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Alexandra Nicaise

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCOM | Neuro & Devel Sci Faculty
Address4301 W Markham
Little Rock AR 72205
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Ionescu RB, Reisz JA, Dzieciatkowska M, Stephenson D, Nicaise AM, Prasad P, Willis CM, Cubero MS, Peruzzotti-Jametti L, Edenhofer F, Frezza C, Pluchino S, D'Alessandro A. Protocol for stable isotopic tracing to assess cellular lipogenic activity in induced neural stem cells. STAR Protoc. 2026 Mar 20; 7(1):104309. PMID: 41485224.
      View in: PubMed
    2. Park B, Nicaise AM, Tsitsipatis D, Pirvan L, Zucha D, Munteanu A, Prasad P, De Novales MLL, Bulgaru C, Kollyfas R, Whitten J, Willis CM, Culig L, Llewellyn J, Ionescu RB, Mekdad M, Sim?es-Abade MBC, Krzak G, Fan J, De S, Ellis MO, Cubero MS, Spathopoulou A, Peruzzotti-Jametti L, Leonardi T, Balmus G, Edenhofer F, Gorospe M, Valihrach L, Mohorianu I, Pluchino S, Beerman I. Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis. Neuron. 2025 Dec 17; 113(24):4158-4177.e10. PMID: 41075785.
      View in: PubMed
    3. Peruzzotti-Jametti L, Vicario N, Volpe G, Rizzi S, Kwok C, Lombardi I, Bergholt MS, Barea-Moya L, D'Angelo A, Nicaise AM, D'Amico G, Krzak G, Willis CM, Gil-Perotin S, Hruba O, Braga A, Stevens MM, Garcia-Verdugo JM, Saeb-Parsy K, Zhao C, Franklin RJM, Edenhofer F, Pluchino S. Remyelination of chronic demyelinated lesions with directly induced neural stem cells. Brain. 2025 Oct 03; 148(10):3505-3513. PMID: 40622272.
      View in: PubMed
    4. Sim?es-Abade MBC, Patterer M, Nicaise AM, Pluchino S. Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis. Front Cell Neurosci. 2024; 18:1488691. PMID: 39744673.
      View in: PubMed
    5. Ionescu RB, Nicaise AM, Reisz JA, Williams EC, Prasad P, Willis CM, Sim?es-Abade MBC, Sbarro L, Dzieciatkowska M, Stephenson D, Suarez Cubero M, Rizzi S, Pirvan L, Peruzzotti-Jametti L, Fossati V, Edenhofer F, Leonardi T, Frezza C, Mohorianu I, D'Alessandro A, Pluchino S. Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis. Cell Stem Cell. 2024 Nov 07; 31(11):1574-1590.e11. PMID: 39437792.
      View in: PubMed
    6. Sutter PA, Willis CM, Menoret A, Nicaise AM, Sacino A, Sikkema AH, Jellison ER, Win KK, Han DK, Church W, Baron W, Vella AT, Crocker SJ. Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses. Proc Natl Acad Sci U S A. 2024 Jan 30; 121(5):e2306816121. PMID: 38266047.
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    7. Sutter PA, M?noret A, Jellison ER, Nicaise AM, Bradbury AM, Vella AT, Bongarzone ER, Crocker SJ. CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy. J Exp Med. 2023 09 04; 220(9). PMID: 37310382.
      View in: PubMed
    8. Bernstock JD, Willis CM, Garcia-Segura ME, Gaude E, Anni D, Lee YJ, Thomas LW, Casey A, Vicario N, Leonardi T, Nicaise AM, Gessler FA, Izzy S, Buffelli MR, Seidlitz J, Srinivasan S, Murphy MP, Ashcroft M, Cambiaghi M, Hallenbeck JM, Peruzzotti-Jametti L. Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance. bioRxiv. 2023 Mar 30. PMID: 37205496.
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    9. Sutter PA, Willis CM, Menoret A, Nicaise AM, Sacino A, Sikkema AH, Jellison E, Win KK, Han DK, Church W, Baron W, Vella AT, Crocker SJ. Astrocytic TIMP-1 regulates production of Anastellin, a novel inhibitor of oligodendrocyte differentiation and FTY720 responses. bioRxiv. 2023 Feb 18. PMID: 36824834.
      View in: PubMed
    10. Willis CM, Nicaise AM, Krzak G, Ionescu RB, Pappa V, D'Angelo A, Agarwal R, Repoll?s-de-Dalmau M, Peruzzotti-Jametti L, Pluchino S. Soluble factors influencing the neural stem cell niche in brain physiology, inflammation, and aging. Exp Neurol. 2022 09; 355:114124. PMID: 35644426.
      View in: PubMed
    11. Nicaise AM, D'Angelo A, Ionescu RB, Krzak G, Willis CM, Pluchino S. The role of neural stem cells in regulating glial scar formation and repair. Cell Tissue Res. 2022 Mar; 387(3):399-414. PMID: 34820704.
      View in: PubMed
    12. Smith JA, Nicaise AM, Ionescu RB, Hamel R, Peruzzotti-Jametti L, Pluchino S. Stem Cell Therapies for Progressive Multiple Sclerosis. Front Cell Dev Biol. 2021; 9:696434. PMID: 34307372.
      View in: PubMed
    13. Pluchino S, Nicaise AM. NSCs: Sentinel Cells of the Brain. Cell Stem Cell. 2021 02 04; 28(2):177-179. PMID: 33545074.
      View in: PubMed
    14. Willis CM, Nicaise AM, Hamel R, Pappa V, Peruzzotti-Jametti L, Pluchino S. Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology. Front Cell Neurosci. 2020; 14:590960. PMID: 33250716.
      View in: PubMed
    15. Nicaise AM, Willis CM, Crocker SJ, Pluchino S. Stem Cells of the Aging Brain. Front Aging Neurosci. 2020; 12:247. PMID: 32848716.
      View in: PubMed
    16. Willis CM, Nicaise AM, Bongarzone ER, Givogri M, Reiter CR, Heintz O, Jellison ER, Sutter PA, TeHennepe G, Ananda G, Vella AT, Crocker SJ. Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age. Sci Rep. 2020 01 21; 10(1):828. PMID: 31964978.
      View in: PubMed
    17. Willis CM, Nicaise AM, Peruzzotti-Jametti L, Pluchino S. The neural stem cell secretome and its role in brain repair. Brain Res. 2020 02 15; 1729:146615. PMID: 31863730.
      View in: PubMed
    18. Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. Systemic TLR2 tolerance enhances central nervous system remyelination. J Neuroinflammation. 2019 Jul 27; 16(1):158. PMID: 31351476.
      View in: PubMed
    19. Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10488-10493. PMID: 31068461.
      View in: PubMed
    20. Nicaise AM, Wagstaff LJ, Willis CM, Paisie C, Chandok H, Robson P, Fossati V, Williams A, Crocker SJ. Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):9030-9039. PMID: 30910981.
      View in: PubMed
    21. Nicaise AM, Johnson KM, Willis CM, Guzzo RM, Crocker SJ. TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling. Mol Neurobiol. 2019 May; 56(5):3380-3392. PMID: 30121936.
      View in: PubMed
    22. Willis CM, M?noret A, Jellison ER, Nicaise AM, Vella AT, Crocker SJ. A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma. Front Neurosci. 2017; 11:335. PMID: 28663721.
      View in: PubMed
    23. Nicaise AM, Banda E, Guzzo RM, Russomanno K, Castro-Borrero W, Willis CM, Johnson KM, Lo AC, Crocker SJ. iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response. Exp Neurol. 2017 Feb; 288:114-121. PMID: 27865736.
      View in: PubMed
    24. Nicaise AM, Bongarzone ER, Crocker SJ. A microglial hypothesis of globoid cell leukodystrophy pathology. J Neurosci Res. 2016 11; 94(11):1049-61. PMID: 27638591.
      View in: PubMed
    25. Claycomb KI, Winokur PN, Johnson KM, Nicaise AM, Giampetruzzi AW, Sacino AV, Snyder EY, Barbarese E, Bongarzone ER, Crocker SJ. Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions. J Neuropathol Exp Neurol. 2014 Oct; 73(10):964-74. PMID: 25192051.
      View in: PubMed
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