubMed
    20. Juvvadi PR, Bobay BG, Gobeil SMC, Cole DC, Venters RA, Heitman J, Spicer LD, Steinbach WJ. FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2020 05 21; 526(1):48-54. PMID: 32192767.
      View in: PubMed
    21. Mayer EF, Maron G, Dallas RH, Ferrolino J, Tang L, Sun Y, Danziger-Isakov L, Paulsen GC, Fisher BT, Vora SB, Englund J, Steinbach WJ, Michaels M, Green M, Yeganeh N, Gibson JE, Dominguez SR, Nicholson MR, Dulek DE, Ardura MI, Rajan S, Gonzalez BE, Beneri C, Herold BC. A multicenter study to define the epidemiology and outcomes of Clostridioides difficile infection in pediatric hematopoietic cell and solid organ transplant recipients. Am J Transplant. 2020 08; 20(8):2133-2142. PMID: 32064754.
      View in: PubMed
    22. Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, Hoenigl M, Jensen HE, Lagrou K, Lewis RE, Mellinghoff SC, Mer M, Pana ZD, Seidel D, Sheppard DC, Wahba R, Akova M, Alanio A, Al-Hatmi AMS, Arikan-Akdagli S, Badali H, Ben-Ami R, Bonifaz A, Bretagne S, Castagnola E, Chayakulkeeree M, Colombo AL, Corzo-León DE, Drgona L, Groll AH, Guinea J, Heussel CP, Ibrahim AS, Kanj SS, Klimko N, Lackner M, Lamoth F, Lanternier F, Lass-Floerl C, Lee DG, Lehrnbecher T, Lmimouni BE, Mares M, Maschmeyer G, Meis JF, Meletiadis J, Morrissey CO, Nucci M, Oladele R, Pagano L, Pasqualotto A, Patel A, Racil Z, Richardson M, Roilides E, Ruhnke M, Seyedmousavi S, Sidharthan N, Singh N, Sinko J, Skiada A, Slavin M, Soman R, Spellberg B, Steinbach W, Tan BH, Ullmann AJ, Vehreschild JJ, Vehreschild MJGT, Walsh TJ, White PL, Wiederhold NP, Zaoutis T, Chakrabarti A. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis. 2019 12; 19(12):e405-e421. PMID: 31699664.
      View in: PubMed
    23. Juvvadi PR, Fox D, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, Lee SC, Chen YL, Mutz M, Spicer LD, Schumacher MA, Heitman J, Steinbach WJ. Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun. 2019 09 19; 10(1):4275. PMID: 31537789.
      View in: PubMed
    24. Danziger-Isakov L, Steinbach WJ, Paulsen G, Munoz FM, Sweet LR, Green M, Michaels MG, Englund JA, Murray A, Halasa N, Dulek DE, Madan RP, Herold BC, Fisher BT. A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection. J Pediatric Infect Dis Soc. 2019 Jul 01; 8(3):197-204. PMID: 29538674.
      View in: PubMed
    25. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Barrington BC, Asfaw YG, Moseley MA, Steinbach WJ. Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. Mol Microbiol. 2019 07; 112(1):62-80. PMID: 30927289.
      View in: PubMed
    26. Fisher BT, Danziger-Isakov L, Sweet LR, Munoz FM, Maron G, Tuomanen E, Murray A, Englund JA, Dulek D, Halasa N, Green M, Michaels MG, Madan RP, Herold BC, Steinbach WJ. A Multicenter Consortium to Define the Epidemiology and Outcomes of Inpatient Respiratory Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients. J Pediatric Infect Dis Soc. 2018 Dec 03; 7(4):275-282. PMID: 29106589.
      View in: PubMed
    27. Spees LP, Martin PL, Kurtzberg J, Stokhuyzen A, McGill L, Prasad VK, Driscoll TA, Parikh SH, Page KM, Vinesett R, Severyn C, Sung AD, Proia AD, Jenkins K, Arshad M, Steinbach WJ, Seed PC, Kelly MS. Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014). Biol Blood Marrow Transplant. 2019 04; 25(4):756-763. PMID: 30481599.
      View in: PubMed
    28. Steinbach WJ, Benjamin DK, Sleasman JW. Funding Pediatric Subspecialty Training: Are T32 Grants the Future? J Pediatr. 2018 11; 202:4-7.e1. PMID: 30360878.
      View in: PubMed
    29. Juvvadi PR, Cole DC, Falloon K, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2018 11 02; 505(3):740-746. PMID: 30292408.
      View in: PubMed
    30. Fisher BT, Robinson PD, Lehrnbecher T, Steinbach WJ, Zaoutis TE, Phillips B, Sung L. Risk Factors for Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review. J Pediatric Infect Dis Soc. 2018 Aug 17; 7(3):191-198. PMID: 28549148.
      View in: PubMed
    31. Renshaw H, Vargas-Muñiz JM, Juvvadi PR, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. J Cell Sci. 2018 02 07; 131(3). PMID: 29222113.
      View in: PubMed
    32. Juvvadi PR, Moseley MA, Hughes CJ, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Geromanos SJ, Wildgoose J, Richardson K, Langridge JI, Vissers JPC, Steinbach WJ. Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs. J Proteome Res. 2018 02 02; 17(2):780-793. PMID: 29251506.
      View in: PubMed
    33. Moseley MA, Hughes CJ, Juvvadi PR, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Steinbach WJ, Geromanos SJ, Wildgoose J, Langridge JI, Richardson K, Vissers JPC. Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization. J Proteome Res. 2018 02 02; 17(2):770-779. PMID: 28901143.
      View in: PubMed
    34. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Steinbach WJ. Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms. FEBS Lett. 2017 11; 591(22):3730-3744. PMID: 29067690.
      View in: PubMed
    35. Moreno-Velásquez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND. Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in ß-1,3-Glucan Synthase Localization. Antimicrob Agents Chemother. 2017 10; 61(10). PMID: 28760907.
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    36. Steinbach WJ, Fisher BT. International Collaborative on Contemporary Epidemiology and Diagnosis of Invasive Fungal Disease in Children. J Pediatric Infect Dis Soc. 2017 Sep 01; 6(suppl_1):S1-S2. PMID: 28927199.
      View in: PubMed
    37. King J, Pana ZD, Lehrnbecher T, Steinbach WJ, Warris A. Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children. J Pediatric Infect Dis Soc. 2017 Sep 01; 6(suppl_1):S12-S21. PMID: 28927201.
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    38. Huppler AR, Fisher BT, Lehrnbecher T, Walsh TJ, Steinbach WJ. Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children. J Pediatric Infect Dis Soc. 2017 Sep 01; 6(suppl_1):S32-S44. PMID: 28927202.
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    39. Wong SSW, Rasid O, Laskaris P, Fekkar A, Cavaillon JM, Steinbach WJ, Ibrahim-Granet O. Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population. Virulence. 2017 11 17; 8(8):1744-1752. PMID: 28594271.
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    40. Lehrnbecher T, Robinson P, Fisher B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, Castagnola E, Davis BL, Dupuis LL, Gaur AH, Tissing WJE, Zaoutis T, Phillips R, Sung L. Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update. J Clin Oncol. 2017 Jun 20; 35(18):2082-2094. PMID: 28459614.
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    41. Vargas-Muñiz JM, Renshaw H, Waitt G, Soderblom EJ, Moseley MA, Palmer JM, Juvvadi PR, Keller NP, Steinbach WJ. Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. Biochem Biophys Res Commun. 2017 04 01; 485(2):221-226. PMID: 28238781.
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    42. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Asfaw YG, Steinbach WJ. A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. mBio. 2017 02 07; 8(1). PMID: 28174315.
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    43. Steinbach WJ. Special Issue "Aspergillus fumigatus: From Diagnosis to Therapy". J Fungi (Basel). 2016 Dec 08; 2(4). PMID: 29376947.
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    44. Lehrnbecher T, Robinson PD, Fisher BT, Castagnola E, Groll AH, Steinbach WJ, Zaoutis TE, Negeri ZF, Beyene J, Phillips B, Sung L. Galactomannan, ß-D-Glucan, and Polymerase Chain Reaction-Based Assays for the Diagnosis of Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. Clin Infect Dis. 2016 Nov 15; 63(10):1340-1348. PMID: 27567122.
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    45. Vargas-Muñiz JM, Juvvadi PR, Steinbach WJ. Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures. Microbiology (Reading). 2016 09; 162(9):1527-1534. PMID: 27559018.
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    46. Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 08 15; 63(4):433-42. PMID: 27481947.
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    47. Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 08 15; 63(4):e1-e60. PMID: 27365388.
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    48. Vargas-Muñiz JM, Renshaw H, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Asfaw Y, Juvvadi PR, Steinbach WJ. Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus. Front Microbiol. 2016; 7:997. PMID: 27446037.
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    49. Juvvadi PR, Lee SC, Heitman J, Steinbach WJ. Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. Virulence. 2017 02 17; 8(2):186-197. PMID: 27325145.
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    50. Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA. Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. mBio. 2016 Apr 26; 7(2):e00492-16. PMID: 27118592.
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    51. Renshaw H, Vargas-Muñiz JM, Richards AD, Asfaw YG, Juvvadi PR, Steinbach WJ. Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis. Infect Immun. 2016 05; 84(5):1556-64. PMID: 26953327.
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    52. Juvvadi PR, Pemble CW, Ma Y, Steinbach WJ. Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. FEBS Lett. 2016 Feb; 590(4):501-8. PMID: 26864964.
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    53. Lamoth F, Juvvadi PR, Steinbach WJ. Editorial: Advances in Aspergillus fumigatus Pathobiology. Front Microbiol. 2016; 7:43. PMID: 26870009.
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    64. Lamoth F, Juvvadi PR, Steinbach WJ. Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis. Front Microbiol. 2015; 6:96. PMID: 25762988.
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    67. Palazzi DL, Arrieta A, Castagnola E, Halasa N, Hubbard S, Brozovich AA, Fisher BT, Steinbach WJ. Candida speciation, antifungal treatment and adverse events in pediatric invasive candidiasis: results from 441 infections in a prospective, multi-national study. Pediatr Infect Dis J. 2014 Dec; 33(12):1294-6. PMID: 24892850.
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    98. Pinchai N, Juvvadi PR, Fortwendel JR, Perfect BZ, Rogg LE, Asfaw YG, Steinbach WJ. The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. Eukaryot Cell. 2010 Mar; 9(3):472-6. PMID: 20097742.
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    100. Horn DL, Neofytos D, Anaissie EJ, Fishman JA, Steinbach WJ, Olyaei AJ, Marr KA, Pfaller MA, Chang CH, Webster KM. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis. 2009 Jun 15; 48(12):1695-703. PMID: 19441981.
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    103. Fortwendel JR, Juvvadi PR, Pinchai N, Perfect BZ, Alspaugh JA, Perfect JR, Steinbach WJ. Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus. Antimicrob Agents Chemother. 2009 Feb; 53(2):476-82. PMID: 19015336.
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    106. Burgos A, Zaoutis TE, Dvorak CC, Hoffman JA, Knapp KM, Nania JJ, Prasad P, Steinbach WJ. Pediatric invasive aspergillosis: a multicenter retrospective analysis of 139 contemporary cases. Pediatrics. 2008 May; 121(5):e1286-94. PMID: 18450871.
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    107. Cowen LE, Steinbach WJ. Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot Cell. 2008 May; 7(5):747-64. PMID: 18375617.
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    108. Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, van Burik JA, Wingard JR, Patterson TF. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008 Feb 01; 46(3):327-60. PMID: 18177225.
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    113. Smith PB, Benjamin DK, Alexander BD, Johnson MD, Finkelman MA, Steinbach WJ. Quantification of 1,3-beta-D-glucan levels in children: preliminary data for diagnostic use of the beta-glucan assay in a pediatric setting. Clin Vaccine Immunol. 2007 Jul; 14(7):924-5. PMID: 17538119.
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    121. Cramer RA, Gamcsik MP, Brooking RM, Najvar LK, Kirkpatrick WR, Patterson TF, Balibar CJ, Graybill JR, Perfect JR, Abraham SN, Steinbach WJ. Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. Eukaryot Cell. 2006 Jun; 5(6):972-80. PMID: 16757745.
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    125. Smith PB, Steinbach WJ, Benjamin DK. Neonatal candidiasis. Infect Dis Clin North Am. 2005 Sep; 19(3):603-15. PMID: 16102651.
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    126. Zaoutis TE, Benjamin DK, Steinbach WJ. Antifungal treatment in pediatric patients. Drug Resist Updat. 2005 Aug; 8(4):235-45. PMID: 16054422.
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    135. Steinbach WJ, Perfect JR, Schell WA, Walsh TJ, Benjamin DK. In vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection. Antimicrob Agents Chemother. 2004 Sep; 48(9):3217-25. PMID: 15328076.
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    140. Benjamin DK, DeLong E, Steinbach WJ. Latent class analysis: an illustrative application for education in the assessment of resident otoscopic skills. Ambul Pediatr. 2004 Jan-Feb; 4(1):13-7. PMID: 14731098.
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    141. Benjamin DK, Miro JM, Hoen B, Steinbach WJ, Fowler VG, Olaison L, Habib G, Abrutyn E, Perfect J, Zass A, Corey GR, Eykyn S, Thuny F, Jiménez-Expósito MJ, Cabell CH. Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD). Scand J Infect Dis. 2004; 36(6-7):453-5. PMID: 15307567.
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    142. Steinbach WJ, Mitchell TG, Schell WA, Espinel-Ingroff A, Coico RF, Walsh TJ, Perfect JR. Status of medical mycology education. Med Mycol. 2003 Dec; 41(6):457-67. PMID: 14725319.
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    143. Benjamin DK, Garges H, Steinbach WJ. Candida bloodstream infection in neonates. Semin Perinatol. 2003 Oct; 27(5):375-83. PMID: 14626501.
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    144. Steinbach WJ, Stevens DA, Denning DW, Moss RB. Advances against aspergillosis. Clin Infect Dis. 2003 Oct 01; 37 Suppl 3:S155-6. PMID: 12975750.
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    145. Steinbach WJ, Stevens DA. Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis. Clin Infect Dis. 2003 Oct 01; 37 Suppl 3:S157-87. PMID: 12975751.
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    146. Steinbach WJ, Stevens DA, Denning DW. Combination and sequential antifungal therapy for invasive aspergillosis: review of published in vitro and in vivo interactions and 6281 clinical cases from 1966 to 2001. Clin Infect Dis. 2003 Oct 01; 37 Suppl 3:S188-224. PMID: 12975752.
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    147. Benjamin DK, DeLong ER, Steinbach WJ, Cotton CM, Walsh TJ, Clark RH. Empirical therapy for neonatal candidemia in very low birth weight infants. Pediatrics. 2003 Sep; 112(3 Pt 1):543-7. PMID: 12949281.
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    148. Benjamin DK, Poole C, Steinbach WJ, Rowen JL, Walsh TJ. Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques. Pediatrics. 2003 Sep; 112(3 Pt 1):634-40. PMID: 12949295.
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    149. Steinbach WJ, Schell WA, Miller JL, Perfect JR. Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide. J Clin Microbiol. 2003 Aug; 41(8):3981-5. PMID: 12904435.
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    150. Trinh JV, Steinbach WJ, Schell WA, Kurtzberg J, Giles SS, Perfect JR. Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy. Med Mycol. 2003 Aug; 41(4):339-45. PMID: 12964727.
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    151. Klaudt MR, Steinbach WJ, Sectish TC. Clinical considerations in the diagnosis of otitis media. Curr Allergy Asthma Rep. 2003 Jul; 3(4):313-20. PMID: 12791208.
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    152. Steinbach WJ, Perfect JR. Newer antifungal therapy for emerging fungal pathogens. Int J Infect Dis. 2003 Mar; 7(1):5-20. PMID: 12718805.
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    153. Blankenship JR, Steinbach WJ, Perfect JR, Heitman J. Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs. Curr Opin Investig Drugs. 2003 Feb; 4(2):192-9. PMID: 12669381.
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    154. Steinbach WJ, Sectish TC, Benjamin DK, Chang KW, Messner AH. Pediatric residents' clinical diagnostic accuracy of otitis media. Pediatrics. 2002 Jun; 109(6):993-8. PMID: 12042534.
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    155. Steinbach WJ, Sectish TC. Pediatric resident training in the diagnosis and treatment of acute otitis media. Pediatrics. 2002 Mar; 109(3):404-8. PMID: 11875132.
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