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Philip Breen

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmaceutical Science, College of Pharmacy
DivisionPharmaceutical Science
Address6/110A ED II
320 UAMS Campus Dr.
Mail Slot # 522
Little Rock AR 72205
Phone501-686-5092
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    Collapse Research 
    Collapse research activities and funding
    HU0001-10-1-0004     (HAUER-JENSEN, MARTIN)Aug 6, 2010 - Feb 13, 2012
    Defense Threat Reduction Agency - Pass Through: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Advanced Drug Development of Gamma-Tocotrienol as a Radiation Countermeasure in Rhesus Macaque Non-Human Primates
    Role: Co-Investigator
    17504     (COMPADRE, CESAR M)Apr 15, 2007 - Apr 14, 2008
    National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium
    Developing Countermeasures for Acute Respiratory Distress Produced by Lunar Dust
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Shrum SA, Nukala U, Shrimali S, Pineda EN, Krager KJ, Thakkar S, Jones DE, Pathak R, Breen PJ, Aykin-Burns N, Compadre CM. Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects. Antioxidants (Basel). 2023 Nov 09; 12(11). PMID: 38001840.
      View in: PubMed
    2. Mery DE, Compadre AJ, Ord??ez PE, Selvik EJ, Morocho V, Contreras J, Malag?n O, Jones DE, Breen PJ, Balick MJ, Gaudio FG, Guzman ML, Compadre CM. Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds. Molecules. 2022 May 04; 27(9). PMID: 35566279.
      View in: PubMed
    3. Yadlapalli JSK, Albayati ZAF, Breen PJ, Dobretsov M, Penthala NR, Hendrickson HP, Crooks PA. A pharmacokinetic study of morphine-6-O-sulfate in rat plasma and brain. Drug Dev Res. 2021 09; 82(6):802-814. PMID: 33427316.
      View in: PubMed
    4. Nukala U, Thakkar S, Krager KJ, Breen PJ, Compadre CM, Aykin-Burns N. Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans). Antioxidants (Basel). 2018 Feb 23; 7(2). PMID: 29473853.
      View in: PubMed
    5. Albayati ZAF, Janganati V, Chen Z, Ponder J, Breen PJ, Jordan CT, Crooks PA. Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia. Bioorg Med Chem. 2017 02 01; 25(3):1235-1241. PMID: 28049618.
      View in: PubMed
    6. Ord??ez PE, Quave CL, Reynolds WF, Varughese KI, Berry B, Breen PJ, Malag?n O, Vidari G, Smeltzer MS, Compadre CM. Corrigendum to "Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity" [J. Ethnopharmacol. 137 (2011) 1055-1059]. J Ethnopharmacol. 2016 06 20; 186:392. PMID: 27165010.
      View in: PubMed
    7. Albayati ZA, Sunkara M, Schmidt-Malan SM, Karau MJ, Morris AJ, Steckelberg JM, Patel R, Breen PJ, Smeltzer MS, Taylor KG, Merten KE, Pierce WM, Crooks PA. Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1865-8. PMID: 26666918.
      View in: PubMed
    8. Jambhekar SS, Breen P. Cyclodextrins in pharmaceutical formulations II: solubilization, binding constant, and complexation efficiency. Drug Discov Today. 2016 Feb; 21(2):363-8. PMID: 26687191.
      View in: PubMed
    9. Jambhekar SS, Breen P. Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex. Drug Discov Today. 2016 Feb; 21(2):356-62. PMID: 26686054.
      View in: PubMed
    10. Krager KJ, Pineda EN, Kharade SV, Kordsmeier M, Howard L, Breen PJ, Compadre CM, Hauer-Jensen M, Aykin-Burns N. Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity. Evid Based Complement Alternat Med. 2015; 2015:148791. PMID: 26425129.
      View in: PubMed
    11. Cardenas VM, Breen PJ, Compadre CM, Delongchamp RR, Barone CP, Phillips MM, Wheeler JG. The smoking habits of the family influence the uptake of e-cigarettes in US children. Ann Epidemiol. 2015 Jan; 25(1):60-2. PMID: 25453726.
      View in: PubMed
    12. Compadre CM, Singh A, Thakkar S, Zheng G, Breen PJ, Ghosh S, Kiaei M, Boerma M, Varughese KI, Hauer-Jensen M. Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability. Drug Dev Res. 2014 Feb; 75(1):10-22. PMID: 24648045.
      View in: PubMed
    13. Jambhekar SS, Breen PJ. Drug dissolution: significance of physicochemical properties and physiological conditions. Drug Discov Today. 2013 Dec; 18(23-24):1173-84. PMID: 24042023.
      View in: PubMed
    14. Ord??ez PE, Quave CL, Reynolds WF, Varughese KI, Berry B, Breen PJ, Malag?n O, Smeltzer MS, Compadre CM. Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity. J Ethnopharmacol. 2011 09 02; 137(2):1055-9. PMID: 21782013.
      View in: PubMed
    15. Gurley BJ, Swain A, Barone GW, Williams DK, Breen P, Yates CR, Stuart LB, Hubbard MA, Tong Y, Cheboyina S. Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos. 2007 Feb; 35(2):240-5. PMID: 17079360.
      View in: PubMed
    16. Gurley B, Hubbard MA, Williams DK, Thaden J, Tong Y, Gentry WB, Breen P, Carrier DJ, Cheboyina S. Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. J Clin Pharmacol. 2006 Feb; 46(2):201-13. PMID: 16432272.
      View in: PubMed
    17. Gurley BJ, Barone GW, Williams DK, Carrier J, Breen P, Yates CR, Song PF, Hubbard MA, Tong Y, Cheboyina S. Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos. 2006 Jan; 34(1):69-74. PMID: 16221754.
      View in: PubMed
    18. Rodr?guez-Morales S, Compadre RL, Castillo R, Breen PJ, Compadre CM. 3D-QSAR, synthesis, and antimicrobial activity of 1-alkylpyridinium compounds as potential agents to improve food safety. Eur J Med Chem. 2005 Sep; 40(9):840-9. PMID: 16194718.
      View in: PubMed
    19. Rodr?guez-Morales S, Zhou X, Salari H, Castillo R, Breen PJ, Compadre CM. Liquid chromatography determination of residue levels on apples treated with cetylpyridinium chloride. J Chromatogr A. 2005 Jan 14; 1062(2):285-9. PMID: 15679166.
      View in: PubMed
    20. Joguparthi V, Breen P, Compadre C, Zhou X, Gann L, Hiller FC, Anderson P. Effect of propellant on the pharmacokinetics and pharmacodynamics of inhaled albuterol in asthmatic subjects. J Aerosol Med. 2003; 16(1):47-53. PMID: 12737684.
      View in: PubMed
    21. Breen PJ, Salari H, Compadre CM. Elimination of Salmonella Contamination from Poultry Tissues by Cetylpyridinium Chloride Solutions. J Food Prot. 1997 Sep; 60(9):1019-1021. PMID: 31207819.
      View in: PubMed
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