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Abdelrahman Fouda

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
Address325 S. Elm St.
Mail Slot # 611
Little Rock AR 72205
Phone501-686-5810
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    Collapse Research 
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    R00EY029373     (FOUDA, ABDELRAHMAN)Sep 1, 2019 - Jan 31, 2025
    NIH/Nat. Eye Institute
    Role of Arginase 1 in Retinal Ischemia Reperfusion Injury
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Shahror RA, Morris CA, Mohammed AA, Wild M, Zaman B, Mitchell CD, Phillips PH, Rusch NJ, Shosha E, Fouda AY. Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions. J Neuroinflammation. 2024 Mar 07; 21(1):65. PMID: 38454477.
      View in: PubMed
    2. Zaidi SAH, Xu Z, Lemtalsi T, Sandow P, Athota S, Liu F, Haigh S, Huo Y, Narayanan SP, Fulton DJR, Rojas MA, Fouda AY, Caldwell RW, Caldwell RB. Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush. Cell Death Dis. 2023 10 10; 14(10):661. PMID: 37816735.
      View in: PubMed
    3. Shosha E, Shahror RA, Morris CA, Xu Z, Lucas R, McGee-Lawrence ME, Rusch NJ, Caldwell RB, Fouda AY. The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury. Cell Death Dis. 2023 09 21; 14(9):621. PMID: 37735154.
      View in: PubMed
    4. Xiao W, Shahror RA, Morris CA, Caldwell RB, Fouda AY. Multi-color Flow Cytometry Protocol to Characterize Myeloid Cells in Mouse Retina Research. Bio Protoc. 2023 Aug 20; 13(16):e4745. PMID: 37638294.
      View in: PubMed
    5. Fouda AY, Xu Z, Suwanpradid J, Rojas M, Shosha E, Lemtalsi T, Patel C, Xing J, Zaidi SA, Zhi W, Stansfield BK, Cheng PN, Narayanan SP, Caldwell RW, Caldwell RB. Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair. Cell Death Dis. 2022 08 29; 13(8):745. PMID: 36038541.
      View in: PubMed
    6. Fouda AY, Ahmed HA, Pillai B, Kozak A, Hardigan T, Ergul A, Fagan SC, Ishrat T. Contralesional angiotensin type 2 receptor activation contributes to recovery in experimental stroke. Neurochem Int. 2022 09; 158:105375. PMID: 35688299.
      View in: PubMed
    7. Stolarz AJ, Mu S, Zhang H, Fouda AY, Rusch NJ, Ding Z. Opinion: Endothelial Cells - Macrophage-Like Gatekeepers? Front Immunol. 2022; 13:902945. PMID: 35619719.
      View in: PubMed
    8. Das A, Ash D, Fouda AY, Sudhahar V, Kim YM, Hou Y, Hudson FZ, Stansfield BK, Caldwell RB, McMenamin M, Littlejohn R, Su H, Regan MR, Merrill BJ, Poole LB, Kaplan JH, Fukai T, Ushio-Fukai M. Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. Nat Cell Biol. 2022 01; 24(1):35-50. PMID: 35027734.
      View in: PubMed
    9. Fouda AY, Eldahshan W, Xu Z, Lemtalsi T, Shosha E, Zaidi SA, Abdelrahman AA, Cheng PN, Narayanan SP, Caldwell RW, Caldwell RB. Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury. Exp Neurol. 2022 02; 348:113923. PMID: 34780773.
      View in: PubMed
    10. Shosha E, Fouda AY, Lemtalsi T, Haigh S, Fulton D, Ibrahim A, Al-Shabrawey M, Caldwell RW, Caldwell RB. Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction. Mol Metab. 2021 11; 53:101273. PMID: 34139341.
      View in: PubMed
    11. Candadai AA, Liu F, Fouda AY, Alfarhan M, Palani CD, Xu Z, Caldwell RB, Narayanan SP. Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis. PLoS One. 2021; 16(3):e0247901. PMID: 33735314.
      View in: PubMed
    12. Fouda AY, Eldahshan W, Narayanan SP, Caldwell RW, Caldwell RB. Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues. Front Pharmacol. 2020; 11:277. PMID: 32256357.
      View in: PubMed
    13. Fouda AY, Xu Z, Narayanan SP, Caldwell RW, Caldwell RB. Utility of LysM-cre and Cdh5-cre Driver Mice in Retinal and Brain Research: An Imaging Study Using tdTomato Reporter Mouse. Invest Ophthalmol Vis Sci. 2020 03 09; 61(3):51. PMID: 32232350.
      View in: PubMed
    14. Shosha E, Fouda AY, Narayanan SP, Caldwell RW, Caldwell RB. Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy? J Clin Med. 2020 Feb 05; 9(2). PMID: 32033258.
      View in: PubMed
    15. Atawia RT, Bunch KL, Fouda AY, Lemtalsi T, Eldahshan W, Xu Z, Saul A, Elmasry K, Al-Shabrawey M, Caldwell RB, Caldwell RW. Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity. J Clin Med. 2020 Jan 22; 9(2). PMID: 31979105.
      View in: PubMed
    16. Alsohaimi A, Fouda AM. Assessment of the Effect of Extract Formulation of Date Palm Kernel on Facial Skin Wrinkles: Biophysical Measurements and Digital Profilometry. J Cosmet Sci. 2019 Nov/Dec; 70(6):277-290. PMID: 31829921.
      View in: PubMed
    17. Palani CD, Fouda AY, Liu F, Xu Z, Mohamed E, Giri S, Smith SB, Caldwell RB, Narayanan SP. Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2019 Dec; 56(12):8589-8602. PMID: 31280447.
      View in: PubMed
    18. Fouda AY, Fagan SC, Ergul A. Brain Vasculature and Cognition. Arterioscler Thromb Vasc Biol. 2019 04; 39(4):593-602. PMID: 30816798.
      View in: PubMed
    19. Eldahshan W, Ishrat T, Pillai B, Sayed MA, Alwhaibi A, Fouda AY, Ergul A, Fagan SC. Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study. Am J Physiol Heart Circ Physiol. 2019 05 01; 316(5):H1192-H1201. PMID: 30822121.
      View in: PubMed
    20. Pichavaram P, Palani CD, Patel C, Xu Z, Shosha E, Fouda AY, Caldwell RB, Narayanan SP. Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration. Front Neurosci. 2018; 12:956. PMID: 30686964.
      View in: PubMed
    21. Xu Z, Fouda AY, Lemtalsi T, Shosha E, Rojas M, Liu F, Patel C, Caldwell RW, Narayanan SP, Caldwell RB. Retinal Neuroprotection From Optic Nerve Trauma by Deletion of Arginase 2. Front Neurosci. 2018; 12:970. PMID: 30618589.
      View in: PubMed
    22. Fouda AY, Xu Z, Shosha E, Lemtalsi T, Chen J, Toque HA, Tritz R, Cui X, Stansfield BK, Huo Y, Rodriguez PC, Smith SB, Caldwell RW, Narayanan SP, Caldwell RB. Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses. Cell Death Dis. 2018 09 25; 9(10):1001. PMID: 30254218.
      View in: PubMed
    23. Ahmed HA, Ishrat T, Pillai B, Fouda AY, Sayed MA, Eldahshan W, Waller JL, Ergul A, Fagan SC. RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial. J Neuroinflammation. 2018 Aug 13; 15(1):229. PMID: 30103772.
      View in: PubMed
    24. Shosha E, Xu Z, Narayanan SP, Lemtalsi T, Fouda AY, Rojas M, Xing J, Fulton D, Caldwell RW, Caldwell RB. Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1. Int J Mol Sci. 2018 Apr 17; 19(4). PMID: 29673160.
      View in: PubMed
    25. Ishrat T, Fouda AY, Pillai B, Eldahshan W, Ahmed H, Waller JL, Ergul A, Fagan SC. Dose-response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke. J Cereb Blood Flow Metab. 2019 08; 39(8):1635-1647. PMID: 29537907.
      View in: PubMed
    26. Fouda AM, Youssef AR, Sharaf Eldin O. Comparative study of amlodipine vs. cilnidipine for the prevention of hepatic ischemia-reperfusion injury in rat model. Fundam Clin Pharmacol. 2018 Apr; 32(2):163-173. PMID: 29172244.
      View in: PubMed
    27. Bhatta A, Yao L, Xu Z, Toque HA, Chen J, Atawia RT, Fouda AY, Bagi Z, Lucas R, Caldwell RB, Caldwell RW. Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. Cardiovasc Res. 2017 Nov 01; 113(13):1664-1676. PMID: 29048462.
      View in: PubMed
    28. Fouda AY, Newsome AS, Spellicy S, Waller JL, Zhi W, Hess DC, Ergul A, Edwards DJ, Fagan SC, Switzer JA. Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial. Stroke. 2017 10; 48(10):2885-2887. PMID: 28887388.
      View in: PubMed
    29. Fouda AY, Pillai B, Dhandapani KM, Ergul A, Fagan SC. Role of interleukin-10 in the neuroprotective effect of the Angiotensin Type 2 Receptor agonist, compound 21, after ischemia/reperfusion injury. Eur J Pharmacol. 2017 Mar 15; 799:128-134. PMID: 28192099.
      View in: PubMed
    30. Alhusban A, Fouda AY, Fagan SC. ARBs improve stroke outcome through an AT2-dependent, BDNF-induced proangiogenic and prorecovery response. Neural Regen Res. 2016 Jun; 11(6):912-3. PMID: 27482214.
      View in: PubMed
    31. Ergul A, Hafez S, Fouda A, Fagan SC. Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research: Focus on Hypertension and Diabetes. Transl Stroke Res. 2016 08; 7(4):248-60. PMID: 27026092.
      View in: PubMed
    32. Fouda AY, Artham S, El-Remessy AB, Fagan SC. Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence. Clin Sci (Lond). 2016 Feb; 130(4):221-38. PMID: 26769658.
      View in: PubMed
    33. Fouda AY, Alhusban A, Ishrat T, Pillai B, Eldahshan W, Waller JL, Ergul A, Fagan SC. Brain-Derived Neurotrophic Factor Knockdown Blocks the Angiogenic and Protective Effects of Angiotensin Modulation After Experimental Stroke. Mol Neurobiol. 2017 01; 54(1):661-670. PMID: 26758277.
      View in: PubMed
    34. Soliman S, Ishrat T, Fouda AY, Patel A, Pillai B, Fagan SC. Sequential Therapy with Minocycline and Candesartan Improves Long-Term Recovery After Experimental Stroke. Transl Stroke Res. 2015 Aug; 6(4):309-22. PMID: 26004281.
      View in: PubMed
    35. Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC. Erratum to: Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice. Mol Neurobiol. 2015 Apr; 51(2):779-80. PMID: 25502293.
      View in: PubMed
    36. Ergul A, Valenzuela JP, Fouda AY, Fagan SC. Cellular connections, microenvironment and brain angiogenesis in diabetes: Lost communication signals in the post-stroke period. Brain Res. 2015 Oct 14; 1623:81-96. PMID: 25749094.
      View in: PubMed
    37. Artham S, Fouda AY, El-Remessy AB, Fagan SC. Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure. Receptors Clin Investig. 2015; 2(3). PMID: 26317114.
      View in: PubMed
    38. Alhusban A, Fouda AY, Ishrat T, Soliman S, Fagan SC. Compound 21 is pro-angiogenic in the brain and results in sustained recovery after ischemic stroke. J Hypertens. 2015 Jan; 33(1):170-80. PMID: 25304472.
      View in: PubMed
    39. Ishrat T, Pillai B, Soliman S, Fouda AY, Kozak A, Johnson MH, Ergul A, Fagan SC. Low-dose candesartan enhances molecular mediators of neuroplasticity and subsequent functional recovery after ischemic stroke in rats. Mol Neurobiol. 2015; 51(3):1542-53. PMID: 25084762.
      View in: PubMed
    40. Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC. Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice. Mol Neurobiol. 2015 Apr; 51(2):766-78. PMID: 24939693.
      View in: PubMed
    41. Ergul A, Abdelsaid M, Fouda AY, Fagan SC. Cerebral neovascularization in diabetes: implications for stroke recovery and beyond. J Cereb Blood Flow Metab. 2014 Apr; 34(4):553-63. PMID: 24496174.
      View in: PubMed
    42. Fouda AY, Kozak A, Alhusban A, Switzer JA, Fagan SC. Anti-inflammatory IL-10 is upregulated in both hemispheres after experimental ischemic stroke: Hypertension blunts the response. Exp Transl Stroke Med. 2013 Nov 13; 5(1):12. PMID: 24499655.
      View in: PubMed
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