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Search Results to Alicia Byrd

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overview DNA damage occurs tens of thousands of times per day in human cells from both endogenous and environmental sources. In order to preserve the genetic material, cells have evolved multiple mechanisms to detect and repair DNA damage. However, inaccurate DNA repair can cause genomic instability such as chromosomal rearrangements and expansion of repetitive sequences which can lead to the development of cancer or diseases such as Fragile X Syndrome. One area my research focuses on is the enzymes that regulate the DNA damage response. In particular, I am interested in a family of enzymes called helicases which remove secondary structures from DNA and RNA. At least 10 different human helicases are involved in DNA repair. My research is focused on understanding the fundamental mechanisms of these enzymes using biophysical and biochemical techniques including ensemble and single molecule kinetics, proteomics, and genomics. The molecular mechanisms of these proteins, both individually and as components of multi-protein complexes, are of interest, as are the effects of posttranslational modifications on their activity.

One or more keywords matched the following items that are connected to Byrd, Alicia

Item TypeName
Academic Article Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor.
Academic Article Displacement of a DNA binding protein by Dda helicase.
Academic Article The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation.
Academic Article Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase.
Academic Article Dda helicase tightly couples translocation on single-stranded DNA to unwinding of duplex DNA: Dda is an optimally active helicase.
Academic Article Structure and Mechanisms of SF1 DNA Helicases.
Academic Article Increasing the length of the single-stranded overhang enhances unwinding of duplex DNA by bacteriophage T4 Dda helicase.
Academic Article Novel, fluorescent, SSB protein chimeras with broad utility.
Academic Article Protein displacement by an assembly of helicase molecules aligned along single-stranded DNA.
Academic Article Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA.
Academic Article Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA.
Concept Bacterial Proteins
Concept Carrier Proteins
Concept DNA-Binding Proteins
Concept Luminescent Proteins
Concept Molecular Motor Proteins
Concept Repressor Proteins
Concept Recombinant Proteins
Concept Escherichia coli Proteins
Concept Viral Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Viral Nonstructural Proteins
Concept Cell Cycle Proteins
Concept Proto-Oncogene Proteins c-kit
Concept Nuclear Proteins
Concept Recombinant Fusion Proteins
Academic Article A CRISPR-based approach for proteomic analysis of a single genomic locus.
Academic Article Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicase.
Academic Article Yeast Pif1 accelerates annealing of complementary DNA strands.
Academic Article A parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase.
Academic Article Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.
Academic Article Yeast Helicase Pif1 Unwinds RNA:DNA Hybrids with Higher Processivity than DNA:DNA Duplexes.
Academic Article SSB binds to the RecG and PriA helicases in vivo in the absence of DNA.
Academic Article Analysis of Protein-protein Interaction Interface between Yeast Mitochondrial Proteins Rim1 and Pif1 Using Chemical Cross-linking Mass Spectrometry.
Academic Article A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4.
Academic Article Structure and function of Pif1 helicase.
Academic Article N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
Grant G-quadruplex DNA as a chemical signaling agent
Grant Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
Grant DNA Helicases: Mechanism and Function
Academic Article DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA.
Academic Article Direct quantification of the translocation activities of Saccharomyces cerevisiae Pif1 helicase.
Academic Article Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases.
Academic Article Genome Maintenance by DNA Helicase B.
Academic Article G-Quadruplex loops regulate PARP-1 enzymatic activation.
Academic Article G-quadruplex DNA inhibits unwinding activity but promotes liquid-liquid phase separation by the DEAD-box helicase Ded1p.
Academic Article A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA.
Academic Article Role and Regulation of Pif1 Family Helicases at the Replication Fork.

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