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IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance.
Gregg RK, Bell JJ, Lee HH, Jain R, Schoenleber SJ, Divekar R, Zaghouani H. IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance. J Immunol. 2005 Jan 15; 174(2):662-70.
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PubMed
subject areas
Amino Acid Sequence
Animals
Antigen-Presenting Cells
Antigens, CD
Antigens, Differentiation
Cell Differentiation
CTLA-4 Antigen
Diabetes Mellitus, Type 1
Down-Regulation
Female
Immune Tolerance
Immunosuppressive Agents
Insulin Antibodies
Interleukin-10
Islets of Langerhans
Lymphocyte Activation
Mice
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Molecular Sequence Data
T-Lymphocyte Subsets
T-Lymphocytes, Regulatory
authors with profiles
Scott Schoenleber