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Search Results to Gunnar Boysen

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research overview Our research focus on the interplay between chemical exposure and nutritional or lifestyle habits, such as diet selection and physical activity. To achieve this we utilize DNA and protein adducts to study carcinogen metabolism, how it is modified by nutritional components and the underlying mechanisms regulating corresponding enzyme activities. In addition, studies investigate exposures related changes in common metabolic pathways, using targeted and un-targeted mass spectrometry based metabolomic approaches. A second line of research applies systems biology approaches such as metabolomics to improve diagnosis of lung cancer patients and to elucidate mechanism that can be targeted with common or novel drugs.

One or more keywords matched the following items that are connected to Boysen, Gunnar

Item TypeName
Academic Article Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma.
Academic Article Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS.
Academic Article Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.
Academic Article Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans.
Concept Magnetic Resonance Spectroscopy
Concept Spectrometry, Mass, Electrospray Ionization
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Tandem Mass Spectrometry
Concept Gas Chromatography-Mass Spectrometry
Concept Mass Spectrometry
Academic Article In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency.
Academic Article LC/MS/MS method for the quantitation of trans-2-hexenal-derived exocyclic 1,N(2)-propanodeoxyguanosine in DNA.
Academic Article Profiling of ecdysteroids in complex biological samples using liquid chromatography/ion trap mass spectrometry.
Academic Article Identification of covalent modifications in P450 2E1 by 1,2-epoxy-3-butene in vitro.
Academic Article Development of an ultraperformance liquid chromatography/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts.
Academic Article Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver.
Academic Article Exposure-response of 1,2:3,4-diepoxybutane-specific N-terminal valine adducts in mice and rats after inhalation exposure to 1,3-butadiene.
Academic Article Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene.
Academic Article A 2-iminohydantoin from the oxidation of guanine.
Academic Article Iminohydantoin lesion induced in DNA by peracids and other epoxidizing oxidants.
Academic Article Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods.
Academic Article Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis.
Academic Article Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links.
Academic Article Formaldehyde-induced histone modifications in vitro.
Academic Article Development of an immuno tandem mass spectrometry (iMALDI) assay for EGFR diagnosis.
Academic Article Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Academic Article Accurate quantitation of standard peptides used for quantitative proteomics.
Academic Article Analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine by ultra high pressure liquid chromatography-heat assisted electrospray ionization-tandem mass spectrometry.
Academic Article Exposure profiling of reactive compounds in complex mixtures.
Academic Article Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers.
Academic Article Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.
Academic Article Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.
Academic Article A mass spectrometric method to simultaneously measure a biomarker and dilution marker in exhaled breath condensate.
Academic Article Response to Interpretation of Mass Spectral Data for the Cisplatin 1,2 Intrastrand Guanine-Guanine Adduct.
Grant A novel approach for quantitation of N-terminal valine adducts
Academic Article A simplified method for detection of N-terminal valine adducts in patients receiving treosulfan.

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