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Christian Herzog

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Nephrology
Address Campus General
200 South Cedar
Mail Slot # 501
Little Rock AR 72202
Phone501-626-8254
ORCID ORCID Icon0000-0001-6024-3491 Additional info
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    Collapse Affiliation 
    Collapse Translational Research Institute: Clinical and Translational Science Award
    CCTR Pilot Study grant: 1UL1RR029884
    Title: Nidogen as a Biomarker in Early Detection of Acute Kidney Injury

    Collapse member of
    IACUC at CAVHS
    American Society of Nephrology

    Collapse Research 
    Collapse research activities and funding
    R44DK130702     (HERZOG, CHRISTIAN)Sep 15, 2022 - Aug 31, 2023
    NIH/National Institutes of Health - Pass Through: Arkana Laboratories
    Development of a Precision Medicine-based Diagnostic Tool for Membranous Nephropathy
    Role: Principal Investigator
    1R41DK130702     (HERZOG, CHRISTIAN)Jul 1, 2021 - Jun 30, 2022
    NIH/National Institutes of Health - Pass Through: Arkana Laboratories
    Development of a Precision Medicine-Based Diagnostic Tool for Membranous Nephropathy
    Role: Principal Investigator
    1R41DK130702-01     (HERZOG, CHRISTIAN)Jul 1, 2021 - Jun 30, 2022
    NIH/National Institutes of Health - Pass Through: Arkana Laboratories
    Development of a Precision Medicine-Based Diagnostic Tool for Membranous Nephropathy
    Role: Principal Investigator
    U01DK103225     (HERZOG, CHRISTIAN)Jul 1, 2017 - Jun 30, 2018
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: University of Pennsylvania
    Pilot: Glomerular biomarkers of progression in IgA nephropathy
    Role: Co-Investigator
    R01DK081690     (KAUSHAL, GUR PRASAD)Mar 1, 2010 - Aug 31, 2015
    NIH
    Meprin A Metalloproteinase in Acute Kidney Injury
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Holthoff JH, Harville Y, Herzog C, Juncos LA, Karakala N, Arthur JM. SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery. BMC Nephrol. 2023 10 11; 24(1):299. PMID: 37821813.
      View in: PubMed
    2. Caza TN, Storey AJ, Hassen SI, Herzog C, Edmondson RD, Arthur JM, Kenan DJ, Larsen CP. Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry. Kidney Int. 2023 03; 103(3):593-606. PMID: 36638888.
      View in: PubMed
    3. Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Herzog C, Liu J, Harville TO. Development of ACE2 autoantibodies after SARS-CoV-2 infection. PLoS One. 2021; 16(9):e0257016. PMID: 34478478.
      View in: PubMed
    4. Caza TN, Hassen SI, Kenan DJ, Storey A, Arthur JM, Herzog C, Edmondson RD, Bourne TD, Beck LH, Larsen CP. Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy. Kidney360. 2021 08 26; 2(8):1275-1286. PMID: 35369660.
      View in: PubMed
    5. Al-Rabadi LF, Caza T, Trivin-Avillach C, Rodan AR, Andeen N, Hayashi N, Williams B, Revelo MP, Clayton F, Abraham J, Lin E, Liou W, Zou CJ, Ramkumar N, Cummins T, Wilkey DW, Kawalit I, Herzog C, Storey A, Edmondson R, Sjoberg R, Yang T, Chien J, Merchant M, Arthur J, Klein J, Larsen C, Beck LH. Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. J Am Soc Nephrol. 2021 Jul; 32(7):1666-1681. PMID: 33952630.
      View in: PubMed
    6. Caza TN, Hassen SI, Kuperman M, Sharma SG, Dvanajscak Z, Arthur J, Edmondson R, Storey A, Herzog C, Kenan DJ, Larsen CP. Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. Kidney Int. 2021 07; 100(1):171-181. PMID: 33045259.
      View in: PubMed
    7. Caza TN, Hassen SI, Dvanajscak Z, Kuperman M, Edmondson R, Herzog C, Storey A, Arthur J, Cossey LN, Sharma SG, Kenan DJ, Larsen CP. NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney Int. 2021 04; 99(4):967-976. PMID: 32828756.
      View in: PubMed
    8. Larsen CP, Sharma SG, Caza TN, Kenan DJ, Storey AJ, Edmondson RD, Herzog C, Arthur JM. Serum amyloid P deposition is a sensitive and specific feature of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int. 2020 03; 97(3):602-608. PMID: 32001064.
      View in: PubMed
    9. Herzog C, Haun RS, Kaushal GP. Role of meprin metalloproteinases in cytokine processing and inflammation. Cytokine. 2019 02; 114:18-25. PMID: 30580156.
      View in: PubMed
    10. Herzog C, Haun RS, Shah SV, Kaushal GP. Proteolytic processing and inactivation of CCL2/MCP-1 by meprins. Biochem Biophys Rep. 2016 Dec; 8:146-150. PMID: 28955950.
      View in: PubMed
    11. Herzog C, Marisiddaiah R, Haun RS, Kaushal GP. Basement membrane protein nidogen-1 is a target of meprin ? in cisplatin nephrotoxicity. Toxicol Lett. 2015 Jul 16; 236(2):110-6. PMID: 25957482.
      View in: PubMed
    12. Herzog C, Haun RS, Ludwig A, Shah SV, Kaushal GP. ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A. J Biol Chem. 2014 May 09; 289(19):13308-22. PMID: 24662289.
      View in: PubMed
    13. Kaushal V, Herzog C, Haun RS, Kaushal GP. Caspase protocols in mice. Methods Mol Biol. 2014; 1133:141-54. PMID: 24567100.
      View in: PubMed
    14. Kaushal GP, Haun RS, Herzog C, Shah SV. Meprin A metalloproteinase and its role in acute kidney injury. Am J Physiol Renal Physiol. 2013 May 01; 304(9):F1150-8. PMID: 23427141.
      View in: PubMed
    15. Herzog C, Yang C, Holmes A, Kaushal GP. zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function. Am J Physiol Renal Physiol. 2012 Oct 15; 303(8):F1239-50. PMID: 22896037.
      View in: PubMed
    16. Wang Z, Herzog C, Kaushal GP, Gokden N, Mayeux PR. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock. 2011 Feb; 35(2):141-7. PMID: 20577148.
      View in: PubMed
    17. Liu L, Yang C, Herzog C, Seth R, Kaushal GP. Proteasome inhibitors prevent cisplatin-induced mitochondrial release of apoptosis-inducing factor and markedly ameliorate cisplatin nephrotoxicity. Biochem Pharmacol. 2010 Jan 15; 79(2):137-46. PMID: 19699182.
      View in: PubMed
    18. Herzog C, Haun RS, Kaushal V, Mayeux PR, Shah SV, Kaushal GP. Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta. Biochem Biophys Res Commun. 2009 Feb 20; 379(4):904-8. PMID: 19135030.
      View in: PubMed
    19. Kaushal GP, Kaushal V, Herzog C, Yang C. Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity. Autophagy. 2008 Jul; 4(5):710-2. PMID: 18497570.
      View in: PubMed
    20. Herzog C, Seth R, Shah SV, Kaushal GP. Role of meprin A in renal tubular epithelial cell injury. Kidney Int. 2007 May; 71(10):1009-18. PMID: 17377510.
      View in: PubMed
    21. Herzog C, Kaushal GP, Haun RS. Generation of biologically active interleukin-1beta by meprin B. Cytokine. 2005 Sep 07; 31(5):394-403. PMID: 16095909.
      View in: PubMed
    22. Pal A, Gu Y, Herzog C, Srivastava SK, Zimniak P, Ji X, Singh SV. Role of arginine 216 in catalytic activity of murine Alpha class glutathione transferases mGSTAl-1 and mGSTA2-2 toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons. Carcinogenesis. 2001 Aug; 22(8):1301-5. PMID: 11470762.
      View in: PubMed
    23. Pal A, Desai DH, Amin S, Srivastava SK, Hu X, Herzog C, Zimniak P, Singh SV. Location of the epoxide function determines specificity of the allelic variants of human glutathione transferase Pi toward benzo[c]chrysene diol epoxide isomers. FEBS Lett. 2000 Dec 08; 486(2):163-6. PMID: 11113459.
      View in: PubMed
    24. Ji X, Blaszczyk J, Xiao B, O'Donnell R, Hu X, Herzog C, Singh SV, Zimniak P. Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1. Biochemistry. 1999 Aug 10; 38(32):10231-8. PMID: 10441116.
      View in: PubMed
    25. Hu X, Herzog C, Zimniak P, Singh SV. Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase. Cancer Res. 1999 May 15; 59(10):2358-62. PMID: 10344744.
      View in: PubMed
    26. Mat? MJ, Zamocky M, Nykyri LM, Herzog C, Alzari PM, Betzel C, Koller F, Fita I. Structure of catalase-A from Saccharomyces cerevisiae. J Mol Biol. 1999 Feb 12; 286(1):135-49. PMID: 9931255.
      View in: PubMed
    27. Hu X, Xia H, Srivastava SK, Herzog C, Awasthi YC, Ji X, Zimniak P, Singh SV. Activity of four allelic forms of glutathione S-transferase hGSTP1-1 for diol epoxides of polycyclic aromatic hydrocarbons. Biochem Biophys Res Commun. 1997 Sep 18; 238(2):397-402. PMID: 9299520.
      View in: PubMed
    28. Zamocky M, Herzog C, Nykyri LM, Koller F. Site-directed mutagenesis of the lower parts of the major substrate channel of yeast catalase A leads to highly increased peroxidatic activity. FEBS Lett. 1995 Jul 03; 367(3):241-5. PMID: 7607315.
      View in: PubMed
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