 Blood-Brain Barrier
"Blood-Brain Barrier" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
| Descriptor ID |
D001812
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| MeSH Number(s) |
A07.035 A08.186.211.035
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| Concept/Terms |
Blood-Brain Barrier- Blood-Brain Barrier
- Barrier, Blood-Brain
- Barriers, Blood-Brain
- Blood Brain Barrier
- Blood-Brain Barriers
- Hemato-Encephalic Barrier
- Barrier, Hemato-Encephalic
- Barriers, Hemato-Encephalic
- Hemato Encephalic Barrier
- Hemato-Encephalic Barriers
- Brain-Blood Barrier
- Barrier, Brain-Blood
- Barriers, Brain-Blood
- Brain Blood Barrier
- Brain-Blood Barriers
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Below are MeSH descriptors whose meaning is more general than "Blood-Brain Barrier".
Below are MeSH descriptors whose meaning is more specific than "Blood-Brain Barrier".
This graph shows the total number of publications written about "Blood-Brain Barrier" by people in UAMS Profiles by year, and whether "Blood-Brain Barrier" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2026 | 0 | 1 | 1 | | 2025 | 1 | 2 | 3 | | 2021 | 0 | 2 | 2 | | 2020 | 1 | 0 | 1 | | 2019 | 1 | 1 | 2 | | 2018 | 2 | 0 | 2 | | 2016 | 3 | 3 | 6 | | 2015 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2012 | 3 | 0 | 3 | | 2011 | 0 | 1 | 1 | | 2010 | 4 | 0 | 4 | | 2009 | 1 | 0 | 1 | | 2008 | 1 | 2 | 3 | | 2007 | 1 | 1 | 2 | | 2005 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2002 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1992 | 1 | 0 | 1 |
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Below are the most recent publications written about "Blood-Brain Barrier" by people in Profiles over the past ten years.
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Katiraei P, Frye RE, Theoharides TC. Gut-Brain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia. Int J Mol Sci. 2026 Feb 12; 27(4).
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Edwards L, Gonzalez AI, Thomas KR, Smirnov DS, Brenner EK, Nation DA, Chang F, Blennow K, Salmon DP, Galasko D, Bangen KJ. Interactive effects of blood-brain barrier breakdown and Alzheimer's disease biomarker status on cognitive decline in older adults without dementia. Alzheimers Dement. 2025 11; 21(11):e70910.
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Amawi H, Hammad AM, Hall FS, Hussein N, Rataan AO, Mrayyan A, Al-Kofahi T, Hmedat A, Ashby CR, Tiwari AK. Revisiting strategies to target ABC transporter-mediated drug resistance in CNS cancer. Cancer Biol Med. 2025 Sep 29; 22(10):1158-80.
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Nehra G, Maloney BJ, Smith RR, Chumboatong W, Abner EL, Nelson PT, Bauer B, Hartz AMS. Plasma S100? is a predictor for pathology and cognitive decline in Alzheimer's disease. Fluids Barriers CNS. 2025 Jan 09; 22(1):4.
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Fouda AY, Eldahshan W, Xu Z, Lemtalsi T, Shosha E, Zaidi SA, Abdelrahman AA, Cheng PN, Narayanan SP, Caldwell RW, Caldwell RB. Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury. Exp Neurol. 2022 02; 348:113923.
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Masterman E, Ahmed Z. Experimental Treatments for Oedema in Spinal Cord Injury: A Systematic Review and Meta-Analysis. Cells. 2021 10 07; 10(10).
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Yan W, Zhang L, Lv F, Moccia M, Carlomagno F, Landry C, Santoro M, Gosselet F, Frett B, Li HY. Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation. Eur J Med Chem. 2021 Apr 15; 216:113265.
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Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Holley J, Sridharan V, Boerma M, Tackett AJ, Willey JS, Pecaut MJ, Delp MD. Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model. FASEB J. 2020 11; 34(11):15516-15530.
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Cuevas E, Rosas-Hernandez H, Burks SM, Ramirez-Lee MA, Guzman A, Imam SZ, Ali SF, Sarkar S. Amyloid Beta 25-35 induces blood-brain barrier disruption in vitro. Metab Brain Dis. 2019 10; 34(5):1365-1374.
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Fouda AY, Fagan SC, Ergul A. Brain Vasculature and Cognition. Arterioscler Thromb Vasc Biol. 2019 04; 39(4):593-602.
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Rosas-Hernandez H, Escudero-Lourdes C, Ramirez-Lee MA, Cuevas E, Lantz SM, Imam SZ, Majeed W, Bourdo SE, Paule MG, Biris AS, Ali SF. Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells. J Appl Toxicol. 2019 07; 39(7):966-973.
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Rosas-Hernandez H, Cuevas E, Escudero-Lourdes C, Lantz SM, Sturdivant NM, Imam SZ, Sarkar S, Slikker W, Paule MG, Balachandran K, Ali SF. Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier. Neurosci Lett. 2018 04 13; 672:123-129.
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Rosas-Hernandez H, Cuevas E, Escudero-Lourdes C, Lantz SM, Gomez-Crisostomo NP, Sturdivant NM, Balachandran K, Imam SZ, Slikker W, Paule MG, Ali SF. Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier. Mol Neurobiol. 2018 01; 55(1):258-266.
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Raja R, Rosenberg GA, Caprihan A. MRI measurements of Blood-Brain Barrier function in dementia: A review of recent studies. Neuropharmacology. 2018 05 15; 134(Pt B):259-271.
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Wang X, Maruvada R, Morris AJ, Liu JO, Wolfgang MJ, Baek DJ, Bittman R, Kim KS. Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. PLoS Pathog. 2016 Oct; 12(10):e1005926.
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Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, Sonntag WE, Ungvari Z, Csiszar A. Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr). 2016 Aug; 38(4):273-289.
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