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En Huang

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentEnvironmental Health Sciences, College of Public Health
DivisionEnvironmental Health Sciences
Address220 UAMS Campus Dr.
Mail Slot # 820
Little Rock AR 72205
Phone501-526-6627
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    Collapse Research 
    Collapse research activities and funding
    1R01AI175440-01A1     (HUANG, EN)Sep 1, 2024 - Aug 31, 2029
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens
    Role: Principal Investigator
    5R01AI175440-02     (HUANG, EN)Sep 1, 2024 - Aug 31, 2029
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens
    Role: Principal Investigator
    5R01AI175440-03     (HUANG, EN)Sep 1, 2024 - Aug 31, 2029
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens
    Role: Principal Investigator
    5R01AI175440-04     (HUANG, EN)Sep 1, 2024 - Aug 31, 2029
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens
    Role: Principal Investigator
    5R01AI175440-05     (HUANG, EN)Sep 1, 2024 - Aug 31, 2029
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens
    Role: Principal Investigator
    2022-69015-36720     (HUANG, EN)Aug 1, 2022 - Jul 31, 2025
    National Institute of Food and Agriculture
    Assessment of antibiotic resistance in fresh vegetables from farm to fork
    Role: Principal Investigator
    1R21AI169138     (DARE, RYAN)May 10, 2022 - Apr 30, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Real-Time High Resolution Method for Genomic Surveillance of ESKAPE pathogens
    Role: Principal Investigator
    R21AI146693     (HUANG, EN)Jul 1, 2019 - Jan 31, 2022
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Novel linear lipopeptide paenipeptins sensitize multidrug-resistant Gram-negative pathogens to antibiotics - Continuation Year 2020-2021
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Huang E, Thompson RN, Moon SH, Keck JM, Lowry MS, Melero J, Jun S-R, Rosenbaum ER, Dare RK. Treatment-emergent cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii is associated with insertion sequence ISAba36 in the siderophore receptor pirA. Antimicrob Agents Chemother. 2024 07 09; 68(7):e0029024. PMID: 38809000.
      View in: PubMed
    2. Huang E, Yang X, Leighton E, Li X. Carbapenem resistance in the food supply chain. J Food Prot. 2023 07; 86(7):100108. PMID: 37244353.
      View in: PubMed
    3. Moon SH, Huang E. Cefiderocol Resistance in Klebsiella pneumoniae Is Linked to SHV Extended-Spectrum ?-Lactamase Activities and Functional Loss of the Outer Membrane Porin OmpK35. Microbiol Spectr. 2023 06 15; 11(3):e0349622. PMID: 37097174.
      View in: PubMed
    4. Udaondo Z, Abram KZ, Gulley T, Garner K, Shray J, Whisnant M, Harris-Spotts A, Crawford M, Kothari A, Wongsurawat T, Moon SH, Huang E, Jun SR. Complete Genome Sequence of a Non-Carbapenemase-Producing Carbapenem-Resistant Providencia rettgeri Strain Isolated from a Clinical Urine Sample in Arkansas. Microbiol Resour Announc. 2022 Aug 18; 11(8):e0047422. PMID: 35894621.
      View in: PubMed
    5. Moon SH, Udaondo Z, Jun SR, Huang E. Cefiderocol heteroresistance in Klebsiella pneumoniae is linked to mutations in the siderophore receptor cirA and ?-lactamase activities. Int J Antimicrob Agents. 2022 09; 60(3):106635. PMID: 35820535.
      View in: PubMed
    6. Wadley T, Moon SH, DeMott MS, Wanchai V, Huang E, Dedon PC, Boysen G, Nookaew I. Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences. Front Microbiol. 2022; 13:871937. PMID: 35531280.
      View in: PubMed
    7. Moon SH, Kaufmann Y, Fujiwara R, Huang E. Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection. BMC Microbiol. 2021 11 24; 21(1):326. PMID: 34819026.
      View in: PubMed
    8. Moon SH, Udaondo Z, Abram KZ, Li X, Yang X, DiCaprio EL, Jun SR, Huang E. Isolation of AmpC- and extended spectrum ?-lactamase-producing Enterobacterales from fresh vegetables in the United States. Food Control. 2022 Feb; 132. PMID: 34629764.
      View in: PubMed
    9. Moon SH, Udaondo Z, Li X, Yang X, Jun SR, Huang E. Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable. J Glob Antimicrob Resist. 2021 09; 26:264-265. PMID: 34329791.
      View in: PubMed
    10. Nookaew I, Jenjaroenpun P, Du H, Wang P, Wu J, Wongsurawat T, Moon SH, Huang E, Wang Y, Boysen G. Detection and Discrimination of DNA Adducts Differing in Size, Regiochemistry, and Functional Group by Nanopore Sequencing. Chem Res Toxicol. 2020 12 21; 33(12):2944-2952. PMID: 32799528.
      View in: PubMed
    11. Moon SH, Kaufmann Y, Huang E. Paenipeptin Analogues Potentiate Clarithromycin and Rifampin against mcr-1-Mediated Polymyxin-Resistant Escherichia coli In Vivo. Antimicrob Agents Chemother. 2020 03 24; 64(4). PMID: 32015033.
      View in: PubMed
    12. Moon SH, Huang E. Novel linear lipopeptide paenipeptin C' binds to lipopolysaccharides and lipoteichoic acid and exerts bactericidal activity by the disruption of cytoplasmic membrane. BMC Microbiol. 2019 01 08; 19(1):6. PMID: 30621590.
      View in: PubMed
    13. Moon SH, Huang E. Lipopeptide Paenipeptin Analogues Potentiate Clarithromycin and Rifampin against Carbapenem-Resistant Pathogens. Antimicrob Agents Chemother. 2018 08; 62(8). PMID: 29844042.
      View in: PubMed
    14. Moon SH, Zhang X, Zheng G, Meeker DG, Smeltzer MS, Huang E. Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin. J Med Chem. 2017 12 14; 60(23):9630-9640. PMID: 29136469.
      View in: PubMed
    15. Huang E, Yang X, Zhang L, Moon SH, Yousef AE. New Paenibacillus strain produces a family of linear and cyclic antimicrobial lipopeptides: cyclization is not essential for their antimicrobial activity. FEMS Microbiol Lett. 2017 04 01; 364(8). PMID: 28333237.
      View in: PubMed
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