Chicoric acid attenuates tumor necrosis factor-a-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-?B signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q. Chicoric acid attenuates tumor necrosis factor-a-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-?B signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model. Int Immunopharmacol. 2022 Oct; 111:109129.