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Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi.

Dome PA, Jeong P, Nam G, Jang H, Rivera A, Floyd Averette A, Park E, Liao TC, Ciofani M, Wu J, Chi JA, Venters RA, Park HJ, Steinbach WJ, Juvvadi PR, Heitman J, Hong J. Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi. Proc Natl Acad Sci U S A. 2025 Jan 07; 122(1):e2419883121.

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