 Immunoglobulin G
"Immunoglobulin G" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
| Descriptor ID |
D007074
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| MeSH Number(s) |
D12.776.124.486.485.114.619.393 D12.776.124.790.651.114.619.393 D12.776.377.715.548.114.619.393
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| Concept/Terms |
IgG(T)- IgG(T)
- Immunoglobulin GT
- GT, Immunoglobulin
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin G".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin G".
This graph shows the total number of publications written about "Immunoglobulin G" by people in UAMS Profiles by year, and whether "Immunoglobulin G" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 1 | 1 | 2 | | 2024 | 2 | 1 | 3 | | 2023 | 0 | 2 | 2 | | 2022 | 0 | 5 | 5 | | 2021 | 2 | 6 | 8 | | 2020 | 2 | 11 | 13 | | 2019 | 0 | 4 | 4 | | 2018 | 0 | 1 | 1 | | 2017 | 2 | 3 | 5 | | 2016 | 1 | 1 | 2 | | 2015 | 1 | 1 | 2 | | 2014 | 1 | 2 | 3 | | 2013 | 1 | 0 | 1 | | 2012 | 6 | 2 | 8 | | 2011 | 0 | 6 | 6 | | 2010 | 1 | 4 | 5 | | 2009 | 2 | 1 | 3 | | 2008 | 4 | 1 | 5 | | 2007 | 2 | 3 | 5 | | 2006 | 1 | 7 | 8 | | 2005 | 2 | 1 | 3 | | 2004 | 1 | 4 | 5 | | 2003 | 1 | 9 | 10 | | 2002 | 0 | 4 | 4 | | 2001 | 0 | 1 | 1 | | 2000 | 2 | 2 | 4 | | 1999 | 1 | 2 | 3 | | 1998 | 0 | 2 | 2 | | 1997 | 1 | 1 | 2 | | 1996 | 0 | 1 | 1 | | 1993 | 1 | 1 | 2 | | 1992 | 1 | 2 | 3 | | 1991 | 1 | 2 | 3 | | 1990 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Immunoglobulin G" by people in Profiles over the past ten years.
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Feng A, Gonzalez MV, Kalaycioglu M, Yin X, Mumau M, Shyamsundar S, Bustamante MS, Chang SE, Dhingra S, Dodig-Crnkovic T, Schwenk JM, Garg T, Yoshizaki K, van Rhee F, Fajgenbaum DC, Utz PJ. Common connective tissue disorder and anti-cytokine autoantibodies are enriched in idiopathic multicentric castleman disease patients. Front Immunol. 2025; 16:1528465.
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Shah M, Bajan K, Samant R. Navigating the labyrinth: Phenotypes of IgG4-related disease. J Postgrad Med. 2025 Jan 01; 71(1):45-48.
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Wei TT, Gao K, Tai JH, Wei YJ, Zhan B. A study of specific immunoglobulin G4 expression in allergic rhinitis and its value in assessing efficacy and in predicting prognosis of sublingual immunotherapy. Kaohsiung J Med Sci. 2025 Jan; 41(1):e12916.
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Klimtchuk ES, Prokaeva T, Spencer BH, Wong S, Ghosh S, Urdaneta A, Morgan G, Wales TE, Gursky O. Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis. J Mol Biol. 2024 Dec 01; 436(23):168837.
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Rickels KL, Jabbehdari S, Krishnan VJ, Chauhan MZ, Ji MH, Tetelbom PS, Sallam AB, Chacko JG, Mansour AM, Uwaydat SH. Posterior Segment Manifestations of Syphilis and Correlation With Serologic Markers of Infection. Ophthalmic Surg Lasers Imaging Retina. 2024 Sep; 55(9):511-516.
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Shah SK, Hagrass HA. Evusheld, a SARS-CoV-2 spike protein-directed attachment inhibitor, appears in serum protein electrophoresis and immunofixation: a case study. Lab Med. 2023 Nov 02; 54(6):e201-e203.
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Sethi S, Casal Moura M, Madden B, Debiec H, Nasr SH, Larsen CP, Gross L, Negron V, Singh RD, Nath KA, Storey AJ, Specks U, Fervenza FC, Ronco P, Caza TN. Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use. Kidney Int. 2023 08; 104(2):343-352.
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Caza TN, Storey AJ, Hassen SI, Herzog C, Edmondson RD, Arthur JM, Kenan DJ, Larsen CP. Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry. Kidney Int. 2023 03; 103(3):593-606.
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Sims MD, Podolsky RH, Childers KL, Higgins B, Trueman J, Homayouni R, Voss DR, Berkiw-Scenna N, Keil H, Kennedy RH, Maine GN. Dried blood spots are a valid alternative to venipuncture for COVID-19 antibody testing. J Immunol Methods. 2023 02; 513:113420.
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Kanchan K, Shankar G, Huffaker MF, Bahnson HT, Chinthrajah RS, Sanda S, Manohar M, Ling H, Paschall JE, Toit GD, Ruczinski I, Togias A, Lack G, Nadeau KC, Jones SM, Nepom GT, Mathias RA. HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success. Front Immunol. 2022; 13:941839.
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Nnawuba KC, Boral BM, Donnell RW. Probable warm autoimmune hemolytic anemia proceeding the administration of the Pfizer mRNA COVID-19 vaccine. Immunohematology. 2022 09 01; 38(3):106-107.
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Smeekens JM, Baloh C, Lim N, Larson D, Qin T, Wheatley L, Kim EH, Jones SM, Burks AW, Kulis MD. Peanut-Specific IgG4 and IgA in Saliva Are Modulated by Peanut Oral Immunotherapy. J Allergy Clin Immunol Pract. 2022 Dec; 10(12):3270-3275.
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Abdallah AO, Mahmoudjafari Z, Atieh T, Ahmed N, Cui W, Shune L, Mohan M, McGuirk J, Remker C, Foss M, Karloff E, Fitch H, Atrash S. Neutralizing antibody responses against SARS-CoV-2 in patients with plasma cell disorders who are on active treatment after two doses of mRNA vaccination. Eur J Haematol. 2022 Nov; 109(5):458-464.
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Hartwell BL, Melo MB, Xiao P, Lemnios AA, Li N, Chang JYH, Yu J, Gebre MS, Chang A, Maiorino L, Carter C, Moyer TJ, Dalvie NC, Rodriguez-Aponte SA, Rodrigues KA, Silva M, Suh H, Adams J, Fontenot J, Love JC, Barouch DH, Villinger F, Ruprecht RM, Irvine DJ. Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity. Sci Transl Med. 2022 07 20; 14(654):eabn1413.
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Manral P, Caza TN, Storey AJ, Beck LH, Borza DB. The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy. Front Immunol. 2022; 13:952235.
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Brown SL, Bauer JJ, Lee J, Ntirandekura E, Stumhofer JS. IgM+ and IgM- memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon rechallenge with P. yoelii. J Leukoc Biol. 2022 11; 112(5):1115-1135.
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Suprun M, Sicherer SH, Wood RA, Jones SM, Leung DYM, Burks AW, Dunkin D, Witmer M, Grishina G, Getts R, Su?rez-Fari?as M, Sampson HA. Mapping Sequential IgE-Binding Epitopes on Major and Minor Egg Allergens. Int Arch Allergy Immunol. 2022; 183(3):249-261.
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Brown NE, Lyons AK, Schuh AJ, Stumpf MM, Harcourt JL, Tamin A, Rasheed MAU, Mills L, Lester SN, Thornburg NJ, Nguyen K, Costantini V, Vinj? J, Huang JY, Gilbert SE, Gable P, Bollinger S, Sabour S, Beshearse E, Surie D, Biedron C, Gregory CJ, Clemmons NS, Whitaker B, Coughlin MM, Seely KA, Garner K, Gulley T, Haney T, Kothari A, Patil N, Halpin AL, McDonald LC, Kutty PK, Brown AC. Descriptive evaluation of antibody responses to severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection in plasma and gingival crevicular fluid in a nursing home cohort-Arkansas, June-August 2020. Infect Control Hosp Epidemiol. 2022 11; 43(11):1610-1617.
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Foureau D, Bhutani M, Guo F, Rigby K, Leonidas M, Tjaden E, Fox A, Atrash S, Paul B, Voorhees PM, Usmani SZ. Comparison of mass spectrometry and flow cytometry in measuring minimal residual disease in multiple myeloma. Cancer Med. 2021 10; 10(20):6933-6936.
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De Gasparo R, Pedotti M, Simonelli L, Nickl P, Muecksch F, Cassaniti I, Percivalle E, Lorenzi JCC, Mazzola F, Magr? D, Michalcikova T, Haviernik J, Honig V, Mrazkova B, Polakova N, Fortova A, Tureckova J, Iatsiuk V, Di Girolamo S, Palus M, Zudova D, Bednar P, Bukova I, Bianchini F, Mehn D, Nencka R, Strakova P, Pavlis O, Rozman J, Gioria S, Sammartino JC, Giardina F, Gaiarsa S, Pan-Hammarstr?m Q, Barnes CO, Bjorkman PJ, Calzolai L, Piralla A, Baldanti F, Nussenzweig MC, Bieniasz PD, Hatziioannou T, Prochazka J, Sedlacek R, Robbiani DF, Ruzek D, Varani L. Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice. Nature. 2021 05; 593(7859):424-428.
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Wang Z, Schmidt F, Weisblum Y, Muecksch F, Barnes CO, Finkin S, Schaefer-Babajew D, Cipolla M, Gaebler C, Lieberman JA, Oliveira TY, Yang Z, Abernathy ME, Huey-Tubman KE, Hurley A, Turroja M, West KA, Gordon K, Millard KG, Ramos V, Da Silva J, Xu J, Colbert RA, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Gazumyan A, Caskey M, Bjorkman PJ, Casellas R, Hatziioannou T, Bieniasz PD, Nussenzweig MC. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature. 2021 04; 592(7855):616-622.
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Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY, Cipolla M, Viant C, Barnes CO, Bram Y, Breton G, H?ggl?f T, Mendoza P, Hurley A, Turroja M, Gordon K, Millard KG, Ramos V, Schmidt F, Weisblum Y, Jha D, Tankelevich M, Martinez-Delgado G, Yee J, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Robbiani DF, Zhao Z, Gazumyan A, Schwartz RE, Hatziioannou T, Bjorkman PJ, Mehandru S, Bieniasz PD, Caskey M, Nussenzweig MC. Evolution of antibody immunity to SARS-CoV-2. Nature. 2021 03; 591(7851):639-644.
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Cohen AA, Gnanapragasam PNP, Lee YE, Hoffman PR, Ou S, Kakutani LM, Keeffe JR, Wu HJ, Howarth M, West AP, Barnes CO, Nussenzweig MC, Bjorkman PJ. Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice. Science. 2021 02 12; 371(6530):735-741.
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Mohan M, Yarlagadda N, Szabo A, Singh A, Pina Oviedo S, Schinke C. Clinical characteristics of testicular extramedullary involvement in multiple myeloma. Am J Hematol. 2021 03 01; 96(3):E77-E81.
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Jenkins AR, Chua A, Chami H, Diaz-Mendoza J, Duggal A, Knight S, Patolia S, Tamae-Kakazu M, Raghu G, Wilson KC. Questionnaires or Serum Immunoglobulin G Testing in the Diagnosis of Hypersensitivity Pneumonitis among Patients with Interstitial Lung Disease. Ann Am Thorac Soc. 2021 01; 18(1):130-147.
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Scurlock AM, Burks AW, Sicherer SH, Leung DYM, Kim EH, Henning AK, Dawson P, Lindblad RW, Berin MC, Cho CB, Davidson WF, Plaut M, Sampson HA, Wood RA, Jones SM. Epicutaneous immunotherapy for treatment of peanut allergy: Follow-up from the Consortium for Food Allergy Research. J Allergy Clin Immunol. 2021 03; 147(3):992-1003.e5.
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Li W, Chen C, Drelich A, Martinez DR, Gralinski LE, Sun Z, Sch?fer A, Kulkarni SS, Liu X, Leist SR, Zhelev DV, Zhang L, Kim YJ, Peterson EC, Conard A, Mellors JW, Tseng CK, Falzarano D, Baric RS, Dimitrov DS. Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2020 11 24; 117(47):29832-29838.
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Katerji R, Smoller BR. Immunoglobulin-G4-related skin disease. Clin Dermatol. 2021 Mar-Apr; 39(2):283-290.
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Lumley SF, Eyre DW, McNaughton AL, Howarth A, Hoosdally S, Hatch SB, Kavanagh J, Chau KK, Downs LO, Cox S, Dunn L, Justice A, Wareing S, Dingle K, Rudkin J, Auckland K, Fyfe A, Bolton J, Paton R, Mentzer AJ, Jeffery K, Andersson MI, James T, Peto TEA, Marsden BD, Screaton G, Cornall RJ, Klenerman P, Ebner D, Stuart DI, Crook DW, Stoesser N, Kennedy SH, Thompson C, Gupta S, Matthews PC. SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020. Euro Surveill. 2020 10; 25(42).
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Rostad CA, Chahroudi A, Mantus G, Lapp SA, Teherani M, Macoy L, Tarquinio KM, Basu RK, Kao C, Linam WM, Zimmerman MG, Shi PY, Menachery VD, Oster ME, Edupuganti S, Anderson EJ, Suthar MS, Wrammert J, Jaggi P. Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C). Pediatrics. 2020 12; 146(6).
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Caza TN, Hassen SI, Dvanajscak Z, Kuperman M, Edmondson R, Herzog C, Storey A, Arthur J, Cossey LN, Sharma SG, Kenan DJ, Larsen CP. NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney Int. 2021 04; 99(4):967-976.
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Suprun M, Sicherer SH, Wood RA, Jones SM, Leung DYM, Henning AK, Dawson P, Burks AW, Lindblad R, Getts R, Su?rez-Fari?as M, Sampson HA. Early epitope-specific IgE antibodies are predictive of childhood peanut allergy. J Allergy Clin Immunol. 2020 11; 146(5):1080-1088.
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Moura DTH, McCarty TR, Ribeiro IB, Funari MP, Oliveira PVAG, Miranda Neto AA, Monte J?nior ESD, Tustumi F, Bernardo WM, Moura EGH, Thompson CC. Diagnostic Characteristics of Serological-Based COVID-19 Testing: A Systematic Review and Meta-Analysis. Clinics (Sao Paulo). 2020; 75:e2212.
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Raghu G, Remy-Jardin M, Ryerson CJ, Myers JL, Kreuter M, Vasakova M, Bargagli E, Chung JH, Collins BF, Bendstrup E, Chami HA, Chua AT, Corte TJ, Dalphin JC, Danoff SK, Diaz-Mendoza J, Duggal A, Egashira R, Ewing T, Gulati M, Inoue Y, Jenkins AR, Johannson KA, Johkoh T, Tamae-Kakazu M, Kitaichi M, Knight SL, Koschel D, Lederer DJ, Mageto Y, Maier LA, Matiz C, Morell F, Nicholson AG, Patolia S, Pereira CA, Renzoni EA, Salisbury ML, Selman M, Walsh SLF, Wuyts WA, Wilson KC. Diagnosis of Hypersensitivity Pneumonitis in Adults. An Official ATS/JRS/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med. 2020 08 01; 202(3):e36-e69.
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Teng F, Han F, Zhu X, Yu L, Gai D, Xu C, Cui Y. Identification of continuous immunoglobulin G epitopes of Dermatophagoides farinae allergens by peptide microarray immunoassay. IUBMB Life. 2020 09; 72(9):1976-1985.
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Zhou X, Bai T, Meckel K, Song J, Jin Y, Kort?m KM, Einsele H, Hou X, Rasche L. COVID-19 infection in patients with multiple myeloma: a German-Chinese experience from W?rzburg and Wuhan. Ann Hematol. 2021 Mar; 100(3):843-846.
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Barnes CO, West AP, Huey-Tubman KE, Hoffmann MAG, Sharaf NG, Hoffman PR, Koranda N, Gristick HB, Gaebler C, Muecksch F, Lorenzi JCC, Finkin S, H?ggl?f T, Hurley A, Millard KG, Weisblum Y, Schmidt F, Hatziioannou T, Bieniasz PD, Caskey M, Robbiani DF, Nussenzweig MC, Bjorkman PJ. Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies. Cell. 2020 08 20; 182(4):828-842.e16.
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Zhang L, Pang R, Xue X, Bao J, Ye S, Dai Y, Zheng Y, Fu Q, Hu Z, Yi Y. Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19. Aging (Albany NY). 2020 Apr 22; 12(8):6536-6542.
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Li A, Sanchez-Petitto G, Tkaczuk KHR, Nageshwar M, Singh Z, Kocoglu M. An Unusual Cause of a Pathological Vertebral Fracture: Solitary Plasmacytoma. Am J Med Sci. 2020 08; 360(2):206-207.
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Larsen CP, Sharma SG, Caza TN, Kenan DJ, Storey AJ, Edmondson RD, Herzog C, Arthur JM. Serum amyloid P deposition is a sensitive and specific feature of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int. 2020 03; 97(3):602-608.
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Sicherer SH, Wood RA, Perry TT, Jones SM, Leung DYM, Henning AK, Dawson P, Burks AW, Lindblad R, Sampson HA. Clinical factors associated with peanut allergy in a high-risk infant cohort. Allergy. 2019 11; 74(11):2199-2211.
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Zhong Z, Jin Q, Zhang J, Park YM, Shrestha D, Bai J, Merchant AT. Serum IgG Antibodies against Periodontal Microbes and Cancer Mortality. JDR Clin Trans Res. 2020 04; 5(2):166-175.
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Jennings T, Ahmed S, Aphale A, Lee J, Valdes-Rodriguez R. Intravenous immunoglobulin G use in patients with chronic inflammatory demyelinating polyneuropathy: An uncommon cause of drug-induced discoid lupus erythematosus. Australas J Dermatol. 2019 Aug; 60(3):e208-e210.
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Morra DE, Pierson SK, Shilling D, Nemat S, Appiani C, Guilfoyle M, Tendler C, van Rhee F, Fajgenbaum DC. Predictors of response to anti-IL6 monoclonal antibody therapy (siltuximab) in idiopathic multicentric Castleman disease: secondary analyses of phase II clinical trial data. Br J Haematol. 2019 01; 184(2):232-241.
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Larsen CP, Trivin-Avillach C, Coles P, Collins AB, Merchant M, Ma H, Wilkey DW, Ambruzs JM, Messias NC, Cossey LN, Rosales IA, Wooldridge T, Walker PD, Colvin RB, Klein J, Salant DJ, Beck LH. LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease. J Am Soc Nephrol. 2018 02; 29(2):644-653.
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Naglak EK, Morrison SG, Morrison RP. Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia. Infect Immun. 2017 10; 85(10).
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Campbell JP, Heaney JLJ, Pandya S, Afzal Z, Kaiser M, Owen R, Child JA, Gregory W, Morgan GJ, Jackson GH, Bunce CM, Drayson MT. Active multiple myeloma suppresses and typically eliminates coexisting MGUS. Br J Cancer. 2017 Sep 05; 117(6):835-839.
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Bakshi RK, Gupta K, Jordan SJ, Brown LT, Press CG, Gorwitz RJ, Papp JR, Morrison SG, Lee JY, Morrison RP, Geisler WM. Immunoglobulin-Based Investigation of Spontaneous Resolution of Chlamydia trachomatis Infection. J Infect Dis. 2017 06 01; 215(11):1653-1656.
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Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, Ware J, Gurish MF, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest. 2017 May 01; 127(5):1714-1724.
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Pandey MK, Burrow TA, Rani R, Martin LJ, Witte D, Setchell KD, Mckay MA, Magnusen AF, Zhang W, Liou B, K?hl J, Grabowski GA. Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease. Nature. 2017 03 02; 543(7643):108-112.
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Wang H, Levi MS, Del Grosso AV, McCormick WM, Bhattacharyya L. An improved size exclusion-HPLC method for molecular size distribution analysis of immunoglobulin G using sodium perchlorate in the eluent. J Pharm Biomed Anal. 2017 May 10; 138:330-343.
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Cao XX, Wang T, Liu YH, Zhou DB, Li J. Successful treatment of scleromyxedema with melphalan and dexamethasone followed by thalidomide maintenance therapy. Leuk Lymphoma. 2016 12; 57(12):2934-2936.
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Luke T, Wu H, Zhao J, Channappanavar R, Coleman CM, Jiao JA, Matsushita H, Liu Y, Postnikova EN, Ork BL, Glenn G, Flyer D, Defang G, Raviprakash K, Kochel T, Wang J, Nie W, Smith G, Hensley LE, Olinger GG, Kuhn JH, Holbrook MR, Johnson RF, Perlman S, Sullivan E, Frieman MB. Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Sci Transl Med. 2016 Feb 17; 8(326):326ra21.
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Heaney CD, Kmush B, Navas-Acien A, Francesconi K, G?ssler W, Schulze K, Fairweather D, Mehra S, Nelson KE, Klein SL, Li W, Ali H, Shaikh S, Merrill RD, Wu L, West KP, Christian P, Labrique AB. Arsenic exposure and hepatitis E virus infection during pregnancy. Environ Res. 2015 Oct; 142:273-80.
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