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Stavros Manolagas

TitleDistinguished Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Endo
Address8/820 Cancer Institute
4104 Outpatient Circle
Mail Slot # 587
Little Rock AR 72205
Phone501-686-5130
vCardDownload vCard
    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentOrthopaedics, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Co-Investigator
    I01BX001405     (MANOLAGAS, STAVROS C.)Jan 1, 2012 - Mar 31, 2021
    NIH
    Androgens, estrogens, and bone loss in males
    Role: Principal Investigator
    R01AR056679     (SCHULLER DE ALMEIDA, MARIA)Dec 1, 2008 - Jan 31, 2022
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Role of FoxOs in Skeletal Homeostasis- Resubmission - Continuation-Continuation - Continuation - Continuation
    Role: Co-Investigator
    R01AR051187     (KOUSTENI, STAVROULA)Feb 1, 2005 - Dec 31, 2008
    NIH
    OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS
    Role: Co-Principal Investigator
    P01AG013918     (MANOLAGAS, STAVROS C.)Aug 27, 1996 - Apr 30, 2018
    NIH
    Molecular and Cellular Mechanisms of Osteoporosis
    Role: Principal Investigator
    R01AR043003     (MANOLAGAS, STAVROS C.)Mar 1, 1994 - Feb 29, 2000
    NIH
    ESTROGENS AND OSTEOCLASTOGENESIS
    Role: Principal Investigator
    R01AR041313     (MANOLAGAS, STAVROS C.)Sep 30, 1991 - Aug 31, 1996
    NIH
    HORMONAL CONTROL OF CYTOKINES IN BONE AND STROMAL CELLS
    Role: Principal Investigator
    R01AI021761     (MANOLAGAS, STAVROS C.)Dec 1, 1984 - Nov 30, 1991
    NIH
    1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Abe Y, Kofman ER, Almeida M, Ouyang Z, Ponte F, Mueller JR, Cruz-Becerra G, Sakai M, Prohaska TA, Spann NJ, Resende-Coelho A, Seidman JS, Stender JD, Taylor H, Fan W, Link VM, Cobo I, Schlachetzki JCM, Hamakubo T, Jepsen K, Sakai J, Downes M, Evans RM, Yeo GW, Kadonaga JT, Manolagas SC, Rosenfeld MG, Glass CK. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1?- and RNA-dependent co-activator of osteoclast gene expression. Mol Cell. 2023 10 05; 83(19):3421-3437.e11. PMID: 37751740.
      View in: PubMed
    2. Palmieri M, Joseph TE, O'Brien CA, Gomez-Acevedo H, Kim HN, Manolagas SC, Ambrogini E. Retraction notice to "Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass" [Bone 170(2023) 116702]. Bone. 2023 11; 176:116885. PMID: 37633107.
      View in: PubMed
    3. Palmieri M, Joseph TE, O'Brien CA, Gomez-Acevedo H, Manolagas SC, Ambrogini E. Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass. PLoS One. 2023; 18(8):e0290458. PMID: 37585400.
      View in: PubMed
    4. Palmieri M, Joseph TE, O'Brien CA, Gomez-Acevedo H, Kim HN, Manolagas SC, Ambrogini E. RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass Bone. 2023 05; 170:116702. PMID: 36773885.
      View in: PubMed
    5. Ponte F, Kim HN, Warren A, Iyer S, Han L, Mannen E, Gomez-Acevedo H, Nookaew I, Almeida M, Manolagas SC. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency. Sci Rep. 2022 06 17; 12(1):10257. PMID: 35715555.
      View in: PubMed
    6. Palmieri M, Joseph TE, O'Brien CA, Gomez-Acevedo H, Manolagas SC, Ambrogini E. Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass. PLoS One. 2022; 17(3):e0265893. PMID: 35349600.
      View in: PubMed
    7. Palmieri M, Almeida M, Nookaew I, Gomez-Acevedo H, Joseph TE, Que X, Tsimikas S, Sun X, Manolagas SC, Witztum JL, Ambrogini E. Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. Aging Cell. 2021 08; 20(8):e13442. PMID: 34278710.
      View in: PubMed
    8. Ling W, Krager K, Richardson KK, Warren AD, Ponte F, Aykin-Burns N, Manolagas SC, Almeida M, Kim HN. Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency. JCI Insight. 2021 05 24; 6(10). PMID: 33878033.
      View in: PubMed
    9. Almeida M, Kim HN, Han L, Zhou D, Thostenson J, Porter RM, Ambrogini E, Manolagas SC, Jilka RL. Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice. Aging Cell. 2020 11; 19(11):e13247. PMID: 33048436.
      View in: PubMed
    10. Palmieri M, Kim HN, Gomez-Acevedo H, Que X, Tsimikas S, Jilka RL, Manolagas SC, Witztum JL, Ambrogini E. A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice. J Bone Miner Res. 2021 01; 36(1):170-185. PMID: 32990984.
      View in: PubMed
    11. Kim HN, Ponte F, Nookaew I, Ucer Ozgurel S, Marques-Carvalho A, Iyer S, Warren A, Aykin-Burns N, Krager K, Sardao VA, Han L, de Cabo R, Zhao H, Jilka RL, Manolagas SC, Almeida M. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Sci Rep. 2020 07 20; 10(1):11933. PMID: 32686739.
      View in: PubMed
    12. Manolagas SC. Osteocalcin promotes bone mineralization but is not a hormone. PLoS Genet. 2020 06; 16(6):e1008714. PMID: 32484816.
      View in: PubMed
    13. Ponte F, Kim HN, Iyer S, Han L, Almeida M, Manolagas SC. Cxcl12 Deletion in Mesenchymal Cells Increases Bone Turnover and Attenuates the Loss of Cortical Bone Caused by Estrogen Deficiency in Mice. J Bone Miner Res. 2020 08; 35(8):1441-1451. PMID: 32154948.
      View in: PubMed
    14. Kim HN, Chang J, Iyer S, Han L, Campisi J, Manolagas SC, Zhou D, Almeida M. Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice. Aging Cell. 2019 06; 18(3):e12923. PMID: 30773784.
      View in: PubMed
    15. Ambrogini E, Que X, Wang S, Yamaguchi F, Weinstein RS, Tsimikas S, Manolagas SC, Witztum JL, Jilka RL. Oxidation-specific epitopes restrain bone formation. Nat Commun. 2018 06 06; 9(1):2193. PMID: 29875355.
      View in: PubMed
    16. Manolagas SC. The Quest for Osteoporosis Mechanisms and Rational Therapies: How Far We've Come, How Much Further We Need to Go. J Bone Miner Res. 2018 03; 33(3):371-385. PMID: 29405383.
      View in: PubMed
    17. Weinstein RS, Hogan EA, Borrelli MJ, Liachenko S, O'Brien CA, Manolagas SC. The Pathophysiological Sequence of Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Male Mice. Endocrinology. 2017 11 01; 158(11):3817-3831. PMID: 28938402.
      View in: PubMed
    18. Piemontese M, Almeida M, Robling AG, Kim HN, Xiong J, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA, Jilka RL. Old age causes de novo intracortical bone remodeling and porosity in mice. JCI Insight. 2017 09 07; 2(17). PMID: 28878136.
      View in: PubMed
    19. Kim HN, Chang J, Shao L, Han L, Iyer S, Manolagas SC, O'Brien CA, Jilka RL, Zhou D, Almeida M. DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age. Aging Cell. 2017 08; 16(4):693-703. PMID: 28401730.
      View in: PubMed
    20. Almeida M, Laurent MR, Dubois V, Claessens F, O'Brien CA, Bouillon R, Vanderschueren D, Manolagas SC. Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev. 2017 01; 97(1):135-187. PMID: 27807202.
      View in: PubMed
    21. Ucer S, Iyer S, Kim HN, Han L, Rutlen C, Allison K, Thostenson JD, de Cabo R, Jilka RL, O'Brien C, Almeida M, Manolagas SC. The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct. J Bone Miner Res. 2017 Mar; 32(3):560-574. PMID: 27714847.
      View in: PubMed
    22. Fujiwara T, Ye S, Castro-Gomes T, Winchell CG, Andrews NW, Voth DE, Varughese KI, Mackintosh SG, Feng Y, Pavlos N, Nakamura T, Manolagas SC, Zhao H. PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. JCI Insight. 2016 Oct 20; 1(17):e86330. PMID: 27777970.
      View in: PubMed
    23. Iyer S, Han L, Ambrogini E, Yavropoulou M, Fowlkes J, Manolagas SC, Almeida M. Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes. J Bone Miner Res. 2017 01; 32(1):60-69. PMID: 27491024.
      View in: PubMed
    24. Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73. PMID: 26956187.
      View in: PubMed
    25. Carson JA, Manolagas SC. Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease. Bone. 2015 Nov; 80:67-78. PMID: 26453497.
      View in: PubMed
    26. Xiong J, Piemontese M, Onal M, Campbell J, Goellner JJ, Dusevich V, Bonewald L, Manolagas SC, O'Brien CA. Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone. PLoS One. 2015; 10(9):e0138189. PMID: 26393791.
      View in: PubMed
    27. Kim HN, Han L, Iyer S, de Cabo R, Zhao H, O'Brien CA, Manolagas SC, Almeida M. Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs. Mol Endocrinol. 2015 Oct; 29(10):1498-509. PMID: 26287518.
      View in: PubMed
    28. Ucer S, Iyer S, Bartell SM, Martin-Millan M, Han L, Kim HN, Weinstein RS, Jilka RL, O'Brien CA, Almeida M, Manolagas SC. The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERa Signaling in Osteoblasts and Osteoclasts. J Bone Miner Res. 2015 Jul; 30(7):1138-49. PMID: 25704845.
      View in: PubMed
    29. Manolagas SC, Compston J, Rao S, Seeman E. A. Michael Parfitt: Enlightened Scholar and Revered Mentor: May 10, 1930-May 18, 2015. J Bone Miner Res. 2015 Aug; 30(8):1349-55. PMID: 26077824.
      View in: PubMed
    30. Piemontese M, Onal M, Xiong J, Wang Y, Almeida M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone. Bone. 2015 Jun; 75:18-26. PMID: 25700544.
      View in: PubMed
    31. Manolagas SC, Kronenberg HM. Reproducibility of results in preclinical studies: a perspective from the bone field. J Bone Miner Res. 2014 Oct; 29(10):2131-40. PMID: 24916175.
      View in: PubMed
    32. Iyer S, Han L, Bartell SM, Kim HN, Gubrij I, de Cabo R, O'Brien CA, Manolagas SC, Almeida M. Sirtuin1 (Sirt1) promotes cortical bone formation by preventing ?-catenin sequestration by FoxO transcription factors in osteoblast progenitors. J Biol Chem. 2014 Aug 29; 289(35):24069-78. PMID: 25002589.
      View in: PubMed
    33. Xiong J, Piemontese M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA. Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency. Bone. 2014 Sep; 66:146-54. PMID: 24933342.
      View in: PubMed
    34. Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun. 2014 Apr 30; 5:3773. PMID: 24781012.
      View in: PubMed
    35. Manolagas SC. Wnt signaling and osteoporosis. Maturitas. 2014 Jul; 78(3):233-7. PMID: 24815296.
      View in: PubMed
    36. Manolagas SC, Almeida M, Jilka RL. The ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Gonadal Steroids. 2014.
    37. Jilka RL, O'Brien CA, Roberson PK, Bonewald LF, Weinstein RS, Manolagas SC. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age. J Bone Miner Res. 2014 Jan; 29(1):103-17. PMID: 23761243.
      View in: PubMed
    38. Manolagas SC, O'Brien CA, Almeida M. The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol. 2013 Dec; 9(12):699-712. PMID: 24042328.
      View in: PubMed
    39. Zhou J, Ye S, Fujiwara T, Manolagas SC, Zhao H. Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. J Biol Chem. 2013 Oct 18; 288(42):30064-30074. PMID: 23990467.
      View in: PubMed
    40. Manolagas SC, Cummings SR. Skeletal aging: from bench to bed side. J Gerontol A Biol Sci Med Sci. 2013 Oct; 68(10):1195-6. PMID: 23974080.
      View in: PubMed
    41. Zhou J, Ye S, Fujiwara T, Manolagas SC, Zhao H. Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/ROS levels and CREB activation. J Biol Chem. 2013.
    42. Iyer S, Ambrogini E, Bartell SM, Han L, Roberson PK, de Cabo R, Jilka RL, Weinstein RS, O'Brien CA, Manolagas SC, Almeida M. FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest. 2013 Aug; 123(8):3409-19. PMID: 23867625.
      View in: PubMed
    43. Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S, Komatsu M, Selig M, Weinstein RS, Zhao H, Jilka RL, Almeida M, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem. 2013 Jun 14; 288(24):17432-40. PMID: 23645674.
      View in: PubMed
    44. Manolagas SC. Steroids and osteoporosis: the quest for mechanisms. J Clin Invest. 2013 May; 123(5):1919-21. PMID: 23635790.
      View in: PubMed
    45. Bartell SM, Han L, Kim HN, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Chambliss KL, Shaul PW, Roberson PK, Weinstein RS, Jilka RL, Almeida M, Manolagas SC. Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass. Mol Endocrinol. 2013 Apr; 27(4):649-56. PMID: 23443267.
      View in: PubMed
    46. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013; 123(1):394 - 404.
    47. Jilka RL, O'Brien CA, Roberson PK, Bonewald, LF, Weinstein RS, Manolagas SC. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates bone porosity with age. J Bone Mineral Res. 2013.
    48. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013 Jan; 123(1):394-404. PMID: 23221342.
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    49. Robert Weinstein, Erin Hogan, Charles O'Brien, Stavros Manolagas. Glucocorticoids Act Directly on Osteocytes to Reduce Bone Vascularity and Strength. Journal of Bone and Mineral Research. 2012; S469.
    50. Jinhu Xiong, Melda Onal, Stavros Manolagas. RANKL Produced by Osteocytes Contributes to the Bone Loss Induced by Hyperparathyroidism. Journal of Bone and Mineral Research. 2012; S14.
    51. Melda Onal, Jinhu Xiong, Shiqiao Ye, Li Han, Robert Jilka, Robert Weinstein, Maria Jose Almeida, Haibo Zhao, Stavros Manolagas, Charles O'Brien. Suppression of Autophagy in Osteoblasts and Osteocytes Increases Oxidative Stress and Recapitulates the Effects of Aging on the Murine Skeleton. Journal of Bone and Mineral Research. 2012; S349.
    52. Shiqiao Ye, Stavros Manolagas, Haibo Zhao. Lis1 Regulates Osteoclastogenesis through Small GTPase Cdc42. Journal of Bone and Mineral Research. 2012; S415.
    53. Shoshana Bartell, Li Han, Aaron Warren, Julie Crawford, Peter Rabinovitch, Stavros Manolagas, Maria Jose Almeida. Targeted Expression of Catalase to Mitochondria in Cells of the Macrophage/Osteoclast Lineage Inhibits Osteoclastogenesis and Increases Bone Mass. Journal of Bone and Mineral Research. 2012; S53.
    54. Shoshana Bartell, Elena Ambrogini, Li Han, Aaron Warren, Julie Crawford, Srividhya Iyer, Joseph Goellner, Haibo Zhao, Charles O'Brien, Stavros Manolagas, Maria Jose Almeida. Gain or Loss of FoxO Function in Osteoclasts alter Bone Mass in Mice. Journal of Bone and Mineral Research. 2012; S284.
    55. Robert Jilka, Annick DeLoose, Leslie Climer, Lynda Bonewald, Robert Weinstein, Charles O'Brien, Stavros Manolagas. Dysfunctional Osteocytes Increase RANKL and Promote Cortical Pore Formation in Their Vicinity: a Mechanical Explanation for the Development of Cortical Porosity with Age. Journal of Bone and Mineral Research. 2012; S348.
    56. Srividhya Iyer, Elena Ambrogini, Li Han, Shoshana Bartell, Aaron Warren, Julie Crawford, Paula Roberson, Robert Weinstein, Charles O'Brien, Maria Jose Almeida, Stavros Manolagas. Deletion of FoxO1, 3, and 4 from Osteoprogenitor Cells Increases Bone Mass throughout Life and Attenuates Adiposity in Aged Bone. Journal of Bone and Mineral Research. 2012; S23.
    57. Srividhya Iyer, Aaron Warren, Martha Martin-Millan, Li Han, Shoshana Bartell, Elena Ambrogini, Jinhu Xiong, Julie Crawford, Robert Weinstein, Robert Jilka, Charles O'Brien, Maria Jose Almeida, Stavros Manolagas. The ERa of Osteoblast Progenitors is Required for Normal Accrual of Cortical Bone Mass Independently of Estrogens. Journal of Bone and Mineral Research. 2012; S68.
    58. Shoshana Bartell, Aaron Warren, Li Han, Srividhya Iyer, Sung Kim, Benita Katzenellenbogen, Ken Chambliss, Philip Shaul, John Katzenellenbogen, Paula Roberson, Robert Weinstein, Charles O'Brien, Robert Jilka, Maria Jose Almeida, Stavros Manolagas. An Estrogen Dendrimer Conjugate Incapable of Stimulating the Nuclear-initiated Actions of Estrogen Receptors Prevents the Loss of Cortical Bone Mass in Estrogen Deficient Mice. Journal of Bone and Mineral Research. 2012; S21.
    59. Manolagas SC, Parfitt AM. For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases. Bone. 2013 Jun; 54(2):272-8. PMID: 23010104.
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    60. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012; 287(35):29851 - 29860.
    61. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012 Aug 24; 287(35):29851-60. PMID: 22782898.
      View in: PubMed
    62. Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC, O'Brien CA. The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice. Mol Endocrinol. 2012 Feb; 26(2):341-8. PMID: 22207718.
      View in: PubMed
    63. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor alpha increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011; 286(52):44326 - 44335.
    64. Ye S, Fowler TW, Pavlos NJ, Ng PY, Liang K, Feng Y, Zheng M, Kurten R, Manolagas SC, Zhao H. LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. PLoS One. 2011; 6(11):e27285. PMID: 22073305.
      View in: PubMed
    65. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor a increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011 Dec 30; 286(52):44326-35. PMID: 22030390.
      View in: PubMed
    66. Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O'Brien CA. Matrix-embedded cells control osteoclast formation. Nat Med. 2011 Sep 11; 17(10):1235-41. PMID: 21909103.
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    67. Weinstein RS, O'Brien CA, Almeida M, Zhao H, Roberson PK, Jilka RL, Manolagas SC. Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice. Endocrinology. 2011 Sep; 152(9):3323-31. PMID: 21771887.
      View in: PubMed
    68. Manolagas SC, Jilka RL. The study of skeletal aging is coming of age: a forum on aging and skeletal health. IBMS BoneKEy. 2011; 8(9):420-27.
    69. Jilka RL, O'Brien CA, Bartell SM, Weinstein RS, Manolagas SC. Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms. J Bone Miner Res. 2010 Nov; 25(11):2427-37. PMID: 20533302.
      View in: PubMed
    70. Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC. Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens. Mol Endocrinol. 2010 Oct; 24(10):2030-7. PMID: 20685851.
      View in: PubMed
    71. Weinstein RS, Jilka RL, Almeida M, Roberson PK, Manolagas SC. Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice. Endocrinology. 2010 Jun; 151(6):2641-9. PMID: 20410195.
      View in: PubMed
    72. Almeida M, Martin-Millan M, Ambrogini E, Bradsher R, Han L, Chen XD, Roberson PK, Weinstein RS, O'Brien CA, Jilka RL, Manolagas SC. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res. 2010 Apr; 25(4):769-81. PMID: 19821774.
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    73. Manolagas SC, Parfitt AM. What old means to bone. Trends Endocrinol Metab. 2010 Jun; 21(6):369-74. PMID: 20223679.
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    74. Andrade AC, Baron J, Manolagas SC, Shaw NJ, Rappold GA, Donaldson MD, Gault EJ, S?vendahl L. Hormones and genes of importance in bone physiology and their influence on bone mineralization and growth in Turner syndrome. Horm Res Paediatr. 2010; 73(3):161-5. PMID: 20197667.
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    75. Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010 Feb 03; 11(2):136-46. PMID: 20142101.
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    76. Martin-Millan M, Almeida M, Ambrogini E, Han L, Zhao H, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010 Feb; 24(2):323-34. PMID: 20053716.
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    77. Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010 Jun; 31(3):266-300. PMID: 20051526.
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    78. Weinstein RS, Wan C, Liu Q, Wang Y, Almeida M, O'Brien CA, Thostenson J, Roberson PK, Boskey AL, Clemens TL, Manolagas SC. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell. 2010 Apr; 9(2):147-61. PMID: 20047574.
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    79. Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL. Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009 Oct 02; 284(40):27438-48. PMID: 19657144.
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    80. Galli C, Fu Q, Wang W, Olsen BR, Manolagas SC, Jilka RL, O'Brien CA. Commitment to the osteoblast lineage is not required for RANKL gene expression. J Biol Chem. 2009 May 08; 284(19):12654-62. PMID: 19279010.
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    81. Weinstein RS, Roberson PK, Manolagas SC. Giant osteoclast formation and long-term oral bisphosphonate therapy. N Engl J Med. 2009 Jan 01; 360(1):53-62. PMID: 19118304.
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    82. Jilka RL, O'Brien CA, Ali AA, Roberson PK, Weinstein RS, Manolagas SC. Intermittent PTH stimulates periosteal bone formation by actions on post-miotic preosteoblasts. Bone. 2009; 44(2):275-86.
    83. Manolagas SC. In: The Merck Manual of Geriatrics. Aging and the musculoskeletal system. 2009.
    84. Plotkin LI, Lezcano V, Thostenson J, Weinstein RS, Manolagas SC, Bellido T. Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo. J Bone Miner Res. 2008 Nov; 23(11):1712-21. PMID: 18597631.
      View in: PubMed
    85. Jilka RL, O'Brien CA, Ali AA, Roberson PK, Weinstein RS, Manolagas SC. Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts. Bone. 2009 Feb; 44(2):275-86. PMID: 19010455.
      View in: PubMed
    86. O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One. 2008 Aug 13; 3(8):e2942. PMID: 18698360.
      View in: PubMed
    87. Manolagas S. De-fense! De-fense! Defense: scavenging H202 while making cholesterol. Endocrinology. 2008; 149(7):3267-73.
    88. Manolagas SC. De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol. Endocrinology. 2008 Jul; 149(7):3264-6. PMID: 18483146.
      View in: PubMed
    89. Jilka RL, Bellido T, Almeida M, Plotkin LI, O'Brien CA, Weinstein RS, Manolagas S. In: Principles of Bone Biology. John Bilezikian, Lawrence Raisz, T. John Martin, eds. Apoptosis of Bone Cells. 2008; 13.
    90. Chen XD, Dusevich V, Feng JQ, Manolagas SC, Jilka RL. Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J Bone Miner Res. 2007 Dec; 22(12):1943-56. PMID: 17680726.
      View in: PubMed
    91. Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O'Brien CA. Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass. Endocrinology. 2008 Jan; 149(1):146-53. PMID: 17932217.
      View in: PubMed
    92. Jilka RL, Weinstein RS, Parfitt AM, Manolagas SC. Quantifying osteoblast and osteocyte apoptosis: challenges and rewards. J Bone Miner Res. 2007 Oct; 22(10):1492-501. PMID: 17542686.
      View in: PubMed
    93. Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Kousteni S, O'Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007 Sep 14; 282(37):27285-27297. PMID: 17623659.
      View in: PubMed
    94. Almeida M, Han L, Martin-Millan M, O'Brien CA, Manolagas SC. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem. 2007 Sep 14; 282(37):27298-27305. PMID: 17623658.
      View in: PubMed
    95. Manolagas SC, Almeida M. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol. 2007 Nov; 21(11):2605-14. PMID: 17622581.
      View in: PubMed
    96. Aguirre JI, Plotkin LI, Gortazar AR, Millan MM, O'Brien CA, Manolagas SC, Bellido T. A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction. J Biol Chem. 2007 Aug 31; 282(35):25501-8. PMID: 17609204.
      View in: PubMed
    97. Plotkin LI, Manolagas SC, Bellido T. Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis. J Biol Chem. 2007 Aug 17; 282(33):24120-30. PMID: 17581824.
      View in: PubMed
    98. Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ. A novel locus on the X chromosome regulates post-maturity bone density changes in mice. Bone. 2007 Mar; 40(3):758-66. PMID: 17185055.
      View in: PubMed
    99. Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol. 2007 Feb; 27(4):1516-30. PMID: 17158928.
      View in: PubMed
    100. Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L. Response to Windahl et al. J Clin Invest. 2006 Nov; 116(11):2834. PMID: 17080186.
      View in: PubMed
    101. Fu Q, Manolagas SC, O'Brien CA. Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol. 2006 Sep; 26(17):6453-68. PMID: 16914731.
      View in: PubMed
    102. Plotkin LI, Manolagas SC, Bellido T. Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. Bone. 2006 Sep; 39(3):443-52. PMID: 16627025.
      View in: PubMed
    103. Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido T. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res. 2006 Apr; 21(4):605-15. PMID: 16598381.
      View in: PubMed
    104. Manolagas SC. Perspective: Choreography from the tomb: an emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling. BoneKEy-Osteovision. 2006; 3(1):5-14.
    105. Manolagas S, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L. Let us not toss out the baby with the bath water. Online Response to Windahl et al. J Clin Invest. 2006; 116:2500-2509.
    106. Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem. 2005 Dec 16; 280(50):41342-51. PMID: 16251184.
      View in: PubMed
    107. Parsons CA, Mroczkowski HJ, McGuigan FE, Albagha OM, Manolagas S, Reid DM, Ralston SH, Shmookler Reis RJ. Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22. Hum Mol Genet. 2005 Nov 01; 14(21):3141-8. PMID: 16183656.
      View in: PubMed
    108. O'Brien CA, Jilka RL, Fu Q, Stewart S, Weinstein RS, Manolagas SC. IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E784-93. PMID: 15956054.
      View in: PubMed
    109. Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC. Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem. 2005 Apr 08; 280(14):14130-7. PMID: 15671029.
      View in: PubMed
    110. Ali AA, Weinstein RS, Stewart SA, Parfitt AM, Manolagas SC, Jilka RL. Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology. 2005 Mar; 146(3):1226-35. PMID: 15591153.
      View in: PubMed
    111. Plotkin LI, Aguirre JI, Kousteni S, Manolagas SC, Bellido T. Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation. J Biol Chem. 2005 Feb 25; 280(8):7317-25. PMID: 15590626.
      View in: PubMed
    112. Chen JR, Plotkin LI, Aguirre JI, Han L, Jilka RL, Kousteni S, Bellido T, Manolagas SC. Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens. J Biol Chem. 2005 Feb 11; 280(6):4632-8. PMID: 15557324.
      View in: PubMed
    113. Manolagas SC, Kousteni S, Chen JR, Schuller M, Plotkin L, Bellido T. Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma. Kidney Int Suppl. 2004 Oct; (91):S41-9. PMID: 15461702.
      View in: PubMed
    114. Zhang J, Dai J, Lu Y, Yao Z, O'Brien CA, Murtha JM, Qi W, Hall DE, Manolagas SC, Ershler WB, Keller ET. In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging. Exp Gerontol. 2004 Feb; 39(2):239-47. PMID: 15036418.
      View in: PubMed
    115. Weinstein RS, Jia D, Powers CC, Stewart SA, Jilka RL, Parfitt AM, Manolagas SC. The skeletal effects of glucocorticoid excess override those of orchidectomy in mice. Endocrinology. 2004 Apr; 145(4):1980-7. PMID: 14715712.
      View in: PubMed
    116. O'Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology. 2004 Apr; 145(4):1835-41. PMID: 14691012.
      View in: PubMed
    117. Ijaz MT, Manolagas SC. A patient with pseudohypoparathyroidism. J Ark Med Soc. 2003 Nov; 100(5):164-6. PMID: 14606225.
      View in: PubMed
    118. Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem. 2003 Dec 12; 278(50):50259-72. PMID: 14523023.
      View in: PubMed
    119. Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC. Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest. 2003 Jun; 111(11):1651-64. PMID: 12782668.
      View in: PubMed
    120. Fu Q, Jilka RL, Manolagas SC, O'Brien CA. Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein. J Biol Chem. 2002 Dec 13; 277(50):48868-75. PMID: 12364326.
      View in: PubMed
    121. Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology. 2002 Jun; 143(6):2376-84. PMID: 12021203.
      View in: PubMed
    122. Weinstein RS, Chen JR, Powers CC, Stewart SA, Landes RD, Bellido T, Jilka RL, Parfitt AM, Manolagas SC. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest. 2002 Apr; 109(8):1041-8. PMID: 11956241.
      View in: PubMed
    123. Manolagas SC, Kousteni S, Jilka RL. Sex steroids and bone. Recent Prog Horm Res. 2002; 57:385-409. PMID: 12017554.
      View in: PubMed
    124. Manolagas SC. Estrogen loss, cytokines, macrophages, lymphocytes, osteoclasts, and bone loss: six characters in search of an author or an endocrine-immune system relay causing osteoporosis?. BoneKEy-Osteovision. 2002; 12.
    125. Plotkin LI, Manolagas SC, Bellido T. Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem. 2002 Mar 08; 277(10):8648-57. PMID: 11741942.
      View in: PubMed
    126. Manolagas SC. Manipulating Programmed Cell Death for Better Living! Sci STKE. 2001 Jun 19; 2001(87):PE1. PMID: 11865191.
      View in: PubMed
    127. Manolagas SC, Kousteni S. Perspective: nonreproductive sites of action of reproductive hormones. Endocrinology. 2001 Jun; 142(6):2200-4. PMID: 11356663.
      View in: PubMed
    128. Manolagas SC. Manipulating Programmed Cell Death for Better Living!. Sci STKE. 2001; 2001(87):E1 - .
    129. Manolagas SC. The role of apoptosis in the pathogenesis and treatment of osteoporosis. Medscape Diabetes & Endocrinology. 2001.
    130. Manolagas SC. Commentary on "restoration of bone mass in the severly osteopenic senescant rat" Learning how to keep Homo sapiens standing tall in old age. J Gerontol A Biol Sci Med Sci. 2000; 55(2):B81-B82.
    131. Riggs BL, Baron R, Boyle WJ, Drezner M, Manolagas SC, Martin TJ, Stewart AF, Suda T, Yasuda H, Aubin J, Goltzman D. Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption. J Bone Mineral Res. 2000; 15(12):2293-2296.
    132. Manolagas SC. Advances in the treatment of osteoporosis. Medscape. 1999.
    133. Manolagas SC, Weinstein RS. Glucocorticoid-induced osteoporosis: new developments in the pathogenesis and treatment. Harrison's Online. 1998.
    134. Manolagas SC. A non-sexist view of osteoporosis. The Federal Practitioner. 1996; 13(9).
    135. Manolagas SC. Estrogens, cytokines, and the pathophysiology of postmenopausal osteoporosis: a 1994 update. 1994; 15:82 - 99.
    136. Manolagas SC, Jilka RL, Girasole G, Passeri G, Bellido T. Estrogens, cytokines, and the pathophysiology of osteoporosis. Current Opinion in Endocrinology and Diabetes. 1994; 1:275-281.
    137. Manolagas SC, Hustmyer FG, Girasole G, Yu XP. Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis (reply letter to the editor). J Bone Miner Res. 1993; 8:777 - 778.
    138. Yoder MC, Manolagas SC. Vitamin D and its role in immune function. 1991; 1:35 - 44.
    139. Woodhouse NJY, Manolagas SC, Bashir R, Zuheir M, Kawi AL, Deftos LS. 1,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol in epileptic patients taking anticonvulsants. 1985; 5(1):27 - 31.
    140. Weinstein RS, Manolagas SC. Apoptosis in glucorticoid-induced bone disease. Current Opinion in Endocrinology and Diabetes. (219-223).
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