 Cytochrome-B(5) Reductase
"Cytochrome-B(5) Reductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
| Descriptor ID |
D042966
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| MeSH Number(s) |
D08.811.682.608.191.237 D12.776.331.186
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| Concept/Terms |
Cytochrome-B(5) Reductase- Cytochrome-B(5) Reductase
- NADH-Cytochrome B5 Reductase
- B5 Reductase, NADH-Cytochrome
- NADH Cytochrome B5 Reductase
Methemoglobin Reductase- Methemoglobin Reductase
- Reductase, Methemoglobin
- NADH-Ferrihemoglobin Reductase
- NADH Ferrihemoglobin Reductase
- Reductase, NADH-Ferrihemoglobin
- NADH Methemoglobin Reductase
- Methemoglobin Reductase, NADH
- Reductase, NADH Methemoglobin
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Below are MeSH descriptors whose meaning is more general than "Cytochrome-B(5) Reductase".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome-B(5) Reductase".
This graph shows the total number of publications written about "Cytochrome-B(5) Reductase" by people in UAMS Profiles by year, and whether "Cytochrome-B(5) Reductase" was a major or minor topic of these publications.
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Below are the most recent publications written about "Cytochrome-B(5) Reductase" by people in Profiles over the past ten years.
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Reed L, Indra R, Mrizova I, Moserova M, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM. Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine. Toxicol Appl Pharmacol. 2019 03 01; 366:64-74.
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Reed L, Mrizova I, Barta F, Indra R, Moserova M, Kopka K, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM. Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice. Arch Toxicol. 2018 Apr; 92(4):1625-1638.
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Stiborov? M, Indra R, Moserov? M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM. NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene. Chem Res Toxicol. 2016 08 15; 29(8):1325-34.
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