Leukoencephalopathy, Progressive Multifocal
"Leukoencephalopathy, Progressive Multifocal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Descriptor ID |
D007968
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MeSH Number(s) |
C02.182.500.300.500 C02.256.721.500 C02.290.575 C02.839.550 C10.228.140.695.750 C10.228.228.210.150.300.500 C10.228.228.245.340.575 C10.228.518.750 C10.314.450
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Concept/Terms |
Leukoencephalopathy, Progressive Multifocal- Leukoencephalopathy, Progressive Multifocal
- Leukoencephalopathies, Progressive Multifocal
- Multifocal Leukoencephalopathies, Progressive
- Multifocal Leukoencephalopathy, Progressive
- Progressive Multifocal Leukoencephalopathies
- JC Polyomavirus Encephalopathy
- Encephalopathies, JC Polyomavirus
- Encephalopathy, JC Polyomavirus
- Progressive Multifocal Leukoencephalopathy
- Encephalitis, JC Polyomavirus
- JC Polyomavirus Encephalitis
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Below are MeSH descriptors whose meaning is more general than "Leukoencephalopathy, Progressive Multifocal".
- Diseases [C]
- Virus Diseases [C02]
- Central Nervous System Viral Diseases [C02.182]
- Encephalitis [C02.182.500]
- Encephalitis, Viral [C02.182.500.300]
- Leukoencephalopathy, Progressive Multifocal [C02.182.500.300.500]
- DNA Virus Infections [C02.256]
- Polyomavirus Infections [C02.256.721]
- Leukoencephalopathy, Progressive Multifocal [C02.256.721.500]
- Encephalitis, Viral [C02.290]
- Leukoencephalopathy, Progressive Multifocal [C02.290.575]
- Slow Virus Diseases [C02.839]
- Leukoencephalopathy, Progressive Multifocal [C02.839.550]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Leukoencephalopathies [C10.228.140.695]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.695.750]
- Central Nervous System Infections [C10.228.228]
- Central Nervous System Viral Diseases [C10.228.228.210]
- Encephalitis [C10.228.228.210.150]
- Encephalitis, Viral [C10.228.228.210.150.300]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.210.150.300.500]
- Encephalitis [C10.228.228.245]
- Encephalitis, Viral [C10.228.228.245.340]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.245.340.575]
- Leukoencephalopathies [C10.228.518]
- Leukoencephalopathy, Progressive Multifocal [C10.228.518.750]
- Demyelinating Diseases [C10.314]
- Leukoencephalopathy, Progressive Multifocal [C10.314.450]
Below are MeSH descriptors whose meaning is more specific than "Leukoencephalopathy, Progressive Multifocal".
This graph shows the total number of publications written about "Leukoencephalopathy, Progressive Multifocal" by people in UAMS Profiles by year, and whether "Leukoencephalopathy, Progressive Multifocal" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2022 | 2 | 0 | 2 | 2021 | 3 | 0 | 3 | 2020 | 0 | 1 | 1 | 2015 | 1 | 0 | 1 | 2013 | 0 | 1 | 1 | 2010 | 1 | 0 | 1 | 2009 | 1 | 0 | 1 | 2007 | 1 | 0 | 1 | 2006 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Leukoencephalopathy, Progressive Multifocal" by people in Profiles over the past ten years.
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Sharma K, Tolaymat S, Yu H, Elkhooly M, Jaiswal S, Jena A, Kakara M, Sriwastava S. Progressive multifocal leukoencephalopathy in anti-CD20 and other monoclonal antibody (mAb) therapies used in multiple sclerosis: A review. J Neurol Sci. 2022 12 15; 443:120459.
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Yu H, Wu H, R S, Kaur A, Pasham SR, Upadhaya R, Sriwastava S. Single-center experience on progressive multifocal leukoencephalopathy (PML) cases, neuroimaging relevance, and management at West Virginia University (WVU). J Med Virol. 2022 08; 94(8):4015-4022.
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Sriwastava S, Khan E, Khalid SH, Kaur A, Feizi P. Progressive multifocal leukoencephalopathy in an immunocompetent patient: A case report and review of literature. J Med Virol. 2022 06; 94(6):2860-2869.
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Sriwastava S, Chaudhary D, Srivastava S, Beard K, Bai X, Wen S, Khalid SH, Lisak RP. Progressive multifocal leukoencephalopathy and sphingosine 1-phosphate receptor modulators used in multiple sclerosis: an updated review of literature. J Neurol. 2022 Mar; 269(3):1678-1687.
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Sriwastava S, Kataria S, Srivastava S, Kazemlou S, Gao S, Wen S, Saber H, Tripathi R, Sheikh Z, Peterson S, Gwinn R, Bernitsas E. Disease-modifying therapies and progressive multifocal leukoencephalopathy in multiple sclerosis: A systematic review and meta-analysis. J Neuroimmunol. 2021 11 15; 360:577721.
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Del Valle L, Sweet T, Parker-Struckhoff A, Perez-Liz G, Pi?a-Oviedo S. JCPyV T-Antigen Activation of the Anti-Apoptotic Survivin Promoter-Its Role in the Development of Progressive Multifocal Leukoencephalopathy. Viruses. 2020 11 03; 12(11).
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