 Proton Pump Inhibitors
"Proton Pump Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
| Descriptor ID |
D054328
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| MeSH Number(s) |
D27.505.519.389.848
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proton Pump Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Proton Pump Inhibitors".
This graph shows the total number of publications written about "Proton Pump Inhibitors" by people in UAMS Profiles by year, and whether "Proton Pump Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 1 | 1 | 2 | | 2024 | 1 | 3 | 4 | | 2023 | 1 | 2 | 3 | | 2022 | 1 | 1 | 2 | | 2021 | 0 | 2 | 2 | | 2020 | 1 | 1 | 2 | | 2019 | 2 | 1 | 3 | | 2018 | 2 | 3 | 5 | | 2017 | 1 | 1 | 2 | | 2016 | 3 | 0 | 3 | | 2015 | 2 | 0 | 2 | | 2014 | 3 | 1 | 4 | | 2013 | 2 | 2 | 4 | | 2012 | 2 | 0 | 2 | | 2011 | 1 | 2 | 3 | | 2010 | 4 | 0 | 4 | | 2009 | 1 | 1 | 2 | | 2008 | 2 | 0 | 2 | | 2007 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2005 | 4 | 2 | 6 | | 2004 | 1 | 0 | 1 | | 2003 | 3 | 1 | 4 | | 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proton Pump Inhibitors" by people in Profiles over the past ten years.
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Azimpouran M, Waters KM, Hendifar AE, Gangi A, Kozak M, Guindi M, Lai KK, Larson BK, Hutchings DA. Gastric neuroendocrine tumors associated with acid suppressant drugs are frequently associated with very prolonged drug use and may show unconventional morphologies. Hum Pathol. 2026 Feb; 168:106013.
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Buccola MJ, Satheesh Babu AK, Paz HA, Porter ND, Srinivasan H, Ricks RL, Rosquist K, Torres JL, Zhong Y, Jalili T, Wankhade UD, Anandh Babu PV. Dietary Prebiotics Modulate Omeprazole-Induced Alterations in the Gut Microbial Signature. Mol Nutr Food Res. 2025 Dec; 69(24):e70307.
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Song Y, Chen E, Chiang YJ, Yao JC, Halperin DM, Chatterjee D, Badgwell BD. Classification of Gastric Neuroendocrine Tumors and Associations With Survival. J Surg Oncol. 2025 Feb; 131(2):204-211.
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Padhi BK, Khatib MN, Zahiruddin QS, Rustagi S, Sharma RK, Sah R, Satapathy P, Rao AP. Adverse cardiovascular outcomes associated with proton pump inhibitor use after percutaneous coronary intervention: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2024 07 17; 24(1):372.
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MacLaren R, Dionne JC, Granholm A, Alhazzani W, Szumita PM, Olsen K, Barletta JF, M?ller MH, Karvellas CJ, Wischmeyer P, DePriest A, Carlos V, Argetsinger D, Carothers JJ, Lee R, Napolitano L, Perri D, Naylor DF. Society of Critical Care Medicine and American Society of Health-System Pharmacists Guideline for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults. Crit Care Med. 2024 Aug 01; 52(8):e421-e430.
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Chehade M, Dellon ES, Spergel JM, Collins MH, Rothenberg ME, Pesek RD, Hirano I, Liu R, Laws E, Mortensen E, Martincova R, Shabbir A, McCann E, Kamal MA, Kosloski MP, Hamilton JD, Samuely C, Lim WK, Wipperman MF, Farrell A, Patel N, Yancopoulos GD, Glotfelty L, Maloney J. Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age. N Engl J Med. 2024 06 27; 390(24):2239-2251.
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Thompson EJ, Jeong A, Helfer VE, Shakhnovich V, Edginton A, Balevic SJ, James LP, Collier DN, Anand R, Gonzalez D. Physiologically-based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population. CPT Pharmacometrics Syst Pharmacol. 2024 Aug; 13(8):1394-1408.
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Gangwani MK, Ahmed Z, Ishtiaq R, Aziz M, Rani A, Dahiya DS, Priyanka F, Arif SF, Lee-Smith W, Sohail AH, Inamdar S, Hassan M. Hepatic encephalopathy with proton pump inhibitor use in post tips patients: a systematic review and meta-analysis. Minerva Gastroenterol (Torino). 2024 Sep; 70(3):353-358.
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Lancaster I, Sethi V, Patel D, Tamboli C, Pacer E, Steinhoff J, Mizrahi M, Willinger A. Antithrombotics and Gastrointestinal Prophylaxis: A Systematic Review. Cardiol Rev. 2024 Nov-Dec 01; 32(6):528-537.
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Hsu PI, Chen KY, Tai WC, Yang JC, Tsay FW, Liu YH, Chen CL, Lee CL, Yeh HZ, Kuo CH, Chuah SK, Lee HC, Shie CB, Shiu SI, Kao JY, Yamaoka Y, Graham DY, Wu DC. Hybrid, High-Dose Dual and Bismuth Quadruple Therapies for First-Line Treatment of Helicobacter pylori Infection in Taiwan: A Multicenter, Open-Label, Randomized Trial. Am J Gastroenterol. 2023 07 01; 118(7):1184-1195.
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Haseeb M, McCarty TR, Jirapinyo P, Thompson CC. Letter to the Editor in Response to ACG Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease. Am J Gastroenterol. 2022 12 01; 117(12):2083.
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Feldman K, Kearns GL, Pearce RE, Abdel-Rahman SM, Steven Leeder J, Friesen A, Staggs VS, Gaedigk A, Weigel J, Shakhnovich V. Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children. Clin Transl Sci. 2022 05; 15(5):1155-1166.
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Shah S, Halvorson A, McBay B, Dorn C, Wilson O, Tuteja S, Chang KM, Cho K, Hauger R, Suzuki A, Hunt C, Siew E, Matheny M, Hung A, Greevy R, Roumie C. Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort. Gut. 2022 07; 71(7):1447-1450.
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Hsu PI, Tsay FW, Kao JY, Peng NJ, Chen YH, Tang SY, Kuo CH, Kao SS, Wang HM, Wu IT, Shie CB, Chuah SK, Wu DC. Tetracycline-levofloxacin versus amoxicillin-levofloxacin quadruple therapies in the second-line treatment of Helicobacter pylori infection. Helicobacter. 2021 Oct; 26(5):e12840.
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Liu JJ, Sloan ME, Owings AH, Figgins E, Gauthier J, Gharaibeh R, Robinson T, Williams H, Sindel CB, Backus F, Ayyalasomayajula K, Parker A, Senitko M, Abraham GE, Claggett B, Horwitz BH, Jobin C, Adelman RM, Diamond G, Glover SC. Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy. Am J Gastroenterol. 2021 08 01; 116(8):1638-1645.
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Chang YL, Tung YC, Tu YK, Yeh HZ, Yang JC, Hsu PI, Kim SE, Wu MF, Liou WS, Shiu SI. Efficacy of second-line regimens for Helicobacter pylori eradication treatment: a systemic review and network meta-analysis. BMJ Open Gastroenterol. 2020 09; 7(1).
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Gadiparthi C, Perisetti A, Sayana H, Tharian B, Inamdar S, Korman A. Gastrointestinal Bleeding in Patients with Severe SARS-CoV-2. Am J Gastroenterol. 2020 08; 115(8):1283-1285.
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Siddiqi A, Chaudhary FS, Naqvi HA, Saleh N, Farooqi R, Yousaf MN. Black esophagus: a syndrome of acute esophageal necrosis associated with active alcohol drinking. BMJ Open Gastroenterol. 2020 08; 7(1).
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Lyons K, Le LC, Pham YT, Borron C, Park JY, Tran CTD, Tran TV, Tran HT, Vu KT, Do CD, Pelucchi C, La Vecchia C, Zgibor J, Boffetta P, Luu HN. Gastric cancer: epidemiology, biology, and prevention: a mini review. Eur J Cancer Prev. 2019 09; 28(5):397-412.
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Hsu PI, Pan CY, Kao JY, Tsay FW, Peng NJ, Kao SS, Chen YH, Tsai TJ, Wu DC, Tsai KW. Short-term and long-term impacts of Helicobacter pylori eradication with reverse hybrid therapy on the gut microbiota. J Gastroenterol Hepatol. 2019 Nov; 34(11):1968-1976.
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Choi K, Abu-Sbeih H, Samdani R, Nogueras Gonzalez G, Raju GS, Richards DM, Gao J, Subudhi S, Stroehlein J, Wang Y. Can Immune Checkpoint Inhibitors Induce Microscopic Colitis or a Brand New Entity? Inflamm Bowel Dis. 2019 01 10; 25(2):385-393.
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Shakhnovich V, Brian Smith P, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M. A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents. Paediatr Drugs. 2018 Oct; 20(5):483-495.
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Lovell DJ, Dare JA, Francis-Sedlak M, Ball J, LaMoreaux BD, Von Scheven E, Reinhardt A, Jerath R, Alpan O, Gupta R, Goldsmith D, Zeft A, Naddaf H, Gottlieb B, Jung L, Holt RJ. A 6-month, multicenter, open-label study of fixed dose naproxen/esomeprazole in adolescent patients with juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2018 Jun 26; 16(1):41.
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Hsu PI, Pan CY, Kao JY, Tsay FW, Peng NJ, Kao SS, Wang HM, Tsai TJ, Wu DC, Chen CL, Tsai KW. Helicobacter pylori eradication with bismuth quadruple therapy leads to dysbiosis of gut microbiota with an increased relative abundance of Proteobacteria and decreased relative abundances of Bacteroidetes and Actinobacteria. Helicobacter. 2018 Aug; 23(4):e12498.
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Pesek RD, Gupta SK. Emerging drugs for eosinophilic esophagitis. Expert Opin Emerg Drugs. 2018 06; 23(2):173-183.
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McCarty TR, Itidiare M, Njei B, Rustagi T. Efficacy of transoral incisionless fundoplication for refractory gastroesophageal reflux disease: a systematic review and meta-analysis. Endoscopy. 2018 07; 50(7):708-725.
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Shakhnovich V, Smith PB, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. J Pediatr. 2018 02; 193:102-108.e1.
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Pesek RD, Rettiganti M, O'Brien E, Beckwith S, Daniel C, Luo C, Scurlock AM, Chandler P, Levy RA, Perry TT, Kennedy JL, Chervinskiy S, Vonlanthen M, Casteel H, Fiedorek SC, Gibbons T, Jones SM. Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2017 08; 119(2):177-183.
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Wu CK, Liang CM, Hsu CN, Hung TH, Yuan LT, Nguang SH, Wang JW, Tseng KL, Ku MK, Yang SC, Tai WC, Shih CW, Hsu PI, Wu DC, Chuah SK. The Role of Adjuvant Acid Suppression on the Outcomes of Bleeding Esophageal Varices after Endoscopic Variceal Ligation. PLoS One. 2017; 12(1):e0169884.
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Hammond DA, Kathe N, Shah A, Martin BC. Cost-Effectiveness of Histamine2 Receptor Antagonists Versus Proton Pump Inhibitors for Stress Ulcer Prophylaxis in Critically Ill Patients. Pharmacotherapy. 2017 01; 37(1):43-53.
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