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Jon Blevins

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address521B Biomedical Research I
325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-296-1253
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    Collapse Research 
    Collapse research activities and funding
    R01AI170892     (BLEVINS, JON S)Aug 8, 2022 - Jul 31, 2026
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Cyclic di-AMP-dependent signaling in tickborne relapsing fever Borrelia
    Role: Principal Investigator

    R01AI170892     (BLEVINS, JON SCOTT)Aug 1, 2022 - Aug 1, 2026
    NIH/NIAID
    Cyclic di-AMP-dependent signaling in tickborne relapsing fever Borrelia
    Role: Principal Investigator

    P30GM145393     (SMELTZER, MARK S)May 5, 2022 - Apr 30, 2027
    NIH
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator

    R21AI156101     (BLEVINS, JON SCOTT)Mar 25, 2021 - Feb 29, 2024
    NIH
    Cyclic di-GMP Second Messenger Signaling in the Tickborne Relapsing Fever Spirochete, Borrelia turicatae
    Role: Principal Investigator

    R01AI146930     (BLEVINS, JON S)Jun 15, 2020 - May 31, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: East Carolina University
    Virulence Mechanisms of Multifunctional Borrelial Proteins
    Role: Principal Investigator

    R01 AI146930     (BLEVINS, JON S)Jun 15, 2020 - May 31, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: East Carolina University
    Virulence Mechanisms of Multifunctional Borrelial Proteins
    Role: Co-Investigator

    R03AI151432     (BLEVINS, JON SCOTT)Feb 10, 2020 - Jan 31, 2022
    NIH
    Developing a system for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii
    Role: Principal Investigator

    R56AI146930     (BLEVINS, JON S)Aug 20, 2019 - Jun 12, 2020
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: East Carolina University
    Virulence Mechanisms of Multifunctional Borrelial Proteins
    Role: Principal Investigator

    117-1006839     (BLEVINS, JON SCOTT)Jul 1, 2015 - Jun 30, 2016
    UAMS College of Medicine
    Blevins Start Up Account
    Role: Principal Investigator

    R21AI119532     (BLEVINS, JON SCOTT)Jun 15, 2015 - May 31, 2019
    NIH
    Rrp2-dependent gene regulation in Borrelia burgdorferi
    Role: Principal Investigator

    R01AI087678     (BLEVINS, JON SCOTT)May 15, 2010 - Apr 30, 2017
    NIH
    RpoS-mediated virulence regulation in Borrelia burgdorferi
    Role: Principal Investigator

    F32AI058487     (BLEVINS, JON SCOTT)Jul 1, 2005 - Jun 30, 2008
    NIH
    New genetic approaches analyzing Borrelia burgdorferi
    Role: Principal Investigator

    Barton CY19     (BLEVINS, JON SCOTT)
    UAMS College of Medicine
    Studying the roles of dinucleotide second messenger molecules in the pathogenesis of the tickborne relapsing fever spirochete, Borrelia turicatae
    Role: Principal Investigator

    BartonCY19     (BLEVINS, JON SCOTT)
    UAMS College of Medicine
    Studying the roles of dinucleotide second messenger molecules in the pathogenesis of the tickborne relapsing fever spirochete, Borrelia turicatae
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Groshong AM, Gibbons NE, Moore BP, Bellamy WT, Blevins JS. The plasmid-encoded members of paralogous gene family 52 are dispensable to the enzootic cycle of Borrelia burgdorferi. Infect Immun. 2024 Aug 09; e0021424. PMID: 39120148.
      View in: PubMed
    2. Murphy BT, Wiepen JJ, Graham DE, Swanson SK, Kashipathy MM, Cooper A, Battaile KP, Johnson DK, Florens L, Blevins JS, Lovell S, Z?ckert WR. Borrelia burgdorferi BB0346 is an Essential, Structurally Variant LolA Homolog that is Primarily Required for Homeostatic Localization of Periplasmic Lipoproteins. bioRxiv. 2024 Aug 06. PMID: 39149330.
      View in: PubMed
    3. Jackson-Litteken CD, Guo W, Hogland BA, Ratliff CT, McFadden L, Fullerton MS, Voth DE, Rego ROM, Blevins JS. Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii. PLoS Negl Trop Dis. 2024 Jul; 18(7):e0012348. PMID: 39038047.
      View in: PubMed
    4. Jackson-Litteken CD, Curtis MW, Armstrong BA, Krishnavajhala A, Filatov S, Blevins JS, Lopez JE. Characterization of the arthropod associated lipoprotein (Alp) in the tick-mammalian transmission cycle of Borrelia turicatae. Ticks Tick Borne Dis. 2022 Nov; 13(6):102052. PMID: 36223678.
      View in: PubMed
    5. Jackson-Litteken CD, Ratliff CT, Kneubehl AR, Siletti C, Pack L, Lan RS, Huynh TN, Lopez JE, Blevins JS. The diadenylate cyclase, CdaA, is critical for Borrelia turicatae virulence and physiology. Infect Immun. 2021; 89:e00787-20.
    6. Graham DE, Groshong AM, Jackson-Litteken CD, Moore BP, Caimano MJ, Blevins JS. The BB0345 Hypothetical Protein of Borrelia burgdorferi Is Essential for Mammalian Infection. Infect Immun. 2020 11 16; 88(12). PMID: 32928963.
      View in: PubMed
    7. Caimano MJ, Groshong AM, Belperron A, Mao J, Hawley KL, Luthra A, Graham DE, Earnhart CG, Marconi RT, Bockenstedt LK, Blevins JS, Radolf JD. The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity. Front Microbiol. 2019; 10:1923. PMID: 31507550.
      View in: PubMed
    8. Jackson-Litteken CD, Zalud AK, Ratliff CT, Latham JI, Bourret TJ, Lopez JE, Blevins JS. Assessing the Contribution of an HtrA Family Serine Protease During Borrelia turicatae Mammalian Infection. Front Cell Infect Microbiol. 2019; 9:290. PMID: 31456953.
      View in: PubMed
    9. Brann KR, Fullerton MS, Onyilagha FI, Prince AA, Kurten RC, Rom JS, Blevins JS, Smeltzer MS, Voth DE. Infection of Primary Human Alveolar Macrophages Alters Staphylococcus aureus Toxin Production and Activity. Infect Immun. 2019 07; 87(7). PMID: 31010814.
      View in: PubMed
    10. Boyle WK, Groshong AM, Drecktrah D, Boylan JA, Gherardini FC, Blevins JS, Samuels DS, Bourret TJ. DksA Controls the Response of the Lyme Disease Spirochete Borrelia burgdorferi to Starvation. J Bacteriol. 2019 02 15; 201(4). PMID: 30478087.
      View in: PubMed
    11. Latham JI, Blevins JS. Generation of Conditional Mutants in Borrelia burgdorferi. Methods Mol Biol. 2018; 1690:225-239. PMID: 29032548.
      View in: PubMed
    12. Yin Y, Yang Y, Xiang X, Wang Q, Yang ZN, Blevins J, Lou Y, Yang XF. Insight into the Dual Functions of Bacterial Enhancer-Binding Protein Rrp2 of Borrelia burgdorferi. J Bacteriol. 2016 05 15; 198(10):1543-52. PMID: 26977110.
      View in: PubMed
    13. Wager B, Shaw DK, Groshong AM, Blevins JS, Skare JT. BB0744 Affects Tissue Tropism and Spatial Distribution of Borrelia burgdorferi. Infect Immun. 2015 Sep; 83(9):3693-703. PMID: 26150534.
      View in: PubMed
    14. Cue D, Junecko JM, Lei MG, Blevins JS, Smeltzer MS, Lee CY. SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. PLoS One. 2015; 10(4):e0123027. PMID: 25853849.
      View in: PubMed
    15. Groshong AM, Fortune DE, Moore BP, Spencer HJ, Skinner RA, Bellamy WT, Blevins JS. BB0238, a presumed tetratricopeptide repeat-containing protein, is required during Borrelia burgdorferi mammalian infection. Infect Immun. 2014 Oct; 82(10):4292-306. PMID: 25069985.
      View in: PubMed
    16. Fortune DE, Lin YP, Deka RK, Groshong AM, Moore BP, Hagman KE, Leong JM, Tomchick DR, Blevins JS. Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection. Infect Immun. 2014 Aug; 82(8):3186-98. PMID: 24842928.
      View in: PubMed
    17. Groshong AM, Blevins JS. Insights into the biology of Borrelia burgdorferi gained through the application of molecular genetics. Adv Appl Microbiol. 2014; 86:41-143. PMID: 24377854.
      View in: PubMed
    18. Groshong AM, Gibbons NE, Yang XF, Blevins JS. Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi. J Bacteriol. 2012 Jul; 194(13):3336-42. PMID: 22544267.
      View in: PubMed
    19. Becker AM, Blevins JS, Tomson FL, Eitson JL, Medeiros JJ, Yarovinsky F, Norgard MV, van Oers NS. Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs. J Immunol. 2010 Jun 15; 184(12):6822-32. PMID: 20483726.
      View in: PubMed
    20. Blevins JS, Xu H, He M, Norgard MV, Reitzer L, Yang XF. Rrp2, a sigma54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner. J Bacteriol. 2009 Apr; 191(8):2902-5. PMID: 19201806.
      View in: PubMed
    21. Blevins, J. S., Doty A, Limke T, Montalto JG. Identification of a source of bovine serum albumin that consistently supports Borrelia burgdorferi cultivation and differential expression. BioProcess Intl. 2009; (7):26-34.
    22. He M, Oman T, Xu H, Blevins J, Norgard MV, Yang XF. Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi. Mol Microbiol. 2008 Dec; 70(6):1453-64. PMID: 19019147.
      View in: PubMed
    23. Ouyang Z, Blevins JS, Norgard MV. Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi. Microbiology (Reading). 2008 Sep; 154(Pt 9):2641-2658. PMID: 18757798.
      View in: PubMed
    24. Yang XF, Goldberg MS, He M, Xu H, Blevins JS, Norgard MV. Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi. Infect Immun. 2008 Oct; 76(10):4439-44. PMID: 18663002.
      View in: PubMed
    25. Blevins JS, Hagman KE, Norgard MV. Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection. BMC Microbiol. 2008 May 28; 8:82. PMID: 18507835.
      View in: PubMed
    26. Machius M, Brautigam CA, Tomchick DR, Ward P, Otwinowski Z, Blevins JS, Deka RK, Norgard MV. Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor. J Mol Biol. 2007 Oct 26; 373(3):681-94. PMID: 17868688.
      View in: PubMed
    27. Blevins JS, Revel AT, Smith AH, Bachlani GN, Norgard MV. Adaptation of a luciferase gene reporter and lac expression system to Borrelia burgdorferi. Appl Environ Microbiol. 2007 Mar; 73(5):1501-13. PMID: 17220265.
      View in: PubMed
    28. Smith AH, Blevins JS, Bachlani GN, Yang XF, Norgard MV. Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN). J Bacteriol. 2007 Mar; 189(5):2139-44. PMID: 17158681.
      View in: PubMed
    29. Deka RK, Brautigam CA, Yang XF, Blevins JS, Machius M, Tomchick DR, Norgard MV. The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum. J Biol Chem. 2006 Mar 24; 281(12):8072-81. PMID: 16418175.
      View in: PubMed
    30. Yang XF, Lybecker MC, Pal U, Alani SM, Blevins J, Revel AT, Samuels DS, Norgard MV. Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J Bacteriol. 2005 Jul; 187(14):4822-9. PMID: 15995197.
      View in: PubMed
    31. Revel AT, Blevins JS, Almaz?n C, Neil L, Kocan KM, de la Fuente J, Hagman KE, Norgard MV. bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6972-7. PMID: 15860579.
      View in: PubMed
    32. O'Leary JO, Langevin MJ, Price CT, Blevins JS, Smeltzer MS, Gustafson JE. Effects of sarA inactivation on the intrinsic multidrug resistance mechanism of Staphylococcus aureus. FEMS Microbiol Lett. 2004 Aug 15; 237(2):297-302. PMID: 15321676.
      View in: PubMed
    33. Blevins JS, Revel AT, Caimano MJ, Yang XF, Richardson JA, Hagman KE, Norgard MV. The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease. Infect Immun. 2004 Aug; 72(8):4864-7. PMID: 15271949.
      View in: PubMed
    34. Beenken KE, Dunman PM, McAleese F, Macapagal D, Murphy E, Projan SJ, Blevins JS, Smeltzer MS. Global gene expression in Staphylococcus aureus biofilms. J Bacteriol. 2004 Jul; 186(14):4665-84. PMID: 15231800.
      View in: PubMed
    35. Sterba KM, Mackintosh SG, Blevins JS, Hurlburt BK, Smeltzer MS. Characterization of Staphylococcus aureus SarA binding sites. J Bacteriol. 2003 Aug; 185(15):4410-7. PMID: 12867449.
      View in: PubMed
    36. Beenken KE, Blevins JS, Smeltzer MS. Mutation of sarA in Staphylococcus aureus limits biofilm formation. Infect Immun. 2003 Jul; 71(7):4206-11. PMID: 12819120.
      View in: PubMed
    37. Blevins JS, Elasri MO, Allmendinger SD, Beenken KE, Skinner RA, Thomas JR, Smeltzer MS. Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infect Immun. 2003 Jan; 71(1):516-23. PMID: 12496203.
      View in: PubMed
    38. Blevins JS, Beenken KE, Elasri MO, Hurlburt BK, Smeltzer MS. Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus. Infect Immun. 2002 Feb; 70(2):470-80. PMID: 11796572.
      View in: PubMed
    39. Elasri MO, Thomas JR, Skinner RA, Blevins JS, Beenken KE, Nelson CL, Smeltzer MS. Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. Bone. 2002 Jan; 30(1):275-80. PMID: 11792597.
      View in: PubMed
    40. Mason WJ, Blevins JS, Beenken K, Wibowo N, Ojha N, Smeltzer MS. Multiplex PCR protocol for the diagnosis of staphylococcal infection. J Clin Microbiol. 2001 Sep; 39(9):3332-8. PMID: 11526172.
      View in: PubMed
    41. Blevins JS, Gillaspy AF, Rechtin TM, Hurlburt BK, Smeltzer MS. The Staphylococcal accessory regulator (sar) represses transcription of the Staphylococcus aureus collagen adhesin gene (cna) in an agr-independent manner. Mol Microbiol. 1999 Jul; 33(2):317-26. PMID: 10411748.
      View in: PubMed
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