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Srinivas Ayyadevara

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentGeriatrics, College of Medicine
DivisionGeriatrics Faculty
Address VA LR
629 Jack Stephens Drive
Mail Slot # 748
Little Rock AR 72205
Phone501-526-7004
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    Collapse Research Funds 
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    R01AG062254     (REIS, ROBERT)Sep 30, 2018 - May 31, 2023
    NIH/Nat. Inst. on Aging
    Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases
    Role: Co-Principal Investigator

    R01AG062254     (SHMOOKLER REIS, ROBERT JOSEPH)Sep 30, 2018 - May 31, 2023
    NIH/NIA
    Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases
    Role: Co-Principal Investigator

    R01AG028088     (ZIMNIAK, PIOTR)Feb 1, 2007 - Oct 31, 2012
    NIH/NIA
    Role of glutathione transferases in life span extension of C. elegans
    Role: Co-Investigator

    P01AG020641     (REIS, ROBERT)Feb 15, 2003 - Jan 31, 2008
    NIH/Nat. Inst. on Aging
    Metabolic Mechanisms Limiting and Protecting Longevity
    Role: Co-Investigator

    P01AG012411     (GRIFFIN, SUE TILTON)Aug 1, 1997 - May 31, 2021
    NIH/NIA
    Early Events in Alzheimer Pathogenesis
    Role: Co-Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Bowroju SK, Mainali N, Ayyadevara S, Penthala NR, Krishnamachari S, Kakraba S, Reis RJS, Crooks PA. Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aß Self-Aggregation and Metal Chelation-Induced Aß Aggregation. Molecules. 2020 Aug 08; 25(16). PMID: 32784464.
      View in: PubMed
    2. Kakraba S, Ayyadevara S, Penthala NR, Balasubramaniam M, Ganne A, Liu L, Alla R, Bommagani SB, Barger SW, Griffin WST, Crooks PA, Shmookler Reis RJ. A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease. Front Mol Neurosci. 2019; 12:310. PMID: 31920540.
      View in: PubMed
    3. Balasubramaniam M, Ayyadevara S, Ganne A, Kakraba S, Penthala NR, Du X, Crooks PA, Griffin ST, Shmookler Reis RJ. Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases. iScience. 2019 Oct 25; 20:248-264. PMID: 31593839.
      View in: PubMed
    4. Tarkhov AE, Alla R, Ayyadevara S, Pyatnitskiy M, Menshikov LI, Shmookler Reis RJ, Fedichev PO. A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories. Sci Rep. 2019 05 14; 9(1):7368. PMID: 31089188.
      View in: PubMed
    5. Ayyadevara S, Ganne A, Hendrix RD, Balasubramaniam M, Shmookler Reis RJ, Barger SW. Functional assessments through novel proteomics approaches: Application to insulin/IGF signaling in neurodegenerative disease'. J Neurosci Methods. 2019 05 01; 319:40-46. PMID: 30412730.
      View in: PubMed
    6. Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ. Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2. Sci Rep. 2018 10 05; 8(1):14891. PMID: 30291272.
      View in: PubMed
    7. Parcon PA, Balasubramaniam M, Ayyadevara S, Jones RA, Liu L, Shmookler Reis RJ, Barger SW, Mrak RE, Griffin WST. Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs. Alzheimers Dement. 2018 02; 14(2):230-242. PMID: 28945989.
      View in: PubMed
    8. Balasubramaniam M, Reis RJS, Ayyadevara S, Wang X, Ganne A, Khaidakov M. Involvement of tRNAs in replication of human mitochondrial DNA and modifying effects of telomerase. Mech Ageing Dev. 2017 09; 166:55-63. PMID: 28765009.
      View in: PubMed
    9. Ayyadevara S, Balasubramaniam M, Kakraba S, Alla R, Mehta JL, Shmookler Reis RJ. Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation. Antioxid Redox Signal. 2017 Dec 10; 27(17):1383-1396. PMID: 28537433.
      View in: PubMed
    10. Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D. Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2017 03 01; 312(3):F516-F532. PMID: 28052876.
      View in: PubMed
    11. Ayyadevara S, Balasubramaniam M, Suri P, Mackintosh SG, Tackett AJ, Sullivan DH, Shmookler Reis RJ, Dennis RA. Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans. Aging (Albany NY). 2016 12 15; 8(12):3486-3497. PMID: 27992858.
      View in: PubMed
    12. Ayyadevara S, Balasubramaniam M, Johnson J, Alla R, Mackintosh SG, Shmookler Reis RJ. PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans. Oncotarget. 2016 Aug 02; 7(31):48870-48886. PMID: 27429199.
      View in: PubMed
    13. Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ. Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging Cell. 2016 10; 15(5):924-39. PMID: 27448508.
      View in: PubMed
    14. Ayyadevara S, Mercanti F, Wang X, Mackintosh SG, Tackett AJ, Prayaga SV, Romeo F, Shmookler Reis RJ, Mehta JL. Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles. Hypertension. 2016 May; 67(5):1006-13. PMID: 26975704.
      View in: PubMed
    15. Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ. A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. . 2016 Feb; 15(2):241-50. PMID: 26719576.
      View in: PubMed
    16. Alagpulinsa DA, Yaccoby S, Ayyadevara S, Shmookler Reis RJ. A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment. . 2015; 16(6):976-86. PMID: 25996477.
      View in: PubMed
    17. Ayyadevara S, Balasubramaniam M, Gao Y, Yu LR, Alla R, Shmookler Reis R. Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Aging Cell. 2015 Feb; 14(1):35-48. PMID: 25510159.
      View in: PubMed
    18. Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol. 2014; 4:289. PMID: 25401086.
      View in: PubMed
    19. Ayyadevara S, Tazearslan C, Alla R, Jiang JC, Jazwinski SM, Shmookler Reis RJ. Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae. Front Genet. 2014; 5:211. PMID: 25136348.
      View in: PubMed
    20. Bharill P, Ayyadevara S, Alla R, Shmookler Reis RJ. Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants. Front Genet. 2013; 4:34. PMID: 23543623.
      View in: PubMed
    21. Ayyadevara S, Bharill P, Dandapat A, Hu C, Khaidakov M, Mitra S, Shmookler Reis RJ, Mehta JL. Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Antioxid Redox Signal. 2013 Feb 10; 18(5):481-90. PMID: 22866967.
      View in: PubMed
    22. Li S, Nagothu K, Ranganathan G, Ali SM, Shank B, Gokden N, Ayyadevara S, Megyesi J, Olivecrona G, Chugh SS, Kersten S, Portilla D. Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F437-48. PMID: 22622461.
      View in: PubMed
    23. Nedosekin DA, Galanzha EI, Ayyadevara S, Shmookler Reis RJ, Zharov VP. Photothermal confocal spectromicroscopy of multiple cellular chromophores and fluorophores. Biophys J. 2012 Feb 08; 102(3):672-81. PMID: 22325291.
      View in: PubMed
    24. Shmookler Reis RJ, Ayyadevara S, Crow WA, Lee T, Delongchamp RR. Gene categories differentially expressed in C. elegans age-1 mutants of extraordinary longevity: new insights from novel data-mining procedures. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):366-75. PMID: 22021389.
      View in: PubMed
    25. Vertino A, Ayyadevara S, Thaden JJ, Shmookler Reis RJ. A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat. Front Genet. 2011; 2:63. PMID: 22303358.
      View in: PubMed
    26. Mitra S, Khaidakov M, Lu J, Ayyadevara S, Szwedo J, Wang XW, Chen C, Khaidakov S, Kasula SR, Stone A, Pogribny I, Mehta JL. Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation. . 2011 Aug; 301(2):H506-13. PMID: 21602467.
      View in: PubMed
    27. Shmookler Reis RJ, Xu L, Lee H, Chae M, Thaden JJ, Bharill P, Tazearslan C, Siegel E, Alla R, Zimniak P, Ayyadevara S. Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging (Albany NY). 2011 Feb; 3(2):125-47. PMID: 21386131.
      View in: PubMed
    28. Khaidakov M, Szwedo J, Mitra S, Ayyadevara S, Dobretsov M, Lu J, Mehta JL. Antiangiogenic and antimitotic effects of aspirin in hypoxia–reoxygenation modulation of the LOX-1-NADPH oxidase axis as a potential mechanism. J Cardiovasc Pharmacol. 2010 Dec; 56(6):635-41. PMID: 20881612.
      View in: PubMed
    29. Johnson CH, Ayyadevara S, McEwen JE, Shmookler Reis RJ. Histoplasma capsulatum and Caenorhabditis elegans: a simple nematode model for an innate immune response to fungal infection. Med Mycol. 2009 Dec; 47(8):808-13. PMID: 20028234.
      View in: PubMed
    30. Ayyadevara S, Tazearslan C, Bharill P, Alla R, Siegel E, Shmookler Reis RJ. Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan. Aging Cell. 2009 Dec; 8(6):706-25. PMID: 19764929.
      View in: PubMed
    31. Shmookler Reis RJ, Bharill P, Tazearslan C, Ayyadevara S. Extreme-longevity mutations orchestrate silencing of multiple signaling pathways. Biochim Biophys Acta. 2009 Oct; 1790(10):1075-83. PMID: 19465083.
      View in: PubMed
    32. Tazearslan C, Ayyadevara S, Bharill P, Shmookler Reis RJ. Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance. PLoS Genet. 2009 Apr; 5(4):e1000452. PMID: 19360094.
      View in: PubMed
    33. Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell. 2008 Jan; 7(1):13-22. PMID: 17996009.
      View in: PubMed
    34. Ayyadevara S, Dandapat A, Singh SP, Siegel ER, Shmookler Reis RJ, Zimniak L, Zimniak P. Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. Mech Ageing Dev. 2007 Feb; 128(2):196-205. PMID: 17157356.
      View in: PubMed
    35. Shmookler Reis RJ, Kang P, Ayyadevara S. Quantitative trait loci define genes and pathways underlying genetic variation in longevity. Exp Gerontol. 2006 Oct; 41(10):1046-54. PMID: 16919411.
      View in: PubMed
    36. Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ, Zimniak P. Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. Aging Cell. 2005 Dec; 4(6):299-307. PMID: 16300482.
      View in: PubMed
    37. Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Benes H, Shmookler Reis RJ, Liebau E, Zimniak P. Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. Aging Cell. 2005 Oct; 4(5):257-71. PMID: 16164425.
      View in: PubMed
    38. Ayyadevara S, Ayyadevara R, Vertino A, Galecki A, Thaden JJ, Shmookler Reis RJ. Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms. Genetics. 2003 Feb; 163(2):557-70. PMID: 12618395.
      View in: PubMed
    39. Ayyadevara S, Ayyadevara R, Hou S, Thaden JJ, Shmookler Reis RJ. Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross. Genetics. 2001 Feb; 157(2):655-66. PMID: 11156986.
      View in: PubMed
    40. Ayyadevara S, Thaden JJ, Shmookler Reis RJ. Anchor polymerase chain reaction display: a high-throughput method to resolve, score, and isolate dimorphic genetic markers based on interspersed repetitive DNA elements. Anal Biochem. 2000 Aug 15; 284(1):19-28. PMID: 10933851.
      View in: PubMed
    41. Ayyadevara S, Thaden JJ, Shmookler Reis RJ. Discrimination of primer 3'-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction. Anal Biochem. 2000 Aug 15; 284(1):11-8. PMID: 10933850.
      View in: PubMed
    42. Cherkasova V, Ayyadevara S, Egilmez N, Shmookler Reis R. Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults. J Mol Biol. 2000 Jul 14; 300(3):433-48. PMID: 10884342.
      View in: PubMed
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