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Chun-Yang Fan

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPathology, College of Medicine
DivisionPathology Administration
Address VA
4301 W Markham St.
Mail Slot # 113/LR
Little Rock AR 72205
Phone501-257-6469
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    Collapse Research 
    Collapse research activities and funding
    K08CA089029     (FAN, CHUN-YANG)Sep 1, 2001 - Aug 31, 2006
    NIH
    Oxidative DNA Damage, DNA Repair and Oral Cancer
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Haun RS, Fan CY, Mackintosh SG, Zhao H, Tackett AJ. CD109 Overexpression in Pancreatic Cancer Identified by Cell-Surface Glycoprotein Capture. J Proteomics Bioinform. 2014; Suppl 10:S10003. PMID: 25635161.
      View in: PubMed
    2. Hou F, Dai Y, Dornhoffer JR, Suen JY, Fan CY, Saad AG, Buckmiller LM, Richter GT. Expression of endoglin (CD105) and endothelial nitric oxide synthase in head and neck arteriovenous malformations. JAMA Otolaryngol Head Neck Surg. 2013 Mar; 139(3):237-43. PMID: 23657220.
      View in: PubMed
    3. Dai Y, Hou F, Buckmiller L, Fan CY, Saad A, Suen J, Richter GT. Decreased eNOS protein expression in involuting and propranolol-treated hemangiomas. Arch Otolaryngol Head Neck Surg. 2012 Feb; 138(2):177-82. PMID: 22351865.
      View in: PubMed
    4. Dai, Y., Hou, F, Stone, A, Carter, W.C, Fan C, Buckmiller, L.M, Saad, A.G., Suen, J.Y, Richter, G.T. Genes Identified in Human Arteriovenous Malformation by Global Gene Expression. Profiling. 19th International Workshop of the International Society for the Study of Vascular Anomalies. 2012.
    5. Bousamra, A, Zhang, H.H, Schichman, S.A, Fan C. Expression of Critical Genes involved in EGFR-Signaling Pathway in HNSCC. USCAP Annual Meeting. 2012.
    6. Dai, Y, Hou, F, Saad, A.G, Buckmiller, L.M, Fan C, Suen, J.Y, Richter, G.T. Beta-2 Adrenergic Receptor Expression in the Mast Cells in Infantile Hemangiomas. Profiling. 19th International Workshop of the International Society for the Study of Vascular Anomalies. 2012.
    7. Clark, L.N, Zhang, H.H, Schichman, S.A, Fan C. Epigenetic Modulation of EGFR-Signaling Genes in HNSCC. USCAP Annual Meeting. 2012.
    8. Hou F, Dai Y, Buckmiller LM, Shafirstein G, Fan CY, Saad AG, Suen JY, Richter GT. A pilot in vivo model of human microcystic lymphatic malformations. Arch Otolaryngol Head Neck Surg. 2011 Dec; 137(12):1280-5. PMID: 22183912.
      View in: PubMed
    9. Dai Y, Hou F, Saad A, Fan CY, Buckmiller LM, Suen JY, Richter GT. Preliminary investigation of human lymphatic malformations in vitro. Laryngoscope. 2011 Nov; 121(11):2435-42. PMID: 22020894.
      View in: PubMed
    10. Shafirstein G, Friedman A, Siegel E, Moreno M, B?umler W, Fan CY, Morehead K, Vural E, Stack BC, Suen JY. Using 5-aminolevulinic acid and pulsed dye laser for photodynamic treatment of oral leukoplakia. Arch Otolaryngol Head Neck Surg. 2011 Nov; 137(11):1117-23. PMID: 22106236.
      View in: PubMed
    11. Zhang H, Xie C, Spencer HJ, Zuo C, Higuchi M, Ranganathan G, Kern PA, Chou MW, Huang Q, Szczesny B, Mitra S, Watson AJ, Margison GP, Fan CY. Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol. 2011 Apr; 178(4):1715-27. PMID: 21435453.
      View in: PubMed
    12. Munkberg, J, Yang, Q, Liu, Y, Fan C. Clusterin overexpression promotes angiogenesis in primary ovarian cancer. USCAP Annual Meeting. 2011.
    13. Dai Y, Xie CH, Neis JP, Fan CY, Vural E, Spring PM. MicroRNA expression profiles of head and neck squamous cell carcinoma with docetaxel-induced multidrug resistance. Head Neck. 2011 Jun; 33(6):786-91. PMID: 21560177.
      View in: PubMed
    14. Vural E, Berb?e M, Acott A, Blagg R, Fan CY, Hauer-Jensen M. Skin graft take rates, granulation, and epithelialization: dependence on myeloid cell hypoxia-inducible factor 1alpha. Arch Otolaryngol Head Neck Surg. 2010 Jul; 136(7):720-3. PMID: 20644069.
      View in: PubMed
    15. Fan CY, Besas J,, Kodavanti PR. Changes in mitogen activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls. Toxicol Appl Pharmacol. 2010; 245(1):18.
    16. Fan CY, Besas J,, Kodavanti PR. Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls. Toxicol Appl Pharmacol. 2010; 245(1):1-8.
    17. Yang, G.F, Xie, D, Liu, Y, Lia, Y.R, He, W.P, Fu, B, Fan C. Overexpression of Clusterin is predictive of aggressive biology of primary ovarian cancer. USCAP Annual Meeting. 2010.
    18. Matta, A, El Jamal, S, Zhang, H.H, Gokden, N, Fan C. Overexpression of Cancer Stem Cell Markers in Renal Cell Carcinoma. USCAP Annual Meeting. 2010.
    19. Ikpatt, O.F., Xie, C.H., Smoller, B.R, Suen, J.Y, Fan C. Gulp1, an adaptor protein required for clearance of apoptotic cells, is frequently inactivated by promoter methylation in HNSCC. USCAP Annual Meeting. 2010.
    20. Quick, C.M, Zhang, H.H, Yang, G.F, Fan C. Epigenetic inactivation of Clusterin Gene may predict for mesenteric metastasis of primary ovarian cancer. USCAP Annual Meeting. 2010.
    21. Zhang, H.H, Stone, A, Schichman, S.A, Smoller, B.R, Suen, J.Y, Fan C. Epigenetic Profiling of Cancer Stem Cells (CSC) in Head and Neck Squamous Cell Carcinoma (HNSCC). USCAP Annual Meeting. 2010.
    22. Fan CY, Cowden J, Simmons SO, Padilla S, Ramabhadran R. Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening. Neurotoxicol Teratol. 2010; 32(1):91-8.
    23. Zuo C, Zhang H, Spencer HJ, Vural E, Suen JY, Schichman SA, Smoller BR, Kokoska MS, Fan CY. Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009 Oct; 141(4):484-90. PMID: 19786217.
      View in: PubMed
    24. Simmons SO, Fan CY, Ramabhadran R. Cellular stress response pathway system as a sentinel ensemble in toxicological screening. Toxicol Sci. 2009; 111(2):202-25.
    25. Richter GT, Bowen T, Boerma M, Fan CY, Hauer-Jensen M, Vural E. Impact of vascular endothelial growth factor on skin graft survival in irradiated rats. Arch Facial Plast Surg. 2009 Mar-Apr; 11(2):110-3. PMID: 19289683.
      View in: PubMed
    26. Cox, R.M, Zhang, H.H, Xie, C, Gokden, N, Fan C. Defective DNA Repair in Renal Cell Carcinoma. USCAP Annual Meeting. 2009.
    27. Lindberg, M.R, Quick, M.C, Zhang, H.H, Phan, D.C, Lamps, L.W, Smoller, B.R, Fan CY. Mitochondrial DNA 4977 basepair deletion occurs more frequently in normal colonic mucosa than in tubular adenoma: its potential role as tumor suppressor in progression of colon cancer. 98th USCAP Annual Meeting. 2009.
    28. Fan C, Xie, C, Zhang, H.H., Lin, Y.C, James, J.Y. Gossypol Suppresses In Vitro Head and Neck Squamous Cell Carcinoma Growth Through Its Inhibition of DNA Methyltransferase 1 and Epigenetic Activation of Tumor Suppressor Genes. USCAP Annual Meeting. 2009.
    29. Fan CY, Xie, C, Zhang, H.H, Smoller, B.R, James, J.Y. Characterization of Epigenetic Alterations of Tumor Suppressor genes in Chemoresistant Head and Neck Squamous Cell Carcinoma. 98th USCAP Annual Meeting. 2009.
    30. Lindberg, M.R, Zhang, H.H, Buckmiller, L.M, Suen, J.Y., Fan C. Frequent Loss of Heterozygosity of a DNA Repair Gene, hOGG1, in Arteriovenous Malformation. USCAP Annual Meeting. 2009.
    31. Lindberg, M.R, Zhang, H.H, Buckmiller, L.M, Suen, J.Y, Fan CY. Frequent Loss of Heterozygosity of a DNA Repair Gene, hOGG1, in Arteriovenous Malformation. 98th USCAP Annual Meeting. 2009.
    32. Phan, D.C, Quick, M.C, Zhang, H.H, Gilbrech, L, Schichman, S.A, Smoller, B.R, Lamps, L.W, Fan C. Frequent Loss of Heterozygosity of a DNA Repair Gene, hOGG1, in Inflammatory Bowel Disease. 98th USCAP Annual Meeting. 2009.
    33. Zhang, H.H, Stone, A, Xie, C, Schichman, S.A, Fan CY. Global Epigenetic Alterations in Head and Neck Squamous Cell Carcinoma. 98th USCAP Annual Meeting. 2009.
    34. Fan C, Xie, C, Zhang, H.H, Smoller, B.R., James, J.Y. Characterization of Epigenetic Alterations of Tumor Suppressor genes in Chemoresistant Head and Neck Squamous Cell Carcinoma. USCAP Annual Meeting. 2009.
    35. Cox, R.M, Zhang, H.H, Xie, C, Gokden, N, Fan CY. Defective DNA Repair in Renal Cell Carcinoma. 98th USCAP Annual Meeting. 2009.
    36. Scrape, S.R., Zhang, H.H, Xie, C, Gokden, N, Fan C. Significant Inhibition of Tumor-Suppressor Genes in Renal Cell Carcinoma. USCAP Annual Meeting. 2009.
    37. Fan CY, Xie, C, Zhang, H.H, Lin, Y.C, James, J.Y. Gossypol Suppresses In Vitro Head and Neck Squamous Cell Carcinoma Growth Through Its Inhibition of DNA Methyltransferase 1 and Epigenetic Activation of Tumor Suppressor Genes. 98th USCAP Annual Meeting. 2009.
    38. Scrape, S.R, Zhang, H.H, Xie, C, Gokden, N, Fan CY. Significant Inhibition of Tumor-Suppressor Genes in Renal Cell Carcinoma. 98th USCAP Annual Meeting. 2009.
    39. Phan, D.C, Quick, M.C, Zhang, H.H, Gilbrech, L, Schichman, S.A, Smoller, B.R, Lamps, L.W, Fan C. Frequent Loss of Heterozygosity of a DNA Repair Gene, hOGG1, in Inflammatory Bowel Disease. USCAP Annual Meeting. 2009.
    40. Vural E, Ramakrishnan J, Cetin N, Buckmiller L, Suen JY, Fan CY. The expression of vascular endothelial growth factor and its receptors in port-wine stains. Otolaryngol Head Neck Surg. 2008 Oct; 139(4):560-4. PMID: 18922344.
      View in: PubMed
    41. Gokden N, Li L, Zhang H, Schafer RF, Schichman S, Scott MA, Smoller BR, Fan CY. Loss of heterozygosity of DNA repair gene, hOGG1, in renal cell carcinoma but not in renal papillary adenoma. Pathol Int. 2008 Jun; 58(6):339-43. PMID: 18477212.
      View in: PubMed
    42. Leakey TI, Zielinski J, Siegfried RN, Siegel ER, Fan CY, Cooney CA. A simple algorithm for quantifying DNA methylation levels on multiple independent CpG sites in bisulfite genomic sequencing electropherograms. Nucleic Acids Res. 2008 Jun; 36(11):e64. PMID: 18480118.
      View in: PubMed
    43. Mizumachi T, Muskhelishvili L, Naito A, Furusawa J, Fan CY, Siegel ER, Kadlubar FF, Kumar U, Higuchi M. Increased distributional variance of mitochondrial DNA content associated with prostate cancer cells as compared with normal prostate cells. Prostate. 2008 Mar 01; 68(4):408-17. PMID: 18196528.
      View in: PubMed
    44. Pashaei S, Li L, Zhang H, Spencer HJ, Schichman SA, Fan CY, Smoller BR. Concordant loss of heterozygosity of DNA repair gene, hOGG1, in melanoma in situ and atypical melanocytic hyperplasia. J Cutan Pathol. 2008 Jun; 35(6):525-31. PMID: 18312439.
      View in: PubMed
    45. Boyette JR, Seibert JW, Fan CY, Stack BC. The etiology of recurrent chordoma presenting as a neck mass: metastasis vs. surgical pathway seeding. Ear Nose Throat J. 2008 Feb; 87(2):106-9. PMID: 18437932.
      View in: PubMed
    46. Xie, C, Li, L.W, Kokoska, M.S, Suen, J.Y, Smoller, B.R, Fan CY. Promoter Methylation of Retinoic Acid Receptor Responder-1 Gene: Early Marker for Head and Neck Squamous Carcinogenesis. 2008.
    47. Boyette JR, Seibert JW, Fan C, Stack BC Jr. The etiology of recurrent chordoma presentating as a neck mass: metastasis vs. surgical pathway seeding. Ear, Nose, & Throat Journal. 2008; 87(2):106-109.
    48. Quick, M.C, Xie, C, Li, L.W, Schaefer, R.F, Kokoska, M, Smoller, B.R, Fan CY. Mitochondrial DNA 4977 basepair deletion occurs more frequently in oral leukoplakia than in head and neck squamous cell carcinoma: its potential role as tumor suppressor in head and neck squamous carcinogenesis. 97th USCAP Annual Meeting. 2008.
    49. Suen, J.Y, Buckmiller, L, Richter, G, Fan CY, Shafirstein, G. SURGICAL TREATMENT OF ARTERIOVENOUS MALFORMATIONS: LONG TERM RESULTS. 2008.
    50. Xie, C, Li, L.W, Kokoska, M, Suen, J.Y, Smoller, B.R, Fan CY. Frequent promoter hypermethylation of retinoic acid receptor responder-1 (RARRES-1) gene in head and neck squamous cell carcinoma (HNSCC). 97th USCAP Annual Meeting. 2008.
    51. Fan CY, Zhang, H.H, Li, L.W, Shafirstein, G, Buckmiller, L.M, Suen, J.Y. Global Gene Expression Profiling Using AffyMetrix Microarray Analysis for Vascular Anomalies (VAs). 2008.
    52. Fan CY, Zhang, H.H, Li, L.W, Shafirstein, G, Buckmiller, L.M, Fink, L.M, Ma, Y.P, Suen, J.Y. Upregulation of Oncogenic Stem Cell Markers, SALL4 and BMI-1 in Vascular Anomalies (VAs). 2008.
    53. Phan, D, Xie, C, Li, L.W, Schaefer, R.F, Kokoska, M, Smoller, B.R, Fan CY. Frequent promoter hypermethylation of retinoic acid receptor responder gene-1 (RARRES-1) in oral leukoplakia: A potential epigenetic marker to predict malignant transformation. 97th USCAP Annual Meeting. 2008.
    54. Xie, C, Zhang, H, Huang, Q, Li, L.W, Higuchi, M, Fan CY. Major mitochondrial DNA deletions in obese transgenic mice overexpressing human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene: a causal relationship between mitochondrial DNA damages and obesity. 97th USCAP Annual Meeting. 2008.
    55. Kokoska, M.S, Li, L.W, Smoller, B.R, Suen, J.Y, Fan CY. Genetic and Epigenetic Alterations in Papillary Thyroid Carcinoma and Hashimoto Thyroiditis. 2008.
    56. Fan CY, Zuo, C, Kokoska, M.S, Suen, J.Y. DNA Demethylating Agents Synergize with Retinoic Acid to Suppress In Vivo Head and Neck Squamous Cell Carcinoma Growth. 2008.
    57. Xie, C, Wu, Y, Kokoska, M.S, Spring, P, Lee, R.J, Ye, W, Lin, Y.C, Suen, J.Y, Fan CY. Epigenetic Effect of Gossypol in the In Vitro Suppression of Head and Neck Squamous Cell Carcinoma Cells (HNSCC). 2008.
    58. Bäumler, W, Myhill, J, Hennings, L, Fan CY, Buckmiller, L, Suen, J.Y, Shafirstein, G. Personalizing Laser Therapy for Patients with Port-Wine Stain. 2008.
    59. Duyka, L.J, Fan CY, Buckmiller, L, Shafirstein, G, Suen, J.Y. Expression of Hormone Receptors in Head and Neck Vascular Anomalies. 17th International Workshop of the International Society for the Study of Vascular Anomalies. 2008.
    60. Suen, J.Y, Buckmiller, L, Richter, G, Fan CY, Shafirstein, G. Natural History of ArterioVenous Malformations. 2008.
    61. Shafirstein, G, Spring, P, Stack, B, Fan CY, Bäumler, W, Suen, J.Y. Utilizing 5-Aminolevulinic acid and pulsed dye laser for photodynamic therapy of oral leukoplakia. 2008.
    62. Vural E, Fan CY, Spring P, Stack BC, Kokoska MS, Hanna EY, Suen JY. Evaluation of the inferior and superior laryngeal nerve stumps for perineural spread in laryngeal cancer. Otolaryngol Head Neck Surg. 2007 Dec; 137(6):889-92. PMID: 18036416.
      View in: PubMed
    63. Mete M, Xu X, Fan CY, Shafirstein G. Automatic delineation of malignancy in histopathological head and neck slides. BMC Bioinformatics. 2007 Nov 01; 8 Suppl 7:S17. PMID: 18047716.
      View in: PubMed
    64. Xie CH, Naito A, Mizumachi T, Evans TT, Douglas MG, Cooney CA, Fan CY, Higuchi M. Mitochondrial regulation of cancer associated nuclear DNA methylation. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):656-61. PMID: 17964537.
      View in: PubMed
    65. Smith JA, Fan CY, Zou C, Bodenner D, Kokoska MS. Methylation status of genes in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg. 2007 Oct; 133(10):1006-11. PMID: 17938324.
      View in: PubMed
    66. Huang Q, Su X, Ai L, Li M, Fan CY, Weiss LM. Promoter hypermethylation of multiple genes in gastric lymphoma. Leuk Lymphoma. 2007; 48(10):1988 - 1996.
    67. Safar AM, Spencer H, Su X, Cooney CA, Shwaiki A, Fan CY. Promoter hypermethylation for molecular nodal staging in non-small cell lung cancer. Arch Pathol Lab Med. 2007 Jun; 131(6):936-41. PMID: 17550322.
      View in: PubMed
    68. Zhang H, Mizumachi T, Carcel-Trullols J, Li L, Naito A, Spencer HJ, Spring PM, Smoller BR, Watson AJ, Margison GP, Higuchi M, Fan CY. Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells. Carcinogenesis. 2007 Aug; 28(8):1629-37. PMID: 17389610.
      View in: PubMed
    69. O'Regan EM, Toner ME, Finn SP, Fan C, Ring M, Murphy N, Timon C, Smyth PC, Cahill S, Flavin RJ, O'Leary JJ. Genetic and epigenetic alteration profiles for p16(ink4a) in head and neck squamous cell carcinoma in young adults and its association with HPV. Human Pathology. 2007; 39:452-458.
    70. Gokden, N, Li, L, Schichman, S.A, Smoller, B.R, Fan CY. Allelic Loss of Cyclin D1, An Oncogene, in Clear Cell Renal Cell Carcinoma and Renal Oncocytoma. 96th USCAP Annual Meeting. 2007.
    71. Vural, E, Fan CY, Spring, P, Stack, B, Kokoska, M, Hanna, E, Suen, J.Y. Perineural spread in squamous cell carcinoma of the larynx: Histopathological evaluation of inferior and superior laryngeal nerve proximal stumps. 6th European Congress of Oto-Rhino-Laryngology Head and Neck Surgery Congress Center Hofburg. 2007.
    72. Fan CY, Zuo, C.L, Kokoska, M, Suen, J.Y. Synergistic suppression of head and neck cancer growth by retinoic acid and DNA demethylating agent, 5-azacytidine. 96th USCAP Annual Meeting. 2007.
    73. Richter, G, Fan CY, Bowen, T, Boerma, M, Hauer-Jensen, M, Vural, E. Impact of VEGF on Skin Graft Survival in the Irradiated Rat Dorsum. 6th European Congress of Oto-Rhino-Laryngology Head and Neck Surgery Congress Center Hofburg. 2007.
    74. Phan, D.C, Duyka, L.J, Gokden, N, Schaefer, R.F, Buckmiller, L.M, Fan CY. Hormonal Regulation of Head and Neck Venous Malformation (VM). 96th USCAP Annual Meeting. 2007.
    75. Arbiser JL, Mann KP, Losken EM, Cohen C, Reddy K, Kokko K, Pollack B, Fan CY, O'Reilly F. Presence of p16 hypermethylation and Epstein-Barr virus infection in transplant-associated hematolymphoid neoplasm of the skin. J Am Acad Dermatol. 2006; 55(5):794 - 798.
    76. Fan CY, Van Hemert RL, Thomas JR, Breau RL. Atypical solitary fibrous tumor of the larynx. Otolaryngol Head Neck Surg. 2006 May; 134(5):880-2. PMID: 16647552.
      View in: PubMed
    77. Kokoska, M, Thomas, M, Schichman, S.A, Smoller, B.R, Suen, J.Y, Li, L.W, Fan CY. Genetic and epigenetic alterations in thyroiditis and thyroid cancer. 2006.
    78. Kokoska, M, Siddiqui, F.N, Fan CY, Ware, J, Baumler, W, Shafirstein, G. Vascular flow and histology in laser treatment. 2006.
    79. Huang, Q, Zhang, H, Weiss, L.M, Fan CY. Mitochondrial damage leading to high frequency of lymphoma and myeloproliferative disorder in transgenetic mice overexpressing a human 8-oxoguanine DNA-glycosylase gene. 2006.
    80. Pashaei, S, Li, L, Zhang, H.H, Schichman, S.A, Fan CY, Smoller, B.R. Simultaneous loss of Heterozygosity of DNA Repair Gene, hOGG1, in Melanoma in situ and Atypical melanocytic Hyperplasia. Annual Meeting of the American Society of Dermatopathology. 2006.
    81. Richter, G.T, Smith, J, Fan CY, Vural, E.A. Histologcal Comparison of Human and Porcine Derived Dermal Matrices. 2006.
    82. Sheehan AM, McGregor DK, Patel A, Shidham V, Fan CY, Chang CC. Expression of human 8-oxoguanine DNA glycosylase (hOGG1) in follicular lymphoma. Mod Pathol. 2005; 18(11):1512 - 1518.
    83. Safar AM, Spencer H, Su X, Coffey M, Cooney CA, Ratnasinghe LD, Hutchins LF, Fan CY. Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. Clin Cancer Res. 2005 Jun 15; 11(12):4400-5. PMID: 15958624.
      View in: PubMed
    84. Boone RT, Zuo C, Fan CY, Dornhoffer J. Modification of atrial natriuretic peptide receptor expression in the rat inner ear. Otol Neurotol. 2005 May; 26(3):534-7. PMID: 15891663.
      View in: PubMed
    85. Puri SK, Si L, Fan CY, Hanna E. Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma. Am J Otolaryngol. 2005 Jan-Feb; 26(1):12-7. PMID: 15635575.
      View in: PubMed
    86. Hanna, E.Y, Lee, S, Fan CY, Suen J.Y. Cummings Otolaryngol Head and Neck Surg, Fredrickson, Harker, Krause, Richardson, Schuller, eds.Otolaryngol Head and Neck Surg, Vol 2, pp. 1348-1377. Benign Neoplasms of the Salivary Gland. 2005.
    87. Hanna E, Sherman A, Cash D, Adams D, Vural E, Fan CY, Suen JY. Quality of life for patients following total laryngectomy vs chemoradiation for laryngeal preservation. Arch Otolaryngol Head Neck Surg. 2004 Jul; 130(7):875-9. PMID: 15262766.
      View in: PubMed
    88. Hanna E, Alexiou M, Morgan J, Badley J, Maddox AM, Penagaricano J, Fan CY, Breau R, Suen J. Intensive chemoradiotherapy as a primary treatment for organ preservation in patients with advanced cancer of the head and neck: efficacy, toxic effects, and limitations. Arch Otolaryngol Head Neck Surg. 2004 Jul; 130(7):861-7. PMID: 15262764.
      View in: PubMed
    89. Zuo C, Ai L, Ratliff P, Suen JY, Hanna E, Brent TP, Fan CY. O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2004 Jun; 13(6):967-75. PMID: 15184253.
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    90. Fan CY. Epigenetic alterations in head and neck cancer: prevalence, clinical significance, and implications. Curr Oncol Rep. 2004 Mar; 6(2):152-61. PMID: 14751093.
      View in: PubMed
    91. Ai L, Vo QN, Zuo C, Li L, Ling W, Suen JY, Hanna E, Brown KD, Fan CY. Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma: promoter hypermethylation with clinical correlation in 100 cases. Cancer Epidemiol Biomarkers Prev. 2004 Jan; 13(1):150-6. PMID: 14744748.
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    92. Arbiser JL, Fan C, Su X, Van Emburgh BO, Cerimele F, Miller MS, Harvell J, Marinkovich P. Involvement of p53 and p16 tumor supressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma. J Invest Dermatol. 2004; 123(4):788-790.
    93. Mukunyadzi P, Huang H, Liu K, Fan CY. Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney. Appl Immunohistochem Mol Morphol. 2003 Dec; 11(4):334-8. PMID: 14663360.
      View in: PubMed
    94. Mukunyadzi P, Ai L, Portilla D, Barnes EL, Fan CY. Expression of peroxisome proliferator-activated receptor gamma in salivary duct carcinoma: immunohistochemical analysis of 15 cases. Mod Pathol. 2003 Dec; 16(12):1218-23. PMID: 14681322.
      View in: PubMed
    95. Chiles MC, Ai L, Zuo C, Fan CY, Smoller BR. E-cadherin promoter hypermethylation in preneoplastic and neoplastic skin lesions. Mod Pathol. 2003 Oct; 16(10):1014-8. PMID: 14559984.
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    96. Ai L, Stephenson KK, Ling W, Zuo C, Mukunyadzi P, Suen JY, Hanna E, Fan CY. The p16 (CDKN2a/INK4a) tumor-suppressor gene in head and neck squamous cell carcinoma: a promoter methylation and protein expression study in 100 cases. Mod Pathol. 2003 Sep; 16(9):944-50. PMID: 13679459.
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    97. Mukunyadzi P, Liu K, Hanna EY, Suen JY, Fan CY. Induced expression of syndecan-1 in the stroma of head and neck squamous cell carcinoma. Mod Pathol. 2003 Aug; 16(8):796-801. PMID: 12920224.
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    98. Smith TP, Alshafie TA, Cruz CP, Fan CY, Brown AT, Wang Y, Eidt JF, Moursi MM. Saratin, an inhibitor of collagen-platelet interaction, decreases venous anastomotic intimal hyperplasia in a canine dialysis access model. Vasc Endovascular Surg. 2003 Jul-Aug; 37(4):259-69. PMID: 12894368.
      View in: PubMed
    99. Tyler LN, Ai L, Zuo C, Fan CY, Smoller BR. Analysis of promoter hypermethylation of death-associated protein kinase and p16 tumor suppressor genes in actinic keratoses and squamous cell carcinomas of the skin. Mod Pathol. 2003 Jul; 16(7):660-4. PMID: 12861061.
      View in: PubMed
    100. Puri SK, Fan CY, Hanna E. Significance of extracapsular lymph node metastases in patients with head and neck squamous cell carcinoma. Curr Opin Otolaryngol Head Neck Surg. 2003 Apr; 11(2):119-23. PMID: 14515090.
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    101. Liu K, Zuo C, Luo QK, Suen JY, Hanna E, Fan CY. Promoter hypermethylation and inactivation of hMLH1, a DNA mismatch repair gene, in head and neck squamous cell carcinoma. Diagn Mol Pathol. 2003 Mar; 12(1):50-6. PMID: 12605036.
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    102. Boone RT, Fan CY, Hanna EY. Well-differentiated carcinoma of the thyroid. Otolaryngol Clin North Am. 2003 Feb; 36(1):73-90, viii. PMID: 12803010.
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    103. Hosal AS, Fan C, Barnes L, Myers EN. Salivary duct carcinoma. Ololaryngology Head & Neck Surg. 2003; 129:720-725.
    104. Liu K, Huang H, Mukunyadzi P, Suen JY, Hanna E, Fan CY. Promoter hypermethylation: an important epigenetic mechanism for hMLH1 gene inactivation in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2002 May; 126(5):548-53. PMID: 12075230.
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    105. Mukunyadzi P, Sanderson RD, Fan CY, Smoller BR. The level of syndecan-1 expression is a distinguishing feature in behavior between keratoacanthoma and invasive cutaneous squamous cell carcinoma. Mod Pathol. 2002 Jan; 15(1):45-9. PMID: 11796840.
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    106. Barnes, E.L, Fan CY. Myers E, Suen JY, eds. Cancer of the Head and Neck. Pathology of the Head and Neck: Basic Considerations and New Concepts. 2002.
    107. Fan CY, Liu KL, Huang HY, Barnes EL, Swalsky PA, Bakker A, Woods J, Finkelstein SD. Frequent allelic imbalance and loss of protein expression of the DNA repair gene hOGG1 in head and neck squamous cell carcinoma. Lab Invest. 2001; 81(10):1429 - 1438.
    108. Fan CY, Melhem MF, Hosal AS, Grandis JR, Barnes EL. Expression of androgen receptor, epidermal growth factor receptor, and transforming growth factor alpha in salivary duct carcinoma. Arch Otolaryngol Head Neck Surg. 2001; 127(9):1075 - 1079.
    109. Hegazy HM, Snyderman CH, Fan CY, Kassam AB. Neurilemmomas of the paranasal sinuses. Am J Otolaryngol. 2001; 22(3):215 - 218.
    110. Fan CY. Genetic alterations in head and neck cancer: interactions among environmental carcinogens, cell cycle control, and host DNA repair. Curr Oncol Rep. 2001; 3(1):66 - 71.
    111. Fan CY, Wang J, Barnes EL. Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature. Am J Surg Pathol. 2000; 24(4):579 - 586.
    112. Zweig JL, Schaitkin BM, Fan CY, Barnes EL. Histopathology of tissue samples removed using the microdebrider technique: implications for endoscopic sinus surgery. Am J Rhinol. 2000; 14(1):27 - 32.
    113. Fan CY, Pan J, Usuda N, Yeldandi AV, Rao MS, Reddy JK. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem. 1998; 273(25):15639 - 15645.
    114. Fan CY, Pan J, Chu R, Lee D, Kluckman KD, Usuda N, Singh I, Yeldandi AV, Rao MS, Maeda N, Reddy JK. Targeted disruption of the peroxisomal fatty acyl-CoA oxidase gene: generation of a mouse model of pseudoneonatal adrenoleukodystrophy. Ann N Y Acad Sci. 1996; 804:530 - 541.
    115. Fan CY, Pan, J, Chu, R, Lee, D, Kluckman, K.D, Usuda, N, Singh, I, Yeldandi, A.V, Rao, M.S, Maeda, N, Reddy, J.K. Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. Journal of Biological Chemistry. 1996; 271(40):24698-24710.
    116. Gerson SL, Zaidi NH, Dumenco LL, Allay E, Fan CY, Liu L, O'Connor PJ. Alkyltransferase transgenic mice: probes of chemical carcinogenesis. Mutat Res. 1994; 307(2):541 - 555.
    117. Alvares, K, Fan CY, Dadras, S, Rachubinski, R, Subramani, S, Yeldandi, A.V, Rao, M.S, Reddy, J.K. An upstream region of the enoyl CoA hydratase/dehydrogenase gene directs luciferase expression in response to peroxisome proliferators in transgenic mice. Cancer Research. 1994; (54):2303-2306.
    118. Lee SM, Rafferty JA, Elder RH, Fan CY, Bromley M, Harris M, Thatcher N, Potter PM, Altermatt HJ, Perinat-Frey T, . Immunohistological examination of the inter- and intracellular distribution of O6-alkylguanine DNA-alkyltransferase in human liver and melanoma. Br J Cancer. 1992; 66(2):355 - 360.
    119. Li YQ, Fan CY, O'Connor PJ, Winton DJ, Potten CS. Target cells for the cytotoxic effects of carcinogens in the murine small bowel. Carcinogenesis. 1992; 13(3):361 - 368.
    120. Rafferty JA, Fan CY, Potter PM, Watson AJ, Cawkwell L, O'Connor PJ, Margison GP. Tissue-specific expression and induction of human O6-alkylguanine-DNA alkyltransferase in transgenic mice. Mol Carcinog. 1992; 6(1):26 - 31.
    121. Santibanez-Koref M, Elder RH, Fan CY, Cawkwell L, McKie JH, Douglas KT, Margison GP, Rafferty JA. Isolation and partial characterization of murine O6-alkylguanine-DNA-alkyltransferase: comparative sequence and structural properties. Mol Carcinog. 1992; 5(2):161 - 169.
    122. Fan CY, Butler WH, O'Connor PJ. Promutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis. IARC Sci Publ. 1991; (105):119 - 122.
    123. Fan CY, Potter PM, Rafferty J, Watson AJ, Cawkwell L, Searle PF, O'Connor PJ, Margison GP. Expression of a human O6-alkylguanine-DNA-alkyltransferase cDNA in human cells and transgenic mice. Nucleic Acids Res. 1990; 18(19):5723 - 5727.
    124. Fan CY, Butler WH, O'Connor PJ. Cell and tissue specific localization of O6-methylguanine in the DNA of rats given N-nitrosodimethylamine: effects of protein deficient and normal diets. Carcinogenesis. 1989; 10(10):1967 - 1970.
    125. O'Connor PJ, Fida S, Fan CY, Bromley M, Saffhill R. Phenobarbital: a non-genotoxic agent which induces the repair of O6-methylguanine from hepatic DNA. Carcinogenesis. 1988; 9(11):2033 - 2038.
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