Hypoglycemic Agents
"Hypoglycemic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances which lower blood glucose levels.
Descriptor ID |
D007004
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MeSH Number(s) |
D27.505.696.422
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Concept/Terms |
Hypoglycemic Agents- Hypoglycemic Agents
- Agents, Hypoglycemic
- Hypoglycemics
- Hypoglycemic Drugs
- Drugs, Hypoglycemic
- Antihyperglycemic Agents
- Agents, Antihyperglycemic
- Antihyperglycemics
Hypoglycemic Effect- Hypoglycemic Effect
- Effect, Hypoglycemic
- Hypoglycemic Effects
- Effects, Hypoglycemic
Antidiabetics- Antidiabetics
- Antidiabetic Drugs
- Drugs, Antidiabetic
- Antidiabetic Agents
- Agents, Antidiabetic
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Below are MeSH descriptors whose meaning is more general than "Hypoglycemic Agents".
Below are MeSH descriptors whose meaning is more specific than "Hypoglycemic Agents".
This graph shows the total number of publications written about "Hypoglycemic Agents" by people in UAMS Profiles by year, and whether "Hypoglycemic Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2022 | 0 | 2 | 2 | 2021 | 0 | 3 | 3 | 2020 | 3 | 3 | 6 | 2019 | 5 | 2 | 7 | 2018 | 2 | 1 | 3 | 2017 | 1 | 3 | 4 | 2016 | 8 | 5 | 13 | 2015 | 5 | 2 | 7 | 2014 | 3 | 1 | 4 | 2013 | 5 | 4 | 9 | 2012 | 7 | 2 | 9 | 2011 | 1 | 1 | 2 | 2010 | 5 | 1 | 6 | 2009 | 3 | 1 | 4 | 2008 | 6 | 1 | 7 | 2007 | 4 | 4 | 8 | 2006 | 2 | 5 | 7 | 2005 | 3 | 4 | 7 | 2004 | 3 | 2 | 5 | 2003 | 3 | 1 | 4 | 2002 | 2 | 1 | 3 | 2001 | 0 | 1 | 1 | 1998 | 1 | 1 | 2 | 1997 | 1 | 0 | 1 | 1996 | 1 | 0 | 1 | 1995 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Hypoglycemic Agents" by people in Profiles over the past ten years.
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González-Saldivar G, Millan-Alanis JM, González-González JG, Sánchez-Gómez RA, Obeso-Fernández J, McCoy RG, Maraka S, Brito JP, Ospina NS, Oyervides-Fuentes S, Rodríguez-Gutiérrez R. Treatment burden and perceptions of glucose-lowering therapy among people living with diabetes. Prim Care Diabetes. 2022 08; 16(4):568-573.
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Gerardo González-González J, Cesar Solis R, Díaz González-Colmenero A, Raygoza-Cortez K, Moreno-Peña PJ, Sánchez AL, McCoy RG, Singh Ospina N, Maraka S, Brito JP, Rodriguez-Gutierrez R. Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Res Clin Pract. 2022 Apr; 186:109821.
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Norgard NB, Lopez-Candales A. The rise of SGLT2 inhibitors: the time is now for cardiovascular specialists to lead the charge. Postgrad Med. 2022 01; 134(1):11-13.
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DeYoung OA, Boehmer K, Hung D, McAdam-Marx C. A historical cohort study of glycemic control in patients with concurrent type 2 diabetes and substance use disorder treated in a primary care setting. Fam Pract. 2021 09 25; 38(5):562-568.
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Park YM, Bookwalter DB, O'Brien KM, Jackson CL, Weinberg CR, Sandler DP. A prospective study of type 2 diabetes, metformin use, and risk of breast cancer. Ann Oncol. 2021 03; 32(3):351-359.
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Tsai CY, Rosa F, Bionaz M, Rezamand P. Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis. J Dairy Res. 2020 Nov; 87(4):416-423.
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Kulkarni AS, Peck BD, Walton RG, Kern PA, Mar JC, Windham ST, Bamman MM, Barzilai N, Peterson CA. Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults. Aging (Albany NY). 2020 10 18; 12(20):19852-19866.
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Lakey H, Boehmer K, Johnson C. Impact of a Pharmacist-Led Group Diabetes Class. J Pharm Pract. 2022 Feb; 35(1):54-56.
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Desai R, Singh S, Parekh T, Sachdeva S, Sachdeva R, Kumar G. COVID-19 and diabetes mellitus: A need for prudence in elderly patients from a pooled analysis. Diabetes Metab Syndr. 2020 Jul - Aug; 14(4):683-685.
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Martin LD, Hoagland MA, Rhodes ET, Wolfsdorf JI, Hamrick JL. Perioperative Management of Pediatric Patients With Type 1 Diabetes Mellitus, Updated Recommendations for Anesthesiologists. Anesth Analg. 2020 04; 130(4):821-827.
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Pabona JMP, Burnett AF, Brown DM, Quick CM, Simmen FA, Montales MTE, Liu SJ, Rose T, Alhallak I, Siegel ER, Simmen RC. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reprod Sci. 2020 01; 27(1):267-277.
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Hacimuftuoglu A, Mohammadzadeh M, Taghizadehghalehjoughi A, Taspinar N, Togar B, Nalci KA, Okkay U, Gundogdu B. The analgesic effect of metformin on paclitaxel-induced neuropathic pain model in rats: By considering pathological results. J Cancer Res Ther. 2020 Jan-Mar; 16(1):34-39.
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Rodriguez-Gutierrez R, Salcido-Montenegro A, Singh-Ospina NM, Maraka S, Iñiguez-Ariza N, Spencer-Bonilla G, Tamhane SU, Lipska KJ, Montori VM, McCoy RG. Documentation of hypoglycemia assessment among adults with diabetes during clinical encounters in primary care and endocrinology practices. Endocrine. 2020 03; 67(3):552-560.
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Amr BS, Lippmann M, Tobbia P, Isom N, Dalia T, Buechler T, Pierpoline M, Patel N, Hockstad E, Wiley M, Tadros P, Mehta A, Earnest M, Chen JG, Gupta K. Impact of short term oral steroid use for intravenous contrast media hypersensitivity prophylaxis in diabetic patients undergoing nonemergent coronary angiography or interventions. Catheter Cardiovasc Interv. 2020 12; 96(7):1392-1398.
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Walton RG, Dungan CM, Long DE, Tuggle SC, Kosmac K, Peck BD, Bush HM, Villasante Tezanos AG, McGwin G, Windham ST, Ovalle F, Bamman MM, Kern PA, Peterson CA. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial. Aging Cell. 2019 12; 18(6):e13039.
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Yun JS, Park YM, Han K, Cha SA, Ahn YB, Ko SH. Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study. Cardiovasc Diabetol. 2019 08 14; 18(1):103.
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King J, McAdam-Marx C, McCaleb R, Davis D, Bemberg GB, Johnson JT. Cost and Utilization Outcomes After Exclusion of Dipeptidyl Peptidase-4 Inhibitors and Other Diabetes Drug Category Changes in a Self-Funded, State Employee Managed Care Plan. J Manag Care Spec Pharm. 2019 Jun; 25(6):646-651.
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Faustino EVS, Hirshberg EL, Asaro LA, Biagas KV, Pinto N, Srinivasan V, Bagdure DN, Steil GM, Coughlin-Wells K, Wypij D, Nadkarni VM, Agus MSD, Mourani PM, Chima R, Thomas NJ, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder KJ, Kandil S, Wintergerst K, Schwarz A, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin JC, Jouvet P, Yanay O, Allen C. Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children. Crit Care Med. 2019 05; 47(5):706-714.
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Kim K, Unni S, Brixner DI, Thomas SM, Olsen CJ, Sterling KL, Mitchell M, McAdam-Marx C. Longitudinal changes in glycated haemoglobin following treatment intensification after inadequate response to two oral antidiabetic agents in patients with type 2 diabetes. Diabetes Obes Metab. 2019 07; 21(7):1725-1733.
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Ruiz-Negrón N, Wander C, McAdam-Marx C, Pesa J, Bailey RA, Bellows BK. Factors Associated with Diabetes-Related Clinical Inertia in a Managed Care Population and Its Effect on Hemoglobin A1c Goal Attainment: A Claims-Based Analysis. J Manag Care Spec Pharm. 2019 Mar; 25(3):304-313.
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Kim K, Unni S, McAdam-Marx C, Thomas SM, Sterling KL, Olsen CJ, Johnstone B, Mitchell M, Brixner D. Influence of Treatment Intensification on A1c in Patients with Suboptimally Controlled Type 2 Diabetes After 2 Oral Antidiabetic Agents. J Manag Care Spec Pharm. 2019 Mar; 25(3):314-322.
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Lansing AH, Stoianova M, Stanger C. Adolescent Emotional Control Moderates Benefits of a Multicomponent Intervention to Improve Type 1 Diabetes Adherence: A Pilot Randomized Controlled Trial. J Pediatr Psychol. 2019 01 01; 44(1):126-136.
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Kalaitzoglou E, Fowlkes JL, Popescu I, Thrailkill KM. Diabetes pharmacotherapy and effects on the musculoskeletal system. Diabetes Metab Res Rev. 2019 02; 35(2):e3100.
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O'Keeffe DT, Maraka S. Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy. Ann Intern Med. 2018 10 02; 169(7):510-511.
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McAdam-Marx C. Economic implications with newer agents to reduce cardiovascular risk in diabetes. Am J Manag Care. 2018 08; 24(13 Suppl):S279-S285.
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Wittbrodt ET, Eudicone JM, Farahbakhshian S, McAdam-Marx C. Comparison of low-dose liraglutide use versus other GLP-1 receptor agonists in patients without type 2 diabetes. Am J Manag Care. 2018 04; 24(8 Suppl):S156-S164.
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Amin SN, Hussein UK, Yassa HD, Hassan SS, Rashed LA. Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats. J Cell Physiol. 2018 08; 233(8):5768-5779.
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Moonschi FH, Hughes CB, Mussman GM, Fowlkes JL, Richards CI, Popescu I. Advances in micro- and nanotechnologies for the GLP-1-based therapy and imaging of pancreatic beta-cells. Acta Diabetol. 2018 May; 55(5):405-418.
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Rozance PJ, Bai S, Kaiser JR. Searching for the Best Oral Treatment for Hypoglycemic Newborns. J Pediatr. 2017 11; 190:10-12.
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Unni S, Wittbrodt E, Ma J, Schauerhamer M, Hurd J, Ruiz-Negrón N, McAdam-Marx C. Comparative effectiveness of once-weekly glucagon-like peptide-1 receptor agonists with regard to 6-month glycaemic control and weight outcomes in patients with type 2 diabetes. Diabetes Obes Metab. 2018 02; 20(2):468-473.
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Geer EB, Shafiq I, Gordon MB, Bonert V, Ayala A, Swerdloff RS, Katznelson L, Lalazar Y, Manuylova E, Pulaski-Liebert KJ, Carmichael JD, Hannoush Z, Surampudi V, Broder MS, Cherepanov D, Eagan M, Lee J, Said Q, Neary MP, Biller BMK. BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. Endocr Pract. 2017 Aug; 23(8):962-970.
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Bader AP, Barone CP, Smeds MR. Risk Factor Modification Behaviors of Practicing Vascular Surgeons. Ann Vasc Surg. 2018 Jan; 46:90-96.
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Singhal M, Unni S, Schauerhamer M, Nguyen H, Hurd J, McAdam-Marx C. Real-World Glycemic Control from GLP-1RA Therapy with and Without Concurrent Insulin in Patients with Type 2 Diabetes. J Manag Care Spec Pharm. 2017 Mar; 23(3):267-275.
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Chung J, Modrall JG, Knowles M, Xiang Q, Lavery LA, Timaran CH, Valentine RJ. Arteriographic Patterns of Atherosclerosis and the Association between Diabetes Mellitus and Ethnicity in Chronic Critical Limb Ischemia. Ann Vasc Surg. 2017 Apr; 40:198-205.
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McAdam-Marx C, Nguyen H, Schauerhamer MB, Singhal M, Unni S, Ye X, Cobden D. Glycemic Control and Weight Outcomes for Exenatide Once Weekly Versus Liraglutide in Patients with Type 2 Diabetes: A 1-Year Retrospective Cohort Analysis. Clin Ther. 2016 Dec; 38(12):2642-2651.
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Saad M, Mahmoud AN, Elgendy IY, Abuzaid A, Barakat AF, Elgendy AY, Al-Ani M, Mentias A, Nairooz R, Bavry AA, Mukherjee D. Cardiovascular outcomes with sodium-glucose cotransporter-2 inhibitors in patients with type II diabetes mellitus: A meta-analysis of placebo-controlled randomized trials. Int J Cardiol. 2017 Feb 01; 228:352-358.
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Azoulay L, Filion KB, Platt RW, Dahl M, Dormuth CR, Clemens KK, Durand M, Hu N, Juurlink DN, Paterson JM, Targownik LE, Turin TC, Ernst P, Suissa S, Dormuth CR, Hemmelgarn BR, Teare GF, Caetano P, Chateau D, Henry DA, Paterson JM, LeLorier J, Levy AR, Ernst P, Platt RW, Sketris IS. Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis. JAMA Intern Med. 2016 Oct 01; 176(10):1464-1473.
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Lansing AH, Stanger C, Budney A, Christiano AS, Casella SJ. Pilot Study of a Web-Delivered Multicomponent Intervention for Rural Teens with Poorly Controlled Type 1 Diabetes. J Diabetes Res. 2016; 2016:7485613.
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Anderson AJ, Andrew R, Homer NZ, Jones GC, Smith K, Livingstone DE, Walker BR, Stimson RH. Metformin Increases Cortisol Regeneration by 11ßHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 10; 101(10):3787-3793.
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Gurgle HE, White K, McAdam-Marx C. SGLT2 inhibitors or GLP-1 receptor agonists as second-line therapy in type 2 diabetes: patient selection and perspectives. Vasc Health Risk Manag. 2016; 12:239-49.
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Choudhary A. Sick Day Management in Children and Adolescents with Type 1 Diabetes. J Ark Med Soc. 2016 Jun; 112(14):284-6.
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Pinheiro BS, Lemos C, Neutzling Kaufmann F, Marques JM, da Silva-Santos CS, Carvalho E, Mackie K, Rodrigues RJ, Cunha RA, Köfalvi A. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 2016 06; 124:222-30.
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Bilandzic A, Fitzpatrick T, Rosella L, Henry D. Risk of Bias in Systematic Reviews of Non-Randomized Studies of Adverse Cardiovascular Effects of Thiazolidinediones and Cyclooxygenase-2 Inhibitors: Application of a New Cochrane Risk of Bias Tool. PLoS Med. 2016 Apr; 13(4):e1001987.
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Yamashita Y, Asakura M, Mitsugi R, Fujii H, Nagai K, Atsuda K, Itoh T, Fujiwara R. MicroRNA expression in the vildagliptin-treated two- and three-dimensional HepG2 cells. Drug Metab Pharmacokinet. 2016 Jun; 31(3):201-9.
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O'Keeffe DT, Maraka S, Rizza RA. HbA1c in the Evaluation of Diabetes Mellitus. JAMA. 2016 Feb 09; 315(6):605-6.
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Hall C, Stone RL, Gehlot A, Zorn KK, Burnett AF. Use of Metformin in Obese Women With Type I Endometrial Cancer Is Associated With a Reduced Incidence of Cancer Recurrence. Int J Gynecol Cancer. 2016 Feb; 26(2):313-7.
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Hasan R, Firwana B, Elraiyah T, Domecq JP, Prutsky G, Nabhan M, Prokop LJ, Henke P, Tsapas A, Montori VM, Murad MH. A systematic review and meta-analysis of glycemic control for the prevention of diabetic foot syndrome. J Vasc Surg. 2016 Feb; 63(2 Suppl):22S-28S.e1-2.
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Burgeiro A, Fuhrmann A, Cherian S, Espinoza D, Jarak I, Carvalho RA, Loureiro M, Patrício M, Antunes M, Carvalho E. Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes. Am J Physiol Endocrinol Metab. 2016 Apr 01; 310(7):E550-64.
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Hosseini A, Tariq MR, Trindade da Rosa F, Kesser J, Iqbal Z, Mora O, Sauerwein H, Drackley JK, Trevisi E, Loor JJ. Insulin Sensitivity in Adipose and Skeletal Muscle Tissue of Dairy Cows in Response to Dietary Energy Level and 2,4-Thiazolidinedione (TZD). PLoS One. 2015; 10(11):e0142633.
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Abualsuod A. Response to Letter to the Editor: Effects of New Antiplatelet Agents and Aldosterone Receptor Antagonists on Mortality in Patients with Myocardial Infarction. Cardiovasc Drugs Ther. 2015 Oct; 29(5):497.
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Pothineni NV, Mehta JL. Follow-up of Glycemic Control and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2015 09 03; 373(10):977-8.
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Shane-McWhorter L, McAdam-Marx C, Lenert L, Petersen M, Woolsey S, Coursey JM, Whittaker TC, Hyer C, LaMarche D, Carroll P, Chuy L. Pharmacist-provided diabetes management and education via a telemonitoring program. J Am Pharm Assoc (2003). 2015 Sep-Oct; 55(5):516-26.
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Low Y, White WD, Habib AS. Postoperative hyperglycemia after 4- vs 8-10-mg dexamethasone for postoperative nausea and vomiting prophylaxis in patients with type II diabetes mellitus: a retrospective database analysis. J Clin Anesth. 2015 Nov; 27(7):589-94.
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Williams ED, Rogers SC, Zhang X, Azhar G, Wei JY. Elevated oxygen consumption rate in response to acute low-glucose stress: Metformin restores rate to normal level. Exp Gerontol. 2015 Oct; 70:157-62.
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Schauerhamer MB, Gurgle H, McAdam-Marx C. Once-weekly exenatide as a treatment for Type 2 diabetes. Expert Rev Cardiovasc Ther. 2015 Jun; 13(6):611-26.
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Abualsuod A, Rutland JJ, Watts TE, Pandat S, Delongchamp R, Mehta JL. The Effect of Metformin Use on Left Ventricular Ejection Fraction and Mortality Post-Myocardial Infarction. Cardiovasc Drugs Ther. 2015 Jun; 29(3):265-75.
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Dunn TN, Akiyama T, Lee HW, Kim JB, Knotts TA, Smith SR, Sears DD, Carstens E, Adams SH. Evaluation of the synuclein-? (SNCG) gene as a PPAR? target in murine adipocytes, dorsal root ganglia somatosensory neurons, and human adipose tissue. PLoS One. 2015; 10(3):e0115830.
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Chiswick CA, Reynolds RM, Denison FC, Whyte SA, Drake AJ, Newby DE, Walker BR, Forbes S, Murray GD, Quenby S, Wray S, Norman JE. Efficacy of metformin in pregnant obese women: a randomised controlled trial. BMJ Open. 2015 Jan 14; 5(1):e006854.
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Diaz EC, Herndon DN, Porter C, Sidossis LS, Suman OE, Børsheim E. Effects of pharmacological interventions on muscle protein synthesis and breakdown in recovery from burns. Burns. 2015 Jun; 41(4):649-57.
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Maraka S, Morey-Vargas OL, Montori VM. Should we use intensive hypoglycemic treatment in patients with advanced type 2 diabetes? Pol Arch Med Wewn. 2014; 124(12):657-8.
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Shane-McWhorter L, Lenert L, Petersen M, Woolsey S, McAdam-Marx C, Coursey JM, Whittaker TC, Hyer C, LaMarche D, Carroll P, Chuy L. The Utah Remote Monitoring Project: improving health care one patient at a time. Diabetes Technol Ther. 2014 Oct; 16(10):653-60.
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McAdam-Marx C, Bellows BK, Unni S, Wygant G, Mukherjee J, Ye X, Brixner DI. Impact of adherence and weight loss on glycemic control in patients with type 2 diabetes: cohort analyses of integrated medical record, pharmacy claims, and patient-reported data. J Manag Care Spec Pharm. 2014 Jul; 20(7):691-700.
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Sardar P, Nairooz R, Chatterjee S. Intensive glucose control for acute myocardial infarction: an unresolved clinical conundrum. JAMA Intern Med. 2014 May; 174(5):825-6.
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Ergul A, Abdelsaid M, Fouda AY, Fagan SC. Cerebral neovascularization in diabetes: implications for stroke recovery and beyond. J Cereb Blood Flow Metab. 2014 Apr; 34(4):553-63.
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McAdam-Marx C, Mukherjee J, Bellows BK, Unni S, Ye X, Iloeje U, Brixner DI. Evaluation of the relationship between weight change and glycemic control after initiation of antidiabetic therapy in patients with type 2 diabetes using electronic medical record data. Diabetes Res Clin Pract. 2014 Mar; 103(3):402-11.
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El Fouhil AF, Ahmed AM, Atteya M, Mohamed RA, Moustafa AS, Al-Roalle AH, Darwish HH. Hypoglycemic effects of date seed extract. Possible mechanism of action, and potential therapeutic implications. Saudi Med J. 2013 Nov; 34(11):1125-32.
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Novak V, Milberg W, Hao Y, Munshi M, Novak P, Galica A, Manor B, Roberson P, Craft S, Abduljalil A. Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes. Diabetes Care. 2014; 37(3):751-9.
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Ferwana M, Firwana B, Hasan R, Al-Mallah MH, Kim S, Montori VM, Murad MH. Pioglitazone and risk of bladder cancer: a meta-analysis of controlled studies. Diabet Med. 2013 Sep; 30(9):1026-32.
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Anderson A, Walker BR. 11ß-HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease. Drugs. 2013 Sep; 73(13):1385-93.
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Coker RH, Hays NP, Williams RH, Xu L, Wolfe RR, Evans WJ. Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults. J Gerontol A Biol Sci Med Sci. 2014 Mar; 69(3):363-70.
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Dai Y, Dai D, Mercanti F, Ding Z, Wang X, Mehta JL. Dipeptidyl peptidase-4 inhibitors in cardioprotection: a promising therapeutic approach. Acta Diabetol. 2013 Dec; 50(6):827-35.
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