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Darin Jones

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCollege of Pharmacy, College of Provost
DivisionPharmaceutical Science
Address200 South Cedar
Mail Slot # 622
Little Rock AR 72202
Phone501-686-6496
ORCID ORCID Icon0000-0003-1581-3453 Additional info
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    Collapse Research 
    Collapse research activities and funding
    P01CA092584     (JONES, DARIN)Sep 1, 2018 - Aug 31, 2021
    NIH/Nat. Cancer Institute - Pass Through: University of California, Berkeley
    Structural Cell Biology of DNA Repair Machines
    Role: Principal Investigator

    R01CA200231     (JONES, DARIN)Sep 1, 2018 - Feb 28, 2021
    NIH/Nat. Cancer Institute - Pass Through: University of Texas Health Science Center at Houston
    Pharmacological Modulation of Poly (ADP-ribose) Metabolism
    Role: Principal Investigator

    R01GM047251     (JONES, DARIN)Aug 1, 2018 - Jul 31, 2022
    NIH/Nat. Inst. of General Medical Sciences - Pass Through: University of New Mexico
    Cellular Functions of Eukaryotic DNA Ligases
    Role: Principal Investigator

    R01CA200231     (AHMED, ZAMAL)Mar 7, 2016 - Feb 28, 2021
    NIH
    PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM
    Role: Co-Principal Investigator

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    1. Moiani D, Link TM, Brosey CA, Katsonis P, Lichtarge O, Kim Y, Joachimiak A, Ma Z, Kim IK, Ahmed Z, Jones DE, Tsutakawa SE, Tainer JA. An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol. 2021; 661:407-431. PMID: 34776222.
      View in: PubMed
    2. Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021 Aug; 7(32). PMID: 34348893.
      View in: PubMed
    3. Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL. An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. Prog Biophys Mol Biol. 2021 08; 163:143-159. PMID: 33675849.
      View in: PubMed
    4. Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186. PMID: 33636189.
      View in: PubMed
    5. Ordóñez PE, Mery DE, Sharma KK, Nemu S, Reynolds WF, Enriquez RG, Burns DC, Malagón O, Jones DE, Guzman ML, Compadre CM. Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine. Molecules. 2020 Oct 20; 25(20). PMID: 33092263.
      View in: PubMed
    6. Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 12 11; 10(1):5654. PMID: 31827085.
      View in: PubMed
    7. Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Erratum to "Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor" [DNA Repair 60C (2017) 29-39]. DNA Repair (Amst). 2018 01; 61:99. PMID: 29273192.
      View in: PubMed
    8. Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 12; 60:29-39. PMID: 29078112.
      View in: PubMed
    9. Ordóñez PE, Sharma KK, Bystrom LM, Alas MA, Enriquez RG, Malagón O, Jones DE, Guzman ML, Compadre CM. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22; 79(4):691-6. PMID: 27057812.
      View in: PubMed
    10. Franco FM, Jones DE, Harris PK, Han Z, Wildman SA, Jarvis CM, Janetka JW. Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem. 2015 May 15; 23(10):2328-43. PMID: 25882520.
      View in: PubMed
    11. Han Z, Harris PK, Jones DE, Chugani R, Kim T, Agarwal M, Shen W, Wildman SA, Janetka JW. Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer. ACS Med Chem Lett. 2014 Nov 13; 5(11):1219-24. PMID: 25408834.
      View in: PubMed
    12. Arhancet GB, Walker DP, Metz S, Fobian YM, Heasley SE, Carter JS, Springer JR, Jones DE, Hayes MJ, Shaffer AF, Jerome GM, Baratta MT, Zweifel B, Moore WM, Masferrer JL, Vazquez ML. Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett. 2013 Feb 15; 23(4):1114-9. PMID: 23260349.
      View in: PubMed
    13. Parlow JJ, Case BL, Dice TA, Fenton RL, Hayes MJ, Jones DE, Neumann WL, Wood RS, Lachance RM, Girard TJ, Nicholson NS, Clare M, Stegeman RA, Stevens AM, Stallings WC, Kurumbail RG, South MS. Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. J Med Chem. 2003 Sep 11; 46(19):4050-62. PMID: 12954058.
      View in: PubMed
    14. South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ. Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Bioorg Med Chem Lett. 2003 Jul 21; 13(14):2319-25. PMID: 12824026.
      View in: PubMed
    15. Davis MO, Hata DJ, Johnson SA, Jones DE, Harmata MA, Evans ML, Walker JC, Smith DS. Cloning, sequence, and expression of a blood group B active recombinant alpha-D-galactosidase from pinto bean (Phaseolus vulgaris). Biochem Mol Biol Int. 1997 Jul; 42(3):453-67. PMID: 9247703.
      View in: PubMed
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