 Mice, Inbred MRL lpr
"Mice, Inbred MRL lpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
| Descriptor ID |
D019463
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| MeSH Number(s) |
B01.050.050.157.520.555 B01.050.050.199.520.520.555 B01.050.150.900.649.865.635.505.500.400.555
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| Concept/Terms |
Mice, Inbred MRL lpr- Mice, Inbred MRL lpr
- Mice, MRL lpr
- MRL lpr Mice
- lpr Mice, MRL
- Mouse, MRL lpr
- MRL lpr Mouse
- lpr Mouse, MRL
- Mouse, Inbred MRL lpr
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Below are MeSH descriptors whose meaning is more general than "Mice, Inbred MRL lpr".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred MRL lpr".
This graph shows the total number of publications written about "Mice, Inbred MRL lpr" by people in UAMS Profiles by year, and whether "Mice, Inbred MRL lpr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2024 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2017 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Inbred MRL lpr" by people in Profiles over the past ten years.
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Choudhury SR, Byrum SD, Blossom SJ. Trichloroethylene metabolite modulates DNA methylation-dependent gene expression in Th1-polarized CD4+ T cells from autoimmune-prone mice. Toxicol Sci. 2024 May 28; 199(2):289-300.
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Scindia Y, Wlazlo E, Ghias E, Cechova S, Loi V, Leeds J, Ledesma J, Helen C, Swaminathan S. Modulation of iron homeostasis with hepcidin ameliorates spontaneous murine lupus nephritis. Kidney Int. 2020 07; 98(1):100-115.
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Blossom SJ, Fernandes L, Bai S, Khare S, Gokulan K, Yuan Y, Dewall M, Simmen FA, Gilbert KM. Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice. Toxicol Sci. 2018 07 01; 164(1):313-327.
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Meadows JR, Parker C, Gilbert KM, Blossom SJ, DeWitt JC. A single dose of trichloroethylene given during development does not substantially alter markers of neuroinflammation in brains of adult mice. J Immunotoxicol. 2017 12; 14(1):95-102.
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Gilbert KM, Bai S, Barnette D, Blossom SJ. Exposure Cessation During Adulthood Did Not Prevent Immunotoxicity Caused by Developmental Exposure to Low-Level Trichloroethylene in Drinking Water. Toxicol Sci. 2017 06 01; 157(2):429-437.
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Gilbert KM, Blossom SJ, Erickson SW, Broadfoot B, West K, Bai S, Li J, Cooney CA. Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells. Toxicol Lett. 2016 Oct 17; 260:1-7.
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