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Fang Zheng

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
Address306C Biomedical Research I
325 S. Elm St.
Mail Slot # 611
Little Rock AR 72205
Phone501-686-7632
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    Collapse Affiliation 
    Collapse member of
    Society for Neuroscience
    ASPET

    Collapse Research 
    Collapse research overview
    I have a long-standing interest in the pathophysiology of epilepsy and stroke. Initially trained as a channel biophysicist, I have also acquired experience and knowledge in molecular biology, biochemistry and pharmacology over the years. This allows me to adopt a multidisciplinary approach in my research. I have a equally long-standing interest in the functional roles of metabotropic glutamate receptor (mGluR), and this interest has led to my recent focus on transient receptor potential (TRPC) channels for the last 6 years. We have demonstrated the unique roles of various TRPC family members in seizure and excitotoxicity.

    Collapse research activities and funding
    R01NS126473     (ZHENG, FANG)Mar 1, 2023 - Feb 29, 2028
    NIH
    The role of the endothelial NPYR1-TRPC3-ET1 signaling axis in neurovascular coupling dysfunction
    Role: Principal Investigator
    R01NS126473     (PHELAN, KEVIN D)Mar 1, 2023 - Feb 29, 2028
    NIH/Nat. Inst. of Neurological Disorders & Stroke
    The role of the endothelial NPYR1-TRPC3-ET1 signaling axis in neurovascular coupling dysfunction
    Role: Principal Investigator
    R03NS116498     (ZHENG, FANG)May 1, 2020 - Oct 31, 2021
    NIH
    The Role of Endothelial TRPC3 Channels in Neurovascular Coupling
    Role: Principal Investigator
    DEAP FY20     (ZHENG, FANG)Jul 22, 2019 - Jul 21, 2020
    UAMS Internal Research Awards
    No FP attached
    Role: Principal Investigator
    DEAPFY20     (ZHENG, FANG)Jul 22, 2019 - Jul 21, 2020
    UAMS Internal Research Awards
    No FP attached
    Role: Principal Investigator
    UAMS/COM-Stroke Foundation     (ZHENG, FANG)Jul 1, 2016 - Jun 30, 2018
    UAMS Stroke - Foundation
    The role of TRPC3 channels in periinfarct depression and stroke
    Role: Principal Investigator
    UAMS/COM-StrokeFoundation     (ZHENG, FANG)Jul 1, 2016 - Jun 30, 2018
    UAMS Stroke - Foundation
    The role of TRPC3 channels in periinfarct depression and stroke
    Role: Principal Investigator
    Research Council Award     (ZHENG, FANG)Nov 20, 2015 - Dec 20, 2018
    UAMS College of Medicine
    The role of TRPC3 channels in neurovascular coupling and peri-infarct depression
    Role: Principal Investigator
    ResearchCouncilAward     (ZHENG, FANG)Nov 20, 2015 - Dec 20, 2018
    UAMS College of Medicine
    The role of TRPC3 channels in neurovascular coupling and peri-infarct depression
    Role: Principal Investigator
    R01NS058503     (ZHENG, FANG)Jul 16, 2009 - Jun 30, 2013
    NIH
    Canonical Transient Receptor Potential Channels and Excitotoxicity
    Role: Principal Investigator
    R03NS050381     (ZHENG, FANG)Jan 1, 2006 - Dec 31, 2008
    NIH
    METABOTROPIC GLUTAMATE RECEPTORS AND EXCITOTOXICITY
    Role: Principal Investigator
    P30NS047546     (DREW, PAUL D)Aug 15, 2004 - Jul 31, 2010
    NIH
    Neuroscience Research Center Core Facility at UAMS
    Role: Co-Investigator
    R01NS039418     (ZHENG, FANG)Dec 1, 1999 - Apr 30, 2013
    NIH
    ZINC-DEPENDENT APPARENT DESENSITIZATION OF NMDA RECEPTOR
    Role: Principal Investigator
    F32NS010193     (ZHENG, FANG)Dec 1, 1996
    NIH
    MODULATION OF NMDA RECEPTORS BY TYROSINE KINASES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Zheng F, Phelan KD, Shwe UT. Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice. Neurol Int. 2023 Dec 06; 15(4):1469-1479. PMID: 38132974.
      View in: PubMed
    2. Phelan KD, Shwe UT, Zheng F. Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons. Pharmaceuticals (Basel). 2023 Sep 13; 16(9). PMID: 37765099.
      View in: PubMed
    3. Zheng F. Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice. Int J Mol Sci. 2023 Aug 09; 24(16). PMID: 37628789.
      View in: PubMed
    4. Wilson CD, Zheng F, Fantegrossi WE. Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice. Psychopharmacology (Berl). 2022 Oct; 239(10):3237-3248. PMID: 35933518.
      View in: PubMed
    5. Cozart MA, Phelan KD, Wu H, Mu S, Birnbaumer L, Rusch NJ, Zheng F. Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus. Sci Rep. 2020 01 21; 10(1):812. PMID: 31964991.
      View in: PubMed
    6. Zheng F, Mu S, Rusch NJ. Leptin Activates Trpm7 Channels in the Carotid Body As a Mechanism of Obesity-Related Hypertension. Circ Res. 2019 11 08; 125(11):1003-1005. PMID: 31697634.
      View in: PubMed
    7. Zheng F. TRPC Channels and Epilepsy. Adv Exp Med Biol. 2017; 976:123-135. PMID: 28508318.
      View in: PubMed
    8. Phelan KD, Shwe UT, Cozart MA, Wu H, Mock MM, Abramowitz J, Birnbaumer L, Zheng F. TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice. Epilepsia. 2017 02; 58(2):247-254. PMID: 28012173.
      View in: PubMed
    9. Phelan KD, Shwe UT, Williams DK, Greenfield LJ, Zheng F. Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. Epilepsy Res. 2015 Nov; 117:90-6. PMID: 26432759.
      View in: PubMed
    10. Phelan KD, Shwe UT, Abramowitz J, Birnbaumer L, Zheng F. Critical role of canonical transient receptor potential channel 7 in initiation of seizures. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11533-8. PMID: 25049394.
      View in: PubMed
    11. Zheng F, Phelan KD. The role of canonical transient receptor potential channels in seizure and excitotoxicity. Cells. 2014 Apr 09; 3(2):288-303. PMID: 24722470.
      View in: PubMed
    12. Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol. 2013 Feb; 83(2):429-38. PMID: 23188715.
      View in: PubMed
    13. Pathan AR, Bowlin BM, Machaca K, Abramowitz J, Zheng F, Rusch NJ. Phenylephrine-induced current and vasoconstriction are blunted in mesenteric arteries of TRPC3 knockout mice. Experimental Biology. 2012.
    14. Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A, Birnbaumer L, Freichel M, Flockerzi V, Zheng F. Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol Pharmacol. 2012 Mar; 81(3):384-92. PMID: 22144671.
      View in: PubMed
    15. Zheng F, Phelan KD, Mock MM, Shwe UT, Valenzuela E. Exploring the role of the high affinity zinc site of the NMDA receptor using an NR2AH128A knockin mouse model. Society for Neuroscience. 2010.
    16. Phelan KD, Mock MM, Shwe UT, Valenzuela E, Wu H, Rhee S, Abramowitz J, Birnbaumer L, Zheng F. The role of TRPC3 in excitotoxicity in the mouse hippocampus. Society for Neuroscience. 2010.
    17. Douglas J. Sheffler, Richard Williams, Thomas M. Bridges, Zixiu Xiang, Alexander S. Kane, Nellie E. Byun, Zheng F, L. Michelle Lewis, Carrie K. Jones, Colleen M. Niswender, Charles D. Weaver, Craig W. Lindsley, P. Jeffrey Conn. A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 (M1 mAChR) Antagonist Reduces Seizures Without Impairing Hippocampal-Dependent Learning. Mol. Pharmacol. 2009; 76(2):356-368 (PMID:19407080).
    18. Weaver CD, Sheffler DJ, Lewis LM, Bridges TM, Williams R, Nalywajko NT, Kennedy JP, Mulder MM, Jadhav S, Aldrich LA, Jones CK, Marlo JE, Niswender CM, Mock MM, Zheng F, Conn PJ, Lindsley CW. Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe. Curr Top Med Chem. 2009; 9(13):1217-1226 (PMID:19807667).
    19. Phelan KD, Mock M, Deitrich A, Birnbaumer L, Zheng F. The role of TRPC1 in mGluR agonist-induced epileptic burst firing and seizure-induced neuronal cell death in the mouse lateral septum. Society for Neuroscience. 2008.
    20. Zheng F, Phelan KD. Pharmacological properties of metabotropic glutamate receptors that mediate epileptic firing in rat lateral septum. Society for Neuroscience. 2007.
    21. Zheng F. The role of the NR1 subunit in zinc-dependent desensitization of NR1/NR2A receptors. Society of Neuroscience. 2006.
    22. Hu B, Zheng F. Molecular determinants of glycine-independent desensitization of NR1/NR2A receptors. J Pharmacol Exp Ther. 2005 May; 313(2):563-9. PMID: 15650113.
      View in: PubMed
    23. Hu B, Zheng F. Fast zinc-dependent desensitization of a chimeric NR2A/NR2B receptor. Society for Neuroscience. 2005.
    24. Hu B, Zheng F. Differential effects on current kinetics by point mutations in the lurcher motif of NR1/NR2A receptors. J Pharmacol Exp Ther. 2005 Mar; 312(3):899-904. PMID: 15501991.
      View in: PubMed
    25. HU B, Zheng F. Molecular determinants of glycine-independent desensitization of NMDA receptors. Society for Neuroscience. 2004.
    26. Low CM, Lyuboslavsky P, French A, Le P, Wyatte K, Thiel WH, Marchan EM, Igarashi K, Kashiwagi K, Gernert K, Williams K, Traynelis SF, Zheng F. Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating. Mol Pharmacol. 2003 Jun; 63(6):1212-22. PMID: 12761330.
      View in: PubMed
    27. Low CM, Lyuboslavsky P, French A, Lee P, Wyatte K, Thiel WH, Marchan E, Igarashi K, Kashiwagi K, Gernert K, Williams K, Traynelis SF, Zheng F. Molecular determinants of proton sensitive NMDA receptor gating. Mol Pharmacol. 2003; 63(6):1212-1222 (PMID:12761330).
    28. Zheng F, Hu B. Alteration of deactivation of NR1/NR2A receptors by point mutations in the Lurcher motif. Society for Neuroscience. 2003.
    29. French A, Le P, Lyuboslavsky P, Wyatte C, Gernert KM, Neyton J, Paoletti P, Low CM, Williams K, Traynelis SF, Zheng F. Contol of NMDA receptor proton sensitivity by residues in the lurcher motif. Society for Neuroscience. 2002.
    30. Herin GA, Zheng F, Le P, Aizenman E. Evidence for an interaction between N-terminal redox sensitive cysteines and a polyamine modulatory site of the NR1/NR2A NMDA receptor. Society for Neuroscience. 2002.
    31. Zheng F, Erreger K, Low CM, Banke T, Lee J, Conn PJ, Traynelis SF. Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nat Neurosci. 2001; 4(9):894-901 (PMID:11528420).
    32. Lyuboslavsky P, Thiel B, Paoletti P, Neyton J, Zheng F, Traynelis SF. Control of H+ sensitivity by residues in the linker region of S2 domain of the NR2 subunits. Society for Neuroscience. 2001.
    33. Erreger K, Zheng F, Traynelis SF. An allosteric interaction between the glutamate and zinc binding sites causes fast desensitization of NR1/NR2A NMDA receptors. Society for Neuroscience. 2001.
    34. Low CM, Zheng F, Lyuboslavsky P, Traynelis SF. Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors. Proc Nat Acasd Sci. 2000; 97(20):11062-11067 (PMID:10984504).
    35. Low CM, Zheng F, Lyuboslavsky P, Traynelis SF. The apparent high-affinity zinc inhibition of recombinant NR1/NR2A receptors is due to enhancement of proton inhibition. Society for Neuroscience. 2000.
    36. Zheng F, Marino M, Conn PJ. A highly conserved tyrosine residue near TM4 of NR2A is phosphorylated by non-receptor tyrosine kinase src. Society for Neuroscience. 2000.
    37. Zheng F, Conn PJ, Traynelis SF. Zinc-dependent desensitization of NR1/NR2A receptors. Society for Neuroscience. 1999.
    38. Traynelis SF, Burgess MF, Zheng F, Lyuboslavsky P, Powers JL. Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit. J Neurosci. 1998; 18(16):6163-6175 (PMID:9698310).
    39. Zheng F, Gingrich MB, Traynellis SF, Conn PJ. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat Neurosci. 1998; 1(3):185-191 (PMID:10195142).
    40. Zheng F, Traynelis SF, Conn PJ. Reduction of zinc sensitivity of recombinant NR1/NR2A and NR1/NR2B receptors by non-receptor tyrosine kinase src. Society for Neuroscience. 1998.
    41. Zheng F, Gingrich MB, Traynellis SF, Conn PJ. Modulation of recombinant NMDA receptor by non-receptor tyrosine kinase src in HEK293 cells. Society for Neuroscience. 1997.
    42. Zheng F, Gallagher JP, Connor JA. Activation of a metabotropic excitatory amino acid receptor potentiates spike-driven calcium increases in neurons of the dorsolateral septum. J Neurosci. 1996; 16(19):6079-6088 (PMID:8815890).
    43. Zheng F, Hasuo H, Gallagher JP. 1S,3R-ACPD-preferring inward current in rat dorsolateral septal neurons is mediated by a novel excitatory amino acid receptor. Neuropharmacology. 1995; 34(8):905-917 (PMID:8532172).
    44. Gallagher JP, Zheng F, Hasuo H, Shinnick-Gallagher P. Activities of neurons within the rat dorsolateral septal nucleus (DLSN). Prog Neurobiol. 1995; 45(5):373-395 (PMID:7617889).
    45. Zheng F, Connor JA. 1S,3R-ACPD increases intracellular calcium levels in rat dorsolateral septal nucleus (DLSN) neurons. Society for Neuroscience. 1995.
    46. Zheng F, Gallagher JP. A native pertussis toxin-sensitive metabotropic glutamate receptor at rat dorsolateral septal nucleus. Neuroscience. 1995; 68:423-434.
    47. Zheng F, Gallagher JP. Pharmacologically distinct, pertussis toxin-resistant inward currents evoked by metabotropic glutamate receptor (mGluR) agonists in rat dorsolateral septal nucleus neurons. J Neurosci. 1995; 15(1 Pt 2):504-510 (PMID:7823158).
    48. Zheng F, Hasuo H, Gallagher JP. A novel ACPD-current in rat central nervous system. Society for Neuroscience. 1994.
    49. Zheng F, Lonart G, Johnson KM, Gallagher JP. (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced burst firing is mediated by a native pertussis toxin-sensitive metabotropic receptor at rat dorsolateral septal nucleus neurons. Neuropharmacology. 1994; 33(1):97-102 (PMID:8183442).
    50. Zheng F, Gallagher JP. Pertussis toxin selectively blocked burst firing induced by 1S,3R-ACPD at rat dorsolateral septal nucleus neurons. Society for Neuroscience. 1993.
    51. Gallagher JP, Zheng F. Distinct subtypes of pertussis toxin?resistant metabotropic glutamate receptors at rat dorsolateral septal nucleus neurons. Society for Neuroscience. 1993.
    52. Zheng F, Gallagher JP. Metabotropic glutamate receptor agonists potentiate a slow afterdepolarization in CNS neurons. Neuroreport. 1992; 3(7):622-624 (PMID:1358255).
    53. Zheng F, Gallagher JP. Metabotropic glutamate receptors are required for the induction of long-term potentiation. Neuron. 1992; 9(1):163-172 (PMID:1352982).
    54. Zheng F, Gallagher JP. Burst firing of rat septal neurons induced by 1S,3R-ACPD requires influx of extracellular calcium. Eur J Pharmacol. 1992; 211(2):281-282 (PMID:1319344).
    55. Zheng F, Gallagher JP. Calcium release from internal stores is required for the met-GluR-dependent LTP in DLSN neurons in vitro. Society for Neuroscience. 1992.
    56. Zheng F, Gallagher JP. Trans-ACPD (trans-D,L-1-amino-1,3-cyclopentanedicarboxylic acid) elicited oscillation of membrane potentials in rat dorsolateral septal nucleus neurons recorded intracellularly in vitro. Neurosci Lett. 1991; 125(2):147 - 150 (PMID:1881593).
    57. Zheng F, Gallagher JP. Long-lasting modulation of synaptic transmission by a selective metabotropic glutamate receptor agonist in dorsolateral septal nucleus (DLSN) neurons in vitro. Society For Neuroscience. 1991.
    58. Zheng F, Gallagher JP. Long-term potentiation (LTP) in rat dorsal lateral septal nucleus (DLSN) is not blocked by D,L-2-amino-5-phosphonopentanoate (AP5). Society for Neuroscience. 1990.
    59. Pathan AR, Bowlin BM, Birnbaumer L, Zheng F, Rusch NJ. Genetic deletion of the TRPC3 channel blunts the development of angiotensin II-induced hypertension in mice. Experimental Biology.
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