 Necrosis
"Necrosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. Distinguish it from APOPTOSIS which is a normal, regulated cellular process.
| Descriptor ID |
D009336
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| MeSH Number(s) |
C23.550.717 G04.299.139.638
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Necrosis".
Below are MeSH descriptors whose meaning is more specific than "Necrosis".
This graph shows the total number of publications written about "Necrosis" by people in UAMS Profiles by year, and whether "Necrosis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 0 | 3 | 3 | | 2023 | 0 | 6 | 6 | | 2022 | 0 | 3 | 3 | | 2021 | 0 | 3 | 3 | | 2020 | 1 | 1 | 2 | | 2019 | 0 | 6 | 6 | | 2018 | 1 | 1 | 2 | | 2017 | 0 | 3 | 3 | | 2016 | 0 | 5 | 5 | | 2015 | 0 | 4 | 4 | | 2014 | 0 | 7 | 7 | | 2013 | 0 | 5 | 5 | | 2012 | 0 | 9 | 9 | | 2011 | 0 | 8 | 8 | | 2010 | 0 | 11 | 11 | | 2009 | 1 | 3 | 4 | | 2008 | 0 | 2 | 2 | | 2007 | 0 | 4 | 4 | | 2006 | 0 | 4 | 4 | | 2005 | 0 | 5 | 5 | | 2004 | 0 | 8 | 8 | | 2003 | 0 | 7 | 7 | | 2001 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 | | 1996 | 0 | 2 | 2 | | 1995 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 | | 1989 | 0 | 1 | 1 |
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Below are the most recent publications written about "Necrosis" by people in Profiles over the past ten years.
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Fadare O, Fard EV, Bhargava R, Desouki MM, Hanley KZ, Ip PPC, Li JJX, Lu B, Medeiros F, Ng JHY, Parkash V, Pinto A, Quick CM, Skala SL, Tokuyama M, Turashvili G, Wei CH, Xing D, Zheng W, Soong TR, Howitt BE. The Malignant Potential of Ovarian Steroid Cell Tumors Revisited: A Multi-institutional Clinicopathologic Analysis of 115 Cases. Am J Surg Pathol. 2024 May 01; 48(5):570-580.
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Wells J, Sorsby SC. Diabetic myonecrosis: An easily overlooked cause of limb pain in diabetic patients. J Am Assoc Nurse Pract. 2024 Mar 01; 36(3):194-196.
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Layer JP, Shiban E, Brehmer S, Diehl CD, de Castro DG, Hamed M, Dejonckheere CS, Cifarelli DT, Friker LL, Herrlinger U, H?lzel M, Vatter H, Schneider M, Combs SE, Schmeel LC, Cifarelli CP, Giordano FA, Sarria GR, Kahl KH. Multicentric Assessment of Safety and Efficacy of Combinatorial Adjuvant Brain Metastasis Treatment by Intraoperative Radiation Therapy and Immunotherapy. Int J Radiat Oncol Biol Phys. 2024 Apr 01; 118(5):1552-1562.
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Guo X, Blanc V, Davidson NO, Velazquez H, Chen TM, Moledina DG, Moeckel GW, Safirstein RL, Desir GV. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Sci Rep. 2023 12 14; 13(1):22255.
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Stough D. Topical Stabilized Super-Oxidized Hypochlorous Acid for Wound Healing in Hair Restoration Surgery: A Real-Time Usage-Controlled Trial Evaluating Safety, Efficacy, and Tolerability. J Drugs Dermatol. 2023 Dec 01; 22(12):1191-1196.
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Gu P, Dube S, Lee Y, Yang S, Li D, Haritunians T, Vasiliauskas E, Bonthala N, Syal G, Yarur A, Ziring D, Targan S, Rabizadeh S, Melmed GY, Fleshner P, McGovern DPB. Comparative Persistence of Non-tumor Necrosis Factor (TNF) vs. TNF Antagonists for Post-operative Prophylaxis in Crohn's Disease (CD). Dig Dis Sci. 2024 Jan; 69(1):235-245.
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Mendoza RP, Wang P, Smith HL, Fitzpatrick CA, Haridas R, Wanjari P, Briese R, Shahid A, McCluggage WG, Bennett JA. Clinicopathologic Analysis and Molecular Profiling of Ovarian Steroid Cell Tumors. Am J Surg Pathol. 2023 12 01; 47(12):1398-1408.
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Thimmarayan G, Schmitz M, Guerrero J, Garcia X, Zhang S, Chau D. A neonate with aseptic cutaneous necrosis related to the migration of the proximal central venous catheter infusion port. Paediatr Anaesth. 2024 01; 34(1):86-88.
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Park SH, Wilson SK, Wen L. Subcoronal Incision for Inflatable Penile Prosthesis Does Not Risk Glans Necrosis. J Urol. 2023 10; 210(4):678-687.
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Khoury T, Rosa M, Nayak A, Karabakhtsian R, Fadare O, Li Z, Turner B, Fang Y, Kumarapeli A, Li X, Numbere N, Villatoro T, Wang JG, Sadeghi S, Attwood K, George A, Bhargava R. Clinicopathologic Predictors of Clinical Outcomes in Mammary Adenoid Cystic Carcinoma: A Multi-institutional Study. Mod Pathol. 2023 02; 36(2):100006.
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Tang C, Livingston MJ, Safirstein R, Dong Z. Cisplatin nephrotoxicity: new insights and therapeutic implications. Nat Rev Nephrol. 2023 01; 19(1):53-72.
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Freeman D, Moreaux K, Beavers B, White G. Cold Panniculitis and Subcutaneous Fat Necrosis of the Newborn: The Continual Sequelae in the Non-pharmacological Conversion of Supraventricular Tachycardia. Clin Pediatr (Phila). 2023 06; 62(5):394-398.
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Kabir MA, Kharel A, Malla S, Kreis ZJ, Nath P, Wolfe JN, Hassan M, Kaur D, Sari-Sarraf H, Tiwari AK, Ray A. Automated detection of apoptotic versus nonapoptotic cell death using label-free computational microscopy. J Biophotonics. 2022 04; 15(4):e202100310.
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Stassen PMC, de Jonge PJF, Bruno MJ, Koch AD, Trindade AJ, Benias PC, Sejpal DV, Siddiqui UD, Chapman CG, Villa E, Tharian B, Inamdar S, Hwang JH, Barakat MT, Andalib I, Gaidhane M, Sarkar A, Shahid H, Tyberg A, Binmoeller K, Watson RR, Nett A, Schlag C, Abdelhafez M, Friedrich-Rust M, Schlachterman A, Chiang AL, Loren D, Kowalski T, Kahaleh M. Safety and efficacy of a novel resection system for direct endoscopic necrosectomy of walled-off pancreas necrosis: a prospective, international, multicenter trial. Gastrointest Endosc. 2022 03; 95(3):471-479.
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Truong A, Zaghiyan KN, Mirocha J, Melmed GY, McGovern DPB, Syal G, Ha CY, Targan SR, Fleshner PR. Antitumour necrosis factor therapy is associated with de novo Crohn's disease after ileal pouch-anal anastomosis. Colorectal Dis. 2021 Sep; 23(9):2416-2424.
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Ho JP, Galex IA, Sadeghi NB, Weledji N, Cabello Bermudez SI, Mitchell BA, Bush DM, Yap E, Davis NC, Catalino MP, Godfrey V, Nielsen JN, Lee YZ, Sasaki-Adams DM. Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing. World Neurosurg. 2021 04; 148:e242-e251.
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Sears SM, Sharp CN, Krueger A, Oropilla GB, Saforo D, Doll MA, Megyesi J, Beverly LJ, Siskind LJ. C57BL/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury. Am J Physiol Renal Physiol. 2020 10 01; 319(4):F674-F685.
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Siddiqi A, Chaudhary FS, Naqvi HA, Saleh N, Farooqi R, Yousaf MN. Black esophagus: a syndrome of acute esophageal necrosis associated with active alcohol drinking. BMJ Open Gastroenterol. 2020 08; 7(1).
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Smith AK, Ropella GEP, McGill MR, Krishnan P, Dutta L, Kennedy RC, Jaeschke H, Hunt CA. Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms. PLoS Comput Biol. 2020 06; 16(6):e1007622.
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Garg PM, Bernieh A, Hitt MM, Kurundkar A, Adams KV, Blackshear C, Maheshwari A, Saad AG. Incomplete resection of necrotic bowel may increase mortality in infants with necrotizing enterocolitis. Pediatr Res. 2021 01; 89(1):163-170.
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Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293.
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Greene E, Flees J, Dhamad A, Alrubaye A, Hennigan S, Pleimann J, Smeltzer M, Murray S, Kugel J, Goodrich J, Robertson A, Wideman R, Rhoads D, Dridi S. Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis. Am J Pathol. 2019 10; 189(10):2077-2089.
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Kennedy RC, Smith AK, Ropella GEP, McGill MR, Jaeschke H, Hunt CA. Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange. Toxicol Sci. 2019 05 01; 169(1):151-166.
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Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease. Kidney Int. 2019 04; 95(4):797-814.
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Clemens MM, Kennon-McGill S, Apte U, James LP, Finck BN, McGill MR. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3? and Wnt/?-catenin signaling. Food Chem Toxicol. 2019 Mar; 125:279-288.
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Patel DM, Patel MV, Patel AD, Kaklotar JC, Patel GR, Patel MM. Non-uremic Calciphylaxis: A Rare and Late Adverse Reaction of Warfarin. Curr Drug Saf. 2019; 14(3):246-248.
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Myers CF, Ipe TS. Bone Marrow Necrosis in Sickle Cell-Beta Thalassemia Patient Mimicking Thrombotic Thrombocytopenic Purpura. Ann Clin Lab Sci. 2018 Sep; 48(5):670-673.
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McNamara DE, Quarato G, Guy CS, Green DR, Moldoveanu T. Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis. J Vis Exp. 2018 08 07; (138).
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Bhattarai D, Worku T, Dad R, Rehman ZU, Gong X, Zhang S. Mechanism of pattern recognition receptors (PRRs) and host pathogen interplay in bovine mastitis. Microb Pathog. 2018 Jul; 120:64-70.
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Kaidar-Person O, Zagar TM, Deal A, Moschos SJ, Ewend MG, Sasaki-Adams D, Lee CB, Collichio FA, Fried D, Marks LB, Chera BS. The incidence of radiation necrosis following stereotactic radiotherapy for melanoma brain metastases: the potential impact of immunotherapy. Anticancer Drugs. 2017 07; 28(6):669-675.
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Wilson SK, Mora-Estaves C, Egydio P, Ralph D, Habous M, Love C, Shamsodini A, Valenzuela R, Yafi FA. Glans Necrosis Following Penile Prosthesis Implantation: Prevention and Treatment Suggestions. Urology. 2017 Sep; 107:144-148.
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Muhs A, Lyles JT, Parlet CP, Nelson K, Kavanaugh JS, Horswill AR, Quave CL. Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models. Sci Rep. 2017 02 10; 7:42275.
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Ni HM, McGill MR, Chao X, Woolbright BL, Jaeschke H, Ding WX. Caspase Inhibition Prevents Tumor Necrosis Factor-a-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in?Vivo and in?Vitro. Am J Pathol. 2016 10; 186(10):2623-36.
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Weemhoff JL, Woolbright BL, Jenkins RE, McGill MR, Sharpe MR, Olson JC, Antoine DJ, Curry SC, Jaeschke H. Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. Liver Int. 2017 03; 37(3):377-384.
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Rosas-Hernandez H, Cuevas E, Lantz SM, Rice KC, Gannon BM, Fantegrossi WE, Gonzalez C, Paule MG, Ali SF. Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells. Neurosci Lett. 2016 08 26; 629:125-130.
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Trindade AJ, Inamdar S, Bitton S. Pediatric application of a lumen-apposing metal stent for transgastric pancreatic abscess drainage and subsequent necrosectomy. Endoscopy. 2016; 48 Suppl 1:E204-5.
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Dai L, Qiao J, Nguyen D, Struckhoff AP, Doyle L, Bonstaff K, Del Valle L, Parsons C, Toole BP, Renne R, Qin Z. Role of heme oxygenase-1 in the pathogenesis and tumorigenicity of Kaposi's sarcoma-associated herpesvirus. Oncotarget. 2016 Mar 01; 7(9):10459-71.
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Dickinson KJ, Blackmon SH. Management of Conduit Necrosis Following Esophagectomy. Thorac Surg Clin. 2015 Nov; 25(4):461-70.
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Woo JS, Fishbein MC, Reemtsen B. Histologic examination of decellularized porcine intestinal submucosa extracellular matrix (CorMatrix) in pediatric congenital heart surgery. Cardiovasc Pathol. 2016 Jan-Feb; 25(1):12-7.
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Slikker W, Liu F, Rainosek SW, Patterson TA, Sadovova N, Hanig JP, Paule MG, Wang C. Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells. Mol Neurobiol. 2015 Oct; 52(2):959-69.
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Martin S, Powell R, Ilyas M, Canon S. Use of appendix for renal transplant urinary diversion after complete transplant ureteral necrosis: a 12-year follow-up. Urology. 2015 Mar; 85(3):674-5.
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Klair JS, Abraham RR, Jones J, Girotra M. A 'shock-ing' endoscopic finding on esophagogastroduodenoscopy. BMJ Case Rep. 2015 Feb 09; 2015.
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Boils CL, Nasr SH, Walker PD, Couser WG, Larsen CP. Update on endocarditis-associated glomerulonephritis. Kidney Int. 2015 Jun; 87(6):1241-9.
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