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Nukhet Aykin-Burns

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmaceutical Science, College of Pharmacy
DivisionPharmaceutical Science
Address441A-2 Biomedical Research II
200 South Cedar
Mail Slot # 522-10
Little Rock AR 72202
Phone501-603-1375
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    Collapse Overview 
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    Collapse Research 
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    1R37CA282349     (LANDES, REID D)Aug 10, 2023 - Jul 31, 2028
    NIH/Nat. Cancer Institute
    Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
    Role: Principal Investigator
    1R37CA282349-01     (LANDES, REID D)Aug 10, 2023 - Jul 31, 2028
    NIH/Nat. Cancer Institute
    Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
    Role: Principal Investigator
    5R37CA282349     (LANDES, REID D)Aug 10, 2023 - Jul 31, 2028
    NIH/Nat. Cancer Institute
    Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
    Role: Principal Investigator
    5R37CA282349-02     (LANDES, REID D)Aug 10, 2023 - Jul 31, 2028
    NIH/Nat. Cancer Institute
    Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
    Role: Principal Investigator
    5R37CA282349-03     (LANDES, REID D)Aug 10, 2023 - Jul 31, 2028
    NIH/Nat. Cancer Institute
    Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
    Role: Principal Investigator
    5R37CA282349-04     (LANDES, REID D)Aug 10, 2023 - Jul 31, 2028
    NIH/Nat. Cancer Institute
    Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
    Role: Principal Investigator
    5R37CA282349-05     (LANDES, REID D)Aug 10, 2023 - Jul 31, 2028
    NIH/Nat. Cancer Institute
    Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
    Role: Principal Investigator
    NNX16A069A     (ALLEN, ANTINO)Jan 1, 2019 - Dec 31, 2020
    National Aeronautics & Space Administration
    Photobiomodulation to Ameliorate Neuronal Degeneration and Cognitive Decline after Mixed Field Irradiation
    Role: Co-Investigator
    P20GM109005     (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025
    NIH
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator
    Project No.15-B-19     (AYKIN-BURNS, NUKHET)Sep 19, 2014 - Sep 30, 2016
    Arkansas Science & Technology Authority
    The Role of Mitochondrial Reactive Oxygen Species and Sirtuin3 in Radiation-Induced Liver Damage
    Role: Principal Investigator
    ProjectNo.15-B     (AYKIN-BURNS, NUKHET)Sep 19, 2014 - Sep 30, 2016
    Arkansas Science & Technology Authority
    The Role of Mitochondrial Reactive Oxygen Species and Sirtuin3 in Radiation-Induced Liver Damage
    Role: Principal Investigator
    R15ES022781     (AYKIN-BURNS, NUKHET)Sep 13, 2013 - Aug 31, 2017
    NIH
    Sirt3: A Key Player Against PCB-Induced Mitochondrial Injury
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Shrum SA, Nukala U, Shrimali S, Pineda EN, Krager KJ, Thakkar S, Jones DE, Pathak R, Breen PJ, Aykin-Burns N, Compadre CM. Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects. Antioxidants (Basel). 2023 Nov 09; 12(11). PMID: 38001840.
      View in: PubMed
    2. McGill MR, Kaufman YJ, LoBianco FV, Schleiff MA, Aykin-Burns N, Miller GP. The role of cytochrome P450 3A4-mediated metabolism in sorafenib and lapatinib hepatotoxicity. Livers. 2023 Jun; 3(2):310-321. PMID: 38037613.
      View in: PubMed
    3. Trujillo M, Odle AK, Aykin-Burns N, Allen AR. Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions?. Biol Reprod. 2023 04 11; 108(4):522-537. PMID: 36539327.
      View in: PubMed
    4. Allen AR, Jones A', LoBianco FV, Krager KJ, Aykin-Burns N. Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model. Behav Brain Res. 2023 04 27; 444:114335. PMID: 36804441.
      View in: PubMed
    5. Wang X, Shao L, Richardson KK, Ling W, Warren A, Krager K, Aykin-Burns N, Hromas R, Zhou D, Almeida M, Kim HN. Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice. J Biol Chem. 2023 02; 299(2):102841. PMID: 36574841.
      View in: PubMed
    6. LoBianco FV, Krager KJ, Johnson E, Godwin CO, Allen AR, Crooks PA, Compadre CM, Borrelli MJ, Aykin-Burns N. Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells. Front Toxicol. 2022; 4:936149. PMID: 36591540.
      View in: PubMed
    7. Das BK, Wang L, Fujiwara T, Zhou J, Aykin-Burns N, Krager KJ, Lan R, Mackintosh SG, Edmondson R, Jennings ML, Wang X, Feng JQ, Barrientos T, Gogoi J, Kannan A, Gao L, Xing W, Mohan S, Zhao H. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. Elife. 2022 06 27; 11. PMID: 35758636.
      View in: PubMed
    8. Richardson KK, Ling W, Krager K, Fu Q, Byrum SD, Pathak R, Aykin-Burns N, Kim HN. Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice. Int J Mol Sci. 2022 Jan 08; 23(2). PMID: 35054859.
      View in: PubMed
    9. Kim HN, Richardson KK, Krager KJ, Ling W, Simmons P, Allen AR, Aykin-Burns N. Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice. Int J Mol Sci. 2021 Oct 28; 22(21). PMID: 34769141.
      View in: PubMed
    10. McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Sharma S, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Davanzo GG, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Moraes-Vieira PM, Vanderburg C, Wallace DC, Schisler JC, Mason CE, Chatterjee A, Meller R, Beheshti A. Role of miR-2392 in driving SARS-CoV-2 infection. Cell Rep. 2021 10 19; 37(3):109839. PMID: 34624208.
      View in: PubMed
    11. McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Sharma S, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Davanzo GG, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Moraes-Vieira PM, Vanderburg C, Wallace DC, Schisler J, Mason CE, Chatterjee A, Meller R, Beheshti A. The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection. bioRxiv. 2021 Aug 18. PMID: 33948587.
      View in: PubMed
    12. Ling W, Krager K, Richardson KK, Warren AD, Ponte F, Aykin-Burns N, Manolagas SC, Almeida M, Kim HN. Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency. JCI Insight. 2021 05 24; 6(10). PMID: 33878033.
      View in: PubMed
    13. Sridharan V, Johnson KA, Landes RD, Cao M, Singh P, Wagoner G, Hayar A, Sprick ED, Eveld KA, Bhattacharyya A, Krager KJ, Aykin-Burns N, Weiler H, Fern?ndez JA, Griffin JH, Boerma M. Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin. PLoS One. 2021; 16(5):e0252142. PMID: 34029348.
      View in: PubMed
    14. Koss B, Shields BD, Taylor EM, Storey AJ, Byrum SD, Gies AJ, Washam CL, Choudhury SR, Hyun Ahn J, Uryu H, Williams JB, Krager KJ, Chiang TC, Mackintosh SG, Edmondson RD, Aykin-Burns N, Gajewski TF, Wang GG, Tackett AJ. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer Res. 2020 11 01; 80(21):4707-4719. PMID: 33004350.
      View in: PubMed
    15. Kim HN, Ponte F, Nookaew I, Ucer Ozgurel S, Marques-Carvalho A, Iyer S, Warren A, Aykin-Burns N, Krager K, Sardao VA, Han L, de Cabo R, Zhao H, Jilka RL, Manolagas SC, Almeida M. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Sci Rep. 2020 07 20; 10(1):11933. PMID: 32686739.
      View in: PubMed
    16. Tascioglu Aliyev A, LoBianco F, Krager KJ, Aykin-Burns N. Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein. J Vis Exp. 2020 06 18; (160). PMID: 32628158.
      View in: PubMed
    17. LoBianco FV, Krager KJ, Carter GS, Alam S, Yuan Y, Lavoie EG, Dranoff JA, Aykin-Burns N. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants (Basel). 2020 May 11; 9(5). PMID: 32403251.
      View in: PubMed
    18. Aykin-Burns N, Pathak R, Boerma M, Kim T, Hauer-Jensen M. Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects. Semin Radiat Oncol. 2019 01; 29(1):55-61. PMID: 30573184.
      View in: PubMed
    19. Alam S, Carter GS, Krager KJ, Li X, Lehmler HJ, Aykin-Burns N. PCB11 Metabolite, 3,3'-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD. Antioxidants (Basel). 2018 Sep 15; 7(9). PMID: 30223548.
      View in: PubMed
    20. Wang L, Fang B, Fujiwara T, Krager K, Gorantla A, Li C, Feng JQ, Jennings ML, Zhou J, Aykin-Burns N, Zhao H. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem. 2018 06 15; 293(24):9248-9264. PMID: 29724825.
      View in: PubMed
    21. Nukala U, Thakkar S, Krager KJ, Breen PJ, Compadre CM, Aykin-Burns N. Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans). Antioxidants (Basel). 2018 Feb 23; 7(2). PMID: 29473853.
      View in: PubMed
    22. Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, McCullough SS, James LP, Hinson JA. Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes. Toxicol Rep. 2017; 4:134-142. PMID: 28503408.
      View in: PubMed
    23. Banerjee S, Aykin-Burns N, Krager KJ, Shah SK, Melnyk SB, Hauer-Jensen M, Pawar SA. Loss of C/EBPd enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016 10; 99:296-307. PMID: 27554969.
      View in: PubMed
    24. Pathak R, Wang J, Garg S, Aykin-Burns N, Petersen KU, Hauer-Jensen M. Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiat Res. 2016 08; 186(2):112-20. PMID: 27459702.
      View in: PubMed
    25. Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med. 2016 Jan; 22(1):78-83. PMID: 26657143.
      View in: PubMed
    26. Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, Letzig LG, James LP, Hinson JA. The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free Radic Biol Med. 2015 Dec; 89:750-7. PMID: 26454079.
      View in: PubMed
    27. Miousse IR, Chalbot MC, Pathak R, Lu X, Nzabarushimana E, Krager K, Aykin-Burns N, Hauer-Jensen M, Demokritou P, Kavouras IG, Koturbash I. In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter. Toxicol Sci. 2015 Dec; 148(2):473-87. PMID: 26342214.
      View in: PubMed
    28. Krager KJ, Pineda EN, Kharade SV, Kordsmeier M, Howard L, Breen PJ, Compadre CM, Hauer-Jensen M, Aykin-Burns N. Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity. Evid Based Complement Alternat Med. 2015; 2015:148791. PMID: 26425129.
      View in: PubMed
    29. Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M. A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. Radiat Res. 2015 Mar; 183(3):357-66. PMID: 25710576.
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    30. Pathak R, Cheema AK, Boca SM, Krager KJ, Hauer-Jensen M, Aykin-Burns N. Modulation of Radiation Response by the Tetrahydrobiopterin Pathway. Antioxidants (Basel). 2015 Jan 22; 4(1):68-81. PMID: 26785338.
      View in: PubMed
    31. Schickling BM, England SK, Aykin-Burns N, Norian LA, Leslie KK, Frieden-Korovkina VP. BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. Oncol Rep. 2015 Feb; 33(2):533-8. PMID: 25422049.
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    32. Cheema AK, Pathak R, Zandkarimi F, Kaur P, Alkhalil L, Singh R, Zhong X, Ghosh S, Aykin-Burns N, Hauer-Jensen M. Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation. J Proteome Res. 2014 Jun 06; 13(6):3065-74. PMID: 24824572.
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    33. Sridharan V, Aykin-Burns N, Tripathi P, Krager KJ, Sharma SK, Moros EG, Corry PM, Nowak G, Hauer-Jensen M, Boerma M. Radiation-induced alterations in mitochondria of the rat heart. Radiat Res. 2014 Mar; 181(3):324-34. PMID: 24568130.
      View in: PubMed
    34. Marine A, Krager KJ, Aykin-Burns N, Macmillan-Crow LA. Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells. Redox Biol. 2014; 2:348-57. PMID: 24563852.
      View in: PubMed
    35. Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler HJ, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci. 2013 Nov; 136(1):39-50. PMID: 23997111.
      View in: PubMed
    36. Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR. Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender. Radiat Res. 2013 Aug; 180(2):156-65. PMID: 23819597.
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    37. Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes. Free Radic Biol Med. 2013 Dec; 65:70-77. PMID: 23770201.
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    38. Pathak R, Pawar SA, Fu Q, Gupta PK, Berb?e M, Garg S, Sridharan V, Wang W, Biju PG, Krager KJ, Boerma M, Ghosh SP, Cheema AK, Hendrickson HP, Aykin-Burns N, Hauer-Jensen M. Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxid Redox Signal. 2014 Mar 20; 20(9):1436-46. PMID: 23521531.
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    39. Owens KM, Aykin-Burns N, Dayal D, Coleman MC, Domann FE, Spitz DR. Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-?) and H2O2. Free Radic Biol Med. 2012 Jan 01; 52(1):160-6. PMID: 22041456.
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    40. Park SH, Ozden O, Jiang H, Cha YI, Pennington JD, Aykin-Burns N, Spitz DR, Gius D, Kim HS. Sirt3, mitochondrial ROS, ageing, and carcinogenesis. Int J Mol Sci. 2011; 12(9):6226-39. PMID: 22016654.
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    41. Schickling BM, Aykin-Burns N, Leslie KK, Spitz DR, Korovkina VP. An inhibitor of K+ channels modulates human endometrial tumor-initiating cells. Cancer Cell Int. 2011 Aug 02; 11(1):25. PMID: 21810252.
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    42. Westin ER, Aykin-Burns N, Buckingham EM, Spitz DR, Goldman FD, Klingelhutz AJ. The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency. Antioxid Redox Signal. 2011 Mar 15; 14(6):985-97. PMID: 21087144.
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    43. Ross C, Alston M, Bickenbach JR, Aykin-Burns N. Oxygen tension changes the rate of migration of human skin keratinocytes in an age-related manner. Exp Dermatol. 2011 Jan; 20(1):58-63. PMID: 21158939.
      View in: PubMed
    44. Aykin-Burns N, Slane BG, Liu AT, Owens KM, O'Malley MS, Smith BJ, Domann FE, Spitz DR. Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species. Radiat Res. 2011 Feb; 175(2):150-8. PMID: 21268708.
      View in: PubMed
    45. Shutt DC, O'Dorisio MS, Aykin-Burns N, Spitz DR. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010 Jun 01; 9(11):853-61. PMID: 20364116.
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    46. Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 2010 Jan 19; 17(1):41-52. PMID: 20129246.
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    47. Dayal D, Martin SM, Owens KM, Aykin-Burns N, Zhu Y, Boominathan A, Pain D, Limoli CL, Goswami PC, Domann FE, Spitz DR. Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiat Res. 2009 Dec; 172(6):737-45. PMID: 19929420.
      View in: PubMed
    48. Zhu Y, Kalen AL, Li L, Lehmler HJ, Robertson LW, Goswami PC, Spitz DR, Aykin-Burns N. Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free Radic Biol Med. 2009 Dec 15; 47(12):1762-71. PMID: 19796678.
      View in: PubMed
    49. Fath MA, Diers AR, Aykin-Burns N, Simons AL, Hua L, Spitz DR. Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer Biol Ther. 2009 Jul; 8(13):1228-36. PMID: 19411865.
      View in: PubMed
    50. Nyunoya T, Monick MM, Klingelhutz AL, Glaser H, Cagley JR, Brown CO, Matsumoto E, Aykin-Burns N, Spitz DR, Oshima J, Hunninghake GW. Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. Am J Respir Crit Care Med. 2009 Feb 15; 179(4):279-87. PMID: 19011155.
      View in: PubMed
    51. Mattson DM, Ahmad IM, Dayal D, Parsons AD, Aykin-Burns N, Li L, Orcutt KP, Spitz DR, Dornfeld KJ, Simons AL. Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism. Free Radic Biol Med. 2009 Jan 15; 46(2):232-7. PMID: 18983911.
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    52. Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Sun L, Nguyen P, Ahn BH, Leclerc J, Deng CX, Spitz DR, Gius D. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci. 2008 Sep 05; 4(5):291-9. PMID: 18781224.
      View in: PubMed
    53. Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. 2008 May 02; 133(3):462-74. PMID: 18455987.
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    54. Ahmad IM, Abdalla MY, Aykin-Burns N, Simons AL, Oberley LW, Domann FE, Spitz DR. 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress. Free Radic Biol Med. 2008 Mar 01; 44(5):826-34. PMID: 18155176.
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    55. Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML, Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ, Oberley LW. Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth. Free Radic Biol Med. 2008 Mar 01; 44(5):856-67. PMID: 18155673.
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    56. Coleman MC, Asbury CR, Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR, Cullen JJ. 2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radic Biol Med. 2008 Feb 01; 44(3):322-31. PMID: 18215740.
      View in: PubMed
    57. Andringa KK, Coleman MC, Aykin-Burns N, Hitchler MJ, Walsh SA, Domann FE, Spitz DR. Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose. Cancer Res. 2006 Feb 01; 66(3):1605-10. PMID: 16452219.
      View in: PubMed
    58. Aykin-Burns N, Ercal N. Effects of selenocystine on lead-exposed Chinese hamster ovary (CHO) and PC-12 cells. Toxicol Appl Pharmacol. 2006 Jul 15; 214(2):136-43. PMID: 16442139.
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    59. Aykin-Burns N, Franklin EA, Ercal N. Effects of N-acetylcysteine on lead-exposed PC-12 cells. Arch Environ Contam Toxicol. 2005 Jul; 49(1):119-23. PMID: 15981033.
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    60. Ahmad IM, Aykin-Burns N, Sim JE, Walsh SA, Higashikubo R, Buettner GR, Venkataraman S, Mackey MA, Flanagan SW, Oberley LW, Spitz DR. Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem. 2005 Feb 11; 280(6):4254-63. PMID: 15561720.
      View in: PubMed
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