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Nirmala Parajuli

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
Address118 Biomedical Research I
325 S. Elm St.
Mail Slot # 611
Little Rock AR 72205
Phone501-686-5290
ORCID ORCID Icon0000-0003-3994-5338 Additional info
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPharmacology and Toxicology, College of Medicine


    Collapse Overview 
    Collapse overview
    My primary research priority is to identify strategies to enhance the viability of kidneys during prolonged cold storage in order to ensure the long-term survival of renal transplants. My research focuses on exploring novel mechanisms by which cold storage alters protein quality and renal function after transplantation, and importantly, to identify a possible therapeutic target that could lead to improved renal outcome after transplantation. Specifically, my laboratory investigates the roles of proteasome, heat shock proteins and complement pathway during cold storage followed by transplantation using rat models.


    Collapse Affiliation 
    Collapse member of
    Nepal Veterinary Association

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Director of Graduate Pharmacology and Therapeutics (PCOL 5107)

    Member of Graduate Council, UAMS

    Member of Institutional Animal Care and Use Committee, UAMS

    Collapse education and training
    Innsbruck Medical University, Innsbruck, AustriaPhD2009Molecular Cell Biology and Oncology
    Seoul National University, Seol, KoreaMS2005Veterinary Immunology
    Tribuwan University, Rampur, NepalBVSc & AH (equivalent to DVM)2001Veterinary Medicine
    University of Arkansas for Medical Sciences, Little Rock, AR, USAPostdoctoral Fellowship2016Acute Kidney Injury

    Collapse Teaching 

    Collapse Research 
    Collapse research overview
    Long-term interest of my laboratory is to understand molecular mechanisms responsible for cold storage (CS)-induced renal damage. My research focuses on exploring novel mechanisms by which CS alters protein quality and renal function after transplantation, and importantly, to identify a possible therapeutic target that could lead to improved renal outcome after transplantation. Specifically, I plan to investigate the roles of proteasome, heat shock proteins and complement pathway during CS plus transplantation. We have established a rat kidney transplantation model, which will be fundamental in studying my independent research project on CS mediated renal damage. In addition, I’m also collaborating with Dr. MacMillan-Crow to study the molecular mechanisms that disrupt mitochondrial dynamics during renal CS and transplantation using our rat kidney transplant model.

    https://www.archildrens.org/research/researchers-at-acri/nirmala-parajuli-phd

    https://pharmtox.uams.edu/faculty/primary-faculty/nirmala-parajuli-ph-d/

    Collapse research activities and funding
    1R01DK123246     (PARAJULI, NIRMALA)Mar 15, 2021 - Jan 31, 2026
    NIH/NIDDK
    Targeting heat shock protein 72 to improve renal function after transplantation
    Role Description: The goal of this project is to test the hypothesis that cold storage-mediated activation of HSF1 and p38MAPK pathways mediate the upregulation of Hsp72 and phosphorylation of Rpt6, leading to proteasome dysfunction and injury after transplantation.
    Role: Select
    19TPA34850057     (PARAJULI, NIRMALA)Jul 1, 2019 - Jun 30, 2022
    American Heart Association
    Targeting renal immunoproteasome during cold storage to improve transplant-associated cardiovascular health - Continuation
    Role Description: The goal of this study is to establish ROS-immunoproteasome-Hsc70 axis as a novel therapeutic target during cold-storage plus transplantation.
    Role: Principal Investigator
    ACRI # 039056     (PARAJULI, NIRMALA)Jul 1, 2019 - Jun 30, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#039056     (PARAJULI, NIRMALA)Jul 1, 2019 - Jun 30, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI # 039052     (PARAJULI, NIRMALA)Apr 1, 2019 - Mar 31, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#039052     (PARAJULI, NIRMALA)Apr 1, 2019 - Mar 31, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI # 037119     (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI #037119     (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#037119     (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI # 039038     (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2019
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#039038     (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2019
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    Barton Award 17-DN-08     (PARAJULI, NIRMALA)Jun 6, 2017 - Jun 6, 2018
    UAMS College of Medicine
    Novel role of immunoproteaseome during renal cold storage and transplantation
    Role: Principal Investigator
    BartonAward17-DN     (PARAJULI, NIRMALA)Jun 6, 2017 - Jun 6, 2018
    UAMS College of Medicine
    Novel role of immunoproteaseome during renal cold storage and transplantation
    Role: Principal Investigator
    16DG27600026     (PARAJULI, NIRMALA)Jul 1, 2016 - Apr 30, 2018
    American Heart Association
    Ubiquitin Proteasome System, Mitochondria, and Renal Cold Storage - Continuation
    Role Description: The goal of this study is to determine the role of proteasome activity to mitochondrial/renal dysfunction during cold-storage plus transplantation.
    Role: Principal Investigator
    R01GM106419     (MACMILLAN-CROW, LEE A)Feb 1, 2014 - Jan 31, 2020
    NIH
    Mitochondrial injury and repair in sepsis-induced acute kidney injury
    Role: Co-Investigator
    R01DK078936     (MACMILLAN-CROW, LEE A)Jan 16, 2009 - Nov 30, 2015
    NIH
    Manganese Superoxide Dismutase and Renal Ischemia/Reperfusion
    Role: Co-Investigator

    Collapse Outreach 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
    List All   |   Timeline
    1. Bhattarai D, Lee SO, MacMillan-Crow LA, Parajuli N. Normal Proteasome Function Is Needed to Prevent Kidney Graft Injury during Cold Storage Followed by Transplantation. Int J Mol Sci. 2024 Feb 10; 25(4). PMID: 38396827.
      View in: PubMed
    2. Bhattarai D, Lee SO, Joshi N, Jun SR, Lo S, Jiang L, Gokden N, Parajuli N. Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function. Kidney360. 2024 Feb 02; (0). PMID: 38303110.
      View in: PubMed
    3. McGraw M, Miller D, Lo S, Parajuli N. Cold Storage Followed by Transplantation Induces Interferon-Gamma and STAT-1 in Kidney Grafts. Int J Mol Sci. 2023 Mar 13; 24(6). PMID: 36982554.
      View in: PubMed
    4. Lo S, Jiang L, Stacks S, Lin H, Parajuli N. Aberrant activation of the complement system in renal grafts is mediated by cold storage. Am J Physiol Renal Physiol. 2021 06 01; 320(6):F1174-F1190. PMID: 33998295.
      View in: PubMed
    5. Shrum S, Tobacyk J, Lo S, Parajuli N, MacMillan-Crow LA. The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury. Arch Biochem Biophys. 2020 07 30; 688:108410. PMID: 32446891.
      View in: PubMed
    6. Lo SB, Blaszak RT, Parajuli N. Targeting Mitochondria during Cold Storage to Maintain Proteasome Function and Improve Renal Outcome after Transplantation. Int J Mol Sci. 2020 May 15; 21(10). PMID: 32429129.
      View in: PubMed
    7. Gnaiger E, ....Palmeira C, Parajuli N, Passos JF, et al. (Mitochondrial Task Group) . Mitochondrial Physiology. Bioenergetics Communication 2020.1. 2020.
      View Publication
    8. Lo S, Byrum SD, Tackett AJ, Parajuli N. Cold Storage Increases Albumin and Advanced Glycation-End Product-Albumin Levels in Kidney Transplants: A Possible Cause for Exacerbated Renal Damage. Transplant Direct. 2019 Jun; 5(6):e454. PMID: 31723591.
      View in: PubMed
    9. Parajuli N. A Cycle of Altered Proteasome and Reactive Oxygen Species Production in Renal Proximal Tubular Cells. Toxicol Forensic Med. 2019; 4(1):13-17. PMID: 32149269.
      View in: PubMed
    10. Tobacyk J, Parajuli N, Shrum S, Crow JP, MacMillan-Crow LA. The first direct activity assay for the mitochondrial protease OMA1. Mitochondrion. 2019 05; 46:1-5. PMID: 30926535.
      View in: PubMed
    11. Lo S, MacMillan-Crow LA, Parajuli N. Renal cold storage followed by transplantation impairs proteasome function and mitochondrial protein homeostasis. Am J Physiol Renal Physiol. 2019 01 01; 316(1):F42-F53. PMID: 30303714.
      View in: PubMed
    12. Parajuli N, Shrum S, Tobacyk J, Harb A, Arthur JM, MacMillan-Crow LA. Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLoS One. 2017; 12(10):e0185542. PMID: 28977005.
      View in: PubMed
    13. Singh P, Parajuli N, Mayeux PR, MacMillan-Crow LA. Renal Mitochondrial Lipid Peroxidation during Sepsis. J Kidney. 2016 Feb; 2(1). PMID: 27104220.
      View in: PubMed
    14. Shrum S, MacMillan-Crow LA, Parajuli N. Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation. J Kidney. 2016 Feb; 2(1). PMID: 27066594.
      View in: PubMed
    15. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Alg?l H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, B?nhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolom? A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, B?dard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, B?nard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, B?ckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouch? M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, B?tikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ce?a V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    16. Patil NK, Parajuli N, MacMillan-Crow LA, Mayeux PR. Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. Am J Physiol Renal Physiol. 2014 Apr 01; 306(7):F734-43. PMID: 24500690.
      View in: PubMed
    17. Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W. Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1. J Leukoc Biol. 2014 Jun; 95(6):853-66. PMID: 24295829.
      View in: PubMed
    18. Hannesd?ttir L, Tymoszuk P, Parajuli N, Wasmer MH, Philipp S, Daschil N, Datta S, Koller JB, Tripp CH, Stoitzner P, M?ller-Holzner E, Wiegers GJ, Sexl V, Villunger A, Doppler W. Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur J Immunol. 2013 Oct; 43(10):2718-29. PMID: 23843024.
      View in: PubMed
    19. Marecki JC, Parajuli N, Crow JP, MacMillan-Crow LA. The use of the Cre/loxP system to study oxidative stress in tissue-specific manganese superoxide dismutase knockout models. Antioxid Redox Signal. 2014 Apr 01; 20(10):1655-70. PMID: 23641945.
      View in: PubMed
    20. Parajuli N, MacMillan-Crow LA. Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis? Am J Physiol Renal Physiol. 2013 Feb 01; 304(3):F257-67. PMID: 23195678.
      View in: PubMed
    21. Parajuli N, Campbell LH, Marine A, Brockbank KG, Macmillan-Crow LA. MitoQ blunts mitochondrial and renal damage during cold preservation of porcine kidneys. PLoS One. 2012; 7(11):e48590. PMID: 23139796.
      View in: PubMed
    22. Parajuli N, Marine A, Simmons S, Saba H, Mitchell T, Shimizu T, Shirasawa T, Macmillan-Crow LA. Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse. Free Radic Biol Med. 2011 Jul 15; 51(2):406-16. PMID: 21571061.
      View in: PubMed
    23. Mitchell T, Saba H, Laakman J, Parajuli N, MacMillan-Crow LA. Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury. Free Radic Biol Med. 2010 Nov 01; 49(8):1273-82. PMID: 20659553.
      View in: PubMed
    24. Parajuli N, M?ller-Holzner E, B?ck G, Werner ER, Villunger A, Doppler W. Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice. Int J Cancer. 2010 Feb 15; 126(4):896-908. PMID: 19653277.
      View in: PubMed
    25. Parajuli N, Doppler W. Precision-cut slice cultures of tumors from MMTV-neu mice for the study of the ex vivo response to cytokines and cytotoxic drugs. In Vitro Cell Dev Biol Anim. 2009 Sep; 45(8):442-50. PMID: 19533258.
      View in: PubMed
    26. Song JH, Kim JI, Kwon HJ, Shim DH, Parajuli N, Cuburu N, Czerkinsky C, Kweon MN. CCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination. J Immunol. 2009 Jun 01; 182(11):6851-60. PMID: 19454681.
      View in: PubMed
    27. Haffner MC, Jurgeit A, Berlato C, Geley S, Parajuli N, Yoshimura A, Doppler W. Interaction and functional interference of glucocorticoid receptor and SOCS1. J Biol Chem. 2008 Aug 08; 283(32):22089-96. PMID: 18524780.
      View in: PubMed
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