 Tumor Necrosis Factor-alpha
"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
| Descriptor ID |
D014409
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| MeSH Number(s) |
D12.644.276.374.500.800 D12.644.276.374.750.626 D12.644.276.972.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D12.776.467.972.626 D23.529.374.500.800 D23.529.374.750.626 D23.529.972.626
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| Concept/Terms |
Tumor Necrosis Factor-alpha- Tumor Necrosis Factor-alpha
- Tumor Necrosis Factor alpha
- Cachectin-Tumor Necrosis Factor
- Cachectin Tumor Necrosis Factor
- TNFalpha
- TNF-alpha
- Tumor Necrosis Factor
- Tumor Necrosis Factor Ligand Superfamily Member 2
- Cachectin
- TNF Superfamily, Member 2
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Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".
This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in UAMS Profiles by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 2 | 2 | 4 | | 2023 | 0 | 3 | 3 | | 2022 | 1 | 3 | 4 | | 2021 | 1 | 2 | 3 | | 2020 | 1 | 3 | 4 | | 2019 | 0 | 1 | 1 | | 2018 | 0 | 5 | 5 | | 2017 | 3 | 2 | 5 | | 2016 | 2 | 4 | 6 | | 2015 | 2 | 8 | 10 | | 2014 | 4 | 6 | 10 | | 2013 | 1 | 7 | 8 | | 2012 | 0 | 6 | 6 | | 2011 | 3 | 5 | 8 | | 2010 | 1 | 6 | 7 | | 2009 | 4 | 6 | 10 | | 2008 | 3 | 5 | 8 | | 2007 | 3 | 3 | 6 | | 2006 | 5 | 9 | 14 | | 2005 | 3 | 10 | 13 | | 2004 | 4 | 2 | 6 | | 2003 | 4 | 8 | 12 | | 2002 | 4 | 3 | 7 | | 2001 | 2 | 3 | 5 | | 2000 | 2 | 3 | 5 | | 1999 | 0 | 2 | 2 | | 1998 | 2 | 2 | 4 | | 1997 | 3 | 2 | 5 | | 1996 | 1 | 2 | 3 | | 1995 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles over the past ten years.
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Adler J, Galanko JA, Ammoury R, Benkov KJ, Bousvaros A, Boyle B, Cabrera JM, Chun KY, Dorsey J, Ebach DR, Firestine AM, Gulati AS, Herfarth HH, Jester TW, Kaplan JL, Leibowitz I, Linville TM, Margolis PA, Minar P, Molle-Rios Z, Moses J, Olano K, Pashankar DS, Pitch L, Saeed SA, Samson CM, Sandberg K, Steiner SJ, Strople JA, Sullivan JS, Wali PD, Kappelman MD. HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease. Am J Gastroenterol. 2025 May 01; 120(5):1076-1086.
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Pinho ACO, Barbosa P, Pereira MJ, Paiva A, Carvalho E, Laranjeira P. The role of CD20+ T cells: Insights in human peripheral blood. Cytometry B Clin Cytom. 2024 05; 106(3):171-180.
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Li W, Hakkak R. Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats. Nutrients. 2024 Mar 28; 16(7).
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Ebach DR, Jester TW, Galanko JA, Firestine AM, Ammoury R, Cabrera J, Bass J, Minar P, Olano K, Margolis P, Sandberg K, Linnville TM, Kaplan J, Pitch L, Steiner SJ, Bass D, Moses J, Adler J, Gulati AS, Wali P, Pashankar D, Ivanova A, Herfarth H, Wohl DA, Benkov KJ, Strople J, Sullivan J, Tung J, Molle-Rios Z, Saeed SA, Bousvaros A, Kappelman MD. High Body Mass Index and Response to Anti-Tumor Necrosis Factor Therapy in Pediatric Crohn's Disease. Am J Gastroenterol. 2024 06 01; 119(6):1110-1116.
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Gu P, Dube S, Lee Y, Yang S, Li D, Haritunians T, Vasiliauskas E, Bonthala N, Syal G, Yarur A, Ziring D, Targan S, Rabizadeh S, Melmed GY, Fleshner P, McGovern DPB. Comparative Persistence of Non-tumor Necrosis Factor (TNF) vs. TNF Antagonists for Post-operative Prophylaxis in Crohn's Disease (CD). Dig Dis Sci. 2024 Jan; 69(1):235-245.
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Shosha E, Shahror RA, Morris CA, Xu Z, Lucas R, McGee-Lawrence ME, Rusch NJ, Caldwell RB, Fouda AY. The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury. Cell Death Dis. 2023 09 21; 14(9):621.
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Li W, Twaddle NC, Spray B, Nounamo B, Monzavi-Karbassi B, Hakkak R. Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats. J Med Food. 2023 Feb; 26(2):120-127.
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Corken A, Ware J, Dai J, Arthur JM, Smyth S, Davis CL, Liu J, Harville TO, Phadnis MA, Mehta JL, Rahmatallah Y, Jain N. Platelet-Dependent Inflammatory Dysregulation in Patients with Stages 4 or 5 Chronic Kidney Disease: A Mechanistic Clinical Study. Kidney360. 2022 12 29; 3(12):2036-2047.
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McCormick JJ, C?t? MD, King KE, McManus MK, Goulet N, Dokladny K, Moseley PL, Kenny GP. Autophagic response to exercise in peripheral blood mononuclear cells from young men is intensity-dependent and is altered by exposure to environmental heat. Am J Physiol Regul Integr Comp Physiol. 2022 Oct 01; 323(4):R467-R482.
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Al-Shudiefat AA, Ludke A, Malik A, Jassal DS, Bagchi AK, Singal PK. Olive oil protects against progression of heart failure by inhibiting remodeling of heart subsequent to myocardial infarction in rats. Physiol Rep. 2022 08; 10(15):e15379.
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Gu P, Luo J, Kim J, Paul P, Limketkai B, Sauk JS, Park S, Parekh N, Zheng K, Rudrapatna V, Syal G, Ha C, McGovern DP, Melmed GY, Fleshner P, Eisenstein S, Ramamoorthy S, Dulai PS, Boland BS, Grunvald E, Mahadevan U, Ohno-Machado L, Sandborn WJ, Singh S. Effect of Obesity on Risk of Hospitalization, Surgery, and Serious Infection in Biologic-Treated Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. Am J Gastroenterol. 2022 10 01; 117(10):1639-1647.
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Meng Q, Wang X, Guo D, Shi C, Gu R, Ma J, Nieman G, Kollisch-Singule M, Luo J, Cooney RN. Nano-chemically Modified Tetracycline-3 (nCMT-3) Attenuates Acute Lung Injury via Blocking sTREM-1 Release and NLRP3 Inflammasome Activation. Shock. 2022 05 01; 57(5):749-758.
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Elsawy H, Alzahrani AM, Alfwuaires M, Abdel-Moneim AM, Khalil M. Nephroprotective effect of naringin in methotrexate induced renal toxicity in male rats. Biomed Pharmacother. 2021 Nov; 143:112180.
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Nagarajan UM, Cho C, Gyorke CE, Nagarajan S, Ezzell JA, Brochu H, Huntress I, Harrell E, Peng X. Tumor Necrosis Factor Alpha-Induced Interleukin-1 Alpha Synthesis and Cell Death Is Increased in Mouse Epithelial Cells Infected With Chlamydia muridarum. J Infect Dis. 2021 08 16; 224(12 Suppl 2):S47-S55.
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Chang JYH, Irvine DJ. Engineering autoreactive T and B cell responses toward active immunotherapy for inflammatory diseases. Proc Natl Acad Sci U S A. 2021 05 18; 118(20).
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Little-Letsinger SE, Turner ND, Ford JR, Suva LJ, Bloomfield SA. Omega-3 fatty acid modulation of serum and osteocyte tumor necrosis factor-a in adult mice exposed to ionizing radiation. J Appl Physiol (1985). 2021 03 01; 130(3):627-639.
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Berman HS, Thomas L, Beynet D, Gates G, Shi V, Hsiao J. Fish tank granuloma during tumor necrosis factor-alpha inhibitor treatment: A case report and literature review. Dermatol Ther. 2020 11; 33(6):e14058.
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Da Silva DM, Enserro DM, Mayadev JS, Skeate JG, Matsuo K, Pham HQ, Lankes HA, Moxley KM, Ghamande SA, Lin YG, Schilder RJ, Birrer MJ, Kast WM. Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929). Clin Cancer Res. 2020 11 01; 26(21):5621-5630.
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Alkhuriji AF, Al Omar SY, Babay ZA, El-Khadragy MF, Mansour LA, Alharbi WG, Khalil MI. Association of IL-1?, IL-6, TNF-a, and TGF?1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome. Dis Markers. 2020; 2020:6076274.
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Syal G, Melmed GY. Is It Time For High Dose Influenza Vaccination In Inflammatory Bowel Diseases? Inflamm Bowel Dis. 2020 03 04; 26(4):603-605.
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Novak T, Hall MW, McDonald DR, Newhams MM, Mistry AJ, Panoskaltsis-Mortari A, Mourani PM, Loftis LL, Weiss SL, Tarquinio KM, Markovitz B, Hartman ME, Schwarz A, Junger WG, Randolph AG. RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness. J Allergy Clin Immunol. 2020 06; 145(6):1673-1680.e11.
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Jenkins SV, Robeson MS, Griffin RJ, Quick CM, Siegel ER, Cannon MJ, Vang KB, Dings RPM. Gastrointestinal Tract Dysbiosis Enhances Distal Tumor Progression through Suppression of Leukocyte Trafficking. Cancer Res. 2019 12 01; 79(23):5999-6009.
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Zychowski KE, Wheeler A, Sanchez B, Harmon M, Steadman Tyler CR, Herbert G, Lucas SN, Ali AM, Avasarala S, Kunda N, Robinson P, Muttil P, Cerrato JM, Bleske B, Smirnova O, Campen MJ. Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia. Cardiovasc Toxicol. 2019 10; 19(5):401-411.
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Hinze CH, Foell D, Johnson AL, Spalding SJ, Gottlieb BS, Morris PW, Kimura Y, Onel K, Li SC, Grom AA, Taylor J, Brunner HI, Huggins JL, Nocton JJ, Haines KA, Edelheit BS, Shishov M, Jung LK, Williams CB, Tesher MS, Costanzo DM, Zemel LS, Dare JA, Passo MH, Ede KC, Olson JC, Cassidy EA, Griffin TA, Wagner-Weiner L, Weiss JE, Vogler LB, Rouster-Stevens KA, Beukelman T, Cron RQ, Kietz D, Schikler K, Mehta J, Ting TV, Verbsky JW, Eberhard AB, Huang B, Giannini EH, Lovell DJ. Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti-Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy. Arthritis Rheumatol. 2019 03; 71(3):451-459.
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Bakshi RK, Gupta K, Jordan SJ, Chi X, Lensing SY, Press CG, Geisler WM. An Adaptive Chlamydia trachomatis-Specific IFN-?-Producing CD4+ T Cell Response Is Associated With Protection Against Chlamydia Reinfection in Women. Front Immunol. 2018; 9:1981.
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Lionikaite V, Westerlund A, Conaway HH, Henning P, Lerner UH. Effects of retinoids on physiologic and inflammatory osteoclastogenesis in vitro. J Leukoc Biol. 2018 12; 104(6):1133-1145.
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Lovell DJ, Johnson AL, Huang B, Gottlieb BS, Morris PW, Kimura Y, Onel K, Li SC, Grom AA, Taylor J, Brunner HI, Huggins JL, Nocton JJ, Haines KA, Edelheit BS, Shishov M, Jung LK, Williams CB, Tesher MS, Costanzo DM, Zemel LS, Dare JA, Passo MH, Ede KC, Olson JC, Cassidy EA, Griffin TA, Wagner-Weiner L, Weiss JE, Vogler LB, Rouster-Stevens KA, Beukelman T, Cron RQ, Kietz D, Schikler K, Schmidt KM, Mehta J, Wahezi DM, Ting TV, Verbsky JW, Eberhard BA, Spalding S, Chen C, Giannini EH. Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti-Tumor Necrosis Factor Therapy in?Children With Polyarticular Forms of Juvenile Idiopathic?Arthritis With Clinically Inactive Disease. Arthritis Rheumatol. 2018 09; 70(9):1508-1518.
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Ding Z, Liu S, Wang X, Theus S, Deng X, Fan Y, Zhou S, Mehta JL. PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages. Cardiovasc Res. 2018 07 01; 114(8):1145-1153.
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Pasiakos SM, Berryman CE, Carbone JW, Murphy NE, Carrigan CT, Bamman MM, Ferrando AA, Young AJ, Margolis LM. Muscle Fn14 gene expression is associated with fat-free mass retention during energy deficit at high altitude. Physiol Rep. 2018 07; 6(14):e13801.
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Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell. 2018 06 07; 70(5):936-948.e7.
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Nabaweesi R, Ramakrishnaiah RH, Aitken ME, Rettiganti MR, Luo C, Maxson RT, Glasier CM, Kenney PJ, Robbins JM. Authors' Reply. J Am Coll Radiol. 2018 06; 15(6):825-826.
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Maarouf M, Clark AK, Lee DE, Shi VY. Targeted treatments for hidradenitis suppurativa: a review of the current literature and ongoing clinical trials. J Dermatolog Treat. 2018 Aug; 29(5):441-449.
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Yang W, Yaggie RE, Jiang MC, Rudick CN, Done J, Heckman CJ, Rosen JM, Schaeffer AJ, Klumpp DJ. Acyloxyacyl hydrolase modulates pelvic pain severity. Am J Physiol Regul Integr Comp Physiol. 2018 03 01; 314(3):R353-R365.
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Arroyo E, Wells AJ, Gordon JA, Varanoske AN, Gepner Y, Coker NA, Church DD, Fukuda DH, Stout JR, Hoffman JR. Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise. Exp Gerontol. 2017 12 15; 100:28-35.
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Habibian JS, Jefic M, Bagchi RA, Lane RH, McKnight RA, McKinsey TA, Morrison RF, Ferguson BS. DUSP5 functions as a feedback regulator of TNFa-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes. Sci Rep. 2017 10 10; 7(1):12879.
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Nejak-Bowen K, Moghe A, Cornuet P, Preziosi M, Nagarajan S, Monga SP. Role and Regulation of p65/?-Catenin Association During Liver Injury and Regeneration: A "Complex" Relationship. Gene Expr. 2017 Jul 07; 17(3):219-235.
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Jordan SJ, Gupta K, Ogendi BMO, Bakshi RK, Kapil R, Press CG, Sabbaj S, Lee JY, Geisler WM. The Predominant CD4+ Th1 Cytokine Elicited to Chlamydia trachomatis Infection in Women Is Tumor Necrosis Factor Alpha and Not Interferon Gamma. Clin Vaccine Immunol. 2017 Apr; 24(4).
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Zhang Y, Jiao G, Song C, Gu S, Brown RE, Zhang J, Zhang P, Gagnon J, Locke S, Stefanova R, Pelletier C, Zhang Y, Lu H. An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by A?25-35. Mar Drugs. 2017 Mar 22; 15(3).
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Srinivasan L, Swarr DT, Sharma M, Cotten CM, Kirpalani H. Systematic Review and Meta-analysis: Gene Association Studies in Neonatal Sepsis. Am J Perinatol. 2017 06; 34(7):684-692.
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Ni HM, McGill MR, Chao X, Woolbright BL, Jaeschke H, Ding WX. Caspase Inhibition Prevents Tumor Necrosis Factor-a-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in?Vivo and in?Vitro. Am J Pathol. 2016 10; 186(10):2623-36.
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Ruebel M, Shankar K, Gaddy D, Lindsey F, Badger T, Andres A. Maternal obesity is associated with ovarian inflammation and upregulation of early growth response factor 1. Am J Physiol Endocrinol Metab. 2016 07 01; 311(1):E269-77.
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Patil CN, Wallace K, LaMarca BD, Moulana M, Lopez-Ruiz A, Soljancic A, Juncos LA, Grande JP, Reckelhoff JF. Low-dose testosterone protects against renal ischemia-reperfusion injury by increasing renal IL-10-to-TNF-a ratio and attenuating T-cell infiltration. Am J Physiol Renal Physiol. 2016 08 01; 311(2):F395-403.
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Gokulan K, Khare S, Williams K, Foley SL. Transmissible Plasmid Containing Salmonella enterica Heidelberg Isolates Modulate Cytokine Production During Early Stage of Interaction with Intestinal Epithelial Cells. DNA Cell Biol. 2016 Aug; 35(8):443-53.
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Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH. Cadmium and arsenic override NF-?B developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46.
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Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73.
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Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T. Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma. Cancer Res. 2016 Mar 01; 76(5):1089-100.
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Zheng J, Wang J, Pouliot M, Authier S, Zhou D, Loose DS, Hauer-Jensen M. Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses. BMC Genomics. 2015 Nov 21; 16:984.
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Erdem H, Gundogdu B, Ankarali H, Yasar M, Sener E, Oktay M, Bahadir A, Uzunlar AK, Gursan N, Ozaydin I, Sahiner C. Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms. Niger J Clin Pract. 2015 Sep-Oct; 18(5):638-43.
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Stolarz AJ, Farris RA, Wiley CA, O'Brien CE, Price ET. Fenofibrate Attenuates Neutrophilic Inflammation in Airway Epithelia: Potential Drug Repurposing for Cystic Fibrosis. Clin Transl Sci. 2015 Dec; 8(6):696-701.
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