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Joseph Holthoff

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Nephrology
AddressB2-129-2 Biomedical Research I
324 UAMS Campus Dr.
Mail Slot # 501
Little Rock AR 72205
Phone501-686-5162
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    Collapse Research 
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    C     (HOLTHOFF, JOSEPH H)Dec 1, 2022 - Dec 30, 2024
    Dialysis Clinic, Inc.
    Investigating the mechanism of protection of IGFBP-1 in a murine model of acute kidney injury
    Role: Principal Investigator
    C-4208     (HOLTHOFF, JOSEPH H)Dec 1, 2022 - Dec 30, 2024
    Dialysis Clinic, Inc.
    Investigating the mechanism of protection of IGFBP-1 in a murine model of acute kidney injury
    Role: Principal Investigator
    F30DK085705     (HOLTHOFF, JOSEPH HUNTER)Apr 1, 2010 - Dec 31, 2014
    NIH
    Preclinical evaluation of resveratrol in sepsis-induced renal injury
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Holthoff JH, Alge JL, Arthur JM, Ayub F, Bin Homam W, Janech MG, Ravula S, Karakala N. Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery. Nephron. 2024 Sep 30; 1-11. PMID: 39348806.
      View in: PubMed
    2. Rai V, Singh M, Holthoff JH. New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report. Genes (Basel). 2024 Sep 27; 15(10). PMID: 39457385.
      View in: PubMed
    3. Holthoff JH, Harville Y, Herzog C, Juncos LA, Karakala N, Arthur JM. SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery. BMC Nephrol. 2023 10 11; 24(1):299. PMID: 37821813.
      View in: PubMed
    4. Holthoff JH, Chandrashekar K, Juncos LA. The Role of Esm-1 in Diabetic Kidney Disease: More Than Just a Biomarker. Kidney360. 2022 12 29; 3(12):1998-2000. PMID: 36591366.
      View in: PubMed
    5. Holthoff JH, Wang Z, Patil NK, Gokden N, Mayeux PR. Rolipram improves renal perfusion and function during sepsis in the mouse. J Pharmacol Exp Ther. 2013 Nov; 347(2):357-64. PMID: 24018639.
      View in: PubMed
    6. Wang Z, Holthoff JH, Seely KA, Pathak E, Spencer HJ, Gokden N, Mayeux PR. Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury. Am J Pathol. 2012 Feb; 180(2):505-16. PMID: 22119717.
      View in: PubMed
    7. Holthoff JH, Wang Z, Seely KA, Gokden N, Mayeux PR. Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury. Kidney Int. 2012 Feb; 81(4):370-8. PMID: 21975863.
      View in: PubMed
    8. Myers CN, Berner GB, Holthoff JH, Martinez-Fonts K, Harper JA, Alford S, Taylor MN, Duina AA. Mutant versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3. PLoS One. 2011; 6(6):e20847. PMID: 21673966.
      View in: PubMed
    9. Seely KA, Holthoff JH, Burns ST, Wang Z, Thakali KM, Gokden N, Rhee SW, Mayeux PR. Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury. Am J Physiol Renal Physiol. 2011 Jul; 301(1):F209-17. PMID: 21511700.
      View in: PubMed
    10. Holthoff JH, Woodling KA, Doerge DR, Burns ST, Hinson JA, Mayeux PR. Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite. Biochem Pharmacol. 2010 Oct 15; 80(8):1260-5. PMID: 20599800.
      View in: PubMed
    11. Wu L, Tiwari MM, Messer KJ, Holthoff JH, Gokden N, Brock RW, Mayeux PR. Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F261-8. PMID: 16926442.
      View in: PubMed
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