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Samrat Roy Choudhury

TitleResearch Associate
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
DivisionBiochem & Molecular Proteomics
Address4104 Outpatient Circle
Mail Slot # 816
Little Rock AR 72205
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    I'm passionate towards translational research. Novel biophysical and biochemical tools has always inspired me to exploit their potential applications in deciphering the intriguing bio-molecular complexities.

    During my doctoral studies I got the chance to design and develop several nanoparticles and nano-conjugates of antimicrobial importance. During the course of graduate research, I have observed how the same chemical elements behave dramatically different at nano-configuration compared to their micronized state in term of physicochemical and biological properties.

    During my first postdoctoral research at Purdue University, I was exposed to a new arena of bio-engineering applications. At Purdue, I learnt to design and target the biomolecular tools like TAL (transcription activator like elements), or CRISPR-Cas9 based fusion protein constructs for loci specific epigenetic editing with spatiotemporal precision..

    My present research at the University of Arkansas for Medical Sciences is focused in understanding the epigenetic regulation in high-risk human cancers . In lateral expansion to identifying the aberrant epigenetic signatures in cancer, I would be interested to utilize my expertise towards the therapeutic interventions in epigenomic anomalies.

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    1. Choudhury SR, Cui Y, Narayanan A, Gilley DP, Huda N, Lo CL, Zhou FC, Yernool D, Irudayaraj J. Optogenetic regulation of site-specific subtelomeric DNA methylation. Oncotarget. 2016 Aug 02; 7(31):50380-50391. PMID: 27391261.
      View in: PubMed
    2. Choudhury SR, Cui Y, Lubecka K, Stefanska B, Irudayaraj J. CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter. Oncotarget. 2016 Jul 19; 7(29):46545-46556. PMID: 27356740.
      View in: PubMed
    3. Choudhury SR, Cui Y, Milton JR, Li J, Irudayaraj J. Selective increase in subtelomeric DNA methylation: an epigenetic biomarker for malignant glioma. Clin Epigenetics. 2015; 7:107. PMID: 26451167.
      View in: PubMed
    4. Roy Choudhury S, Mandal A, Ghosh M, Basu S, Chakravorty D, Goswami A. Investigation of antimicrobial physiology of orthorhombic and monoclinic nanoallotropes of sulfur at the interface of transcriptome and metabolome. Appl Microbiol Biotechnol. 2013 Jul; 97(13):5965-78. PMID: 23546420.
      View in: PubMed
    5. Choudhury SR, Roy S, Goswami A, Basu S. Polyethylene glycol-stabilized sulphur nanoparticles: an effective antimicrobial agent against multidrug-resistant bacteria. J Antimicrob Chemother. 2012 May; 67(5):1134-7. PMID: 22269475.
      View in: PubMed
    6. Choudhury SR, Ghosh M, Mandal A, Chakravorty D, Pal M, Pradhan S, Goswami A. Surface-modified sulfur nanoparticles: an effective antifungal agent against Aspergillus niger and Fusarium oxysporum. Appl Microbiol Biotechnol. 2011 Apr; 90(2):733-43. PMID: 21350853.
      View in: PubMed
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