 Antineoplastic Agents, Alkylating
"Antineoplastic Agents, Alkylating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
| Descriptor ID |
D018906
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| MeSH Number(s) |
D27.505.519.124.035 D27.505.954.248.150 D27.888.569.035.035
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| Concept/Terms |
Antineoplastic Agents, Alkylating- Antineoplastic Agents, Alkylating
- Antineoplastic Alkylating Agents
- Alkylating Agents, Antineoplastic
- Antineoplastic Drugs, Alkylating
- Antineoplastics, Alkylating
- Alkylating Antineoplastic Drugs
- Alkylating Drugs, Antineoplastic
- Antineoplastic Alkylating Drugs
- Drugs, Antineoplastic Alkylating
- Alkylating Antineoplastic Agents
- Alkylating Antineoplastics
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Below are MeSH descriptors whose meaning is more general than "Antineoplastic Agents, Alkylating".
Below are MeSH descriptors whose meaning is more specific than "Antineoplastic Agents, Alkylating".
This graph shows the total number of publications written about "Antineoplastic Agents, Alkylating" by people in UAMS Profiles by year, and whether "Antineoplastic Agents, Alkylating" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2016 | 2 | 0 | 2 | | 2013 | 2 | 0 | 2 | | 2011 | 2 | 2 | 4 | | 2010 | 3 | 0 | 3 | | 2009 | 3 | 0 | 3 | | 2008 | 2 | 1 | 3 | | 2007 | 3 | 2 | 5 | | 2006 | 1 | 1 | 2 | | 2005 | 2 | 0 | 2 | | 2004 | 0 | 2 | 2 | | 2003 | 1 | 4 | 5 | | 2002 | 0 | 2 | 2 | | 2001 | 0 | 2 | 2 | | 2000 | 1 | 1 | 2 | | 1999 | 1 | 1 | 2 | | 1997 | 0 | 1 | 1 |
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Below are the most recent publications written about "Antineoplastic Agents, Alkylating" by people in Profiles over the past ten years.
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Alexander TC, Kiffer F, Groves T, Anderson J, Wang J, Hayar A, Chen MT, Rodriguez A, Allen AR. Effects of thioTEPA chemotherapy on cognition and motor coordination. Synapse. 2019 06; 73(6):e22085.
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Chemaitilly W, Li Z, Krasin MJ, Brooke RJ, Wilson CL, Green DM, Klosky JL, Barnes N, Clark KL, Farr JB, Fernandez-Pineda I, Bishop MW, Metzger M, Pui CH, Kaste SC, Ness KK, Srivastava DK, Robison LL, Hudson MM, Yasui Y, Sklar CA. Premature Ovarian Insufficiency in Childhood Cancer Survivors: A Report From the St. Jude Lifetime Cohort. J Clin Endocrinol Metab. 2017 07 01; 102(7):2242-2250.
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Voorhees PM, Usmani SZ. The role of high-dose melphalan and autologous stem cell transplant in the rapidly evolving era of modern multiple myeloma therapy. Clin Adv Hematol Oncol. 2016 Sep; 14(9):719-28.
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Kaur V, Swami A, Shebli A, Shalin S, Veeraputhiran M, Emanuel P, Jethava Y. A rare case of blastic plasmacytoid dendritic cell neoplasm with deletion 7q.31, in the setting of heavy pre-treatment with alkylating chemotherapy. J Oncol Pharm Pract. 2017 Oct; 23(7):552-556.
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