 High-Throughput Screening Assays
"High-Throughput Screening Assays" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.
| Descriptor ID |
D057166
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| MeSH Number(s) |
E05.916.680
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| Concept/Terms |
High-Throughput Screening Assays- High-Throughput Screening Assays
- Assay, High-Throughput Screening
- High Throughput Screening Assays
- High-Throughput Screening Assay
- Screening Assay, High-Throughput
- Screening Assays, High-Throughput
High-Throughput Screening Methods- High-Throughput Screening Methods
- High Throughput Screening Methods
- High-Throughput Screening Method
- Methods, High-Throughput Screening
- Screening Method, High-Throughput
- Screening Methods, High-Throughput
High-Throughput Biological Assays- High-Throughput Biological Assays
- Assay, High-Throughput Biological
- Assays, High-Throughput Biological
- Biological Assay, High-Throughput
- Biological Assays, High-Throughput
- High Throughput Biological Assays
- High-Throughput Biological Assay
High-Throughput Chemical Assays- High-Throughput Chemical Assays
- Assay, High-Throughput Chemical
- Assays, High-Throughput Chemical
- Chemical Assay, High-Throughput
- Chemical Assays, High-Throughput
- High Throughput Chemical Assays
- High-Throughput Chemical Assay
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Below are MeSH descriptors whose meaning is more general than "High-Throughput Screening Assays".
Below are MeSH descriptors whose meaning is more specific than "High-Throughput Screening Assays".
This graph shows the total number of publications written about "High-Throughput Screening Assays" by people in UAMS Profiles by year, and whether "High-Throughput Screening Assays" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2019 | 2 | 3 | 5 | | 2018 | 1 | 2 | 3 | | 2016 | 0 | 2 | 2 | | 2015 | 1 | 1 | 2 | | 2014 | 3 | 1 | 4 | | 2013 | 1 | 1 | 2 | | 2012 | 1 | 1 | 2 | | 2011 | 1 | 1 | 2 |
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Below are the most recent publications written about "High-Throughput Screening Assays" by people in Profiles over the past ten years.
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Fullerton MS, Colonne PM, Dragan AL, Brann KR, Kurten RC, Voth DE. Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells. mSphere. 2021 08 25; 6(4):e0044221.
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Chen J, Lin Z, Barrett L, Dai L, Qin Z. Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG). Bioorg Chem. 2020 06; 99:103847.
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Chen J, Dai L, Goldstein A, Zhang H, Tang W, Forrest JC, Post SR, Chen X, Qin Z. Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation. PLoS Pathog. 2019 12; 15(12):e1008156.
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Wadsworth PA, Folorunso O, Nguyen N, Singh AK, D'Amico D, Powell RT, Brunell D, Allen J, Stephan C, Laezza F. High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na+ channel complex. Sci Rep. 2019 11 15; 9(1):16890.
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Lingemann M, McCarty T, Liu X, Buchholz UJ, Surman S, Martin SE, Collins PL, Munir S. The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. PLoS Pathog. 2019 08; 15(8):e1007963.
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Seo JE, Tryndyak V, Wu Q, Dreval K, Pogribny I, Bryant M, Zhou T, Robison TW, Mei N, Guo X. Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay. Arch Toxicol. 2019 05; 93(5):1433-1448.
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Gonsalves S, Mahony J, Rao A, Dunbar S, Juretschko S. Multiplexed detection and identification of respiratory pathogens using the NxTAG® respiratory pathogen panel. Methods. 2019 04 01; 158:61-68.
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Huang L, Kushner NL, Theriault ME, Pisu D, Tan S, McNamara CW, Petrassi HM, Russell DG, Brown AC. The Deconstructed Granuloma: A Complex High-Throughput Drug Screening Platform for the Discovery of Host-Directed Therapeutics Against Tuberculosis. Front Cell Infect Microbiol. 2018; 8:275.
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Parrales A, McDonald P, Ottomeyer M, Roy A, Shoenen FJ, Broward M, Bruns T, Thamm DH, Weir SJ, Neville KA, Iwakuma T, Fulbright JM. Comparative oncology approach to drug repurposing in osteosarcoma. PLoS One. 2018; 13(3):e0194224.
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Knowlton JJ, Fernández de Castro I, Ashbrook AW, Gestaut DR, Zamora PF, Bauer JA, Forrest JC, Frydman J, Risco C, Dermody TS. The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nat Microbiol. 2018 04; 3(4):481-493.
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Slavov SH, Beger RD. Rigorous 3-dimensional spectral data activity relationship approach modeling strategy for ToxCast estrogen receptor data classification, validation, and feature extraction. Environ Toxicol Chem. 2017 03; 36(3):823-830.
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Balasubramanian A, Manzano M, Teramoto T, Pilankatta R, Padmanabhan R. High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. Antiviral Res. 2016 10; 134:6-16.
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Bagchi RA, Mozolevska V, Abrenica B, Czubryt MP. Development of a high throughput luciferase reporter gene system for screening activators and repressors of human collagen Ia2 gene expression. Can J Physiol Pharmacol. 2015 Oct; 93(10):887-92.
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Franco FM, Jones DE, Harris PK, Han Z, Wildman SA, Jarvis CM, Janetka JW. Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem. 2015 May 15; 23(10):2328-43.
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Jang DS, Penthala NR, Apostolov EO, Wang X, Fahmi T, Crooks PA, Basnakian AG. Novel high-throughput deoxyribonuclease 1 assay. J Biomol Screen. 2015 Feb; 20(2):202-11.
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Dyall J, Coleman CM, Hart BJ, Venkataraman T, Holbrook MR, Kindrachuk J, Johnson RF, Olinger GG, Jahrling PB, Laidlaw M, Johansen LM, Lear-Rooney CM, Glass PJ, Hensley LE, Frieman MB. Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug; 58(8):4885-93.
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van Laar R, Flinchum R, Brown N, Ramsey J, Riccitelli S, Heuck C, Barlogie B, Shaughnessy JD. Translating a gene expression signature for multiple myeloma prognosis into a robust high-throughput assay for clinical use. BMC Med Genomics. 2014 May 17; 7:25.
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Manzano M, Padia J, Padmanabhan R. Small molecule inhibitor discovery for dengue virus protease using high-throughput screening. Methods Mol Biol. 2014; 1138:331-44.
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Bøgsted M, Bilgrau AE, Wardell CP, Bertsch U, Schmitz A, Bødker JS, Kjeldsen MK, Goldschmidt H, Morgan GJ, Dybkaer K, Johnsen HE. Proof of the concept to use a malignant B cell line drug screen strategy for identification and weight of melphalan resistance genes in multiple myeloma. PLoS One. 2013; 8(12):e83252.
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