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overview Dr. James is the Director of the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research interest is in translational studies of acetaminophen toxicity. She and her collaborators developed novel approaches for the quantitation of acetaminophen protein adducts in peripheral blood samples. She also directs clinical trials in children to develop safe and effective drug dosing strategies in a number of disease areas.

One or more keywords matched the following items that are connected to James, Laura

Item TypeName
Academic Article Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Academic Article Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose.
Academic Article Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.
Academic Article Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.
Academic Article Biomarkers for risk stratification of febrile neutropenia among children with malignancy: a pilot study.
Academic Article UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients.
Academic Article Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.
Academic Article Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: a pilot randomized, double-blind, placebo-controlled trial.
Academic Article Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations.
Academic Article Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Academic Article Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection.
Academic Article Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
Academic Article Predicting risk in patients with acetaminophen overdose.
Concept C-Reactive Protein
Concept Protein Precursors
Concept Fas Ligand Protein
Concept HMGB1 Protein
Concept Protein Binding
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 1
Concept JNK Mitogen-Activated Protein Kinases
Concept Protein Biosynthesis
Concept Protein Isoforms
Academic Article Protein tyrosine phosphatase 1B modulates GSK3ß/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity
Academic Article Detection of Acetaminophen Protein Adducts in Children with Acute Liver Failure of Indeterminate Etiology
Academic Article Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes.
Academic Article The role of intrahepatic CD3+/CD4-/CD8- double negative T (DN T) cells in enhanced acetaminophen toxicity.
Academic Article Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity.
Academic Article Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation.
Academic Article The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes.
Academic Article An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure.
Academic Article Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers.
Academic Article MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity.
Grant NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
Grant Identification of new mechanistic biomarkers of adverse responses to acetaminophe
Grant Dipstick Assay for Detection of Acetaminophen Protein Adducts
Grant Evaluation of a Biomarker for Acetaminophen Toxicity
Academic Article Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen.
Academic Article Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Academic Article Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children.
Academic Article Acute Liver Failure of unclear cause? Acetaminophen-protein adducts make the diagnosis.
Academic Article Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.

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