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Immunoreceptor Tyrosine-Based Activation Motif

"Immunoreceptor Tyrosine-Based Activation Motif" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.


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This graph shows the total number of publications written about "Immunoreceptor Tyrosine-Based Activation Motif" by people in UAMS Profiles by year, and whether "Immunoreceptor Tyrosine-Based Activation Motif" was a major or minor topic of these publications.
Bar chart showing 1 publications over 1 distinct years, with a maximum of 1 publications in 2013
To see the data from this visualization as text, click here.
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