The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion.

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The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion.

Fu Q, Berb?e M, Boerma M, Wang J, Schmid HA, Hauer-Jensen M. The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion. Radiat Res. 2009 Jun; 171(6):698-707.

View in: PubMed

subject areas

Animals
Bacterial Translocation
Blood Cells
Cesium Radioisotopes
Chemokine CXCL9
Citrulline
Dose-Response Relationship, Radiation
Interleukin-12
Intestinal Mucosa
Jejunum
Kaplan-Meier Estimate
Liver
Male
Mice
Pancreas
Radiation Injuries, Experimental
Radiation-Protective Agents
Random Allocation
Somatostatin
Thermoluminescent Dosimetry
Treatment Outcome
Whole-Body Irradiation

authors with profiles

Qiang Fu
Marjan Boerma