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Maria Schuller De Almeida

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Endo
Address825 Cancer Institute Trailer 4
4104 Outpatient Circle
Mail Slot # 587
Little Rock AR 72205
Phone501-686-7856
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim HN, Chang J, Shao L, Han L, Iyer S, Manolagas SC, O'Brien CA, Jilka RL, Zhou D, Almeida M. DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age. Aging Cell. 2017 Aug; 16(4):693-703. PMID: 28401730.
      View in: PubMed
    2. Almeida M, Laurent MR, Dubois V, Claessens F, O'Brien CA, Bouillon R, Vanderschueren D, Manolagas SC. Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev. 2017 01; 97(1):135-187. PMID: 27807202.
      View in: PubMed
    3. Ucer S, Iyer S, Kim HN, Han L, Rutlen C, Allison K, Thostenson JD, de Cabo R, Jilka RL, O'Brien C, Almeida M, Manolagas SC. The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct. J Bone Miner Res. 2017 Mar; 32(3):560-574. PMID: 27714847.
      View in: PubMed
    4. Iyer S, Han L, Ambrogini E, Yavropoulou M, Fowlkes J, Manolagas SC, Almeida M. Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes. J Bone Miner Res. 2017 Jan; 32(1):60-69. PMID: 27491024.
      View in: PubMed
    5. Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73. PMID: 26956187.
      View in: PubMed
    6. Kim HN, Han L, Iyer S, de Cabo R, Zhao H, O'Brien CA, Manolagas SC, Almeida M. Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs. Mol Endocrinol. 2015 Oct; 29(10):1498-509. PMID: 26287518; PMCID: PMC4588729 [Available on 10/01/16].
    7. Ucer S, Iyer S, Bartell SM, Martin-Millan M, Han L, Kim HN, Weinstein RS, Jilka RL, O'Brien CA, Almeida M, Manolagas SC. The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERa Signaling in Osteoblasts and Osteoclasts. J Bone Miner Res. 2015 Jul; 30(7):1138-49. PMID: 25704845; PMCID: PMC4871247.
    8. Piemontese M, Onal M, Xiong J, Wang Y, Almeida M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone. Bone. 2015 Jun; 75:18-26. PMID: 25700544; PMCID: PMC4387016.
    9. Iyer S, Han L, Bartell SM, Kim HN, Gubrij I, de Cabo R, O'Brien CA, Manolagas SC, Almeida M. Sirtuin1 (Sirt1) promotes cortical bone formation by preventing ß-catenin sequestration by FoxO transcription factors in osteoblast progenitors. J Biol Chem. 2014 Aug 29; 289(35):24069-78. PMID: 25002589; PMCID: PMC4148840.
    10. Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun. 2014 Apr 30; 5:3773. PMID: 24781012; PMCID: PMC4015330.
    11. Manolagas SC, O'Brien CA, Almeida M. The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol. 2013 Dec; 9(12):699-712. PMID: 24042328; PMCID: PMC3971652.
    12. Iyer S, Ambrogini E, Bartell SM, Han L, Roberson PK, de Cabo R, Jilka RL, Weinstein RS, O'Brien CA, Manolagas SC, Almeida M. FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest. 2013 Aug; 123(8):3409-19. PMID: 23867625; PMCID: PMC3726166.
    13. Almeida M, O'Brien CA. Basic biology of skeletal aging: role of stress response pathways. J Gerontol A Biol Sci Med Sci. 2013 Oct; 68(10):1197-208. PMID: 23825036; PMCID: PMC3779633.
    14. Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S, Komatsu M, Selig M, Weinstein RS, Zhao H, Jilka RL, Almeida M, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem. 2013 Jun 14; 288(24):17432-40. PMID: 23645674; PMCID: PMC3682543.
    15. Bartell SM, Han L, Kim HN, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Chambliss KL, Shaul PW, Roberson PK, Weinstein RS, Jilka RL, Almeida M, Manolagas SC. Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass. Mol Endocrinol. 2013 Apr; 27(4):649-56. PMID: 23443267; PMCID: PMC3607700.
    16. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013; 123(1):394 - 404.
    17. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013 Jan; 123(1):394-404. PMID: 23221342; PMCID: PMC3533305.
    18. Shoshana Bartell, Li Han, Aaron Warren, Julie Crawford, Peter Rabinovitch, Stavros Manolagas, Maria Jose Almeida. Targeted Expression of Catalase to Mitochondria in Cells of the Macrophage/Osteoclast Lineage Inhibits Osteoclastogenesis and Increases Bone Mass. Journal of Bone and Mineral Research. 2012; S53.
    19. Shoshana Bartell, Elena Ambrogini, Li Han, Aaron Warren, Julie Crawford, Srividhya Iyer, Joseph Goellner, Haibo Zhao, Charles O'Brien, Stavros Manolagas, Maria Jose Almeida. Gain or Loss of FoxO Function in Osteoclasts alter Bone Mass in Mice. Journal of Bone and Mineral Research. 2012; S284.
    20. Srividhya Iyer, Aaron Warren, Martha Martin-Millan, Li Han, Shoshana Bartell, Elena Ambrogini, Jinhu Xiong, Julie Crawford, Robert Weinstein, Robert Jilka, Charles O'Brien, Maria Jose Almeida, Stavros Manolagas. The ERa of Osteoblast Progenitors is Required for Normal Accrual of Cortical Bone Mass Independently of Estrogens. Journal of Bone and Mineral Research. 2012; S68.
    21. Srividhya Iyer, Elena Ambrogini, Li Han, Shoshana Bartell, Aaron Warren, Julie Crawford, Paula Roberson, Robert Weinstein, Charles O'Brien, Maria Jose Almeida, Stavros Manolagas. Deletion of FoxO1, 3, and 4 from Osteoprogenitor Cells Increases Bone Mass throughout Life and Attenuates Adiposity in Aged Bone. Journal of Bone and Mineral Research. 2012; S23.
    22. Shoshana Bartell, Aaron Warren, Li Han, Srividhya Iyer, Sung Kim, Benita Katzenellenbogen, Ken Chambliss, Philip Shaul, John Katzenellenbogen, Paula Roberson, Robert Weinstein, Charles O'Brien, Robert Jilka, Maria Jose Almeida, Stavros Manolagas. An Estrogen Dendrimer Conjugate Incapable of Stimulating the Nuclear-initiated Actions of Estrogen Receptors Prevents the Loss of Cortical Bone Mass in Estrogen Deficient Mice. Journal of Bone and Mineral Research. 2012; S21.
    23. Melda Onal, Jinhu Xiong, Shiqiao Ye, Li Han, Robert Jilka, Robert Weinstein, Maria Jose Almeida, Haibo Zhao, Stavros Manolagas, Charles O'Brien. Suppression of Autophagy in Osteoblasts and Osteocytes Increases Oxidative Stress and Recapitulates the Effects of Aging on the Murine Skeleton. Journal of Bone and Mineral Research. 2012; S349.
    24. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012; 287(35):29851 - 29860.
    25. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012 Aug 24; 287(35):29851-60. PMID: 22782898; PMCID: PMC3436192.
    26. Almeida M. Aging mechanisms in bone. BoneKEy Reports. 2012; 1:102.
    27. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor alpha increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011; 286(52):44326 - 44335.
    28. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor a increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011 Dec 30; 286(52):44326-35. PMID: 22030390; PMCID: PMC3247937.
    29. Weinstein RS, O'Brien CA, Almeida M, Zhao H, Roberson PK, Jilka RL, Manolagas SC. Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice. Endocrinology. 2011 Sep; 152(9):3323-31. PMID: 21771887; PMCID: PMC3159783.
    30. Almeida M. Unraveling the role of FoxOs in bone--insights from mouse models. Bone. 2011 Sep; 49(3):319-27. PMID: 21664311; PMCID: PMC3143252.
    31. Jilka RL, Almeida M, Ambrogini E, Han L, Roberson PK, Weinstein RS, Manolagas SC. Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration. Aging Cell. 2010 Oct; 9(5):851-67. PMID: 20698835; PMCID: PMC2958819.
    32. Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC. Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens. Mol Endocrinol. 2010 Oct; 24(10):2030-7. PMID: 20685851; PMCID: PMC2954638.
    33. Weinstein RS, Jilka RL, Almeida M, Roberson PK, Manolagas SC. Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice. Endocrinology. 2010 Jun; 151(6):2641-9. PMID: 20410195; PMCID: PMC2875832.
    34. Almeida M, Martin-Millan M, Ambrogini E, Bradsher R, Han L, Chen XD, Roberson PK, Weinstein RS, O'Brien CA, Jilka RL, Manolagas SC. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res. 2010 Apr; 25(4):769-81. PMID: 19821774; PMCID: PMC3153331.
    35. Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010 Feb 03; 11(2):136-46. PMID: 20142101; PMCID: PMC2819984.
    36. Martin-Millan M, Almeida M, Ambrogini E, Han L, Zhao H, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010 Feb; 24(2):323-34. PMID: 20053716; PMCID: PMC2817608.
    37. Almeida M. Osteoporosis: Pathophysiology and Clinical Management. The basic biology of estrogen and bone. 2010.
    38. Almeida M. Aging and oxidative stress: a new look at old bone. BoneKEy-Osteovision. 2010; 7(10):340-52.
    39. Weinstein RS, Wan C, Liu Q, Wang Y, Almeida M, O'Brien CA, Thostenson J, Roberson PK, Boskey AL, Clemens TL, Manolagas SC. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell. 2010 Apr; 9(2):147-61. PMID: 20047574; PMCID: PMC2858771.
    40. Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL. Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009 Oct 02; 284(40):27438-48. PMID: 19657144; PMCID: PMC2785673.
    41. Jilka RL, Bellido T, Almeida M, Plotkin LI, O'Brien CA, Weinstein RS, Manolagas SC. Principles of Bone Biology. Apoptosis of Bone Cells. 2008.
    42. Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Kousteni S, O'Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007 Sep 14; 282(37):27285-97. PMID: 17623659; PMCID: PMC3119455.
    43. Almeida M, Han L, Martin-Millan M, O'Brien CA, Manolagas SC. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem. 2007 Sep 14; 282(37):27298-305. PMID: 17623658.
      View in: PubMed
    44. Manolagas SC, Almeida M. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol. 2007 Nov; 21(11):2605-14. PMID: 17622581.
      View in: PubMed
    45. Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol. 2007 Feb; 27(4):1516-30. PMID: 17158928; PMCID: PMC1800724.
    46. Almeida M, Han L, O'brien CA, Kousteni S, Manolagas SC. Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha. Endocrinology. 2006 Apr; 147(4):1986-96. PMID: 16384865.
      View in: PubMed
    47. Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem. 2005 Dec 16; 280(50):41342-51. PMID: 16251184.
      View in: PubMed
    48. Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC. Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem. 2005 Apr 08; 280(14):14130-7. PMID: 15671029.
      View in: PubMed
    49. Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC. Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest. 2003 Jun; 111(11):1651-64. PMID: 12782668; PMCID: PMC156107.
    50. Rousseau M, Pereira-Mouries L, Almeida MJ, Milet C, Lopez E. The water-soluble matrix fraction from the nacre of Pinctada maxima produces earlier mineralization of MC3T3-E1 mouse pre-osteoblasts. Comp Biochem Physiol B Biochem Mol Biol. 2003; 135(1):1 - 7.
    51. Pereira-Mouries L, Almeida MJ, Ribeiro C, Peduzzi J, Barthelemy M, Milet C, Lopez E. Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima. Eur J Biochem. 2002; 269(20):4994 - 5003.
    52. Mouries LP, Almeida MJ, Milet C, Berland S, Lopez E. Bioactivity of nacre water-soluble organic matrix from the bivalve mollusk Pinctada maxima in three mammalian cell types: fibroblasts, bone marrow stromal cells and osteoblasts. Comp Biochem Physiol B Biochem Mol Biol. 2002; 132(1):217 - 229.
    53. Almeida MJ, Pereira L, Milet C, Haigle J, Barbosa M, Lopez E. Comparative effects of nacre water-soluble matrix and dexamethasone on the alkaline phosphatase activity of MRC-5 fibroblasts. J Biomed Mater Res. 2001; 57(2):306 - 312.
    54. Bedouet L, Schuller MJ, Marin F, Milet C, Lopez E, Giraud M. Soluble proteins of the nacre of the giant oyster Pinctada maxima and of the abalone Haliotis tuberculata: extraction and partial analysis of nacre proteins. Comp Biochem Physiol B Biochem Mol Biol. 2001; 128(3):389 - 400.
    55. Zeutz F, Bedouet L, Almeida MJ, Milet C, Lopez E. Characterization and quantification of chitosan extracted from the nacre of the abalone Haliotis tuberculata and the oyster Pinctada maxima. Marine Biotechnology. 2001; 3:36-44.
    56. Almeida MJ, Milet C, Peduzzi J, Pereira L, Haigle J, Barthelemy M, Lopez E. Effect of water-soluble matrix fraction extracted from the nacre of Pinctada maxima on the alkaline phosphatase activity of cultured fibroblasts. J Exp Zool. 2000; 288(4):327 - 334.
    57. Lamghari M, Almeida MJ, Berland S, Huet H, Laurent A, Milet C, Lopez E. Stimulation of bone marrow cells and bone formation by nacre: in vivo and in vitro studies. Bone. 1999; 25(2 Suppl):91S - 94S.
    58. Almeida MJ, Coimbra J, Machado J, Coelho MA, Soares de Silva P. L-3,4-dihydroxyphenylalanine (L-DOPA) secreted by oysters (Crassostrea gigas) mantle cells: functional aspects. Comparative Biochemistry and Phisiology. 1998; 120B:709-713.
    59. Soares da Silva IM, Almeida MJ, Serrao PM, Coelho MA, Machado J. L-3,4-dihydroxyphenylalanine (L-DOPA) in Anodonta cygnea: variation with acidosis. Comparative Biochemistry and Phisiology. 1998; 120A:463-468.
    60. Almeida MJ, Machado J, Moura T, Pinheiro, Coimbra J. Modifications in Crassostrea gigas shell composition treated with lead. Aquatic Toxicology. 1998; 40:323-334.
    61. Almeida MJ, Machado J, Moura G, Azevedo M, Coimbra J. Temporal and local variations in biochemical composition of Crassostrea gigas shells. Journal of Sea Research. 1998; 40:233-249.
    62. Almeida MJ, Machado J, Coimbra J. Growth and biochemical composition of Crassostrea gigas (Thunberg) and Ostrea edulis (Linne) in two estuaries from the North of Portugal. Journal of Shellfish Research. 1998; 18(1):139-146.
    63. Almeida MJ, Machado J, Coimbra J. Growth and biochemical composition of Crassostrea gigas (Thunberg) at three fishfarm earthen ponds. Journal of Shellfish Research. 1997; 16(2):455-462.
    64. Almeida MJ, Machado J, Coimbra J. The effect of Polydora sp. infestation on the shell calcification of the oyster Crassostrea gigas. Bulletin de l'Institut Oceanographique. 1996; 14(4):195-202.
    65. Almeida MJ, Coimbra J, Machado J, Moura G, Vilarinho L, Soares da Silva P, Ribeiro C. Amino acids and metal content of Crassostrea gigas shell infested by Polydora sp. in the prismatic layer insoluble matrix and blister membrane. Aquatic Living Resources. 1996; 9(2):179-186.
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