 Immunosuppressive Agents
"Immunosuppressive Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
| Descriptor ID |
D007166
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| MeSH Number(s) |
D27.505.696.477.656
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Immunosuppressive Agents".
Below are MeSH descriptors whose meaning is more specific than "Immunosuppressive Agents".
This graph shows the total number of publications written about "Immunosuppressive Agents" by people in UAMS Profiles by year, and whether "Immunosuppressive Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 1 | 1 | 2 | | 2024 | 2 | 1 | 3 | | 2023 | 0 | 2 | 2 | | 2022 | 1 | 2 | 3 | | 2021 | 1 | 4 | 5 | | 2020 | 0 | 1 | 1 | | 2019 | 3 | 3 | 6 | | 2018 | 2 | 2 | 4 | | 2017 | 2 | 2 | 4 | | 2016 | 0 | 4 | 4 | | 2015 | 1 | 1 | 2 | | 2014 | 5 | 7 | 12 | | 2013 | 5 | 1 | 6 | | 2012 | 3 | 3 | 6 | | 2011 | 3 | 4 | 7 | | 2010 | 0 | 1 | 1 | | 2009 | 3 | 2 | 5 | | 2008 | 1 | 2 | 3 | | 2007 | 0 | 2 | 2 | | 2006 | 0 | 2 | 2 | | 2005 | 1 | 2 | 3 | | 2004 | 6 | 2 | 8 | | 2003 | 5 | 2 | 7 | | 2002 | 0 | 1 | 1 | | 2001 | 1 | 3 | 4 | | 2000 | 1 | 1 | 2 | | 1998 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 1996 | 1 | 2 | 3 | | 1991 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunosuppressive Agents" by people in Profiles over the past ten years.
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Guimbellot JS, Chalamalla A, Baker E, Ryan KJ, Dowell A, Abouelenein S, Bartlett LE, Bergeron J, Turner G, Acosta EP, Ramos KJ. Elexacaftor-tezacaftor-ivacaftor pharmacokinetics with concurrent tacrolimus administration after lung transplant. J Cyst Fibros. 2025 May; 24(3):534-541.
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Creber NJ, Muzaffar J, Gowrishankar S, Borsetto D, Phillips V, Smith ME. Current and emerging approaches to cochlear immunosuppression with translation to human inner ear stem cell therapy: A systematic review. PLoS One. 2025; 20(2):e0318165.
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Chen JM, Mangus RS, Sharfuddin AA, Powelson JA, Yaqub MS, Adebiyi OO, Jan MY, Lutz AJ, Fridell JA. The Use of Long-Term Monthly Basiliximab Infusions as Rescue Maintenance Immunosuppression in Pancreas Transplant Recipients. Clin Transplant. 2024 Dec; 38(12):e70050.
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Adler J, Galanko JA, Ammoury R, Benkov KJ, Bousvaros A, Boyle B, Cabrera JM, Chun KY, Dorsey J, Ebach DR, Firestine AM, Gulati AS, Herfarth HH, Jester TW, Kaplan JL, Leibowitz I, Linville TM, Margolis PA, Minar P, Molle-Rios Z, Moses J, Olano K, Pashankar DS, Pitch L, Saeed SA, Samson CM, Sandberg K, Steiner SJ, Strople JA, Sullivan JS, Wali PD, Kappelman MD. HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease. Am J Gastroenterol. 2025 May 01; 120(5):1076-1086.
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Alrbyawi H, Annaji M, Fasina O, Palakurthi S, Boddu SHS, Hassan N, Tiwari AK, Suryawanshi A, Babu RJ. Rapidly Dissolving Trans-scleral Microneedles for Intraocular Delivery of Cyclosporine A. AAPS PharmSciTech. 2024 Feb 01; 25(2):28.
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Katibian DJ, Solitano V, Polk DB, Nguyen T, Ma C, Syal G, Kobayashi T, Hibi T, Buhl S, Ainsworth MA, Jairath V, Singh S. Withdrawal of Immunomodulators or TNF Antagonists in Patients With Inflammatory Bowel Diseases in Remission on Combination Therapy: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2024 01; 22(1):22-33.e6.
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Wagle Shukla A, Lunny C, Mahboob O, Khalid U, Joyce M, Jha N, Nagaraja N, Shukla AM. Tremor Induced by Cyclosporine, Tacrolimus, Sirolimus, or Everolimus: A Review of the Literature. Drugs R D. 2023 Dec; 23(4):301-329.
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Ly S, Nedosekin D, Wong HK. Review of an Anti-CD20 Monoclonal Antibody for the Treatment of Autoimmune Diseases of the Skin. Am J Clin Dermatol. 2023 Mar; 24(2):247-273.
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Syal G, Melmed GY, Almario CV, Spiegel BMR. Azathioprine Withdrawal Is Cost-Effective in Patients with Crohn's Disease in Remission on Infliximab and Azathioprine. Dig Dis Sci. 2023 02; 68(2):404-413.
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Kreher MA, Noland MMB, Konda S, Longo MI, Valdes-Rodriguez R. Risk of melanoma and nonmelanoma skin cancer with immunosuppressants, part I: Calcineurin inhibitors, thiopurines, IMDH inhibitors, mTOR inhibitors, and corticosteroids. J Am Acad Dermatol. 2023 Mar; 88(3):521-530.
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Golbus AL, Ochoa BV, Hardy WA, Helke KL, Kavarana MN, Kwon JH, Rajab TK. Immunosuppressive regimens in porcine transplantation models. Transplant Rev (Orlando). 2022 12; 36(4):100725.
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Cao XX, Duan MH, Zhao AL, Cai H, Chen J, Gao XM, Liu T, Cai HC, Zhang L, Sun J, Liang ZY, Zhou DB, Li J. Treatment outcomes and prognostic factors of patients with adult Langerhans cell histiocytosis. Am J Hematol. 2022 02 01; 97(2):203-208.
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Shih T, De DR, Thompson AM, Seivright JR, Atluri S, Ederle A, Swigert A, Jaros JA, Hsiao JL, Shi VY. Global geographic bibliometric analysis of hidradenitis suppurativa publications. Int J Dermatol. 2022 11; 61(11):e453-e455.
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Abedin S, Rashid N, Schroeder M, Romee R, Nauffal M, Alhaj Moustafa M, Kharfan-Dabaja MA, Palmer J, Hogan W, Hefazi M, Larson S, Holtan S, DeFilipp Z, Jayani R, Dholaria B, Pidala J, Khimani F, Grunwald MR, Butler C, Hamadani M. Ruxolitinib resistance or intolerance in steroid-refractory acute graft-versus-host disease - a real-world outcomes analysis. Br J Haematol. 2021 11; 195(3):429-432.
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Syal G, Shemtov R, Bonthala N, Vasiliauskas EA, Feldman EJ, Zaghiyan K, Ha CY, McGovern DPB, Targan SR, Melmed GY, Fleshner PR. Pre-pouch Ileitis is Associated with Development of Crohn's Disease-like Complications and Pouch Failure. J Crohns Colitis. 2021 Jun 22; 15(6):960-968.
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Smith M, Ryan KJ, Gutierrez H, Sanchez LHG, Anderson JN, Acosta EP, Benner KW, Guimbellot JS. Ivacaftor-elexacaftor-tezacaftor and tacrolimus combination in cystic fibrosis. J Cyst Fibros. 2022 01; 21(1):e8-e10.
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Rhone ET, Bardhi E, Bontha SV, Walker PD, Almenara JA, Dumur CI, Cathro H, Maluf D, Mas V. An Integrated Transcriptomic Approach to Identify Molecular Markers of Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients. Int J Mol Sci. 2021 May 21; 22(11).
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Tarhini AA, Kang N, Lee SJ, Hodi FS, Cohen GI, Hamid O, Hutchins LF, Sosman JA, Kluger HM, Eroglu Z, Koon HB, Lawrence DP, Kendra KL, Minor DR, Lee CB, Albertini MR, Flaherty LE, Petrella TM, Streicher H, Sondak VK, Kirkwood JM. Immune adverse events (irAEs) with adjuvant ipilimumab in melanoma, use of immunosuppressants and association with outcome: ECOG-ACRIN E1609 study analysis. J Immunother Cancer. 2021 05; 9(5).
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Rick J, Thompson AM, Hsiao JL, Liao W, Shi VY. Immunosuppressants, immunomodulators and COVID-19 vaccines: anticipating patient concerns. J Dermatolog Treat. 2022 05; 33(3):1794-1797.
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Chacko JA, Strati P, Stout PW, Archer RL, Baltz BP, Chacko JG. Primary mediastinal large B-cell lymphoma in a patient on Fingolimod for relapsing-remitting multiple sclerosis. Mult Scler Relat Disord. 2021 Apr; 49:102776.
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Collier EK, Seivright JR, Shi VY, Hsiao JL. Pregnancy and breastfeeding in hidradenitis suppurativa: A review of medication safety. Dermatol Ther. 2021 01; 34(1):e14674.
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Rajab TK. Evidence-based surgical hypothesis: Partial heart transplantation can deliver growing valve implants for congenital cardiac surgery. Surgery. 2021 Apr; 169(4):983-985.
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Price KN, Frew JW, Hsiao JL, Shi VY. COVID-19 and immunomodulator/immunosuppressant use in dermatology. J Am Acad Dermatol. 2020 05; 82(5):e173-e175.
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Madsen SR, Hendricks AJ, Shi VY. Growing Patient Education in Dermatology: An Upside-Down Tree Analogy for Immunomodulatory Therapies J Drugs Dermatol. 2020 Jan 01; 19(1):28-29.
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Guthrie J, King C, Battle L, Field H, Motwani P, Wong H, Kaley J, Shiver M, Gao L. Pyoderma gangrenosum developing after chest tube placement in a patient with chronic lymphocytic leukemia. Cutis. 2019 Nov; 104(5):E23-E26.
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Wang JN, Qiu Y, Niu N, Zhang Y, Li J, Zhou DB, Cao XX. Successful treatment of central nervous system involved Erdheim-Chester disease by intermediate-dose cytarabine as first-line therapy. Acta Oncol. 2020 Mar; 59(3):302-305.
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Sood AK, McShane DB, Googe PB, Wu EY. Successful Treatment of PAPA Syndrome with Dual Adalimumab and Tacrolimus Therapy. J Clin Immunol. 2019 11; 39(8):832-835.
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Hendricks AJ, Lio PA, Shi VY. Management Recommendations for Dupilumab Partial and Non-durable Responders in Atopic Dermatitis. Am J Clin Dermatol. 2019 Aug; 20(4):565-569.
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Fervenza FC, Appel GB, Barbour SJ, Rovin BH, Lafayette RA, Aslam N, Jefferson JA, Gipson PE, Rizk DV, Sedor JR, Simon JF, McCarthy ET, Brenchley P, Sethi S, Avila-Casado C, Beanlands H, Lieske JC, Philibert D, Li T, Thomas LF, Green DF, Juncos LA, Beara-Lasic L, Blumenthal SS, Sussman AN, Erickson SB, Hladunewich M, Canetta PA, Hebert LA, Leung N, Radhakrishnan J, Reich HN, Parikh SV, Gipson DS, Lee DK, da Costa BR, J?ni P, Cattran DC. Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy. N Engl J Med. 2019 07 04; 381(1):36-46.
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Thumma S, Idrees S, Phuyal P, Manchala V, Mattana J. When the Standard Treatment Fails: Rituximab Therapy for Refractory TTP. Am J Ther. 2019 Jul/Aug; 26(4):e552-e553.
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Samanta D, Cobb S, Arya K. Sneddon Syndrome: A Comprehensive Overview. J Stroke Cerebrovasc Dis. 2019 Aug; 28(8):2098-2108.
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McLawhorn JM, Khattab M, Martinez-Parachini R, Thind S, Kirkpatrick A, Vaseer S. Osteoarticular Sporotrichosis vs Rheumatoid Arthritis: A Tale of Two Granulomatous Arthritides. Am J Med. 2019 07; 132(7):826-829.
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Almuwaqqat Z, Roberts JW, Bashtawi Y. A rare and serious cause of pancytopenia in a patient with systemic lupus erythematosus: haemophagocytic lymphohistiocytosis. BMJ Case Rep. 2018 Sep 27; 2018.
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Briasoulis A, Inampudi C, Pala M, Asleh R, Alvarez P, Bhama J. Induction immunosuppressive therapy in cardiac transplantation: a systematic review and meta-analysis. Heart Fail Rev. 2018 09; 23(5):641-649.
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Maldonado AQ, West-Thielke P, Dew MA, Peipert JD, Heldenbrand S, Kaiser TE, Chisholm-Burns M, Potter LM. Meeting report: Consensus recommendations for a research agenda to address immunosuppressant nonadherence in organ transplantation. Clin Transplant. 2018 09; 32(9):e13362.
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Fridell JA, Mangus RS, Chen JM, Taber TE, Cabrales AE, Sharfuddin AA, Yaqub MS, Powelson JA. Steroid-free three-drug maintenance regimen for pancreas transplant alone: Comparison of induction with rabbit antithymocyte globulin +/- rituximab. Am J Transplant. 2018 12; 18(12):3000-3006.
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Grace RF, Despotovic JM, Bennett CM, Bussel JB, Neier M, Neunert C, Crary SE, Pastore YD, Klaassen RJ, Rothman JA, Hege K, Breakey VR, Rose MJ, Shimano KA, Buchanan GR, Geddis A, Haley KM, Lorenzana A, Thompson A, Jeng M, Neufeld EJ, Brown T, Forbes PW, Lambert MP. Physician decision making in selection of second-line treatments in immune thrombocytopenia in children. Am J Hematol. 2018 07; 93(7):882-888.
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Ali TK, Gibbons A, Cartes C, Zarei-Ghanavati S, Gomaa M, Gonzalez I, Gonzalez AE, Ozturk HE, Betancurt C, Perez VL. Use of Autologous Serum Tears for the Treatment of Ocular Surface Disease From Patients With Systemic Autoimmune Diseases. Am J Ophthalmol. 2018 05; 189:65-70.
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Samanta D. Surendra Nath Sehgal: A pioneer in rapamycin discovery. Indian J Cancer. 2017 Oct-Dec; 54(4):697-698.
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Johnson DC, Lenive O, Mitchell J, Jackson G, Owen R, Drayson M, Cook G, Jones JR, Pawlyn C, Davies FE, Walker BA, Wardell C, Gregory WM, Cairns D, Morgan GJ, Houlston RS, Kaiser MF. Neutral tumor evolution in myeloma is associated with poor prognosis. Blood. 2017 10 05; 130(14):1639-1643.
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Wong SSW, Rasid O, Laskaris P, Fekkar A, Cavaillon JM, Steinbach WJ, Ibrahim-Granet O. Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population. Virulence. 2017 11 17; 8(8):1744-1752.
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Matin A, Sharma S, Mathur P, Apewokin SK. Myelosuppression-sparing treatment of central nervous system nocardiosis in a multiple myeloma patient utilizing a tedizolid-based regimen: a case report. Int J Antimicrob Agents. 2017 Apr; 49(4):488-492.
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Willis E, Ramakrishnaiah R, Archer R. Neuromyelitis Optica Spectrum Disorder in a Pediatric Patient. J Ark Med Soc. 2016 Aug; 113(2):34-35.
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Rowan DJ, Hartley CP, Carrillo-Polanco LF, Oshima K, Hagen CE. Diagnostic phrasing is independently correlated with the decision to treat for graft-versus-host disease: retrospective review of colon biopsies with rare apoptosis. Histopathology. 2016 Nov; 69(5):802-811.
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Yeboah MM, Hye Khan MA, Chesnik MA, Sharma A, Paudyal MP, Falck JR, Imig JD. The epoxyeicosatrienoic acid analog PVPA ameliorates cyclosporine-induced hypertension and renal injury in rats. Am J Physiol Renal Physiol. 2016 09 01; 311(3):F576-85.
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Simian D, Flux? D, Flores L, Lubascher J, Ib??ez P, Figueroa C, Kronberg U, Acu?a R, Moreno M, Quera R. Inflammatory bowel disease: A descriptive study of 716 local Chilean patients. World J Gastroenterol. 2016 Jun 14; 22(22):5267-75.
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Hou Y, Li HJ, Li MT, Xu D, Zhou DB, Zeng XF. A successful case of second autologous haematopoietic stem cell transplantation for post-transplant systemic sclerosis relapse. Clin Exp Rheumatol. 2016 Sep-Oct; 34 Suppl 100(5):207.
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Wilken R, Fung MA, Shi VY, Cheng MY, Patel F, Sultani H, Maverakis E. Cyclosporine-induced sebaceous hyperplasia in a hematopoetic stem cell transplant patient: delayed onset of a common adverse event. Dermatol Online J. 2016 Jan 15; 22(1).
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Stine KC. Risk organ + LCH gets the one-two punch? Blood. 2015 Sep 17; 126(12):1399-400.
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