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Search Results to Alan Tackett

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overview My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item TypeName
Academic Article Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Academic Article The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
Academic Article Proteomic and genomic characterization of chromatin complexes at a boundary.
Academic Article A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.
Academic Article MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity.
Academic Article Saccharomyces cerevisiae Yta7 regulates histone gene expression.
Academic Article Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.
Academic Article Misregulation of Rad50 expression in melanoma cells.
Academic Article A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes.
Academic Article Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini.
Academic Article A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.
Academic Article Mapping the local protein interactome of the NuA3 histone acetyltransferase.
Academic Article ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus.
Academic Article Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.
Academic Article Application of MassSQUIRM for quantitative measurements of lysine demethylase activity.
Academic Article Purification of a specific native genomic locus for proteomic analysis.
Academic Article Quantitative analysis of histone exchange for transcriptionally active chromatin.
Concept Histone Deacetylases
Concept Chromosomal Proteins, Non-Histone
Concept Histone Code
Concept Histone-Lysine N-Methyltransferase
Concept Histones
Concept Histone Acetyltransferases
Concept Histone Demethylases
Concept Jumonji Domain-Containing Histone Demethylases
Academic Article Mitotic phosphorylation of histone H3 threonine 80.
Academic Article Analysis of Histone Exchange during Chromatin Purification
Academic Article A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodeling
Academic Article Yng 1 PHD finger binding to histone H3 trimethylated at lysine 4 promotes NuA3 HAT activity at lysine 14 of H3 and transcriptional at a subset of targeted ORFs
Academic Article A CRISPR-based approach for proteomic analysis of a single genomic locus.
Academic Article A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.
Academic Article A selective phenelzine analogue inhibitor of histone demethylase LSD1.
Academic Article Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis.
Academic Article The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.
Academic Article Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Academic Article Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.
Academic Article DNA methylation on N(6)-adenine in mammalian embryonic stem cells.
Academic Article ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Academic Article Role of EZH2 histone methyltrasferase in melanoma progression and metastasis.
Academic Article Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.
Academic Article Analysis of Histone Exchange during Chromatin Purification.
Academic Article KDM5 lysine demethylases are involved in maintenance of 3'UTR length.
Academic Article Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
Academic Article Indicators of responsiveness to immune checkpoint inhibitors.
Academic Article In Vivo Metabolic Tracing Demonstrates the Site-Specific Contribution of Hepatic Ethanol Metabolism to Histone Acetylation.
Academic Article Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot.
Grant Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
Grant Development of MassSQUIRM to Quantitatively Measure Lysine Methylation
Grant Development of technology for high resolution epigenetic profiling of chromatin
Grant Technology for Identification of Epiproteomes in Tissue Samples
Grant Biochemistry of recombination in meiosis
Grant Identifying the Epigenetic Regulation of Arsenic Exposure
Grant Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
Grant Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes- Resubmission
Academic Article PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation.
Academic Article Histone Modifications as Biomarkers for Immunotherapy.
Academic Article Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma.
Academic Article ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
Academic Article A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.
Academic Article TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.

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