Nirmala Parajuli
Title | Associate Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Pharmacology & Toxicology, College of Medicine |
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Address | 118 Biomedical Research I 325 S. Elm St. Mail Slot # 611 Little Rock AR 72205
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Phone | 501-686-5290 |
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ORCID
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vCard | Download vCard |
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Title | Associate Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Pharmacology and Toxicology, College of Medicine |
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Overview My primary research priority is to identify strategies to enhance the viability of kidneys during prolonged cold storage in order to ensure the long-term survival of renal transplants. My research focuses on exploring novel mechanisms by which cold storage alters protein quality and renal function after transplantation, and importantly, to identify a possible therapeutic target that could lead to improved renal outcomes after transplantation. Specifically, my laboratory investigates the roles of the proteasome, heat shock proteins, and the complement pathway during cold storage followed by transplantation using rat models.
Affiliation Nepal Veterinary Association
Biography Director of Graduate Pharmacology and Therapeutics (PHAR 51073)
Member of Graduate Council, UAMS
Member of Institutional Animal Care and Use Committee, UAMS
Innsbruck Medical University, Innsbruck, Austria | PhD | 2009 | Molecular Cell Biology and Oncology | Seoul National University, Seol, Korea | MS | 2005 | Veterinary Immunology | Tribuwan University, Rampur, Nepal | BVSc & AH (equivalent to DVM) | 2001 | Veterinary Medicine | University of Arkansas for Medical Sciences, Little Rock, AR, USA | Postdoctoral Fellowship | 2016 | Acute Kidney Injury |
Teaching Lecturer of Graduate Pharmacology and Therapeutics (PCOL 5107), Pharmacology of Immunosuppression, 1 hour/yearLecturer of Scientific Communications and Ethics 4 (PCOL 5120), Vertebrate animals in grant proposal, 1 hour/yearLecturer of Graduate Pharmacology and Therapeutics (PCOL 5107), Drug-drug interactions, 1 hour/yearLecturer of Graduate Pharmacology and Therapeutics (PCOL 5107), Prostaglandins/leukotrienes and NSAIDS, 1 hour/yearLecturer of Graduate Pharmacology and Therapeutics (PCOL 5107), Histamine pharmacology, 1 hour/yearLecturer of Graduate Pharmacology and Therapeutics (PCOL 5107), Histamine pharmacology, 1 hour/yearLecturer of Principles and Methods of Pharmacology and Toxicology, Anesthesia and blood sampling (PCOL 5105 / INTX 5105), 2 hours/yearLecturer of Graduate Principles and Methods of Pharmacology, Renal ischemia and reperfusion, 2 hours/yearLecturer of System Therapeutics (PCOL 6101), Complement Therapeutics, 1 hour/yearLecturer of Principles and Method, Nephrotoxicity, 1 hour/yearSmall Group Leader of Scientific Communication and Ethics 3, Proposal Writing, 7 hours/yearSmall Group Leader of Scientific Communication and Ethics 4, Proposal Writing, 10 hours/yearLecturer of Principles of Pharmacology and Methods (PHAR 51053), Nephrotoxicity, 1 hour/year Research Long-term interest of my laboratory is to understand molecular mechanisms responsible for cold storage (CS)-induced renal damage. My research focuses on exploring novel mechanisms by which CS alters protein quality and renal function after transplantation, and importantly, to identify a possible therapeutic target that could lead to improved renal outcome after transplantation. Specifically, I plan to investigate the roles of proteasome, heat shock proteins and complement pathway during CS plus transplantation. We have established a rat kidney transplantation model, which will be fundamental in studying my independent research project on CS mediated renal damage. In addition, I’m also collaborating with Dr. MacMillan-Crow to study the molecular mechanisms that disrupt mitochondrial dynamics during renal CS and transplantation using our rat kidney transplant model.
https://www.archildrens.org/research/researchers-at-acri/nirmala-parajuli-phd
https://pharmtox.uams.edu/faculty/primary-faculty/nirmala-parajuli-ph-d/
1R01DK123246 (PARAJULI, NIRMALA)Mar 15, 2021 - Jan 31, 2026 NIH/NIDDK Targeting heat shock protein 72 to improve renal function after transplantation Role Description: The goal of this project is to test the hypothesis that cold storage-mediated activation of HSF1 and p38MAPK pathways mediate the upregulation of Hsp72 and phosphorylation of Rpt6, leading to proteasome dysfunction and injury after transplantation. Role: Select |
| 19TPA34850057 (PARAJULI, NIRMALA)Jul 1, 2019 - Jun 30, 2022 American Heart Association Targeting renal immunoproteasome during cold storage to improve transplant-associated cardiovascular health - Continuation Role Description: The goal of this study is to establish ROS-immunoproteasome-Hsc70 axis as a novel therapeutic target during cold-storage plus transplantation. Role: Principal Investigator |
| ACRI # 039056 (PARAJULI, NIRMALA)Jul 1, 2019 - Jun 30, 2020 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| ACRI#039056 (PARAJULI, NIRMALA)Jul 1, 2019 - Jun 30, 2020 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| ACRI # 039052 (PARAJULI, NIRMALA)Apr 1, 2019 - Mar 31, 2020 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| ACRI#039052 (PARAJULI, NIRMALA)Apr 1, 2019 - Mar 31, 2020 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| ACRI # 037119 (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2021 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| ACRI #037119 (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2021 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| ACRI#037119 (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2021 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| ACRI # 039038 (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2019 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| ACRI#039038 (PARAJULI, NIRMALA)May 1, 2018 - Jun 30, 2019 UAMS ACHRI Flow Through No FP attached Role: Principal Investigator |
| Barton Award 17-DN-08 (PARAJULI, NIRMALA)Jun 6, 2017 - Jun 6, 2018 UAMS College of Medicine Novel role of immunoproteaseome during renal cold storage and transplantation Role: Principal Investigator |
| BartonAward17-DN (PARAJULI, NIRMALA)Jun 6, 2017 - Jun 6, 2018 UAMS College of Medicine Novel role of immunoproteaseome during renal cold storage and transplantation Role: Principal Investigator |
| 16DG27600026 (PARAJULI, NIRMALA)Jul 1, 2016 - Apr 30, 2018 American Heart Association Ubiquitin Proteasome System, Mitochondria, and Renal Cold Storage - Continuation Role Description: The goal of this study is to determine the role of proteasome activity to mitochondrial/renal dysfunction during cold-storage plus transplantation. Role: Principal Investigator |
| R01GM106419 (MACMILLAN-CROW, LEE A)Feb 1, 2014 - Jan 31, 2020 NIH Mitochondrial injury and repair in sepsis-induced acute kidney injury Role: Co-Investigator |
| R01DK078936 (MACMILLAN-CROW, LEE A)Jan 16, 2009 - Nov 30, 2015 NIH Manganese Superoxide Dismutase and Renal Ischemia/Reperfusion Role: Co-Investigator |
Outreach Scientific Journals (Peer Reviewed)Scientific Abstract Reviewer of Kidney Week 2022, American Society of NephrologyAd hoc Reviewer, Tyrolean Science Fund, AustriaAd hoc Reviewer, NIH/NIDDK KUFD, SEP R01 ApplicationsAd hoc Reviewer, American Heart Association CDA ApplicationsAd hoc Reviewer, NIH/NIDDK DPPS KUFD, R03/R21/R01 ApplicationsAd hoc Reviewer, NIH Urology/Nephrology SBIR/STTR Special Emphasis Panel ZRG1 DKUS-B (11) BPeer Reviewer, American Heart Association, Molecular Signaling and Cell Transport Fellowship Study SectionPeer Reviewer, DoD-RTRP, Graft Rejection-Tissue Preservation Study SectionAd hoc Reviewer (Out-of-State), Ohio Cancer ResearchAd hoc Reviewer, Marion B. Lyon New Scientist Development Award, Arkansas Children’s Research Institute Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Sharma A, Jun SR, Bhattarai D, Panday S, Venugopal G, Panawan O, Washam C, Mackintosh S, Byrum S, Udaondo Z, Arthur JM, MacMillan-Crow LA, Parajuli N. Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants. Transplantation. 2025 05 01; 109(5):806-822. PMID: 39716351.
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Bhattarai D, Lee SO, MacMillan-Crow LA, Parajuli N. Normal Proteasome Function Is Needed to Prevent Kidney Graft Injury during Cold Storage Followed by Transplantation. Int J Mol Sci. 2024 Feb 10; 25(4). PMID: 38396827.
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Bhattarai D, Lee SO, Joshi N, Jun SR, Lo S, Jiang L, Gokden N, Parajuli N. Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function. Kidney360. 2024 May 01; 5(5):743-752. PMID: 38303110.
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McGraw M, Miller D, Lo S, Parajuli N. Cold Storage Followed by Transplantation Induces Interferon-Gamma and STAT-1 in Kidney Grafts. Int J Mol Sci. 2023 Mar 13; 24(6). PMID: 36982554.
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Shrum S, Tobacyk J, Lo S, Parajuli N, MacMillan-Crow LA. The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury. Arch Biochem Biophys. 2020 07 30; 688:108410. PMID: 32446891.
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Lo SB, Blaszak RT, Parajuli N. Targeting Mitochondria during Cold Storage to Maintain Proteasome Function and Improve Renal Outcome after Transplantation. Int J Mol Sci. 2020 May 15; 21(10). PMID: 32429129.
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Gnaiger E, ....Palmeira C, Parajuli N, Passos JF, et al. (Mitochondrial Task Group) . Mitochondrial Physiology. Bioenergetics Communication 2020.1. 2020.
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Parajuli N. A Cycle of Altered Proteasome and Reactive Oxygen Species Production in Renal Proximal Tubular Cells. Toxicol Forensic Med. 2019; 4(1):13-17. PMID: 32149269.
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Tobacyk J, Parajuli N, Shrum S, Crow JP, MacMillan-Crow LA. The first direct activity assay for the mitochondrial protease OMA1. Mitochondrion. 2019 05; 46:1-5. PMID: 30926535.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 31723591.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 30303714.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 26799652.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 18524780.
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Parajuli N, Shrum S, Tobacyk J, Harb A, Arthur JM, MacMillan-Crow LA. Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLoS One. 2017; 12(10):e0185542. PMID: 28977005.
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Singh P, Parajuli N, Mayeux PR, MacMillan-Crow LA. Renal Mitochondrial Lipid Peroxidation during Sepsis. J Kidney. 2016 Feb; 2(1). PMID: 27104220.
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Shrum S, MacMillan-Crow LA, Parajuli N. Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation. J Kidney. 2016 Feb; 2(1). PMID: 27066594.
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Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W. Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1. J Leukoc Biol. 2014 Jun; 95(6):853-66. PMID: 24295829.
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Hannesd?ttir L, Tymoszuk P, Parajuli N, Wasmer MH, Philipp S, Daschil N, Datta S, Koller JB, Tripp CH, Stoitzner P, M?ller-Holzner E, Wiegers GJ, Sexl V, Villunger A, Doppler W. Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur J Immunol. 2013 Oct; 43(10):2718-29. PMID: 23843024.
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Marecki JC, Parajuli N, Crow JP, MacMillan-Crow LA. The use of the Cre/loxP system to study oxidative stress in tissue-specific manganese superoxide dismutase knockout models. Antioxid Redox Signal. 2014 Apr 01; 20(10):1655-70. PMID: 23641945.
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Parajuli N, Campbell LH, Marine A, Brockbank KG, Macmillan-Crow LA. MitoQ blunts mitochondrial and renal damage during cold preservation of porcine kidneys. PLoS One. 2012; 7(11):e48590. PMID: 23139796.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 24500690.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 23195678.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 33998295.
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Parajuli N, Marine A, Simmons S, Saba H, Mitchell T, Shimizu T, Shirasawa T, Macmillan-Crow LA. Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse. Free Radic Biol Med. 2011 Jul 15; 51(2):406-16. PMID: 21571061.
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Mitchell T, Saba H, Laakman J, Parajuli N, MacMillan-Crow LA. Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury. Free Radic Biol Med. 2010 Nov 01; 49(8):1273-82. PMID: 20659553.
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Parajuli N, M?ller-Holzner E, B?ck G, Werner ER, Villunger A, Doppler W. Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice. Int J Cancer. 2010 Feb 15; 126(4):896-908. PMID: 19653277.
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Parajuli N, Doppler W. Precision-cut slice cultures of tumors from MMTV-neu mice for the study of the ex vivo response to cytokines and cytotoxic drugs. In Vitro Cell Dev Biol Anim. 2009 Sep; 45(8):442-50. PMID: 19533258.
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Song JH, Kim JI, Kwon HJ, Shim DH, Parajuli N, Cuburu N, Czerkinsky C, Kweon MN. CCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination. J Immunol. 2009 Jun 01; 182(11):6851-60. PMID: 19454681.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2009 | 2 | 2010 | 2 | 2011 | 4 | 2012 | 1 | 2013 | 3 | 2016 | 2 | 2017 | 1 | 2018 | 4 | 2019 | 2 | 2020 | 3 | 2023 | 1 | 2024 | 2 | 2025 | 1 |
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