Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
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MeSH Number(s) |
E05.393.620.500
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Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
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Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in UAMS Profiles by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2023 | 0 | 1 | 1 | 2022 | 0 | 2 | 2 | 2021 | 1 | 1 | 2 | 2019 | 0 | 4 | 4 | 2018 | 1 | 6 | 7 | 2017 | 0 | 5 | 5 | 2016 | 1 | 3 | 4 | 2015 | 0 | 3 | 3 | 2014 | 2 | 6 | 8 | 2013 | 1 | 2 | 3 | 2012 | 0 | 11 | 11 | 2011 | 1 | 7837 | 7838 | 2010 | 2 | 12 | 14 | 2009 | 0 | 7 | 7 | 2008 | 4 | 12 | 16 | 2007 | 3 | 10 | 13 | 2006 | 5 | 13 | 18 | 2005 | 4 | 10 | 14 | 2004 | 1 | 7 | 8 | 2003 | 1 | 13 | 14 | 2002 | 1 | 12 | 13 | 2001 | 1 | 6 | 7 | 2000 | 3 | 3 | 6 | 1999 | 1 | 3 | 4 | 1998 | 2 | 4 | 6 | 1997 | 1 | 11 | 12 | 1996 | 6 | 4 | 10 | 1995 | 1 | 5 | 6 | 1994 | 2 | 2 | 4 | 1993 | 0 | 6 | 6 | 1992 | 1 | 2 | 3 | 1991 | 2 | 1 | 3 | 1990 | 0 | 2 | 2 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles over the past ten years.
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Chang KM, Haghamad A, Saunders-Hao P, Shaffer A, Mirsaidi N, Zimilover A, Epstein M, Jain S, Streva V, Juretschko S, Demissie S, Gautam-Goyal P. The clinical impact of early detection of ESBL-producing Enterobacterales with PCR-based blood culture assays. Am J Infect Control. 2024 01; 52(1):73-80.
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Hardgrave H, Burdine L, Patel R, Giorgakis E. Negative COVID-19 Plasma PCR Following COVID-19+ Donor Kidney Transplant. Transplantation. 2022 09 01; 106(9):e422-e423.
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Bridwell MR, Bajaj S, Gress TW, Hambuchen MD, Clay TB. Impact of MRSA polymerase chain reaction (PCR) wound swabs on antibiotic de-escalation in skin and soft tissue infections. Diagn Microbiol Infect Dis. 2022 Jul; 103(3):115722.
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Johann DJ, Laun S, Shin IJ, Weigman R, Stephens O, Roberge A, Liu M, Greisman V, Steliga M, Muesse J, Peterson E, Emmert-Buck MR, Tangrea MA. Microdissection Methods Utilizing Single-Cell Subtype Analysis and the Impact on Precision Medicine. Methods Mol Biol. 2022; 2394:93-107.
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Alkam D, Wongsurawat T, Nookaew I, Richardson AR, Ussery D, Smeltzer MS, Jenjaroenpun P. Is amplification bias consequential in transposon sequencing (TnSeq) assays? A case study with a Staphylococcus aureus TnSeq library subjected to PCR-based and amplification-free enrichment methods. Microb Genom. 2021 10; 7(10).
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Verma A, Carney K, Taylor M, Amsler K, Morgan J, Gruszynski K, Erol E, Carter C, Locke S, Callipare A, Shah DH. Occurrence of potentially zoonotic and cephalosporin resistant enteric bacteria among shelter dogs in the Central and South-Central Appalachia. BMC Vet Res. 2021 Sep 25; 17(1):313.
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Clay TB, Orwig KW, Stevens RA, Davis EP, Jennings TM, Long TE, Riley BL, Hambuchen MD. Correlation of MRSA polymerase chain reaction (PCR) wound swab testing and wound cultures in skin and soft tissue infections. Diagn Microbiol Infect Dis. 2021 Aug; 100(4):115389.
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Kozaczek M, Bottje W, Greene E, Lassiter K, Kong B, Dridi S, Korourian S, Hakkak R. Comparison of liver gene expression by RNAseq and PCR analysis after 8 weeks of feeding soy protein isolate- or casein-based diets in an obese liver steatosis rat model. Food Funct. 2019 Dec 11; 10(12):8218-8229.
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Kushnir VM, Mullady DK, Das K, Lang G, Hollander TG, Murad FM, Jackson SA, Toney NA, Finkelstein SD, Edmundowicz SA. The Diagnostic Yield of Malignancy Comparing Cytology, FISH, and Molecular Analysis of Cell Free Cytology Brush Supernatant in Patients With Biliary Strictures Undergoing Endoscopic Retrograde Cholangiography (ERC): A Prospective Study. J Clin Gastroenterol. 2019 10; 53(9):686-692.
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Klepser DG, Klepser ME, Murry JS, Borden H, Olsen KM. Evaluation of a community pharmacy-based influenza and group A streptococcal pharyngitis disease management program using polymerase chain reaction point-of-care testing. J Am Pharm Assoc (2003). 2019 Nov - Dec; 59(6):872-879.
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Ormseth MJ, Solus JF, Sheng Q, Ye F, Wu Q, Guo Y, Oeser AM, Allen RM, Vickers KC, Stein CM. Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls. J Rheumatol. 2020 02; 47(2):188-196.
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Barnes RC, Kim H, Fang C, Bennett W, Nemec M, Sirven MA, Suchodolski JS, Deutz N, Britton RA, Mertens-Talcott SU, Talcott ST. Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6-Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals. Mol Nutr Food Res. 2019 01; 63(2):e1800512.
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Kelly MS, Surette MG, Smieja M, Rossi L, Luinstra K, Steenhoff AP, Goldfarb DM, Pernica JM, Arscott-Mills T, Boiditswe S, Mazhani T, Rawls JF, Cunningham CK, Shah SS, Feemster KA, Seed PC. Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana. Pediatr Infect Dis J. 2018 11; 37(11):1176-1183.
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Bari K, Luckett K, Kaiser T, Diwan T, Cuffy M, Schoech MR, Safdar K, Blackard JT, Apewokin S, Paterno F, Sherman KE, Zucker SD, Anwar N, Shah SA. Hepatitis C transmission from seropositive, nonviremic donors to non-hepatitis C liver transplant recipients. Hepatology. 2018 05; 67(5):1673-1682.
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Harik N, DeBiasi RL. Neonatal nonpolio enterovirus and parechovirus infections. Semin Perinatol. 2018 04; 42(3):191-197.
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Wongsurawat T, Woo CC, Giannakakis A, Lin XY, Cheow ESH, Lee CN, Richards M, Sze SK, Nookaew I, Kuznetsov VA, Sorokin V. Distinctive molecular signature and activated signaling pathways in aortic smooth muscle cells of patients with myocardial infarction. Atherosclerosis. 2018 04; 271:237-244.
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Walker BA. Whole Exome Sequencing in Multiple Myeloma to Identify Somatic Single Nucleotide Variants and Key Translocations Involving Immunoglobulin Loci and MYC. Methods Mol Biol. 2018; 1792:71-95.
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Battachariyya S, Tytarenko R, Heuck C, Greally J, Verma A. Genome Wide Mapping of Methylated and Hydroxyl-Methylated Cytosines Using a Modified HpaII Tiny Fragment Enrichment by Ligation Mediated PCR Tagged Sequencing Protocol. Methods Mol Biol. 2018; 1792:167-177.
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Kaldhone PR, Han J, Deck J, Khajanchi B, Nayak R, Foley SL, Ricke SC. Evaluation of the Genetics and Functionality of Plasmids in Incompatibility Group I1-Positive Salmonella enterica. Foodborne Pathog Dis. 2018 03; 15(3):168-176.
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Huppler AR, Fisher BT, Lehrnbecher T, Walsh TJ, Steinbach WJ. Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children. J Pediatric Infect Dis Soc. 2017 Sep 01; 6(suppl_1):S32-S44.
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Cao XX, Meng Q, Cai H, He TH, Zhang CL, Su W, Sun J, Li Y, Xu W, Zhou DB, Li J. Detection of MYD88 L265P and WHIM-like CXCR4 mutation in patients with IgM monoclonal gammopathy related disease. Ann Hematol. 2017 Jun; 96(6):971-976.
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Pan J, Li D, Xu Y, Zhang J, Wang Y, Chen M, Lin S, Huang L, Chung EJ, Citrin DE, Wang Y, Hauer-Jensen M, Zhou D, Meng A. Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice. Int J Radiat Oncol Biol Phys. 2017 10 01; 99(2):353-361.
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Bagu ET, Miah S, Dai C, Spriggs T, Ogunbolude Y, Beaton E, Sanders M, Goel RK, Bonham K, Lukong KE. Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Oncotarget. 2017 Feb 14; 8(7):11442-11459.
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Duina AA, Turkal CE. Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast. J Vis Exp. 2017 01 26; (119).
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Kothari A, Shalin SC, Crescencio JC, Burgess MJ. Skin lesion in a patient with acute myeloid leukemia. Transpl Infect Dis. 2017 Feb; 19(1).
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Lehrnbecher T, Robinson PD, Fisher BT, Castagnola E, Groll AH, Steinbach WJ, Zaoutis TE, Negeri ZF, Beyene J, Phillips B, Sung L. Galactomannan, ?-D-Glucan, and Polymerase Chain Reaction-Based Assays for the Diagnosis of Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. Clin Infect Dis. 2016 Nov 15; 63(10):1340-1348.
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Nguy L, Shubbar E, Jern?s M, Nookaew I, Lundgren J, Olsson B, Nilsson H, Guron G. Adenine-induced chronic renal failure in rats decreases aortic relaxation rate and alters expression of proteins involved in vascular smooth muscle calcium handling. Acta Physiol (Oxf). 2016 12; 218(4):250-264.
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Gillies CE, Otto EA, Vega-Warner V, Robertson CC, Sanna-Cherchi S, Gharavi A, Crawford B, Bhimma R, Winkler C, Kang HM, Sampson MG. tarSVM: Improving the accuracy of variant calls derived from microfluidic PCR-based targeted next generation sequencing using a support vector machine. BMC Bioinformatics. 2016 Jun 10; 17(1):233.
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Kanth P, Bronner MP, Boucher KM, Burt RW, Neklason DW, Hagedorn CH, Delker DA. Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype. Cancer Prev Res (Phila). 2016 06; 9(6):456-65.
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Rowan NR, Lee S, Sahu N, Kanaan A, Cox S, Phillips CD, Wang EW. The role of viruses in the clinical presentation of chronic rhinosinusitis. Am J Rhinol Allergy. 2015 Nov-Dec; 29(6):e197-200.
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Boyanton BL, Freij BJ, Robinson-Dunn B, Makin J, Runge JK, Luna RA. Neonatal Pasteurella multocida subsp. septica Meningitis Traced to Household Cats: Molecular Linkage Analysis Using Repetitive-Sequence-Based PCR. J Clin Microbiol. 2016 Jan; 54(1):230-2.
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