 Homologous Recombination
"Homologous Recombination" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An exchange of DNA between matching or similar sequences.
| Descriptor ID |
D059765
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| MeSH Number(s) |
G05.355.760.615
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| Concept/Terms |
Homologous Recombination- Homologous Recombination
- Homologous Recombinations
- Recombination, Homologous
- Recombinations, Homologous
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Below are MeSH descriptors whose meaning is more general than "Homologous Recombination".
Below are MeSH descriptors whose meaning is more specific than "Homologous Recombination".
This graph shows the total number of publications written about "Homologous Recombination" by people in UAMS Profiles by year, and whether "Homologous Recombination" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 1 | 2 | | 2023 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 | | 2019 | 1 | 1 | 2 | | 2018 | 2 | 1 | 3 | | 2017 | 1 | 3 | 4 | | 2015 | 2 | 1 | 3 | | 2014 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 | | 2012 | 1 | 1 | 2 |
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Below are the most recent publications written about "Homologous Recombination" by people in Profiles over the past ten years.
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Protacio RU, Wahls WP. Targeted Forward Genetics: Saturating Mutational Analyses of Specific Target Loci Within the Genome. Methods Mol Biol. 2025; 2862:223-239.
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Salunkhe S, Daley JM, Kaur H, Tomimatsu N, Xue C, Raina VB, Jasper AM, Rogers CM, Li W, Zhou S, Mojidra R, Kwon Y, Fang Q, Ji JH, Badamchi Shabestari A, Fitzgerald O, Dinh H, Mukherjee B, Habib AA, Hromas R, Mazin AV, Wasmuth EV, Olsen SK, Libich DS, Zhou D, Zhao W, Greene EC, Burma S, Sung P. Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination. Nature. 2024 Oct; 634(8033):482-491.
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de la Pe?a Avalos B, Paquet N, Trop?e R, Coulombe Y, Palacios H, Leung JW, Masson JY, Duijf PHG, Dray E. The protein phosphatase EYA4 promotes homologous recombination (HR) through dephosphorylation of tyrosine 315 on RAD51. Nucleic Acids Res. 2024 Feb 09; 52(3):1173-1187.
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Rawal Y, Jia L, Meir A, Zhou S, Kaur H, Ruben EA, Kwon Y, Bernstein KA, Jasin M, Taylor AB, Burma S, Hromas R, Mazin AV, Zhao W, Zhou D, Wasmuth EV, Greene EC, Sung P, Olsen SK. Structural insights into BCDX2 complex function in homologous recombination. Nature. 2023 Jul; 619(7970):640-649.
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Fleury H, MacEachern MK, Stiefel CM, Anand R, Sempeck C, Nebenfuehr B, Maurer-Alcal? K, Ball K, Proctor B, Belan O, Taylor E, Ortega R, Dodd B, Weatherly L, Dansoko D, Leung JW, Boulton SJ, Arnoult N. The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining. Mol Cell. 2023 05 04; 83(9):1429-1445.e8.
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Lee D, Apelt K, Lee SO, Chan HR, Luijsterburg MS, Leung JWC, Miller KM. ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination. Nucleic Acids Res. 2022 04 22; 50(7):3922-3943.
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Protacio RU, Mukiza TO, Davidson MK, Wahls WP. Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination. Genetics. 2022 02 04; 220(2).
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Daley JM, Tomimatsu N, Hooks G, Wang W, Miller AS, Xue X, Nguyen KA, Kaur H, Williamson E, Mukherjee B, Hromas R, Burma S, Sung P. Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions. Nat Commun. 2020 06 18; 11(1):3088.
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Hazeslip L, Zafar MK, Chauhan MZ, Byrd AK. Genome Maintenance by DNA Helicase B. Genes (Basel). 2020 05 21; 11(5).
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Storey AJ, Wang HP, Protacio RU, Davidson MK, Wahls WP. Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast. G3 (Bethesda). 2019 12 03; 9(12):4097-4106.
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Mukiza TO, Protacio RU, Davidson MK, Steiner WW, Wahls WP. Diverse DNA Sequence Motifs Activate Meiotic Recombination Hotspots Through a Common Chromatin Remodeling Pathway. Genetics. 2019 11; 213(3):789-803.
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Makharashvili N, Arora S, Yin Y, Fu Q, Wen X, Lee JH, Kao CH, Leung JW, Miller KM, Paull TT. Sae2/CtIP prevents R-loop accumulation in eukaryotic cells. Elife. 2018 12 07; 7.
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Storey AJ, Wang HP, Protacio RU, Davidson MK, Tackett AJ, Wahls WP. Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot. Epigenetics Chromatin. 2018 10 29; 11(1):64.
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Wang W, Daley JM, Kwon Y, Xue X, Krasner DS, Miller AS, Nguyen KA, Williamson EA, Shim EY, Lee SE, Hromas R, Sung P. A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection. J Biol Chem. 2018 11 02; 293(44):17061-17069.
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Pawlyn C, Loehr A, Ashby C, Tytarenko R, Deshpande S, Sun J, Fedorchak K, Mughal T, Davies FE, Walker BA, Morgan GJ. Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition? Leukemia. 2018 07; 32(7):1561-1566.
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Hromas R, Kim HS, Sidhu G, Williamson E, Jaiswal A, Totterdale TA, Nole J, Lee SH, Nickoloff JA, Kong KY. The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells. Breast Cancer Res. 2017 Nov 16; 19(1):122.
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Nickoloff JA, Jones D, Lee SH, Williamson EA, Hromas R. Drugging the Cancers Addicted to DNA Repair. J Natl Cancer Inst. 2017 11 01; 109(11).
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Li G, Ward C, Yeasmin R, Skiena S, Krug LT, Forrest JC. A codon-shuffling method to prevent reversion during production of replication-defective herpesvirus stocks: Implications for herpesvirus vaccines. Sci Rep. 2017 03 13; 7:44404.
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Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes Dev. 2017 02 01; 31(3):260-274.
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Yazinski SA, Comaills V, Buisson R, Genois MM, Nguyen HD, Ho CK, Todorova Kwan T, Morris R, Lauffer S, Nussenzweig A, Ramaswamy S, Benes CH, Haber DA, Maheswaran S, Birrer MJ, Zou L. ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. Genes Dev. 2017 02 01; 31(3):318-332.
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Duina AA, Turkal CE. Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast. J Vis Exp. 2017 01 26; (119).
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Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ. A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther. 2016 Feb; 15(2):241-50.
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Wu Y, Lee SH, Williamson EA, Reinert BL, Cho JH, Xia F, Jaiswal AS, Srinivasan G, Patel B, Brantley A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X, Kim HS, Beissbarth T, Gaedcke J, Burma S, Nickoloff JA, Hromas RA. EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair. PLoS Genet. 2015 Dec; 11(12):e1005675.
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Gong F, Chiu LY, Cox B, Aymard F, Clouaire T, Leung JW, Cammarata M, Perez M, Agarwal P, Brodbelt JS, Legube G, Miller KM. Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. Genes Dev. 2015 Jan 15; 29(2):197-211.
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Byrum SD, Taverna SD, Tackett AJ. Purification of specific chromatin loci for proteomic analysis. Methods Mol Biol. 2015; 1228:83-92.
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