 Immunoglobulin Class Switching
"Immunoglobulin Class Switching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
| Descriptor ID |
D017578
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| MeSH Number(s) |
G05.355.330.401.501.450 G12.425.742.500.501.450 G12.500.349.500.501.450
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| Concept/Terms |
Immunoglobulin Class Switching- Immunoglobulin Class Switching
- Class Switching, Immunoglobulin
- Class Switchings, Immunoglobulin
- Immunoglobulin Class Switchings
- Switching, Immunoglobulin Class
- Switchings, Immunoglobulin Class
- Class Switching
- Class Switchings
- Switching, Class
- Switchings, Class
- Isotype Switching
- Isotype Switchings
- Switching, Isotype
- Switchings, Isotype
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Class Switching".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Class Switching".
This graph shows the total number of publications written about "Immunoglobulin Class Switching" by people in UAMS Profiles by year, and whether "Immunoglobulin Class Switching" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2011 | 0 | 2 | 2 | | 2007 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Class Switching" by people in Profiles over the past ten years.
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Xu Y, Zhou H, Post G, Zan H, Casali P. Rad52 mediates class-switch DNA recombination to IgD. Nat Commun. 2022 02 21; 13(1):980.
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Patrick GJ, Liu H, Alphonse MP, Dikeman DA, Youn C, Otterson JC, Wang Y, Ravipati A, Mazhar M, Denny G, Ortines RV, Zhang E, Miller RJ, Dillen CA, Liu Q, Nolan SJ, Nguyen K, Marcello L, Do DC, Wier EM, Zhang Y, Caviness G, Klimowicz AC, Mierz DV, Fine JS, Sun G, Goldbach-Mansky R, Marusina AI, Merleev AA, Maverakis E, Garza LA, Milner JD, Gao P, Ramanujam M, Raymond EL, Archer NK, Miller LS. Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease. J Clin Invest. 2021 03 01; 131(5).
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