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Samrat Roy Choudhury

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Hematology
Address1120 Marshall Street
Mail Slot # 512-1
Little Rock AR 72202
ORCID ORCID Icon0000-0002-6555-3031 Additional info
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    Collapse Overview 
    Collapse overview
    Epigenetic alterations, including DNA methylation, histone covalent modifications and super-enhancer regulation of dysregulated transcriptional networks have attracted a significant amount of attention for the prevention and treatment of different genetic disorders with cancer at the forefront, mainly due to the inherent reversibility of epigenetic states.

    As a part of my postdoctoral training at the Purdue University and University of Arkansas for Medical Sciences (UAMS), I developed my understanding of epigenetic regulation of gene dysfunctions in cancer. I study epigenetic abnormalities on Next Generation sequencing platforms (RRBS, 850K-array, TAB, ChIP, RNA-seq. etc.) and use TALE or CRISPR based synthetic proteins for targeted perturbations of the epigenomic lesions

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    Collapse Affiliation 
    Collapse member of
    American Association for Research on Cancer (AACR)
    The American Society of Hematology (ASH)
    WPRCI, UAMS Cancer Biology Group
    Collapse collaborator
    Tackett, Alan

    Collapse Biography 
    Collapse education and training
    University of Arkansas for Medical Sciences, AR, USAResearch Associate11/2020Cancer Epigenetics
    Purdue University, IN, USAPostdoctoral Research Assistant08/2016Cancer Epigenetics
    University of Calcutta, IndiaPh.D.06/2013Biotechnology

    Collapse Research 
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    Acute Myeloid Leukemia is the third most prevalent cancer among the hematological malignancies in the United States, presented with a diverse array of epigenetic abnormalities including chromosomal alterations or recurrent mutations in the epigenetic modifiers.
    The Roy Choudhury laboratory investigates the epigenetic regulatory mechanisms at the enhancers and promoters of the critical oncogenes and tumor suppressors that drive malignant proliferation and invasion during leukemogenesis across the molecular subgroups of AML patients. Using the multi-omics platform, we intend to identify the alterations in DNA-methylation, histone covalent modifications and accessibility of the transcription factors to the aberrantly expressed genes in and outside the topologically assorted domains (TAD) of the leukemic blasts. We employ a combination of in vitro and in vivo mouse models to design and target CRISPR or small molecule based perturbation strategies to reverse the dysfunctional epigenetic states and malignant growth.

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    1. Frett B, Stephens KE, Koss B, Melnyk S, Farrar J, Saha D, Roy Choudhury S. Enhancer-activated RET confers protection against oxidative stress to KMT2A-rearranged acute myeloid leukemia. Cancer Sci. 2024 Mar; 115(3):963-973. PMID: 38226414.
      View in: PubMed
    2. Roy Choudhury S, Heflin B, Taylor E, Koss B, Avaritt NL, Tackett AJ. CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells. Cells. 2023 02 24; 12(5). PMID: 36899866.
      View in: PubMed
    3. Roy Choudhury S, Byrum SD, Alkam D, Ashby C, Zhan F, Tackett AJ, Van Rhee F. Expression of integrin ?-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics. Clin Epigenetics. 2023 02 04; 15(1):18. PMID: 36737807.
      View in: PubMed
    4. Roy Choudhury S, Ashby C, Zhan F, van Rhee F. Epigenetic Deregulation of Telomere-Related Genes in Newly Diagnosed Multiple Myeloma Patients. Cancers (Basel). 2021 Dec 17; 13(24). PMID: 34944968.
      View in: PubMed
    5. Choudhury SR, Ashby C, Tytarenko R, Bauer M, Wang Y, Deshpande S, Den J, Schinke C, Zangari M, Thanendrarajan S, Davies FE, van Rhee F, Morgan GJ, Walker BA. The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma. J Hematol Oncol. 2020 08 06; 13(1):108. PMID: 32762714.
      View in: PubMed
    6. Choudhury SR, Walker BA. A Rapid and Robust Protocol for Reduced Representation Bisulfite Sequencing in Multiple Myeloma. Methods Mol Biol. 2018; 1792:179-191. PMID: 29797260.
      View in: PubMed
    7. Choudhury SR, Ordaz J, Lo CL, Damayanti NP, Zhou F, Irudayaraj J. From the Cover: Zinc oxide Nanoparticles-Induced Reactive Oxygen Species Promotes Multimodal Cyto- and Epigenetic Toxicity. Toxicol Sci. 2017 03 01; 156(1):261-274. PMID: 28115643.
      View in: PubMed
    8. Lo CL, Choudhury SR, Irudayaraj J, Zhou FC. Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics. Sci Rep. 2017 02 09; 7:42047. PMID: 28181538.
      View in: PubMed
    9. Choudhury SR, Cui Y, Narayanan A, Gilley DP, Huda N, Lo CL, Zhou FC, Yernool D, Irudayaraj J. Optogenetic regulation of site-specific subtelomeric DNA methylation. Oncotarget. 2016 Aug 02; 7(31):50380-50391. PMID: 27391261.
      View in: PubMed
    10. Choudhury SR, Cui Y, Lubecka K, Stefanska B, Irudayaraj J. CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter. Oncotarget. 2016 Jul 19; 7(29):46545-46556. PMID: 27356740.
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    11. Choudhury SR, Cui Y, Milton JR, Li J, Irudayaraj J. Selective increase in subtelomeric DNA methylation: an epigenetic biomarker for malignant glioma. Clin Epigenetics. 2015; 7:107. PMID: 26451167.
      View in: PubMed
    12. Cui Y, Choudhury SR, Irudayaraj J. Quantitative real-time kinetics of optogenetic proteins CRY2 and CIB1/N using single-molecule tools. Anal Biochem. 2014 Aug 01; 458:58-60. PMID: 24780222.
      View in: PubMed
    13. Roy Choudhury S, Mandal A, Ghosh M, Basu S, Chakravorty D, Goswami A. Investigation of antimicrobial physiology of orthorhombic and monoclinic nanoallotropes of sulfur at the interface of transcriptome and metabolome. Appl Microbiol Biotechnol. 2013 Jul; 97(13):5965-78. PMID: 23546420.
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    14. Roy Choudhury S, Ghosh M, Goswami A. Inhibitory effects of sulfur nanoparticles on membrane lipids of Aspergillus niger: a novel route of fungistasis. Curr Microbiol. 2012 Jul; 65(1):91-7. PMID: 22538469.
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    15. Choudhury SR, Roy S, Goswami A, Basu S. Polyethylene glycol-stabilized sulphur nanoparticles: an effective antimicrobial agent against multidrug-resistant bacteria. J Antimicrob Chemother. 2012 May; 67(5):1134-7. PMID: 22269475.
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    16. Choudhury SR, Ghosh M, Mandal A, Chakravorty D, Pal M, Pradhan S, Goswami A. Surface-modified sulfur nanoparticles: an effective antifungal agent against Aspergillus niger and Fusarium oxysporum. Appl Microbiol Biotechnol. 2011 Apr; 90(2):733-43. PMID: 21350853.
      View in: PubMed
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