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Stavros Manolagas

TitleDistinguished Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Endo
Address8/820 Cancer Institute
4104 Outpatient Circle
Mail Slot # 587
Little Rock AR 72205
Phone501-686-5130
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentOrthopaedics, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    P20GM125503     (OBRIEN, CHARLES)Feb 16, 2018 - Jan 31, 2023
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Co-Investigator
    P01AG013918     (MANOLAGAS, STAVROS)May 1, 2015 - Apr 30, 2018
    NIH/Nat. Inst. on Aging
    Molecular and Cellular Mechanisms of Osteoporosis - Continuation
    Role: Principal Investigator
    I01BX001405     (MANOLAGAS, STAVROS C.)Jan 1, 2012 - Mar 31, 2021
    NIH
    Androgens, estrogens, and bone loss in males
    Role: Principal Investigator
    R01AR056679     (SCHULLER DE ALMEIDA, MARIA)Dec 1, 2008 - Jan 31, 2021
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Role of FoxOs in Skeletal Homeostasis- Resubmission
    Role: Co-Investigator
    R01AR051187     (KOUSTENI, STAVROULA)Feb 1, 2005 - Dec 31, 2008
    NIH
    OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS
    Role: Co-Principal Investigator
    R01AR043003     (MANOLAGAS, STAVROS C.)Mar 1, 1994 - Feb 29, 2000
    NIH
    ESTROGENS AND OSTEOCLASTOGENESIS
    Role: Principal Investigator
    R01AR041313     (MANOLAGAS, STAVROS C.)Sep 30, 1991 - Aug 31, 1996
    NIH
    HORMONAL CONTROL OF CYTOKINES IN BONE AND STROMAL CELLS
    Role: Principal Investigator
    R01AI021761     (MANOLAGAS, STAVROS C.)Dec 1, 1984 - Nov 30, 1991
    NIH
    1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Manolagas SC, Almeida M, Jilka RL. The ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Gonadal Steroids. 2014.
    2. Zhou J, Ye S, Fujiwara T, Manolagas SC, Zhao H. Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/ROS levels and CREB activation. J Biol Chem. 2013.
    3. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013; 123(1):394 - 404.
    4. Jilka RL, O'Brien CA, Roberson PK, Bonewald, LF, Weinstein RS, Manolagas SC. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates bone porosity with age. J Bone Mineral Res. 2013.
    5. Robert Weinstein, Erin Hogan, Charles O'Brien, Stavros Manolagas. Glucocorticoids Act Directly on Osteocytes to Reduce Bone Vascularity and Strength. Journal of Bone and Mineral Research. 2012; S469.
    6. Jinhu Xiong, Melda Onal, Stavros Manolagas. RANKL Produced by Osteocytes Contributes to the Bone Loss Induced by Hyperparathyroidism. Journal of Bone and Mineral Research. 2012; S14.
    7. Melda Onal, Jinhu Xiong, Shiqiao Ye, Li Han, Robert Jilka, Robert Weinstein, Maria Jose Almeida, Haibo Zhao, Stavros Manolagas, Charles O'Brien. Suppression of Autophagy in Osteoblasts and Osteocytes Increases Oxidative Stress and Recapitulates the Effects of Aging on the Murine Skeleton. Journal of Bone and Mineral Research. 2012; S349.
    8. Shiqiao Ye, Stavros Manolagas, Haibo Zhao. Lis1 Regulates Osteoclastogenesis through Small GTPase Cdc42. Journal of Bone and Mineral Research. 2012; S415.
    9. Shoshana Bartell, Elena Ambrogini, Li Han, Aaron Warren, Julie Crawford, Srividhya Iyer, Joseph Goellner, Haibo Zhao, Charles O'Brien, Stavros Manolagas, Maria Jose Almeida. Gain or Loss of FoxO Function in Osteoclasts alter Bone Mass in Mice. Journal of Bone and Mineral Research. 2012; S284.
    10. Shoshana Bartell, Li Han, Aaron Warren, Julie Crawford, Peter Rabinovitch, Stavros Manolagas, Maria Jose Almeida. Targeted Expression of Catalase to Mitochondria in Cells of the Macrophage/Osteoclast Lineage Inhibits Osteoclastogenesis and Increases Bone Mass. Journal of Bone and Mineral Research. 2012; S53.
    11. Robert Jilka, Annick DeLoose, Leslie Climer, Lynda Bonewald, Robert Weinstein, Charles O'Brien, Stavros Manolagas. Dysfunctional Osteocytes Increase RANKL and Promote Cortical Pore Formation in Their Vicinity: a Mechanical Explanation for the Development of Cortical Porosity with Age. Journal of Bone and Mineral Research. 2012; S348.
    12. Srividhya Iyer, Elena Ambrogini, Li Han, Shoshana Bartell, Aaron Warren, Julie Crawford, Paula Roberson, Robert Weinstein, Charles O'Brien, Maria Jose Almeida, Stavros Manolagas. Deletion of FoxO1, 3, and 4 from Osteoprogenitor Cells Increases Bone Mass throughout Life and Attenuates Adiposity in Aged Bone. Journal of Bone and Mineral Research. 2012; S23.
    13. Srividhya Iyer, Aaron Warren, Martha Martin-Millan, Li Han, Shoshana Bartell, Elena Ambrogini, Jinhu Xiong, Julie Crawford, Robert Weinstein, Robert Jilka, Charles O'Brien, Maria Jose Almeida, Stavros Manolagas. The ERa of Osteoblast Progenitors is Required for Normal Accrual of Cortical Bone Mass Independently of Estrogens. Journal of Bone and Mineral Research. 2012; S68.
    14. Shoshana Bartell, Aaron Warren, Li Han, Srividhya Iyer, Sung Kim, Benita Katzenellenbogen, Ken Chambliss, Philip Shaul, John Katzenellenbogen, Paula Roberson, Robert Weinstein, Charles O'Brien, Robert Jilka, Maria Jose Almeida, Stavros Manolagas. An Estrogen Dendrimer Conjugate Incapable of Stimulating the Nuclear-initiated Actions of Estrogen Receptors Prevents the Loss of Cortical Bone Mass in Estrogen Deficient Mice. Journal of Bone and Mineral Research. 2012; S21.
    15. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012; 287(35):29851 - 29860.
    16. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor alpha increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011; 286(52):44326 - 44335.
    17. Manolagas SC, Jilka RL. The study of skeletal aging is coming of age: a forum on aging and skeletal health. IBMS BoneKEy. 2011; 8(9):420-27.
    18. Jilka RL, O'Brien CA, Ali AA, Roberson PK, Weinstein RS, Manolagas SC. Intermittent PTH stimulates periosteal bone formation by actions on post-miotic preosteoblasts. Bone. 2009; 44(2):275-86.
    19. Manolagas SC. In: The Merck Manual of Geriatrics. Aging and the musculoskeletal system. 2009.
    20. Manolagas S. De-fense! De-fense! Defense: scavenging H202 while making cholesterol. Endocrinology. 2008; 149(7):3267-73.
    21. Jilka RL, Bellido T, Almeida M, Plotkin LI, O'Brien CA, Weinstein RS, Manolagas S. In: Principles of Bone Biology. John Bilezikian, Lawrence Raisz, T. John Martin, eds. Apoptosis of Bone Cells. 2008; 13.
    22. Manolagas SC. Perspective: Choreography from the tomb: an emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling. BoneKEy-Osteovision. 2006; 3(1):5-14.
    23. Manolagas S, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L. Let us not toss out the baby with the bath water. Online Response to Windahl et al. J Clin Invest. 2006; 116:2500-2509.
    24. Manolagas SC. Estrogen loss, cytokines, macrophages, lymphocytes, osteoclasts, and bone loss: six characters in search of an author or an endocrine-immune system relay causing osteoporosis?. BoneKEy-Osteovision. 2002; 12.
    25. Manolagas SC. Manipulating Programmed Cell Death for Better Living!. Sci STKE. 2001; 2001(87):E1 - .
    26. Manolagas SC. The role of apoptosis in the pathogenesis and treatment of osteoporosis. Medscape Diabetes & Endocrinology. 2001.
    27. Manolagas SC. Commentary on "restoration of bone mass in the severly osteopenic senescant rat" Learning how to keep Homo sapiens standing tall in old age. J Gerontol A Biol Sci Med Sci. 2000; 55(2):B81-B82.
    28. Riggs BL, Baron R, Boyle WJ, Drezner M, Manolagas SC, Martin TJ, Stewart AF, Suda T, Yasuda H, Aubin J, Goltzman D. Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption. J Bone Mineral Res. 2000; 15(12):2293-2296.
    29. Manolagas SC. Advances in the treatment of osteoporosis. Medscape. 1999.
    30. Manolagas SC, Weinstein RS. Glucocorticoid-induced osteoporosis: new developments in the pathogenesis and treatment. Harrison's Online. 1998.
    31. Manolagas SC. A non-sexist view of osteoporosis. The Federal Practitioner. 1996; 13(9).
    32. Manolagas SC. Estrogens, cytokines, and the pathophysiology of postmenopausal osteoporosis: a 1994 update. 1994; 15:82 - 99.
    33. Manolagas SC, Jilka RL, Girasole G, Passeri G, Bellido T. Estrogens, cytokines, and the pathophysiology of osteoporosis. Current Opinion in Endocrinology and Diabetes. 1994; 1:275-281.
    34. Manolagas SC, Hustmyer FG, Girasole G, Yu XP. Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis (reply letter to the editor). J Bone Miner Res. 1993; 8:777 - 778.
    35. Yoder MC, Manolagas SC. Vitamin D and its role in immune function. 1991; 1:35 - 44.
    36. Woodhouse NJY, Manolagas SC, Bashir R, Zuheir M, Kawi AL, Deftos LS. 1,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol in epileptic patients taking anticonvulsants. 1985; 5(1):27 - 31.
    37. Weinstein RS, Manolagas SC. Apoptosis in glucorticoid-induced bone disease. Current Opinion in Endocrinology and Diabetes. (219-223).
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