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Jon Blevins

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address521B Biomedical Research I
325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-296-1253
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    Collapse Research Funds 
    Collapse research activities
    R01AI146930     (BLEVINS, JON)Jun 15, 2020 - May 31, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: East Carolina University
    Virulence Mechanisms of Multifunctional Borrelial Proteins
    Role: Principal Investigator

    R03AI151432     (BLEVINS, JON SCOTT)Feb 10, 2020 - Jan 31, 2022
    NIH/NIAID
    Developing a system for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii
    Role: Principal Investigator

    R56AI146930     (BLEVINS, JON)Aug 20, 2019 - Jun 12, 2020
    NIH/National Institutes of Health - Pass Through: East Carolina University
    Virulence Mechanisms of Multifunctional Borrelial Proteins
    Role: Principal Investigator

    S10 OD026736     (MACKINTOSH, SAMUEL)Aug 1, 2019 - Jul 31, 2020
    NIH/Office of the Director
    Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer
    Role: Co-Investigator

    R21AI119532     (BLEVINS, JON SCOTT)Jun 15, 2015 - May 31, 2017
    NIH/NIAID
    Rrp2-dependent gene regulation in Borrelia burgdorferi
    Role: Principal Investigator

    R01AI087678     (BLEVINS, JON SCOTT)Aug 23, 2013 - Apr 30, 2015
    NIH/NIAID
    RpoS-mediated virulence regulation in Borrelia burgdorferi
    Role: Principal Investigator

    P20GM103625     (SMELTZER, MARK S)Aug 15, 2012 - Apr 30, 2022
    NIH/NIGMS
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator

    F32AI058487     (BLEVINS, JON SCOTT)Jul 1, 2005 - Jun 30, 2008
    NIH/NIAID
    New genetic approaches analyzing Borrelia burgdorferi
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Graham DE, Groshong AM, Jackson-Litteken CD, Moore BP, Caimano MJ, Blevins JS. The BB0345 hypothetical protein of Borrelia burgdorferi is essential for mammalian infection. Infect Immun. 2020 Sep 14. PMID: 32928963.
      View in: PubMed
    2. Caimano MJ, Groshong AM, Belperron A, Mao J, Hawley KL, Luthra A, Graham DE, Earnhart CG, Marconi RT, Bockenstedt LK, Blevins JS, Radolf JD. The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity. Front Microbiol. 2019; 10:1923. PMID: 31507550.
      View in: PubMed
    3. Jackson-Litteken CD, Zalud AK, Ratliff CT, Latham JI, Bourret TJ, Lopez JE, Blevins JS. Assessing the Contribution of an HtrA Family Serine Protease During Borrelia turicatae Mammalian Infection. Front Cell Infect Microbiol. 2019; 9:290. PMID: 31456953.
      View in: PubMed
    4. Brann KR, Fullerton MS, Onyilagha FI, Prince AA, Kurten RC, Rom JS, Blevins JS, Smeltzer MS, Voth DE. Infection of Primary Human Alveolar Macrophages Alters Staphylococcus aureus Toxin Production and Activity. Infect Immun. 2019 07; 87(7). PMID: 31010814.
      View in: PubMed
    5. Boyle WK, Groshong AM, Drecktrah D, Boylan JA, Gherardini FC, Blevins JS, Samuels DS, Bourret TJ. DksA Controls the Response of the Lyme Disease Spirochete Borrelia burgdorferi to Starvation. J Bacteriol. 2019 02 15; 201(4). PMID: 30478087.
      View in: PubMed
    6. Latham JI, Blevins JS. Generation of Conditional Mutants in Borrelia burgdorferi. Methods Mol Biol. 2018; 1690:225-239. PMID: 29032548.
      View in: PubMed
    7. Yin Y, Yang Y, Xiang X, Wang Q, Yang ZN, Blevins J, Lou Y, Yang XF. Insight into the Dual Functions of Bacterial Enhancer-Binding Protein Rrp2 of Borrelia burgdorferi. J Bacteriol. 2016 05 15; 198(10):1543-52. PMID: 26977110.
      View in: PubMed
    8. Wager B, Shaw DK, Groshong AM, Blevins JS, Skare JT. BB0744 Affects Tissue Tropism and Spatial Distribution of Borrelia burgdorferi. Infect Immun. 2015 Sep; 83(9):3693-703. PMID: 26150534.
      View in: PubMed
    9. Cue D, Junecko JM, Lei MG, Blevins JS, Smeltzer MS, Lee CY. SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. PLoS One. 2015; 10(4):e0123027. PMID: 25853849.
      View in: PubMed
    10. Groshong AM, Fortune DE, Moore BP, Spencer HJ, Skinner RA, Bellamy WT, Blevins JS. BB0238, a presumed tetratricopeptide repeat-containing protein, is required during Borrelia burgdorferi mammalian infection. Infect Immun. 2014 Oct; 82(10):4292-306. PMID: 25069985.
      View in: PubMed
    11. Fortune DE, Lin YP, Deka RK, Groshong AM, Moore BP, Hagman KE, Leong JM, Tomchick DR, Blevins JS. Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection. Infect Immun. 2014 Aug; 82(8):3186-98. PMID: 24842928.
      View in: PubMed
    12. Groshong AM, Blevins JS. Insights into the biology of Borrelia burgdorferi gained through the application of molecular genetics. Adv Appl Microbiol. 2014; 86:41-143. PMID: 24377854.
      View in: PubMed
    13. Fortune, D.E.,, Lin, Y.,, Groshong, A.M.,, Deka, R.K.,, Leong, J.M.,, Norgard, M.V.,, Tomchick, D.R.,, Blevins, J. S. Structural and functional analysis of the decorin binding adhesin (DbpA) of the Lyme disease spirochete, Borrelia burgdorferi. 2013.
    14. Blevins, J. S., Groshong, A. M. Assessing the role of the putative RpoS-regulated gene, bb0238, during Borrelia burgdorferi mammalian infection. 2013.
    15. Groshong AM, Gibbons NE, Yang XF, Blevins JS. Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi. J Bacteriol. 2012 Jul; 194(13):3336-42. PMID: 22544267.
      View in: PubMed
    16. Groshong, A.M.,, Yang, X.F, Gibbons, N.E.,, Blevins, J. S. Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi. J. Bacteriol. 2012; (194:3336-3342).
    17. Becker AM, Blevins JS, Tomson FL, Eitson JL, Medeiros JJ, Yarovinsky F, Norgard MV, van Oers NS. Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs. J Immunol. 2010 Jun 15; 184(12):6822-32. PMID: 20483726.
      View in: PubMed
    18. Becker, A.M.,, Blevins, J. S., Wight-Carter, M.,, Medeiros J.J.,, Murray S.,, Richardson J.A, Norgard, M.V, Van Oers, N.S.C. A full complement of CD3 ?ITAMs is necessary for NKT cell development and function. J. Immunol. 2010; 184:6822-6832.
    19. Blevins JS, Xu H, He M, Norgard MV, Reitzer L, Yang XF. Rrp2, a sigma54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner. J Bacteriol. 2009 Apr; 191(8):2902-5. PMID: 19201806.
      View in: PubMed
    20. Blevins, J. S., Doty A, Limke T, Montalto JG. Identification of a source of bovine serum albumin that consistently supports Borrelia burgdorferi cultivation and differential expression. BioProcess Intl. 2009; (7):26-34.
    21. Blevins J, Xu H, He M, Norgard MV, Reitzer L, Yang SF. Rrp2, a o-54 -dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner. J.Bacteriol. 2009; 191:2902-2905.
    22. Blevins, J. S., Doty, A.,, Limke, T, Montalto, J.G. Identification of a source of bovine serum albumin that consistently supports Borrelia burgdorferi cultivation and differential expression. BioProcess. 2009; (7:26-34.).
    23. He M, Oman T, Xu H, Blevins J, Norgard MV, Yang XF. Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi. Mol Microbiol. 2008 Dec; 70(6):1453-64. PMID: 19019147.
      View in: PubMed
    24. Ouyang Z, Blevins JS, Norgard MV. Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi. Microbiology (Reading). 2008 Sep; 154(Pt 9):2641-2658. PMID: 18757798.
      View in: PubMed
    25. Yang XF, Goldberg MS, He M, Xu H, Blevins JS, Norgard MV. Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi. Infect Immun. 2008 Oct; 76(10):4439-44. PMID: 18663002.
      View in: PubMed
    26. Blevins JS, Hagman KE, Norgard MV. Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection. BMC Microbiol. 2008 May 28; 8:82. PMID: 18507835.
      View in: PubMed
    27. He, M.,, Oman, T.,, Blevins, J. S., Norgard, M.V.,, Yang, X.F. Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi. Mol. Microbiol. 2008; (70:1453-1464).
    28. Yang, X.F, Goldberg, M.S.,, He, M.,, Xu, H.,, Blevins, J. S., Norgard M.V. Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi. Infect. Immun. 2008; 76:4439-4444.
    29. Machius M, Brautigam CA, Tomchick DR, Ward P, Otwinowski Z, Blevins JS, Deka RK, Norgard MV. Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor. J Mol Biol. 2007 Oct 26; 373(3):681-94. PMID: 17868688.
      View in: PubMed
    30. Blevins JS, Revel AT, Smith AH, Bachlani GN, Norgard MV. Adaptation of a luciferase gene reporter and lac expression system to Borrelia burgdorferi. Appl Environ Microbiol. 2007 Mar; 73(5):1501-13. PMID: 17220265.
      View in: PubMed
    31. Machius M, Brautigam CA, Tomchick DR, Ward P, Otwinowski Z, Blevins, J. S., Deka RK, Norgard MV. Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum:putative role of Tp0655(TpPotD) as a polyamine receptor. J Mol. Biol. 2007; 373:681-694.
    32. Smith AH, Blevins, J. S., Bachlani GN, Yang XY, Norgard MV. Evidence that RpoS(o~s) in Borrelia burgdorferi is controlled directly by RpoN(o~54 /o~N). J. Bacteriol. 2007; 189:2139-2144.
    33. Smith AH, Blevins JS, Bachlani GN, Yang XF, Norgard MV. Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN). J Bacteriol. 2007 Mar; 189(5):2139-44. PMID: 17158681.
      View in: PubMed
    34. Deka RK, Brautigam CA, Yang XF, Blevins JS, Machius M, Tomchick DR, Norgard MV. The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum. J Biol Chem. 2006 Mar 24; 281(12):8072-81. PMID: 16418175.
      View in: PubMed
    35. Deka RK, Brautigam CA, Yang XF, Blevins, J. S., Machius M, Tomchick DR, Norgard MV. The PnrA (Tp0319;Tmpc) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within a ATP-binding cassette(ABC)-like operon in Treponema pallidum. J. Biol. Chem. 2006; 281:8072-8081.
    36. Yang XF, Lybecker MC, Pal U, Alani SM, Blevins J, Revel AT, Samuels DS, Norgard MV. Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J Bacteriol. 2005 Jul; 187(14):4822-9. PMID: 15995197.
      View in: PubMed
    37. Revel AT, Blevins JS, Almazán C, Neil L, Kocan KM, de la Fuente J, Hagman KE, Norgard MV. bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6972-7. PMID: 15860579.
      View in: PubMed
    38. Yang X, Lybecker MC, Pal U, Alani SM, Blevins, J. S., Revel AT, Samuels DS, Norgard MV. Analysis of the ospC regulatory element controlled by the Rrp2-RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J. Bacteriol. 2005; 187:4822-4829.
    39. O'Leary JO, Langevin MJ, Price CT, Blevins JS, Smeltzer MS, Gustafson JE. Effects of sarA inactivation on the intrinsic multidrug resistance mechanism of Staphylococcus aureus. FEMS Microbiol Lett. 2004 Aug 15; 237(2):297-302. PMID: 15321676.
      View in: PubMed
    40. Blevins JS, Revel AT, Caimano MJ, Yang XF, Richardson JA, Hagman KE, Norgard MV. The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease. Infect Immun. 2004 Aug; 72(8):4864-7. PMID: 15271949.
      View in: PubMed
    41. Beenken KE, Dunman PM, McAleese F, Macapagal D, Murphy E, Projan SJ, Blevins JS, Smeltzer MS. Global gene expression in Staphylococcus aureus biofilms. J Bacteriol. 2004 Jul; 186(14):4665-84. PMID: 15231800.
      View in: PubMed
    42. O'Leary JO, Langevin MJ, Price CTD, Blevins, J. S., Smeltzer MS, Gustafson JE. Effects of sarA inactivation on intrinsic multi-antibacterial resistance of Staphylococcus aureus. FEMS Microbiol. Lett. 2004; 237:297-302.
    43. Sterba KM, Mackintosh SG, Blevins JS, Hurlburt BK, Smeltzer MS. Characterization of Staphylococcus aureus SarA binding sites. J Bacteriol. 2003 Aug; 185(15):4410-7. PMID: 12867449.
      View in: PubMed
    44. Beenken KE, Blevins JS, Smeltzer MS. Mutation of sarA in Staphylococcus aureus limits biofilm formation. Infect Immun. 2003 Jul; 71(7):4206-11. PMID: 12819120.
      View in: PubMed
    45. Blevins JS, Elasri MO, Allmendinger SD, Beenken KE, Skinner RA, Thomas JR, Smeltzer MS. Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infect Immun. 2003 Jan; 71(1):516-23. PMID: 12496203.
      View in: PubMed
    46. Blevins, J. S., Elasri MO, Allmendinger SA, Beenken KE, Skinner RA, Thomas JR, Smeltzer MS. Role sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infect. Immun. 2003; 71:516-523.
    47. Blevins JS, Beenken KE, Elasri MO, Hurlburt BK, Smeltzer MS. Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus. Infect Immun. 2002 Feb; 70(2):470-80. PMID: 11796572.
      View in: PubMed
    48. Mason WJ, Blevins, J. S., Beenken KE, Gardner MR, Wibowo N, Ojha N, Smeltzer MS. Multiplex PCR protocol for the diagnosis of staphylococcus infection. J. Clin. Micro. 2001; 39:3332-3338.
    49. Oman, T.,, He, M.,, Blevins, J. S., Yang, X.F. Analysis of regulatory elements involved in the activation and repression of ospA expression in Borrelia burgdorferi. 2012.
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