MAP Kinase Signaling System
"MAP Kinase Signaling System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Descriptor ID |
D020935
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MeSH Number(s) |
G02.111.087.800.560 G02.149.115.800.560 G03.495.553.560 G04.299.880.560
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Concept/Terms |
ERK1-2 Pathway- ERK1-2 Pathway
- ERK1 2 Pathway
- ERK1-2 Pathways
- Pathway, ERK1-2
- Pathways, ERK1-2
- ERK1 and ERK2 Pathway
p38 Kinase Pathway- p38 Kinase Pathway
- Kinase Pathway, p38
- Kinase Pathways, p38
- Pathway, p38 Kinase
- Pathways, p38 Kinase
- p38 Kinase Pathways
- p38 Kinase Signaling Pathway
MAP Kinase Cascade- MAP Kinase Cascade
- Cascade, MAP Kinase
- Kinase Cascade, MAP
- MAP Kinase Cascades
- MAP Kinase Signaling Cascades
- MAP Kinase Modules
- MAP Kinase Module
- Module, MAP Kinase
MEK-ERK Pathway- MEK-ERK Pathway
- MEK ERK Pathway
- MEK-ERK Pathways
- Pathway, MEK-ERK
- Pathways, MEK-ERK
JNK Pathway- JNK Pathway
- JNK Pathways
- Pathway, JNK
- Pathways, JNK
- JNK Signaling Pathway
- JNK Signaling Pathways
- Pathway, JNK Signaling
- Pathways, JNK Signaling
- Signaling Pathway, JNK
- Signaling Pathways, JNK
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Signaling System".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Signaling System".
This graph shows the total number of publications written about "MAP Kinase Signaling System" by people in UAMS Profiles by year, and whether "MAP Kinase Signaling System" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2021 | 1 | 1 | 2 | 2020 | 1 | 2 | 3 | 2019 | 1 | 2 | 3 | 2018 | 2 | 2 | 4 | 2017 | 1 | 0 | 1 | 2016 | 3 | 3 | 6 | 2015 | 1 | 2 | 3 | 2014 | 1 | 2 | 3 | 2013 | 1 | 6 | 7 | 2012 | 2 | 5 | 7 | 2011 | 1 | 2 | 3 | 2009 | 1 | 0 | 1 | 2008 | 3 | 2 | 5 | 2007 | 1 | 4 | 5 | 2006 | 3 | 3 | 6 | 2005 | 0 | 2 | 2 | 2004 | 2 | 2 | 4 | 2003 | 2 | 3 | 5 | 2002 | 1 | 4 | 5 | 2001 | 0 | 1 | 1 | 2000 | 1 | 1 | 2 |
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Below are the most recent publications written about "MAP Kinase Signaling System" by people in Profiles over the past ten years.
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Win S, Min RWM, Zhang J, Kanel G, Wanken B, Chen Y, Li M, Wang Y, Suzuki A, Aung FWM, Murray SF, Aghajan M, Than TA, Kaplowitz N. Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Hepatology. 2021 12; 74(6):3127-3145.
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Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M. SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021 04 07; 6(58).
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Najjar RS, Akhavan NS, Pourafshar S, Arjmandi BH, Feresin RG. Cornus officinalis var. koreana Kitam polyphenol extract decreases pro-inflammatory markers in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages by reducing Akt phosphorylation. J Ethnopharmacol. 2021 Apr 24; 270:113734.
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Ding Z, Wang X, Liu S, Zhou S, Kore RA, Mu S, Deng X, Fan Y, Mehta JL. NLRP3 inflammasome via IL-1? regulates PCSK9 secretion. Theranostics. 2020; 10(16):7100-7110.
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Choi YD, Jung JY, Baek M, Khan S, Song PI, Ryu S, Koo JY, Chauhan SC, Tsin A, Choi C, Kim WJ, Kim M. APE1 Promotes Pancreatic Cancer Proliferation through GFRa1/Src/ERK Axis-Cascade Signaling in Response to GDNF. Int J Mol Sci. 2020 May 19; 21(10).
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Heo SY, Jeong MS, Lee HS, Kim YJ, Park SH, Jung WK. Phlorofucofuroeckol A from Ecklonia cava ameliorates TGF-?1-induced fibrotic response of human tracheal fibroblasts via the downregulation of MAPKs and SMAD 2/3 pathways inactivated TGF-? receptor. Biochem Biophys Res Commun. 2020 Feb 12; 522(3):626-632.
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Arnold MG, Gokulan K, Doerge DR, Vanlandingham M, Cerniglia CE, Khare S. A single or short time repeated arsenic oral exposure in mice impacts mRNA expression for signaling and immunity related genes in the gut. Food Chem Toxicol. 2019 Oct; 132:110597.
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Robb R, Yang L, Shen C, Wolfe AR, Webb A, Zhang X, Vedaie M, Saji M, Jhiang S, Ringel MD, Williams TM. Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair. Clin Cancer Res. 2019 08 01; 25(15):4749-4760.
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Garces S, Yin CC, Patel KP, Khoury JD, Manning JT, Li S, Xu J, Pina-Oviedo S, Johnson MR, Gonz?lez S, Molg? M, Ruiz-Cordero R, Medeiros LJ. Focal Rosai-Dorfman disease coexisting with lymphoma in the same anatomic site: a localized histiocytic proliferation associated with MAPK/ERK pathway activation. Mod Pathol. 2019 01; 32(1):16-26.
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Heo SY, Ko SC, Nam SY, Oh J, Kim YM, Kim JI, Kim N, Yi M, Jung WK. Fish bone peptide promotes osteogenic differentiation of MC3T3-E1 pre-osteoblasts through upregulation of MAPKs and Smad pathways activated BMP-2 receptor. Cell Biochem Funct. 2018 Apr; 36(3):137-146.
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Levada K, Guldiken N, Zhang X, Vella G, Mo FR, James LP, Haybaeck J, Kessler SM, Kiemer AK, Ott T, Hartmann D, H?ser N, Ziol M, Trautwein C, Strnad P. Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling. J Hepatol. 2018 05; 68(5):996-1005.
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Bright MD, Clarke PA, Workman P, Davies FE. Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling. Cell Signal. 2018 04; 44:127-137.
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Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep; 47(5):572-580.
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Chen G, Xu Z, Chang G, Hou J, Hu L, Zhang Y, Yu D, Li B, Chang S, Xie Y, Zhang Y, Wei R, Wu H, Xiao W, Sun X, Tao Y, Gao L, Dai B, Shi J, Zhu W. The blueberry component pterostilbene has potent anti-myeloma activity in bortezomib-resistant cells. Oncol Rep. 2017 Jul; 38(1):488-496.
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Xie B, Xu Z, Hu L, Chen G, Wei R, Yang G, Li B, Chang G, Sun X, Wu H, Zhang Y, Dai B, Tao Y, Shi J, Zhu W. Pterostilbene Inhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo. Int J Mol Sci. 2016 Nov 17; 17(11).
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Gonzalez AM, Hoffman JR, Townsend JR, Jajtner AR, Boone CH, Beyer KS, Baker KM, Wells AJ, Mangine GT, Robinson EH, Church DD, Oliveira LP, Fukuda DH, Stout JR. Intramuscular MAPK signaling following high volume and high intensity resistance exercise protocols in trained men. Eur J Appl Physiol. 2016 Sep; 116(9):1663-70.
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Ghosh SP, Pathak R, Kumar P, Biswas S, Bhattacharyya S, Kumar VP, Hauer-Jensen M, Biswas R. Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen. Radiat Res. 2016 05; 185(5):485-95.
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Li J, Pan Q, Rowan PD, Trotter TN, Peker D, Regal KM, Javed A, Suva LJ, Yang Y. Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells. Oncotarget. 2016 Mar 08; 7(10):11299-309.
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Zhao Y, Feresin RG, Falcon-Perez JM, Salazar G. Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity. Traffic. 2016 Mar; 17(3):267-88.
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Liu YL, Yan Y, Webster C, Shao L, Lensing SY, Ni H, Feng W, Colorado N, Pathak R, Xiang Z, Hauer-Jensen M, Li S, Zhou D, Emanuel PD. Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy. Blood. 2016 Apr 14; 127(15):1912-22.
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Heuck CJ, Jethava Y, Khan R, van Rhee F, Zangari M, Chavan S, Robbins K, Miller SE, Matin A, Mohan M, Ali SM, Stephens PJ, Ross JS, Miller VA, Davies F, Barlogie B, Morgan G. Inhibiting MEK in MAPK pathway-activated myeloma. Leukemia. 2016 Apr; 30(4):976-80.
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Kundumani-Sridharan V, Subramani J, Das KC. Thioredoxin Activates MKK4-NF?B Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells. J Biol Chem. 2015 Jul 10; 290(28):17505-19.
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McCoin CS, Knotts TA, Ono-Moore KD, Oort PJ, Adams SH. Long-chain acylcarnitines activate cell stress and myokine release in C2C12 myotubes: calcium-dependent and -independent effects. Am J Physiol Endocrinol Metab. 2015 Jun 01; 308(11):E990-E1000.
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Dai L, Chen Y, Bonstaff K, Doyle L, Toole B, Parsons C, Qin Z. Induction of hyaluronan production by oncogenic KSHV and the contribution to viral pathogenesis in AIDS patients. Cancer Lett. 2015 Jul 01; 362(2):158-66.
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